Osimertinib (mesylate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.202604
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.118625
EEF2 eukaryotic translation elongation factor 2 0.116605
ERRFI1 ERBB receptor feedback inhibitor 1 0.099499
GRAMD1B GRAM domain containing 1B 0.062953
TPM3 tropomyosin 3 0.0596435
KTN1 kinectin 1 (kinesin receptor) 0.0595456
PCBP2 poly(rC) binding protein 2 0.0553402
YBX3 Y box binding protein 3 0.0533674
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0526661
MYH9 myosin, heavy chain 9, non-muscle 0.0495412
SRRM2 serine/arginine repetitive matrix 2 0.0480538
BRD2 bromodomain containing 2 0.04342
TLN1 talin 1 0.0406054
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0394341
SFPQ splicing factor proline/glutamine-rich 0.0375011
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.037278
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0362907
MKI67 marker of proliferation Ki-67 0.0358255
SET SET nuclear proto-oncogene 0.0357771
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0349276
DOCK5 dedicator of cytokinesis 5 0.0336932
RPL3 ribosomal protein L3 0.0328097
MCL1 myeloid cell leukemia 1 0.0317129
ANKRD36 ankyrin repeat domain 36 0.0311753
MACF1 microtubule-actin crosslinking factor 1 0.0299566
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0298515
FTH1 ferritin, heavy polypeptide 1 0.0297748
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0295838
KDM2A lysine (K)-specific demethylase 2A 0.0291462
DCAF8 DDB1 and CUL4 associated factor 8 0.0290333
HDGF hepatoma-derived growth factor 0.0282654
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.027154
ZNF638 zinc finger protein 638 0.0270567
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0261248
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0258235
CCDC200 coiled-coil domain containing 200 0.0256022
EIF4B eukaryotic translation initiation factor 4B 0.0255022
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0254084
MSN moesin 0.0252203
WDR43 WD repeat domain 43 0.0250666
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0243758
RPS3 ribosomal protein S3 0.0241974
NIPBL Nipped-B homolog (Drosophila) 0.0237928
ELL2 elongation factor, RNA polymerase II, 2 0.023773
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0233167
ANO6 anoctamin 6 0.0232169
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0231643
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0230042
ANKRD36B ankyrin repeat domain 36B 0.0228749
CSNK1A1 casein kinase 1, alpha 1 0.022797
RPS7 ribosomal protein S7 0.0225729
TPI1 triosephosphate isomerase 1 0.0222929
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.0221412
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0220381
SRRM1 serine/arginine repetitive matrix 1 0.0216197
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0216119
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0214578
PNN pinin, desmosome associated protein 0.0211175
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0210663
ACTN1 actinin, alpha 1 0.0209767
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0205038
SAMD4A sterile alpha motif domain containing 4A 0.0203926
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0202678
RRM2 ribonucleotide reductase M2 0.0202314
RPS2 ribosomal protein S2 0.0201398
FLNA filamin A, alpha 0.0198338
MARCHF4 membrane associated ring-CH-type finger 4 0.0198063
CSDE1 cold shock domain containing E1, RNA-binding 0.0196626
NCAPD2 non-SMC condensin I complex, subunit D2 0.0195005
USP9X ubiquitin specific peptidase 9, X-linked 0.01948
NCAPG2 non-SMC condensin II complex, subunit G2 0.0190167
PRPF8 pre-mRNA processing factor 8 0.0188991
CEP250 centrosomal protein 250kDa 0.0188658
SFTPA2 surfactant protein A2 0.0185189
PTMS parathymosin 0.0184821
TOP2B topoisomerase (DNA) II beta 180kDa 0.0182559
COPA coatomer protein complex, subunit alpha 0.0181361
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0179957
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0176915
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0175739
ATP11A ATPase, class VI, type 11A 0.0175072
TRIP12 thyroid hormone receptor interactor 12 0.0174078
THRAP3 thyroid hormone receptor associated protein 3 0.0173582
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0173493
MSH6 mutS homolog 6 0.0172557
R3HDM2 R3H domain containing 2 0.0172219
UBAP2L ubiquitin associated protein 2-like 0.0169046
THSD4 thrombospondin, type I, domain containing 4 0.0169037
PLEC plectin 0.0168971
NBR1 neighbor of BRCA1 gene 1 0.0167191
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0166657
LRP6 low density lipoprotein receptor-related protein 6 0.0164768
HSPA8 heat shock 70kDa protein 8 0.0161724
RPS18 ribosomal protein S18 0.0161599
ATXN2 ataxin 2 0.016115
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.016053
PRKCE protein kinase C, epsilon 0.0160196
NFE2L1 nuclear factor, erythroid 2-like 1 0.0158252
TCIM transcriptional and immune response regulator 0.0158153

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.507443
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0982255
TPT1 tumor protein, translationally-controlled 1 -0.0689337
TMSB10 thymosin beta 10 -0.0656741
PTMA prothymosin, alpha -0.0651934
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0621405
RPLP0 ribosomal protein, large, P0 -0.0509259
RPS21 ribosomal protein S21 -0.0482653
GNAS GNAS complex locus -0.0464225
RPLP1 ribosomal protein, large, P1 -0.0443499
VIM vimentin -0.0443488
RPS8 ribosomal protein S8 -0.0427221
ACTG1 actin gamma 1 -0.041634
RPS15 ribosomal protein S15 -0.0413398
KPNB1 karyopherin (importin) beta 1 -0.0397365
RPS29 ribosomal protein S29 -0.0389649
RPL12 ribosomal protein L12 -0.0384048
RPL35A ribosomal protein L35a -0.0381098
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0364584
RPL34 ribosomal protein L34 -0.0353565
MYL12B myosin, light chain 12B, regulatory -0.0350831
RPL23 ribosomal protein L23 -0.0327892
RPS24 ribosomal protein S24 -0.0323058
RPL19 ribosomal protein L19 -0.03202
RPL32 ribosomal protein L32 -0.0314598
RPL8 ribosomal protein L8 -0.0311555
S100A10 S100 calcium binding protein A10 -0.0302837
TFPI2 tissue factor pathway inhibitor 2 -0.0300708
CCND2 cyclin D2 -0.02974
RPS6 ribosomal protein S6 -0.029636
PDE4D phosphodiesterase 4D, cAMP-specific -0.0295577
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0282116
NCOA7 nuclear receptor coactivator 7 -0.0268069
RPL38 ribosomal protein L38 -0.0266991
GPHN gephyrin -0.0266848
HMGA1 high mobility group AT-hook 1 -0.0264238
TUBA1B tubulin, alpha 1b -0.0262093
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0252468
TUBB tubulin, beta class I -0.0247235
TMEM263 transmembrane protein 263 -0.0246931
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0246138
RPS19 ribosomal protein S19 -0.0230595
UBE2H ubiquitin-conjugating enzyme E2H -0.0230487
RPL5 ribosomal protein L5 -0.0229693
RPS25 ribosomal protein S25 -0.0227065
RPS10 ribosomal protein S10 -0.0224213
DEK DEK proto-oncogene -0.0222569
PCNP PEST proteolytic signal containing nuclear protein -0.022144
ZFR zinc finger RNA binding protein -0.0218442
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0212932
VDAC1 voltage-dependent anion channel 1 -0.0212692
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.021147
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0211178
RPL6 ribosomal protein L6 -0.0209258
FUS FUS RNA binding protein -0.0207795
RPS20 ribosomal protein S20 -0.0206988
GLO1 glyoxalase I -0.0205745
RPLP2 ribosomal protein, large, P2 -0.0201643
TM4SF1 transmembrane 4 L six family member 1 -0.0199949
RPL36 ribosomal protein L36 -0.0198232
NF1 neurofibromin 1 -0.0197856
RAB1A RAB1A, member RAS oncogene family -0.0195366
FTL ferritin, light polypeptide -0.0192832
TAS2R14 taste receptor, type 2, member 14 -0.0191593
ZNFX1 zinc finger, NFX1-type containing 1 -0.0190491
CD2AP CD2-associated protein -0.0185783
LDHB lactate dehydrogenase B -0.0185031
GARS1 glycyl-tRNA synthetase 1 -0.0184763
NPEPPS aminopeptidase puromycin sensitive -0.0183788
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0180779
H1-0 H1.0 linker histone -0.0180322
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0179459
TMEM123 transmembrane protein 123 -0.0178426
RPS23 ribosomal protein S23 -0.0178057
RPS16 ribosomal protein S16 -0.0177373
OLA1 Obg-like ATPase 1 -0.0176317
SLC38A2 solute carrier family 38, member 2 -0.0173822
FOXN2 forkhead box N2 -0.0173214
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0172419
RPL37 ribosomal protein L37 -0.017239
RPL36A ribosomal protein L36a -0.0172193
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0171264
MARCHF6 membrane associated ring-CH-type finger 6 -0.0170411
PFN1 profilin 1 -0.016879
KLF6 Kruppel-like factor 6 -0.0168595
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0166487
RPL31 ribosomal protein L31 -0.0166115
RAD21 RAD21 homolog (S. pombe) -0.0165722
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.01656
TMEM131 transmembrane protein 131 -0.016429
AHNAK AHNAK nucleoprotein -0.0162748
WASF2 WAS protein family, member 2 -0.0162489
RPS5 ribosomal protein S5 -0.0162324
S100A6 S100 calcium binding protein A6 -0.0161604
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0161218
FNDC3B fibronectin type III domain containing 3B -0.0160852
HDLBP high density lipoprotein binding protein -0.0160771
SRPK1 SRSF protein kinase 1 -0.0160526
RPS11 ribosomal protein S11 -0.0158575
CBX3 chromobox homolog 3 -0.0158389