Osimertinib (mesylate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.150646
PTMA prothymosin, alpha 0.0922151
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0900386
NAMPT nicotinamide phosphoribosyltransferase 0.0735576
TRIO trio Rho guanine nucleotide exchange factor 0.0675301
MATR3 matrin 3 0.0673634
RPS6 ribosomal protein S6 0.0616503
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0611113
ZNF292 zinc finger protein 292 0.0609008
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0599527
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0594909
RNF145 ring finger protein 145 0.0581237
RBM39 RNA binding motif protein 39 0.0562052
RPL37A ribosomal protein L37a 0.0552303
PICALM phosphatidylinositol binding clathrin assembly protein 0.0548658
PNISR PNN-interacting serine/arginine-rich protein 0.0538039
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0512923
KRT17 keratin 17, type I 0.0505842
EEF2 eukaryotic translation elongation factor 2 0.0494123
NKD1 naked cuticle homolog 1 (Drosophila) 0.048923
KDM3A lysine (K)-specific demethylase 3A 0.0481975
RPL31 ribosomal protein L31 0.0476309
SEPTIN7 septin 7 0.0473294
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0467964
PCBP2 poly(rC) binding protein 2 0.0466705
VIM vimentin 0.0464383
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0457221
IGFBP3 insulin-like growth factor binding protein 3 0.0456066
FTL ferritin, light polypeptide 0.045093
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0438384
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0422968
FMNL2 formin-like 2 0.0414477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0410244
NDRG1 N-myc downstream regulated 1 0.0403379
EIF1 eukaryotic translation initiation factor 1 0.0402323
RAB2A RAB2A, member RAS oncogene family 0.0401606
GOLGA4 golgin A4 0.0399998
PRRC2C proline-rich coiled-coil 2C 0.0393426
TJP1 tight junction protein 1 0.038418
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0379194
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0373434
LCORL ligand dependent nuclear receptor corepressor-like 0.0364628
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0363554
TRA2A transformer 2 alpha homolog (Drosophila) 0.0363545
CHD1 chromodomain helicase DNA binding protein 1 0.0357033
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0354865
RSAD2 radical S-adenosyl methionine domain containing 2 0.0352777
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0351957
GARS1 glycyl-tRNA synthetase 1 0.0348241
KTN1 kinectin 1 (kinesin receptor) 0.0346366
FNDC3B fibronectin type III domain containing 3B 0.0344459
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0339193
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0336371
DLG1 discs, large homolog 1 (Drosophila) 0.0332647
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0325332
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0313327
TMSB10 thymosin beta 10 0.0306695
LAMB3 laminin, beta 3 0.0289858
USP3 ubiquitin specific peptidase 3 0.027693
RPS27A ribosomal protein S27a 0.0275644
RICTOR RPTOR independent companion of MTOR, complex 2 0.0261897
COPA coatomer protein complex, subunit alpha 0.0252223
LIMCH1 LIM and calponin homology domains 1 0.0251675
PUM2 pumilio RNA-binding family member 2 0.0247368
RPLP2 ribosomal protein, large, P2 0.0241579
SETD5 SET domain containing 5 0.0240453
RAB6A RAB6A, member RAS oncogene family 0.0235333
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0234491
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0233443
MAML3 mastermind-like 3 (Drosophila) 0.0232689
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0211637
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0201684
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0200117
B2M beta-2-microglobulin 0.0199959
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0198514
PDE4D phosphodiesterase 4D, cAMP-specific 0.0185066
ERRFI1 ERBB receptor feedback inhibitor 1 0.0184643
QKI QKI, KH domain containing, RNA binding 0.0184267
FXR1 fragile X mental retardation, autosomal homolog 1 0.0182983
RPLP1 ribosomal protein, large, P1 0.0179953
RTN4 reticulon 4 0.0177522
NOP58 NOP58 ribonucleoprotein 0.0175344
CANX calnexin 0.0173144
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0172197
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0172025
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0171762
SPAG9 sperm associated antigen 9 0.0164467
NAP1L1 nucleosome assembly protein 1-like 1 0.0164323
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0162489
RPS3 ribosomal protein S3 0.0161351
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0156254
ANKRD11 ankyrin repeat domain 11 0.0155946
ZFAND3 zinc finger, AN1-type domain 3 0.0155132
WSB1 WD repeat and SOCS box containing 1 0.0150707
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0138398
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0136709
RPS12 ribosomal protein S12 0.013366
RPS19 ribosomal protein S19 0.0131534
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0130532
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0115857

decreased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator -0.202063
LMO7 LIM domain 7 -0.104791
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.101614
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.100419
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0912874
DPYD dihydropyrimidine dehydrogenase -0.0898445
INHBA inhibin, beta A -0.0824838
NALF1 NALCN channel auxiliary factor 1 -0.080097
OSMR oncostatin M receptor -0.0755813
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0679644
CD44 CD44 molecule (Indian blood group) -0.0662732
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0627969
ATOSA atos homolog A -0.0627034
ASPH aspartate beta-hydroxylase -0.0593113
BACE2 beta-site APP-cleaving enzyme 2 -0.058308
PRKCA protein kinase C, alpha -0.0576463
TTC3 tetratricopeptide repeat domain 3 -0.0570016
TMEM165 transmembrane protein 165 -0.0562492
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0545902
AK1 adenylate kinase 1 -0.0517186
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0496642
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0493574
AKAP13 A kinase (PRKA) anchor protein 13 -0.0488073
MBNL2 muscleblind-like splicing regulator 2 -0.0463616
FAF1 Fas (TNFRSF6) associated factor 1 -0.0460214
PKM pyruvate kinase, muscle -0.0457955
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0457316
RUNX1 runt-related transcription factor 1 -0.0455436
ANXA2 annexin A2 -0.0432688
RPL19 ribosomal protein L19 -0.0424123
ARHGAP12 Rho GTPase activating protein 12 -0.0411992
MT2A metallothionein 2A -0.0411676
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.041019
RPS21 ribosomal protein S21 -0.0407454
SAMD4A sterile alpha motif domain containing 4A -0.0403879
SMYD3 SET and MYND domain containing 3 -0.0403088
COL6A3 collagen, type VI, alpha 3 -0.0399437
TOP1 topoisomerase (DNA) I -0.0392382
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0368743
ESYT2 extended synaptotagmin-like protein 2 -0.0365374
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0362126
KMT2C lysine (K)-specific methyltransferase 2C -0.033332
MARCHF6 membrane associated ring-CH-type finger 6 -0.0318569
ENO1 enolase 1, (alpha) -0.0310433
VCL vinculin -0.0307894
S100A9 S100 calcium binding protein A9 -0.0302465
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0299416
GNAS GNAS complex locus -0.0298409
DSCAM Down syndrome cell adhesion molecule -0.0297796
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0292891
UBE2H ubiquitin-conjugating enzyme E2H -0.0285326
EGFR epidermal growth factor receptor -0.0284485
MACF1 microtubule-actin crosslinking factor 1 -0.0278933
CALU calumenin -0.0278424
STC1 stanniocalcin 1 -0.0269019
NF1 neurofibromin 1 -0.0266147
USP34 ubiquitin specific peptidase 34 -0.0264963
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0253461
DST dystonin -0.0248596
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0239096
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0236466
PTPRM protein tyrosine phosphatase, receptor type, M -0.0236149
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0231549
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0224601
RAD51B RAD51 paralog B -0.022003
PSD3 pleckstrin and Sec7 domain containing 3 -0.0197905
MBNL1 muscleblind-like splicing regulator 1 -0.0197837
RPL35A ribosomal protein L35a -0.0186544
RIGI RNA sensor RIG-I -0.0181286
TM4SF1 transmembrane 4 L six family member 1 -0.0179025
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.017077
FN1 fibronectin 1 -0.0166555
JMJD1C jumonji domain containing 1C -0.0166137
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0159121
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0154105
PGK1 phosphoglycerate kinase 1 -0.0154055
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0154018
IGF1R insulin-like growth factor 1 receptor -0.0150021
BIRC6 baculoviral IAP repeat containing 6 -0.0143638
CEMIP cell migration inducing protein, hyaluronan binding -0.0143566
LAMC2 laminin, gamma 2 -0.0143514
TPT1 tumor protein, translationally-controlled 1 -0.0142792
SRPK2 SRSF protein kinase 2 -0.0141319
NCOR1 nuclear receptor corepressor 1 -0.0129335
NIPBL Nipped-B homolog (Drosophila) -0.0122049
AKAP9 A kinase (PRKA) anchor protein 9 -0.00967638
SBF2 SET binding factor 2 -0.00897529
FNDC3A fibronectin type III domain containing 3A -0.00891004
SEPTIN9 septin 9 -0.00709485
KMT2E lysine (K)-specific methyltransferase 2E -0.00707517
FBXO11 F-box protein 11 -0.0068457
MCL1 myeloid cell leukemia 1 -0.00670172
ZBTB20 zinc finger and BTB domain containing 20 -0.00662237
MYH9 myosin, heavy chain 9, non-muscle -0.00659463
SVIL supervillin -0.0065514
SLK STE20-like kinase -0.00652766
MXD1 MAX dimerization protein 1 -0.00642801
TXNRD1 thioredoxin reductase 1 -0.00628349
PRELID2 PRELI domain containing 2 -0.00522721
ANTXR2 anthrax toxin receptor 2 -0.00489791