Osimertinib (mesylate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

91 genes differentially expressed following the Osimertinib (mesylate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.250557
AKAP12 A kinase (PRKA) anchor protein 12 0.198188
IGFBP3 insulin-like growth factor binding protein 3 0.176801
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.175552
CANX calnexin 0.137229
TMSB10 thymosin beta 10 0.12763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.126902
FN1 fibronectin 1 0.11683
NDRG1 N-myc downstream regulated 1 0.111731
PTMA prothymosin, alpha 0.0911976
PGK1 phosphoglycerate kinase 1 0.0906715
TFG TRK-fused gene 0.0828626
RPL35A ribosomal protein L35a 0.0824681
CDH13 cadherin 13 0.0818286
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0797748
ZBTB20 zinc finger and BTB domain containing 20 0.0789313
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0732487
ITGA6 integrin, alpha 6 0.0712443
PRRC2C proline-rich coiled-coil 2C 0.0711951
RPS16 ribosomal protein S16 0.0689232
MT2A metallothionein 2A 0.0662302
RAB1A RAB1A, member RAS oncogene family 0.0653112
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0611397
SNX9 sorting nexin 9 0.0604862
RPS6 ribosomal protein S6 0.0540948
SRRM2 serine/arginine repetitive matrix 2 0.0533007
AFF4 AF4/FMR2 family, member 4 0.0524966
MATR3 matrin 3 0.0506447
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0501648
RPLP2 ribosomal protein, large, P2 0.0479356
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0452926
ANKRD11 ankyrin repeat domain 11 0.0428389
JMJD1C jumonji domain containing 1C 0.0408736
PCBP2 poly(rC) binding protein 2 0.0371212
FTL ferritin, light polypeptide 0.0354126
PDE4D phosphodiesterase 4D, cAMP-specific 0.0332751
LAMB3 laminin, beta 3 0.0311302
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0301588
RPS8 ribosomal protein S8 0.0275776
RAD51B RAD51 paralog B 0.0275561
BIRC6 baculoviral IAP repeat containing 6 0.0268813
ZFAND3 zinc finger, AN1-type domain 3 0.0256028
ANKRD17 ankyrin repeat domain 17 0.0239592
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0197443
VIM vimentin 0.0185643
DSCAM Down syndrome cell adhesion molecule 0.0169506
NAV2 neuron navigator 2 0.0154338
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0145787
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0117207
PRELID2 PRELI domain containing 2 0.0112426
WASF2 WAS protein family, member 2 0.00888877
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.00702096
B2M beta-2-microglobulin 0.00587324
EZR ezrin 0.00575573
GMDS GDP-mannose 4,6-dehydratase 0.00434367
FNDC3B fibronectin type III domain containing 3B 0.00134805

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.241448
EXT1 exostosin glycosyltransferase 1 -0.207397
VCL vinculin -0.191282
PDE10A phosphodiesterase 10A -0.160573
EFNA5 ephrin-A5 -0.135764
PSD3 pleckstrin and Sec7 domain containing 3 -0.132037
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.103796
HDLBP high density lipoprotein binding protein -0.102394
MAML2 mastermind-like 2 (Drosophila) -0.0994323
LMO7 LIM domain 7 -0.0967264
TPT1 tumor protein, translationally-controlled 1 -0.0949812
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0920886
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0757015
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0640174
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0577057
NKD1 naked cuticle homolog 1 (Drosophila) -0.0439266
GOLGA4 golgin A4 -0.0435396
RPL26 ribosomal protein L26 -0.0427404
MACF1 microtubule-actin crosslinking factor 1 -0.0411275
RBM25 RNA binding motif protein 25 -0.0393652
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0385251
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0346329
ZNF292 zinc finger protein 292 -0.0334214
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0270306
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0207278
STAG2 stromal antigen 2 -0.0126235
TRIO trio Rho guanine nucleotide exchange factor -0.0121824
ASPH aspartate beta-hydroxylase -0.0105056
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00875948
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00838347
CARD16 caspase recruitment domain family, member 16 -0.00751409
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.00696889
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.00183293
RPLP1 ribosomal protein, large, P1 -0.00150274
P4HB prolyl 4-hydroxylase, beta polypeptide -4.90703E-4