| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0935206 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0897223 |
| SPAG9 | sperm associated antigen 9 | 0.0778475 |
| FAM13A | family with sequence similarity 13, member A | 0.0690234 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0601265 |
| LAMB3 | laminin, beta 3 | 0.0555032 |
| PTMA | prothymosin, alpha | 0.053741 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.051876 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.049355 |
| TOP1 | topoisomerase (DNA) I | 0.0489579 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0483583 |
| RPS3 | ribosomal protein S3 | 0.0430825 |
| ARRDC3 | arrestin domain containing 3 | 0.0426695 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0425095 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0405019 |
| H1-0 | H1.0 linker histone | 0.040453 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0399531 |
| RUNX1 | runt-related transcription factor 1 | 0.0396652 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0395618 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0388663 |
| HELZ | helicase with zinc finger | 0.0388256 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0386665 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0385305 |
| PGK1 | phosphoglycerate kinase 1 | 0.0380716 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0375212 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0368692 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0367448 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0359352 |
| RNF145 | ring finger protein 145 | 0.0356563 |
| UVRAG | UV radiation resistance associated | 0.0353624 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0352059 |
| PDE8A | phosphodiesterase 8A | 0.0341861 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0341093 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0339817 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0333867 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0322301 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0318309 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0308542 |
| MT2A | metallothionein 2A | 0.0307547 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0306138 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0303038 |
| SEC61G | Sec61 gamma subunit | 0.0296572 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0288242 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.028605 |
| MATR3 | matrin 3 | 0.0286021 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0284077 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0272867 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0271109 |
| NPTN | neuroplastin | 0.0267837 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0265432 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0264946 |
| ZNF292 | zinc finger protein 292 | 0.0263853 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0262229 |
| WDR45B | WD repeat domain 45B | 0.0258226 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0257343 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0257341 |
| RBM39 | RNA binding motif protein 39 | 0.0255842 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0255168 |
| NUP58 | nucleoporin 58 | 0.0255097 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0252167 |
| TPD52 | tumor protein D52 | 0.0250868 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0249861 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0248415 |
| RPS12 | ribosomal protein S12 | 0.0244983 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0243751 |
| PCBP2 | poly(rC) binding protein 2 | 0.02433 |
| SMAD3 | SMAD family member 3 | 0.0242633 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0242406 |
| TMEM165 | transmembrane protein 165 | 0.0242034 |
| RPL35A | ribosomal protein L35a | 0.0241107 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0236497 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0236041 |
| HBP1 | HMG-box transcription factor 1 | 0.0235238 |
| DTNA | dystrobrevin, alpha | 0.0231134 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0229876 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0229246 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0229067 |
| ATF4 | activating transcription factor 4 | 0.0228971 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0228723 |
| ATP13A3 | ATPase type 13A3 | 0.0226906 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0225235 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.022399 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0223815 |
| RLF | rearranged L-myc fusion | 0.0223243 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0221724 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0220375 |
| ANXA2 | annexin A2 | 0.0219132 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0216289 |
| FTL | ferritin, light polypeptide | 0.0215585 |
| MYOF | myoferlin | 0.0215269 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0214782 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0213776 |
| CCNL1 | cyclin L1 | 0.0213067 |
| NGLY1 | N-glycanase 1 | 0.0212978 |
| RPS8 | ribosomal protein S8 | 0.0211764 |
| B2M | beta-2-microglobulin | 0.0210546 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0210346 |
| RPL37A | ribosomal protein L37a | 0.021034 |
| JMJD1C | jumonji domain containing 1C | 0.0210225 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0209684 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.191815 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121125 |
| TXNRD1 | thioredoxin reductase 1 | -0.077913 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0744672 |
| ASPH | aspartate beta-hydroxylase | -0.0714608 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0481739 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0453148 |
| SCEL | sciellin | -0.0362103 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0356265 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0330036 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0329994 |
| ACTG1 | actin gamma 1 | -0.0319848 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0316953 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0311407 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0303227 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0300952 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0297425 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0292946 |
| OSMR | oncostatin M receptor | -0.0291429 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.02846 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0278545 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0256602 |
| EFNA5 | ephrin-A5 | -0.0253294 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0251223 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0244807 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0234697 |
| FOXP1 | forkhead box P1 | -0.0219918 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0208519 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0208175 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0206613 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0205998 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0203278 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0203169 |
| LMO7 | LIM domain 7 | -0.0190952 |
| CUX1 | cut-like homeobox 1 | -0.0188185 |
| MGAT4C | MGAT4 family, member C | -0.0187646 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0185623 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0184525 |
| EGR1 | early growth response 1 | -0.018227 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0176853 |
| SMYD3 | SET and MYND domain containing 3 | -0.0172488 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0170536 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0167105 |
| TNS3 | tensin 3 | -0.0166372 |
| CCND1 | cyclin D1 | -0.0165824 |
| EHBP1 | EH domain binding protein 1 | -0.0164732 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0162511 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0161847 |
| CMIP | c-Maf inducing protein | -0.0159564 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0158502 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0152662 |
| RIN2 | Ras and Rab interactor 2 | -0.0152517 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0149426 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0147965 |
| NDRG1 | N-myc downstream regulated 1 | -0.0144465 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.014363 |
| ZNF609 | zinc finger protein 609 | -0.0139049 |
| POTEF | POTE ankyrin domain family, member F | -0.0138832 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0138461 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0138424 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0137459 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0137235 |
| SUMF1 | sulfatase modifying factor 1 | -0.0136597 |
| PKM | pyruvate kinase, muscle | -0.0132948 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0132371 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0126607 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0125987 |
| EXOC4 | exocyst complex component 4 | -0.012281 |
| CAV2 | caveolin 2 | -0.0122679 |
| S100A10 | S100 calcium binding protein A10 | -0.0122395 |
| KRT7 | keratin 7, type II | -0.0121795 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0121495 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0121325 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0120279 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0119939 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0119706 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0118018 |
| EXOC6B | exocyst complex component 6B | -0.0117796 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0116238 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0115894 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0112981 |
| KRT8 | keratin 8, type II | -0.0112736 |
| RAD51B | RAD51 paralog B | -0.0111241 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0110798 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0110533 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0109345 |
| TAOK3 | TAO kinase 3 | -0.0108682 |
| HMGA1 | high mobility group AT-hook 1 | -0.0107041 |
| SH3D19 | SH3 domain containing 19 | -0.0106604 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0106379 |
| BPTF | bromodomain PHD finger transcription factor | -0.0106194 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0105341 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0105018 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0104506 |
| DSG2 | desmoglein 2 | -0.0104242 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0103815 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0102542 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0101954 |
| PRKCA | protein kinase C, alpha | -0.0101329 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0101178 |
