| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.15236 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.147007 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.124594 |
| NDRG1 | N-myc downstream regulated 1 | 0.11029 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.100185 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0981669 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0973122 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0841596 |
| LAMB3 | laminin, beta 3 | 0.078164 |
| PCBP2 | poly(rC) binding protein 2 | 0.0681207 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0649779 |
| VEGFA | vascular endothelial growth factor A | 0.064336 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0634982 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0617522 |
| MSN | moesin | 0.0597361 |
| TPM3 | tropomyosin 3 | 0.059387 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0584872 |
| CTSB | cathepsin B | 0.0565313 |
| CALR | calreticulin | 0.0553906 |
| DSPP | dentin sialophosphoprotein | 0.0541627 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.054068 |
| FN1 | fibronectin 1 | 0.052671 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0522709 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0514092 |
| CANX | calnexin | 0.0505306 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.050456 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0483152 |
| LAMC2 | laminin, gamma 2 | 0.0475066 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0458684 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0450508 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0443941 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0432886 |
| CCNL1 | cyclin L1 | 0.0395416 |
| BRD2 | bromodomain containing 2 | 0.0385552 |
| ARRDC3 | arrestin domain containing 3 | 0.0382377 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0379393 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0367133 |
| LDHA | lactate dehydrogenase A | 0.0363761 |
| MKI67 | marker of proliferation Ki-67 | 0.0362316 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0354338 |
| FLNA | filamin A, alpha | 0.0345946 |
| HDGF | hepatoma-derived growth factor | 0.0336874 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0328989 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0325155 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0324495 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0317159 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0313238 |
| PLEC | plectin | 0.0312188 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.030258 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0300592 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0299181 |
| NUP58 | nucleoporin 58 | 0.0298313 |
| RPL3 | ribosomal protein L3 | 0.0296975 |
| ANXA5 | annexin A5 | 0.0295034 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0291847 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0288535 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.028693 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0286751 |
| EZR | ezrin | 0.027173 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0270531 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0270262 |
| RCOR1 | REST corepressor 1 | 0.026458 |
| SET | SET nuclear proto-oncogene | 0.0261484 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0261443 |
| RPS3A | ribosomal protein S3A | 0.0257857 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0256848 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0256029 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0252664 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0252212 |
| PNN | pinin, desmosome associated protein | 0.0251876 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.025057 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0250212 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0249134 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0247988 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0246802 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0243556 |
| PCM1 | pericentriolar material 1 | 0.0240938 |
| SPAG5 | sperm associated antigen 5 | 0.0239522 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0236858 |
| ATP13A3 | ATPase type 13A3 | 0.0233442 |
| RNF145 | ring finger protein 145 | 0.0233064 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0232336 |
| CCNY | cyclin Y | 0.022919 |
| CLDN4 | claudin 4 | 0.0227845 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0226388 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0223378 |
| TPX2 | TPX2, microtubule-associated | 0.0222206 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0221424 |
| TMSB4X | thymosin beta 4, X-linked | 0.0218789 |
| RBM39 | RNA binding motif protein 39 | 0.0215923 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0212576 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0212552 |
| ANXA1 | annexin A1 | 0.0208312 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0206159 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0206157 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0203762 |
| MCL1 | myeloid cell leukemia 1 | 0.0201152 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0200376 |
| RBM25 | RNA binding motif protein 25 | 0.0197795 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0197556 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.280848 |
| ACTG1 | actin gamma 1 | -0.173712 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.126442 |
| TMSB10 | thymosin beta 10 | -0.110591 |
| FTL | ferritin, light polypeptide | -0.107288 |
| S100A6 | S100 calcium binding protein A6 | -0.10199 |
| PTMA | prothymosin, alpha | -0.0880204 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0827938 |
| RPL34 | ribosomal protein L34 | -0.0812012 |
| S100A10 | S100 calcium binding protein A10 | -0.0776229 |
| LMO7 | LIM domain 7 | -0.0767278 |
| RPLP1 | ribosomal protein, large, P1 | -0.0766551 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0721484 |
| ERBIN | erbb2 interacting protein | -0.0714923 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0642583 |
| GNAS | GNAS complex locus | -0.0636451 |
| RPL35A | ribosomal protein L35a | -0.0632519 |
| RPLP0 | ribosomal protein, large, P0 | -0.0627788 |
| FBXO32 | F-box protein 32 | -0.0601207 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0600045 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0564751 |
| SQSTM1 | sequestosome 1 | -0.0542602 |
| RPL8 | ribosomal protein L8 | -0.0536955 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0535323 |
| CD2AP | CD2-associated protein | -0.0532185 |
| RPS8 | ribosomal protein S8 | -0.0526768 |
| RPL32 | ribosomal protein L32 | -0.0493044 |
| RPS24 | ribosomal protein S24 | -0.0480302 |
| RPL23 | ribosomal protein L23 | -0.0479355 |
| RPS23 | ribosomal protein S23 | -0.0479028 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0475875 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0464056 |
| CCND1 | cyclin D1 | -0.0445368 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0435434 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0426188 |
| RPL19 | ribosomal protein L19 | -0.0418622 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0412047 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0398548 |
| TMEM263 | transmembrane protein 263 | -0.0398445 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.039767 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0391614 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0389431 |
| RPL28 | ribosomal protein L28 | -0.0382057 |
| KRT7 | keratin 7, type II | -0.0377746 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0375832 |
| RPS29 | ribosomal protein S29 | -0.0375111 |
| RPS25 | ribosomal protein S25 | -0.0372643 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0358907 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0357919 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0357234 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0353852 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0351556 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0348707 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0347865 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0345455 |
| POTEF | POTE ankyrin domain family, member F | -0.0343661 |
| RPL27A | ribosomal protein L27a | -0.0343635 |
| RPL30 | ribosomal protein L30 | -0.0339856 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0339632 |
| TMEM123 | transmembrane protein 123 | -0.0339507 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0338777 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0327916 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.032747 |
| CSTB | cystatin B (stefin B) | -0.03248 |
| RPS5 | ribosomal protein S5 | -0.0323903 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0321405 |
| RPS6 | ribosomal protein S6 | -0.0319501 |
| RPS21 | ribosomal protein S21 | -0.0318365 |
| RASAL2 | RAS protein activator like 2 | -0.0318251 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0317151 |
| KRT19 | keratin 19, type I | -0.0306721 |
| CAVIN1 | caveolae associated protein 1 | -0.0305839 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0303524 |
| NF1 | neurofibromin 1 | -0.0302072 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0299718 |
| WASF2 | WAS protein family, member 2 | -0.0296162 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0292663 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0291914 |
| ARF1 | ADP-ribosylation factor 1 | -0.0291279 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0289117 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0283925 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0281663 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0280833 |
| OGA | O-GlcNAcase | -0.0277342 |
| MEF2A | myocyte enhancer factor 2A | -0.0276498 |
| RPS20 | ribosomal protein S20 | -0.0275813 |
| RPL12 | ribosomal protein L12 | -0.0275652 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0274579 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0274524 |
| CD63 | CD63 molecule | -0.0273549 |
| RPL6 | ribosomal protein L6 | -0.0273306 |
| SVIL | supervillin | -0.0272324 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0271785 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.02705 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0268096 |
| RPL9 | ribosomal protein L9 | -0.0267127 |
| CTSD | cathepsin D | -0.0264819 |
| RPL37 | ribosomal protein L37 | -0.0264169 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0263206 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0262311 |
