Osimertinib (mesylate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.101737
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.101224
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0963421
PCLO piccolo presynaptic cytomatrix protein 0.0508605
TMSB4X thymosin beta 4, X-linked 0.0464611
EEF2 eukaryotic translation elongation factor 2 0.0455744
VIM vimentin 0.0454475
RPL35A ribosomal protein L35a 0.045228
RPS12 ribosomal protein S12 0.0444149
RPL23 ribosomal protein L23 0.0437654
FTH1 ferritin, heavy polypeptide 1 0.0436091
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0376839
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.032435
PA2G4 proliferation-associated 2G4, 38kDa 0.0307524
RPL26 ribosomal protein L26 0.0304965
CNRIP1 cannabinoid receptor interacting protein 1 0.0300975
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0292975
RPL12 ribosomal protein L12 0.0278787
PCBP2 poly(rC) binding protein 2 0.027594
TENM2 teneurin transmembrane protein 2 0.0264728
SFTPA2 surfactant protein A2 0.0261959
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0261445
RPL11 ribosomal protein L11 0.0253638
CDH19 cadherin 19, type 2 0.0252154
NACA nascent polypeptide-associated complex alpha subunit 0.0246616
LRRC4C leucine rich repeat containing 4C 0.0243324
SAMD4A sterile alpha motif domain containing 4A 0.0242049
RPL9 ribosomal protein L9 0.0239585
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0236839
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0231659
PDIA6 protein disulfide isomerase family A, member 6 0.0230528
RPS3 ribosomal protein S3 0.0223995
B2M beta-2-microglobulin 0.0221908
RPL37A ribosomal protein L37a 0.0220369
YBX1 Y box binding protein 1 0.021996
EIF5B eukaryotic translation initiation factor 5B 0.0218474
CTSB cathepsin B 0.0217062
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0214089
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0211381
TMSB10 thymosin beta 10 0.0208247
SSRP1 structure specific recognition protein 1 0.0207762
XPO1 exportin 1 0.0207423
RPS14 ribosomal protein S14 0.0206338
LURAP1L leucine rich adaptor protein 1-like 0.0202643
HMCN1 hemicentin 1 0.0199211
RPS26 ribosomal protein S26 0.0194475
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.019153
APOE apolipoprotein E 0.0191096
RSL1D1 ribosomal L1 domain containing 1 0.0190056
NTM neurotrimin 0.0189976
ATP5F1E ATP synthase F1 subunit epsilon 0.0189884
ADM adrenomedullin 0.0189684
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0184655
RACK1 receptor for activated C kinase 1 0.0183269
DDIT4 DNA-damage-inducible transcript 4 0.0181779
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0181521
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.018105
SRRM2 serine/arginine repetitive matrix 2 0.0179431
XPOT exportin, tRNA 0.0177016
TCEA1 transcription elongation factor A (SII), 1 0.017541
HDGF hepatoma-derived growth factor 0.017294
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0169817
AFAP1 actin filament associated protein 1 0.0168367
ERRFI1 ERBB receptor feedback inhibitor 1 0.0168309
SNX3 sorting nexin 3 0.0167522
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0166785
EIF4B eukaryotic translation initiation factor 4B 0.0166741
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0164933
FILIP1 filamin A interacting protein 1 0.0164596
MYH9 myosin, heavy chain 9, non-muscle 0.0163959
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0162903
CCN2 cellular communication network factor 2 0.0162299
ZFP36 ZFP36 ring finger protein 0.0162017
SREBF1 sterol regulatory element binding transcription factor 1 0.0160844
ARRDC3 arrestin domain containing 3 0.0160161
SEM1 SEM1 26S proteasome subunit 0.0158374
TPM3 tropomyosin 3 0.0157823
SERF2 small EDRK-rich factor 2 0.0157574
TARBP1 TAR (HIV-1) RNA binding protein 1 0.0156847
SCFD1 sec1 family domain containing 1 0.0155315
RPL27 ribosomal protein L27 0.0154434
CHMP5 charged multivesicular body protein 5 0.0154001
CBX3 chromobox homolog 3 0.0153579
ATF4 activating transcription factor 4 0.0151979
CALR calreticulin 0.0151519
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.015076
RAI1 retinoic acid induced 1 0.0149648
SDF4 stromal cell derived factor 4 0.0149254
CALCR calcitonin receptor 0.0148951
RPS8 ribosomal protein S8 0.0147816
MCM3 minichromosome maintenance complex component 3 0.0145984
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.014543
H4C15 H4 clustered histone 15 0.0144803
ZFP36L1 ZFP36 ring finger protein-like 1 0.0144045
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.0143998
SENP1 SUMO1/sentrin specific peptidase 1 0.0143305
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0142978
RPLP2 ribosomal protein, large, P2 0.0142321
DHFR dihydrofolate reductase 0.0141214
PABPN1 poly(A) binding protein, nuclear 1 0.0140387

decreased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 -0.112493
ADGRL2 adhesion G protein-coupled receptor L2 -0.11162
DST dystonin -0.107383
ZNF292 zinc finger protein 292 -0.105939
TSC22D2 TSC22 domain family, member 2 -0.105532
ZFAND3 zinc finger, AN1-type domain 3 -0.100731
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0927078
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0878908
COL5A2 collagen, type V, alpha 2 -0.0850156
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0816095
CDH10 cadherin 10, type 2 (T2-cadherin) -0.081527
CADM2 cell adhesion molecule 2 -0.0768905
SRP54 signal recognition particle 54kDa -0.0745793
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0736812
FOXP2 forkhead box P2 -0.0712128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0693794
COL3A1 collagen, type III, alpha 1 -0.0683405
CLTC clathrin, heavy chain (Hc) -0.0674416
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0663086
TENM3 teneurin transmembrane protein 3 -0.0659887
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0647266
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0639301
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0625123
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0618765
EMP1 epithelial membrane protein 1 -0.061083
PDGFC platelet derived growth factor C -0.0602765
ACTG1 actin gamma 1 -0.0584044
MEIS2 Meis homeobox 2 -0.0576799
KMT2C lysine (K)-specific methyltransferase 2C -0.0567543
RLF rearranged L-myc fusion -0.0544191
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0537819
PGAP1 post-GPI attachment to proteins 1 -0.0535767
ITGAV integrin, alpha V -0.0525838
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0525268
FNDC3B fibronectin type III domain containing 3B -0.052278
SMYD3 SET and MYND domain containing 3 -0.0515224
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0491946
USP3 ubiquitin specific peptidase 3 -0.0491393
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0482418
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0480244
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0473514
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0464936
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0459976
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0458563
SRPK2 SRSF protein kinase 2 -0.0458322
ATP5F1B ATP synthase F1 subunit beta -0.0455441
ANKRD33B ankyrin repeat domain 33B -0.0453285
HDAC9 histone deacetylase 9 -0.0450239
ENAH enabled homolog (Drosophila) -0.0450167
DPYD dihydropyrimidine dehydrogenase -0.0448547
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0445526
ADAM9 ADAM metallopeptidase domain 9 -0.0439312
HMGA2 high mobility group AT-hook 2 -0.0433183
TLK1 tousled-like kinase 1 -0.0430457
KPNB1 karyopherin (importin) beta 1 -0.0430254
APP amyloid beta (A4) precursor protein -0.0428305
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0422786
TXNRD1 thioredoxin reductase 1 -0.0420728
NCOR1 nuclear receptor corepressor 1 -0.0420478
RHEB Ras homolog enriched in brain -0.0418761
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0418495
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0415976
JMJD1C jumonji domain containing 1C -0.0412785
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0412711
FBXO11 F-box protein 11 -0.0409304
CAMKMT calmodulin-lysine N-methyltransferase -0.04087
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0406796
FIGN fidgetin -0.0396194
NIPBL Nipped-B homolog (Drosophila) -0.0395829
MARCHF6 membrane associated ring-CH-type finger 6 -0.0395058
RAD21 RAD21 homolog (S. pombe) -0.0393844
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0392232
PRKD1 protein kinase D1 -0.0392179
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0390754
ANXA2 annexin A2 -0.0389885
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0384144
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0381428
GNAS GNAS complex locus -0.0373353
PUM1 pumilio RNA-binding family member 1 -0.0373112
CXADR coxsackie virus and adenovirus receptor -0.0368415
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0367227
EVI5 ecotropic viral integration site 5 -0.0367177
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0362892
SIK3 SIK family kinase 3 -0.0361095
ABI2 abl-interactor 2 -0.0357801
TBC1D12 TBC1 domain family, member 12 -0.0357697
GLG1 golgi glycoprotein 1 -0.0355516
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0350293
RBM39 RNA binding motif protein 39 -0.0349217
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0347721
UBE2H ubiquitin-conjugating enzyme E2H -0.0343602
NEK7 NIMA-related kinase 7 -0.034359
PBX3 pre-B-cell leukemia homeobox 3 -0.0342933
POTEF POTE ankyrin domain family, member F -0.034239
SEPTIN7 septin 7 -0.0341101
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0338339
SMC4 structural maintenance of chromosomes 4 -0.0335147
CLASP2 cytoplasmic linker associated protein 2 -0.0333566
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0333264
ACTN4 actinin, alpha 4 -0.0333118