| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Osimertinib (mesylate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.155422 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.114437 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0916427 |
| ZFP36 | ZFP36 ring finger protein | 0.0793939 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0645785 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0639629 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0624946 |
| SFTPA2 | surfactant protein A2 | 0.0545243 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0537245 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0523684 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0520045 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0472379 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0454767 |
| SPAG9 | sperm associated antigen 9 | 0.0454206 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0453225 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0436168 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0419377 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0401649 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0393763 |
| ANLN | anillin, actin binding protein | 0.0383265 |
| SNX14 | sorting nexin 14 | 0.0378337 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0369835 |
| PCBP2 | poly(rC) binding protein 2 | 0.0365329 |
| PTMA | prothymosin, alpha | 0.0357346 |
| MATR3 | matrin 3 | 0.0357316 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0355582 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.035291 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0344879 |
| BRD2 | bromodomain containing 2 | 0.0329803 |
| SMAD3 | SMAD family member 3 | 0.0315762 |
| VCL | vinculin | 0.0305935 |
| ADM | adrenomedullin | 0.0305079 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0296922 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0295762 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.0287072 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0284743 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0278964 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0275201 |
| ARRDC3 | arrestin domain containing 3 | 0.0272217 |
| NUP58 | nucleoporin 58 | 0.0271211 |
| RPS2 | ribosomal protein S2 | 0.0268835 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0267899 |
| KIF5B | kinesin family member 5B | 0.026001 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0249654 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.024905 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0245998 |
| GOLGA4 | golgin A4 | 0.0245605 |
| ZNF292 | zinc finger protein 292 | 0.024121 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0239647 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0237878 |
| CDK19 | cyclin-dependent kinase 19 | 0.0236003 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0235401 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0233629 |
| RPS3 | ribosomal protein S3 | 0.0230612 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0230228 |
| CENPF | centromere protein F, 350/400kDa | 0.0226767 |
| SUCO | SUN domain containing ossification factor | 0.0212084 |
| CANX | calnexin | 0.0211001 |
| SET | SET nuclear proto-oncogene | 0.0208789 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0208292 |
| CALR | calreticulin | 0.02062 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0206072 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0206008 |
| MKI67 | marker of proliferation Ki-67 | 0.0205 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0202964 |
| CA8 | carbonic anhydrase VIII | 0.0202131 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0200585 |
| AFDN | afadin, adherens junction formation factor | 0.0200434 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0197736 |
| YBX1 | Y box binding protein 1 | 0.0196811 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0196124 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0195814 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0194368 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0192141 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0191055 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0189538 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.018854 |
| RBM39 | RNA binding motif protein 39 | 0.0188146 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0188102 |
| SRP54 | signal recognition particle 54kDa | 0.0187275 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0185959 |
| WDR43 | WD repeat domain 43 | 0.0182844 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0181017 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0180781 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0180451 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0179839 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0178934 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0178702 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0178553 |
| ANXA2 | annexin A2 | 0.0176742 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0176224 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0176203 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0175953 |
| CEP350 | centrosomal protein 350kDa | 0.0174498 |
| CEP192 | centrosomal protein 192kDa | 0.0171509 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0170974 |
| ZNF638 | zinc finger protein 638 | 0.0170788 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0170343 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0170235 |
| IMMT | inner membrane protein, mitochondrial | 0.017018 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.231333 |
| RPS16 | ribosomal protein S16 | -0.156858 |
| AHNAK | AHNAK nucleoprotein | -0.105539 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.103917 |
| VIM | vimentin | -0.103203 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.077102 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0746061 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0670049 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0626784 |
| CTSD | cathepsin D | -0.0545946 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0526078 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0519018 |
| TMSB10 | thymosin beta 10 | -0.0483102 |
| RPLP0 | ribosomal protein, large, P0 | -0.0472025 |
| SQSTM1 | sequestosome 1 | -0.0461747 |
| HMGA2 | high mobility group AT-hook 2 | -0.044502 |
| ACTG1 | actin gamma 1 | -0.0435015 |
| FTL | ferritin, light polypeptide | -0.0431718 |
| PTK2 | protein tyrosine kinase 2 | -0.0427389 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0422192 |
| RPLP1 | ribosomal protein, large, P1 | -0.0417184 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.038753 |
| DST | dystonin | -0.0377921 |
| EHBP1 | EH domain binding protein 1 | -0.037122 |
| UPP1 | uridine phosphorylase 1 | -0.0365933 |
| ZNF780B | zinc finger protein 780B | -0.036234 |
| CD44 | CD44 molecule (Indian blood group) | -0.036168 |
| S100A6 | S100 calcium binding protein A6 | -0.0354957 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0346581 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0339807 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0334817 |
| EGFR | epidermal growth factor receptor | -0.032602 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0326016 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0321122 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0304967 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0299837 |
| RPS24 | ribosomal protein S24 | -0.029689 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0289821 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0289243 |
| RPLP2 | ribosomal protein, large, P2 | -0.0282308 |
| RASAL2 | RAS protein activator like 2 | -0.0281863 |
| MEF2A | myocyte enhancer factor 2A | -0.0278327 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0268404 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0267136 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0266533 |
| ATG7 | autophagy related 7 | -0.0266142 |
| PHF14 | PHD finger protein 14 | -0.0262272 |
| PRSS23 | protease, serine, 23 | -0.0254377 |
| EXOC4 | exocyst complex component 4 | -0.0249983 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0248849 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0248465 |
| TCF12 | transcription factor 12 | -0.0246926 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0234823 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0233163 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.023303 |
| HDAC9 | histone deacetylase 9 | -0.0232951 |
| RPS23 | ribosomal protein S23 | -0.0231724 |
| RPL27A | ribosomal protein L27a | -0.0229735 |
| DIAPH2 | diaphanous-related formin 2 | -0.0228433 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0225933 |
| RPL36A | ribosomal protein L36a | -0.0225779 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0219085 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0218354 |
| CUX1 | cut-like homeobox 1 | -0.0216829 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0216385 |
| XPO1 | exportin 1 | -0.0215783 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0214869 |
| NAV2 | neuron navigator 2 | -0.0214672 |
| TNS3 | tensin 3 | -0.0214151 |
| TMEM123 | transmembrane protein 123 | -0.0213089 |
| HMGA1 | high mobility group AT-hook 1 | -0.0209646 |
| RPS5 | ribosomal protein S5 | -0.0207724 |
| KRT8 | keratin 8, type II | -0.0206876 |
| ZNF407 | zinc finger protein 407 | -0.0206414 |
| FBL | fibrillarin | -0.0205921 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0205368 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0204055 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0201447 |
| RPL35A | ribosomal protein L35a | -0.0201312 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0200336 |
| FBXO27 | F-box protein 27 | -0.0199407 |
| MYO10 | myosin X | -0.0195393 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0195299 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0193552 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0193055 |
| FMNL2 | formin-like 2 | -0.0192743 |
| RPL8 | ribosomal protein L8 | -0.019163 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.019071 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0189358 |
| RPS21 | ribosomal protein S21 | -0.0188627 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0188235 |
| NHSL1 | NHS-like 1 | -0.0187991 |
| FRMD5 | FERM domain containing 5 | -0.0186683 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0186373 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0186249 |
| MAP1B | microtubule-associated protein 1B | -0.0186147 |
| RPL38 | ribosomal protein L38 | -0.018601 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0182762 |
| RPS8 | ribosomal protein S8 | -0.0181931 |
| ACTN4 | actinin, alpha 4 | -0.0181182 |
