| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.145183 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0910076 |
| VIM | vimentin | 0.0888339 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0875788 |
| TXNRD1 | thioredoxin reductase 1 | 0.0642691 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.059442 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0590869 |
| FGB | fibrinogen beta chain | 0.0575588 |
| IGF2 | insulin-like growth factor 2 | 0.0570398 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0521879 |
| TPM3 | tropomyosin 3 | 0.0517219 |
| ENO1 | enolase 1, (alpha) | 0.0471873 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0427725 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0421684 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0392327 |
| LDHA | lactate dehydrogenase A | 0.0372256 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0367763 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0360456 |
| CANX | calnexin | 0.0357141 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0350261 |
| TPM4 | tropomyosin 4 | 0.034849 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0345764 |
| HDAC9 | histone deacetylase 9 | 0.0340658 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0336903 |
| OSMR | oncostatin M receptor | 0.032914 |
| PYGL | phosphorylase, glycogen, liver | 0.0328026 |
| ANXA2 | annexin A2 | 0.0323454 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0320789 |
| CALR | calreticulin | 0.031801 |
| ANGPTL4 | angiopoietin-like 4 | 0.0306116 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0303485 |
| FAM107B | family with sequence similarity 107, member B | 0.0291502 |
| S100A6 | S100 calcium binding protein A6 | 0.0285045 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.028322 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0282666 |
| HLA-E | major histocompatibility complex, class I, E | 0.0275353 |
| HDGF | hepatoma-derived growth factor | 0.0269713 |
| STC1 | stanniocalcin 1 | 0.0268193 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0253749 |
| FDPS | farnesyl diphosphate synthase | 0.025303 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0252377 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0249666 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0248733 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0248226 |
| HLA-B | major histocompatibility complex, class I, B | 0.0246801 |
| CALU | calumenin | 0.024601 |
| PTMA | prothymosin, alpha | 0.0244242 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0233921 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0229766 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.022944 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0226319 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0224656 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0221999 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.022176 |
| MKI67 | marker of proliferation Ki-67 | 0.0220494 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0219014 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.021757 |
| CLTC | clathrin, heavy chain (Hc) | 0.0212424 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0212385 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0210437 |
| FAM168A | family with sequence similarity 168, member A | 0.0209685 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.020872 |
| GRAMD1B | GRAM domain containing 1B | 0.0203631 |
| PGK1 | phosphoglycerate kinase 1 | 0.0199536 |
| FGA | fibrinogen alpha chain | 0.0195176 |
| IL6 | interleukin 6 | 0.0194064 |
| LAMB1 | laminin, beta 1 | 0.0193414 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0193214 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.018992 |
| KIF5B | kinesin family member 5B | 0.0185728 |
| RBM8A | RNA binding motif protein 8A | 0.0185107 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0183414 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0183072 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.0177695 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0175757 |
| MCL1 | myeloid cell leukemia 1 | 0.01755 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0174491 |
| SVIL | supervillin | 0.0173031 |
| CLU | clusterin | 0.017131 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0171277 |
| HM13 | histocompatibility (minor) 13 | 0.0170857 |
| NTN4 | netrin 4 | 0.0170329 |
| APP | amyloid beta (A4) precursor protein | 0.0169853 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0169849 |
| MYO19 | myosin XIX | 0.0169238 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0168343 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0168021 |
| PLS3 | plastin 3 | 0.0167883 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0167605 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0167362 |
| B2M | beta-2-microglobulin | 0.0167325 |
| RPS7 | ribosomal protein S7 | 0.0166982 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.016652 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0166278 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0166234 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0165218 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0164951 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.016457 |
| SET | SET nuclear proto-oncogene | 0.0162242 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0162205 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.158478 |
| FTL | ferritin, light polypeptide | -0.155374 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.111312 |
| PARD3 | par-3 family cell polarity regulator | -0.0974074 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0796109 |
| RPLP1 | ribosomal protein, large, P1 | -0.0748491 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0709731 |
| RPL23 | ribosomal protein L23 | -0.0674729 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0651514 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0649135 |
| RPL19 | ribosomal protein L19 | -0.0632561 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0627784 |
| RPS19 | ribosomal protein S19 | -0.0580961 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0518687 |
| RPS21 | ribosomal protein S21 | -0.0498473 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0446601 |
| DST | dystonin | -0.0413097 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0368232 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0362172 |
| RBM39 | RNA binding motif protein 39 | -0.0349944 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0346224 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0346058 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0341021 |
| RPS5 | ribosomal protein S5 | -0.0337913 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0336653 |
| RPL36 | ribosomal protein L36 | -0.0329691 |
| PFN1 | profilin 1 | -0.032478 |
| USP34 | ubiquitin specific peptidase 34 | -0.0322498 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0319209 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0315182 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0312805 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0309777 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0304808 |
| RPL8 | ribosomal protein L8 | -0.0296597 |
| RBM25 | RNA binding motif protein 25 | -0.0296532 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0290403 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0289018 |
| PTK2 | protein tyrosine kinase 2 | -0.0284828 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0279979 |
| RPS29 | ribosomal protein S29 | -0.0276464 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0274894 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0274566 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0268363 |
| RASAL2 | RAS protein activator like 2 | -0.0264649 |
| ZNF207 | zinc finger protein 207 | -0.0261706 |
| RPS23 | ribosomal protein S23 | -0.0259261 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0258994 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0257554 |
| ACTG1 | actin gamma 1 | -0.0253411 |
| ZNF292 | zinc finger protein 292 | -0.0253382 |
| RPL7 | ribosomal protein L7 | -0.0252049 |
| RAD51B | RAD51 paralog B | -0.0251654 |
| ANKRD11 | ankyrin repeat domain 11 | -0.025091 |
| HMGB1 | high mobility group box 1 | -0.0249618 |
| RPL32 | ribosomal protein L32 | -0.0246122 |
| NOP58 | NOP58 ribonucleoprotein | -0.0244641 |
| RPL18 | ribosomal protein L18 | -0.0238868 |
| GNAS | GNAS complex locus | -0.0238407 |
| RPS20 | ribosomal protein S20 | -0.023737 |
| CMIP | c-Maf inducing protein | -0.0236498 |
| USP3 | ubiquitin specific peptidase 3 | -0.0236103 |
| NPR2 | natriuretic peptide receptor 2 | -0.0235632 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0235531 |
| CTBP2 | C-terminal binding protein 2 | -0.0234196 |
| RPS16 | ribosomal protein S16 | -0.0233053 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0230915 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0230512 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0228406 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0226078 |
| RPL28 | ribosomal protein L28 | -0.0223627 |
| PRR16 | proline rich 16 | -0.0223513 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0219974 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0219833 |
| NRG1 | neuregulin 1 | -0.0217394 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0217123 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0216335 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0215623 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0213239 |
| SIK3 | SIK family kinase 3 | -0.0211638 |
| EXOC6B | exocyst complex component 6B | -0.0211592 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0209765 |
| RPL34 | ribosomal protein L34 | -0.0207753 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0206556 |
| NHSL1 | NHS-like 1 | -0.0205902 |
| MED13 | mediator complex subunit 13 | -0.0205447 |
| QKI | QKI, KH domain containing, RNA binding | -0.0203789 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.0203253 |
| FOXO3 | forkhead box O3 | -0.0203203 |
| RPS8 | ribosomal protein S8 | -0.0202488 |
| FAM168B | family with sequence similarity 168, member B | -0.0199745 |
| PHIP | pleckstrin homology domain interacting protein | -0.0196629 |
| RPL35A | ribosomal protein L35a | -0.0195608 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0193169 |
| RPL12 | ribosomal protein L12 | -0.0192885 |
| NEK7 | NIMA-related kinase 7 | -0.0192476 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0191736 |
| TLK1 | tousled-like kinase 1 | -0.0191347 |
| KLF6 | Kruppel-like factor 6 | -0.0189256 |
| FMNL2 | formin-like 2 | -0.0187376 |
| HMGA1 | high mobility group AT-hook 1 | -0.0187375 |
