Osimertinib (mesylate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Osimertinib (mesylate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.164035
PTMA prothymosin, alpha 0.116146
TMSB4X thymosin beta 4, X-linked 0.089944
TMSB10 thymosin beta 10 0.0569988
EEF2 eukaryotic translation elongation factor 2 0.0493372
FTL ferritin, light polypeptide 0.042612
XPO1 exportin 1 0.033735
RPL35A ribosomal protein L35a 0.0328462
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0326366
DDIT4 DNA-damage-inducible transcript 4 0.025999
ZFP36L1 ZFP36 ring finger protein-like 1 0.0251455
PCBP2 poly(rC) binding protein 2 0.0246781
PLIN2 perilipin 2 0.0238113
RPS3 ribosomal protein S3 0.0237522
GARS1 glycyl-tRNA synthetase 1 0.0233135
RACK1 receptor for activated C kinase 1 0.0232691
YBX1 Y box binding protein 1 0.0228839
ENO2 enolase 2 (gamma, neuronal) 0.02051
EIF1 eukaryotic translation initiation factor 1 0.020094
RPL23 ribosomal protein L23 0.0200647
HILPDA hypoxia inducible lipid droplet-associated 0.0190931
ARRDC3 arrestin domain containing 3 0.0185024
SFTPA2 surfactant protein A2 0.0181551
VIM vimentin 0.0173836
RPL12 ribosomal protein L12 0.016813
RPL37A ribosomal protein L37a 0.0166842
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0164299
LGALS3 lectin, galactoside-binding, soluble, 3 0.0159334
VEGFA vascular endothelial growth factor A 0.0159217
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0158928
PCDH1 protocadherin 1 0.0151409
RPS12 ribosomal protein S12 0.0149822
RPL36 ribosomal protein L36 0.0144972
HDGF hepatoma-derived growth factor 0.0138806
RPS19 ribosomal protein S19 0.0138041
TPI1 triosephosphate isomerase 1 0.0135251
CALR calreticulin 0.0134807
TXNIP thioredoxin interacting protein 0.0131522
RPS14 ribosomal protein S14 0.0131244
RPS7 ribosomal protein S7 0.0128216
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0127519
ATF4 activating transcription factor 4 0.0119156
B2M beta-2-microglobulin 0.0116749
RPS8 ribosomal protein S8 0.0115711
RPS27A ribosomal protein S27a 0.0114722
SZRD1 SUZ RNA binding domain containing 1 0.0111989
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0110968
FDPS farnesyl diphosphate synthase 0.010883
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0108122
SRRM2 serine/arginine repetitive matrix 2 0.010764
ADM adrenomedullin 0.0106832
PTMS parathymosin 0.0106812
SREBF1 sterol regulatory element binding transcription factor 1 0.0105678
RPL26 ribosomal protein L26 0.010544
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0102444
PABPN1 poly(A) binding protein, nuclear 1 0.0102222
SET SET nuclear proto-oncogene 0.0100715
AHDC1 AT hook, DNA binding motif, containing 1 0.0100324
RPS26 ribosomal protein S26 0.00998642
DOCK6 dedicator of cytokinesis 6 0.00990319
AHNAK2 AHNAK nucleoprotein 2 0.00983936
RPS27 ribosomal protein S27 0.00974222
LGALS1 lectin, galactoside-binding, soluble, 1 0.00963932
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.00958354
RPS3A ribosomal protein S3A 0.00949974
RPS17 ribosomal protein S17 0.00925971
RAB6A RAB6A, member RAS oncogene family 0.00916908
GPX4 glutathione peroxidase 4 0.0091526
WSB1 WD repeat and SOCS box containing 1 0.00912151
RPL18 ribosomal protein L18 0.00911998
PREPL prolyl endopeptidase-like 0.00904225
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00902061
RPL27 ribosomal protein L27 0.00894518
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00887702
BHLHE40 basic helix-loop-helix family, member e40 0.00872361
CIB1 calcium and integrin binding 1 (calmyrin) 0.00855482
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00839835
TRIP10 thyroid hormone receptor interactor 10 0.00838401
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.00821613
ZFP36 ZFP36 ring finger protein 0.00804786
OGA O-GlcNAcase 0.00794654
HMGB2 high mobility group box 2 0.00790592
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00788243
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.00775045
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.007691
NFE2L1 nuclear factor, erythroid 2-like 1 0.00762731
EIF5 eukaryotic translation initiation factor 5 0.0076085
RPL11 ribosomal protein L11 0.00759544
CLIC1 chloride intracellular channel 1 0.00757011
SLK STE20-like kinase 0.00747802
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.00737404
RPL37 ribosomal protein L37 0.00736382
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.00731027
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0072809
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.00726862
RPL35 ribosomal protein L35 0.00723345
RNF145 ring finger protein 145 0.00723313
SDF4 stromal cell derived factor 4 0.00711089
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00704806
CAMLG calcium modulating ligand 0.00701052

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.344651
PSD3 pleckstrin and Sec7 domain containing 3 -0.18327
TM4SF1 transmembrane 4 L six family member 1 -0.143104
TXNRD1 thioredoxin reductase 1 -0.140293
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.107388
CD44 CD44 molecule (Indian blood group) -0.104112
DST dystonin -0.094238
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0904055
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0834291
TP63 tumor protein p63 -0.0827723
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0790073
WWTR1 WW domain containing transcription regulator 1 -0.0788746
USP34 ubiquitin specific peptidase 34 -0.0738778
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0722612
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0719174
BCAR3 breast cancer anti-estrogen resistance 3 -0.0712381
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0683059
RUNX1 runt-related transcription factor 1 -0.0645229
GCLM glutamate-cysteine ligase, modifier subunit -0.0630561
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0625159
CAPRIN2 caprin family member 2 -0.0614724
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0610489
TRIO trio Rho guanine nucleotide exchange factor -0.0584317
MT2A metallothionein 2A -0.0557165
CMIP c-Maf inducing protein -0.0552554
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0544238
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0536287
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0518492
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0517105
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0515694
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0506148
JMJD1C jumonji domain containing 1C -0.0504567
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0493705
FMNL2 formin-like 2 -0.0474807
EHBP1 EH domain binding protein 1 -0.0471936
MACF1 microtubule-actin crosslinking factor 1 -0.0469295
NPAS2 neuronal PAS domain protein 2 -0.0464143
EZR ezrin -0.0449967
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0447685
KMT2E lysine (K)-specific methyltransferase 2E -0.0437632
ZMYND8 zinc finger, MYND-type containing 8 -0.0433215
ZEB1 zinc finger E-box binding homeobox 1 -0.0425022
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.042393
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0416945
EMP1 epithelial membrane protein 1 -0.0416489
DPYD dihydropyrimidine dehydrogenase -0.0416428
ARHGAP5 Rho GTPase activating protein 5 -0.0413681
ACTG1 actin gamma 1 -0.0406897
SLC38A2 solute carrier family 38, member 2 -0.0404891
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0401309
LOC112694756 uncharaterized LOC112694756 -0.0390306
SDCCAG8 serologically defined colon cancer antigen 8 -0.0386534
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0386508
ADGRG6 adhesion G protein-coupled receptor G6 -0.038126
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0377717
ZFAND3 zinc finger, AN1-type domain 3 -0.0377056
SMYD3 SET and MYND domain containing 3 -0.0371041
PDE10A phosphodiesterase 10A -0.0365577
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0364266
APP amyloid beta (A4) precursor protein -0.0363601
FBXO11 F-box protein 11 -0.0360864
ZBTB38 zinc finger and BTB domain containing 38 -0.0360789
PTK2 protein tyrosine kinase 2 -0.0356832
RTN4 reticulon 4 -0.0353761
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0352296
RIGI RNA sensor RIG-I -0.0352133
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0349936
AHNAK AHNAK nucleoprotein -0.0346949
SPAG9 sperm associated antigen 9 -0.0341201
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0340754
FAF1 Fas (TNFRSF6) associated factor 1 -0.0340176
BIRC2 baculoviral IAP repeat containing 2 -0.0331211
TPT1 tumor protein, translationally-controlled 1 -0.0328634
MT1E metallothionein 1E -0.0327967
BMERB1 bMERB domain containing 1 -0.0322916
NCEH1 neutral cholesterol ester hydrolase 1 -0.0321931
SPRY4 sprouty homolog 4 (Drosophila) -0.0321121
TAS2R14 taste receptor, type 2, member 14 -0.0318114
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0317607
WNK1 WNK lysine deficient protein kinase 1 -0.0317475
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0313924
BIRC3 baculoviral IAP repeat containing 3 -0.0312279
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0311928
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0310412
TRIP12 thyroid hormone receptor interactor 12 -0.0310385
BIRC6 baculoviral IAP repeat containing 6 -0.0308377
KTN1 kinectin 1 (kinesin receptor) -0.0308284
SMAD3 SMAD family member 3 -0.0307834
TSC22D1 TSC22 domain family, member 1 -0.030767
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.030502
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.030231
USP12 ubiquitin specific peptidase 12 -0.0297306
BPTF bromodomain PHD finger transcription factor -0.0297227
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0296539
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0295449
CSNK1A1 casein kinase 1, alpha 1 -0.0293049
LOXL2 lysyl oxidase-like 2 -0.0292991
VMP1 vacuole membrane protein 1 -0.0291771
TAOK1 TAO kinase 1 -0.0289619
VCL vinculin -0.0289154