| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.160564 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.1096 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0916432 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0860929 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0827159 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0812469 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0750897 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0721688 |
| MCL1 | myeloid cell leukemia 1 | 0.0683833 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0670565 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0646225 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0630312 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0598583 |
| CANX | calnexin | 0.0584321 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0575135 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0526277 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0523269 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0517051 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0479914 |
| SPAG9 | sperm associated antigen 9 | 0.0450843 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0419543 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0412301 |
| SFTPA2 | surfactant protein A2 | 0.0409247 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0401776 |
| CTBP2 | C-terminal binding protein 2 | 0.0390217 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0383554 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0364599 |
| KYNU | kynureninase | 0.0362526 |
| FLNB | filamin B, beta | 0.0361794 |
| FN1 | fibronectin 1 | 0.03613 |
| STC1 | stanniocalcin 1 | 0.0347953 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0343099 |
| WDR43 | WD repeat domain 43 | 0.033741 |
| INHBA | inhibin, beta A | 0.0330292 |
| RPS2 | ribosomal protein S2 | 0.0320156 |
| VCL | vinculin | 0.031971 |
| COPA | coatomer protein complex, subunit alpha | 0.0317272 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0312078 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0305516 |
| CD109 | CD109 molecule | 0.0296608 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0294325 |
| MYOF | myoferlin | 0.0290918 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0285725 |
| RPL3 | ribosomal protein L3 | 0.0284822 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0281304 |
| HSPA8 | heat shock 70kDa protein 8 | 0.027749 |
| RNF145 | ring finger protein 145 | 0.0277274 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0276709 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0275191 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0274959 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0270716 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0261418 |
| PCBP2 | poly(rC) binding protein 2 | 0.026024 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0259411 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0258531 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0258404 |
| BMERB1 | bMERB domain containing 1 | 0.0257143 |
| ATP13A3 | ATPase type 13A3 | 0.0256243 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0252699 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0249901 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0248702 |
| TPR | translocated promoter region, nuclear basket protein | 0.0239953 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0239109 |
| CD44 | CD44 molecule (Indian blood group) | 0.0236981 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0236349 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.023474 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0232582 |
| MSN | moesin | 0.0229452 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0227897 |
| FLNA | filamin A, alpha | 0.0227791 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0225467 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0223888 |
| PGK1 | phosphoglycerate kinase 1 | 0.0222844 |
| OXSR1 | oxidative stress responsive 1 | 0.0222138 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0222079 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0221112 |
| RPS7 | ribosomal protein S7 | 0.0220611 |
| BMP6 | bone morphogenetic protein 6 | 0.0220092 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0219077 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0218077 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0215311 |
| PCBP3 | poly(rC) binding protein 3 | 0.0215114 |
| FAT1 | FAT atypical cadherin 1 | 0.0210586 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0209291 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0206606 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0206546 |
| RUNX1 | runt-related transcription factor 1 | 0.0205559 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0205557 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0204962 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0204554 |
| STC2 | stanniocalcin 2 | 0.0203489 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0202881 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0202063 |
| MKI67 | marker of proliferation Ki-67 | 0.0200205 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0199521 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0199433 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0194678 |
| NUP58 | nucleoporin 58 | 0.0194554 |
| MATR3 | matrin 3 | 0.0193521 |
| TMSB4X | thymosin beta 4, X-linked | 0.0192265 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.403412 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.221766 |
| TXNRD1 | thioredoxin reductase 1 | -0.111919 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.107242 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0834082 |
| RPS6 | ribosomal protein S6 | -0.080499 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0773145 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0767842 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0767495 |
| SMYD3 | SET and MYND domain containing 3 | -0.0759191 |
| FTL | ferritin, light polypeptide | -0.073331 |
| VIM | vimentin | -0.073116 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0724471 |
| RPLP0 | ribosomal protein, large, P0 | -0.0705506 |
| RPS24 | ribosomal protein S24 | -0.0694619 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0692959 |
| COL5A2 | collagen, type V, alpha 2 | -0.0647223 |
| RPLP1 | ribosomal protein, large, P1 | -0.0588078 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0560553 |
| RPS23 | ribosomal protein S23 | -0.0545253 |
| ASPH | aspartate beta-hydroxylase | -0.0529849 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0500633 |
| TMSB10 | thymosin beta 10 | -0.0494309 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.046765 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0455786 |
| PTGR1 | prostaglandin reductase 1 | -0.0449819 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0441458 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0439469 |
| NRCAM | neuronal cell adhesion molecule | -0.043205 |
| ACTG1 | actin gamma 1 | -0.0430406 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0409197 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0408048 |
| RPL19 | ribosomal protein L19 | -0.0405484 |
| S100A10 | S100 calcium binding protein A10 | -0.0389645 |
| PRKD3 | protein kinase D3 | -0.0382061 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.035979 |
| GNAS | GNAS complex locus | -0.035959 |
| RPL36A | ribosomal protein L36a | -0.0347902 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0346305 |
| LSAMP | limbic system-associated membrane protein | -0.0343452 |
| RPL34 | ribosomal protein L34 | -0.0343404 |
| RPS21 | ribosomal protein S21 | -0.0342129 |
| RPS8 | ribosomal protein S8 | -0.0341341 |
| RPL9 | ribosomal protein L9 | -0.0339511 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0337873 |
| MAP1B | microtubule-associated protein 1B | -0.0335504 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0328305 |
| JMJD1C | jumonji domain containing 1C | -0.0326324 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0325746 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0320067 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0308417 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0308189 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0307243 |
| SRGN | serglycin | -0.0306973 |
| XPO1 | exportin 1 | -0.0304286 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0303177 |
| RPL35A | ribosomal protein L35a | -0.0301021 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0299234 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0299004 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0298456 |
| TUBA1B | tubulin, alpha 1b | -0.0296834 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0294996 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0293091 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0290465 |
| RPL23 | ribosomal protein L23 | -0.0285613 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.028398 |
| CADM2 | cell adhesion molecule 2 | -0.028289 |
| TNPO1 | transportin 1 | -0.0282652 |
| RPL38 | ribosomal protein L38 | -0.0278093 |
| RPS25 | ribosomal protein S25 | -0.0270939 |
| RTN4 | reticulon 4 | -0.0261878 |
| TBXT | T-box transcription factor T | -0.0257953 |
| RPS15 | ribosomal protein S15 | -0.0256865 |
| RPL7A | ribosomal protein L7a | -0.025678 |
| PFN1 | profilin 1 | -0.0256309 |
| POTEF | POTE ankyrin domain family, member F | -0.025521 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0253025 |
| RPLP2 | ribosomal protein, large, P2 | -0.0251817 |
| KPNB1 | karyopherin (importin) beta 1 | -0.025157 |
| RPS19 | ribosomal protein S19 | -0.0250458 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.025003 |
| RPL32 | ribosomal protein L32 | -0.0249577 |
| PKM | pyruvate kinase, muscle | -0.0249222 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0248683 |
| RPL31 | ribosomal protein L31 | -0.024517 |
| PALLD | palladin, cytoskeletal associated protein | -0.0240287 |
| NDRG1 | N-myc downstream regulated 1 | -0.0236977 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0236309 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0234196 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0234029 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0232307 |
| HLA-B | major histocompatibility complex, class I, B | -0.0231313 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.0229853 |
| RPS29 | ribosomal protein S29 | -0.0228845 |
| RPL39 | ribosomal protein L39 | -0.0228596 |
| PERP | PERP, TP53 apoptosis effector | -0.0226977 |
| GPHN | gephyrin | -0.0223405 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0223163 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0222947 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0221321 |
