| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.153908 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.140274 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.112792 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0755845 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0714508 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0637616 |
| GOLGA4 | golgin A4 | 0.0627419 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0596909 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0524982 |
| PCBP2 | poly(rC) binding protein 2 | 0.0514278 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0503968 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.049726 |
| DSCAM | Down syndrome cell adhesion molecule | 0.047096 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0453154 |
| TMSB4X | thymosin beta 4, X-linked | 0.0437183 |
| SMAD3 | SMAD family member 3 | 0.0436132 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0435681 |
| VEGFA | vascular endothelial growth factor A | 0.0425279 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0424784 |
| ATP13A3 | ATPase type 13A3 | 0.0422065 |
| RBM39 | RNA binding motif protein 39 | 0.0412039 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0392041 |
| FAM20C | family with sequence similarity 20, member C | 0.0391467 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0382236 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0381342 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0369509 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0350444 |
| RPS2 | ribosomal protein S2 | 0.0349795 |
| RNF145 | ring finger protein 145 | 0.0347924 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.034383 |
| FAM107B | family with sequence similarity 107, member B | 0.0341842 |
| ADM | adrenomedullin | 0.0339309 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0338336 |
| CCNY | cyclin Y | 0.0337785 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0332998 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0331821 |
| SFTPA2 | surfactant protein A2 | 0.0317966 |
| COPA | coatomer protein complex, subunit alpha | 0.0317663 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0309317 |
| CANX | calnexin | 0.0306193 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0302112 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0297389 |
| APP | amyloid beta (A4) precursor protein | 0.0296288 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0289536 |
| FAM13A | family with sequence similarity 13, member A | 0.0287364 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0282145 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0281254 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0279148 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0268379 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0267141 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0266428 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0266216 |
| KIF5B | kinesin family member 5B | 0.0265926 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0265228 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0264394 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0261806 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0259093 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.025776 |
| YEATS2 | YEATS domain containing 2 | 0.0254174 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0246936 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0246397 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0245531 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0244761 |
| CEP250 | centrosomal protein 250kDa | 0.0239955 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0229346 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0228119 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0227996 |
| BRD2 | bromodomain containing 2 | 0.0227154 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0226892 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0226789 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0224155 |
| RPS3 | ribosomal protein S3 | 0.0223982 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.022021 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0218681 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0218613 |
| GOLGA3 | golgin A3 | 0.0218119 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.021689 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0213173 |
| SUN1 | Sad1 and UNC84 domain containing 1 | 0.0212551 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0210034 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0209341 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0207246 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0206926 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0206506 |
| RPL3 | ribosomal protein L3 | 0.0204685 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0204496 |
| LAMB3 | laminin, beta 3 | 0.0203535 |
| SPAG9 | sperm associated antigen 9 | 0.0202266 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0201335 |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 | 0.0200622 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0200397 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0199767 |
| MEMO1 | mediator of cell motility 1 | 0.0199424 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0198124 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.019709 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0196796 |
| WDR43 | WD repeat domain 43 | 0.0196764 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0194877 |
| ATF4 | activating transcription factor 4 | 0.019373 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0191847 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.454585 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.145395 |
| VIM | vimentin | -0.106629 |
| FTL | ferritin, light polypeptide | -0.0985359 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0822726 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0795894 |
| GPC6 | glypican 6 | -0.0764896 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0762931 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.072403 |
| HMGA1 | high mobility group AT-hook 1 | -0.0722221 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0655705 |
| NDRG1 | N-myc downstream regulated 1 | -0.0642814 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0640304 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0623538 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0609879 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0589955 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0581095 |
| CDCP1 | CUB domain containing protein 1 | -0.058036 |
| NRP1 | neuropilin 1 | -0.055561 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0553791 |
| HMGA2 | high mobility group AT-hook 2 | -0.0522203 |
| MT2A | metallothionein 2A | -0.0515748 |
| MAP1B | microtubule-associated protein 1B | -0.0496152 |
| FN1 | fibronectin 1 | -0.0495536 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0494809 |
| TMSB10 | thymosin beta 10 | -0.0450456 |
| POTEF | POTE ankyrin domain family, member F | -0.0443281 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0441609 |
| EGR1 | early growth response 1 | -0.0440323 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0423389 |
| PKM | pyruvate kinase, muscle | -0.0418761 |
| NRG1 | neuregulin 1 | -0.0415187 |
| ASPH | aspartate beta-hydroxylase | -0.0409809 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0401535 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0394686 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0388648 |
| RPS6 | ribosomal protein S6 | -0.0388632 |
| IER3 | immediate early response 3 | -0.0386363 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0380196 |
| RAD51B | RAD51 paralog B | -0.0377391 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0373956 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0370543 |
| SYT1 | synaptotagmin I | -0.0369058 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0361742 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.035388 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0352879 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0349608 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0347847 |
| RPL34 | ribosomal protein L34 | -0.0346443 |
| CCNI | cyclin I | -0.0345081 |
| ATXN1 | ataxin 1 | -0.0345075 |
| DST | dystonin | -0.0343159 |
| RPLP0 | ribosomal protein, large, P0 | -0.0340062 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0335014 |
| UBC | ubiquitin C | -0.0334116 |
| S100A10 | S100 calcium binding protein A10 | -0.0326617 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0324634 |
| USP34 | ubiquitin specific peptidase 34 | -0.0320269 |
| IL6ST | interleukin 6 signal transducer | -0.0320141 |
| RPS25 | ribosomal protein S25 | -0.0312354 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0311938 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0311787 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0308956 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0308078 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0307624 |
| CA12 | carbonic anhydrase XII | -0.0301514 |
| PTK2 | protein tyrosine kinase 2 | -0.0301456 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0300812 |
| TXNRD1 | thioredoxin reductase 1 | -0.0298827 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0298132 |
| TMEM123 | transmembrane protein 123 | -0.0297651 |
| RPS24 | ribosomal protein S24 | -0.0296646 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0295391 |
| TMEM263 | transmembrane protein 263 | -0.0294894 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0292128 |
| JMJD1C | jumonji domain containing 1C | -0.0289338 |
| CUX1 | cut-like homeobox 1 | -0.0288672 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0282175 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0281685 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.027983 |
| S100A6 | S100 calcium binding protein A6 | -0.0279804 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0273812 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0273026 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0272145 |
| CD44 | CD44 molecule (Indian blood group) | -0.0269484 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0269006 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0268382 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0267517 |
| PFN1 | profilin 1 | -0.0266257 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0266037 |
| RGS17 | regulator of G-protein signaling 17 | -0.0264883 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0264293 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.026176 |
| GNAS | GNAS complex locus | -0.02612 |
| RPS23 | ribosomal protein S23 | -0.0260762 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0260451 |
| RPL28 | ribosomal protein L28 | -0.0258741 |
| RPS21 | ribosomal protein S21 | -0.0257389 |
| TCF12 | transcription factor 12 | -0.025241 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0252265 |
