| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Osimertinib (mesylate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.170816 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.140127 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.106981 |
| LAMB3 | laminin, beta 3 | 0.106781 |
| KRT17 | keratin 17, type I | 0.0694542 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0573791 |
| CCNL1 | cyclin L1 | 0.0565227 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0559423 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.055527 |
| B2M | beta-2-microglobulin | 0.0552245 |
| MT2A | metallothionein 2A | 0.0507332 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.047725 |
| CALR | calreticulin | 0.0474673 |
| PCBP2 | poly(rC) binding protein 2 | 0.0461608 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0449519 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0436382 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0415764 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0404257 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0400065 |
| VEGFA | vascular endothelial growth factor A | 0.0384153 |
| CANX | calnexin | 0.0377016 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0374218 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0361951 |
| HMGB2 | high mobility group box 2 | 0.035617 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0352952 |
| SET | SET nuclear proto-oncogene | 0.0347692 |
| TMSB4X | thymosin beta 4, X-linked | 0.033117 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0324983 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0319747 |
| RPS2 | ribosomal protein S2 | 0.0304751 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0302982 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0299109 |
| TPI1 | triosephosphate isomerase 1 | 0.0294704 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0292168 |
| MYO6 | myosin VI | 0.0286462 |
| BRD2 | bromodomain containing 2 | 0.0285329 |
| RPS3 | ribosomal protein S3 | 0.0283888 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0282612 |
| KIF5B | kinesin family member 5B | 0.0278929 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0275016 |
| DSPP | dentin sialophosphoprotein | 0.0274623 |
| RBM25 | RNA binding motif protein 25 | 0.0271027 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0270785 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0262764 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0257549 |
| PNN | pinin, desmosome associated protein | 0.0257477 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0255802 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0254972 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0244455 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0242874 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0238911 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0237675 |
| RPL23 | ribosomal protein L23 | 0.0235117 |
| RPS7 | ribosomal protein S7 | 0.0233469 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0231529 |
| YBX1 | Y box binding protein 1 | 0.0216836 |
| RPS18 | ribosomal protein S18 | 0.0214321 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0214294 |
| TPM3 | tropomyosin 3 | 0.0213449 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.0210774 |
| TFG | TRK-fused gene | 0.021036 |
| RPL12 | ribosomal protein L12 | 0.0206729 |
| HDGF | hepatoma-derived growth factor | 0.0205947 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0205511 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0204453 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0203105 |
| YBX3 | Y box binding protein 3 | 0.0202833 |
| AHR | aryl hydrocarbon receptor | 0.0202318 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0199621 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0193544 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0193051 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0191685 |
| PCDH1 | protocadherin 1 | 0.0191289 |
| GOLGA4 | golgin A4 | 0.0190636 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0189662 |
| RPS12 | ribosomal protein S12 | 0.0186394 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0186162 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0184903 |
| RPL37A | ribosomal protein L37a | 0.0181103 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0179811 |
| GPX4 | glutathione peroxidase 4 | 0.0178874 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0178767 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0176209 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0174635 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.017368 |
| WDR43 | WD repeat domain 43 | 0.0171307 |
| ADM | adrenomedullin | 0.0170091 |
| RIOK3 | RIO kinase 3 | 0.0169397 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0167454 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0166242 |
| DUSP5 | dual specificity phosphatase 5 | 0.0165822 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0165742 |
| RACK1 | receptor for activated C kinase 1 | 0.0165305 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0163084 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0162399 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0161726 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0160568 |
| IRS2 | insulin receptor substrate 2 | 0.0159627 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0159394 |
| SNW1 | SNW domain containing 1 | 0.015909 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.498005 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.136455 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0871209 |
| ACTG1 | actin gamma 1 | -0.0827163 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0820765 |
| KRT19 | keratin 19, type I | -0.0729436 |
| RUNX1 | runt-related transcription factor 1 | -0.0691658 |
| MUC4 | mucin 4, cell surface associated | -0.0676591 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0657677 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0553922 |
| HMGA1 | high mobility group AT-hook 1 | -0.054745 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0542266 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0538497 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0533965 |
| NDRG1 | N-myc downstream regulated 1 | -0.0529547 |
| TMEM123 | transmembrane protein 123 | -0.0519523 |
| DSG2 | desmoglein 2 | -0.0519353 |
| AHNAK | AHNAK nucleoprotein | -0.0485113 |
| JMJD1C | jumonji domain containing 1C | -0.0481754 |
| RPS23 | ribosomal protein S23 | -0.0474815 |
| HLA-B | major histocompatibility complex, class I, B | -0.0473066 |
| ACTN4 | actinin, alpha 4 | -0.04607 |
| EGFR | epidermal growth factor receptor | -0.0453306 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0449779 |
| WWC1 | WW and C2 domain containing 1 | -0.044693 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0443978 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0431256 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0430298 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0429703 |
| ERBIN | erbb2 interacting protein | -0.0426525 |
| NF1 | neurofibromin 1 | -0.0425801 |
| CD2AP | CD2-associated protein | -0.0417465 |
| RPS15 | ribosomal protein S15 | -0.041452 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0411196 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0409352 |
| FNDC3B | fibronectin type III domain containing 3B | -0.040878 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0404283 |
| LDHA | lactate dehydrogenase A | -0.0398648 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0390027 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0388954 |
| OSMR | oncostatin M receptor | -0.0388725 |
| RPS24 | ribosomal protein S24 | -0.0387924 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0386405 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0378097 |
| TAOK1 | TAO kinase 1 | -0.0374479 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0371345 |
| ANXA2 | annexin A2 | -0.0364097 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0363358 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0357519 |
| RPS5 | ribosomal protein S5 | -0.0352045 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0351756 |
| SQSTM1 | sequestosome 1 | -0.0350718 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0350026 |
| RPS11 | ribosomal protein S11 | -0.0347059 |
| RPL34 | ribosomal protein L34 | -0.0346645 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0346488 |
| FAM3C | family with sequence similarity 3, member C | -0.0342901 |
| PLSCR1 | phospholipid scramblase 1 | -0.0342055 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.033889 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0337288 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0336734 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0330945 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0325583 |
| LMO7 | LIM domain 7 | -0.0324222 |
| RPS21 | ribosomal protein S21 | -0.0323162 |
| RPL8 | ribosomal protein L8 | -0.0321904 |
| RPL36A | ribosomal protein L36a | -0.0319454 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0319333 |
| KRT8 | keratin 8, type II | -0.0315892 |
| UBC | ubiquitin C | -0.0315107 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0315055 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0303004 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0301929 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0301247 |
| HLA-A | major histocompatibility complex, class I, A | -0.0295543 |
| FNIP1 | folliculin interacting protein 1 | -0.0290236 |
| FBXO34 | F-box protein 34 | -0.0286985 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.028627 |
| HLA-C | major histocompatibility complex, class I, C | -0.028476 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0282746 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0279643 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0278449 |
| CD44 | CD44 molecule (Indian blood group) | -0.0274697 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0274108 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.027333 |
| BPTF | bromodomain PHD finger transcription factor | -0.0271475 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.026744 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.02674 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0266094 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0265948 |
| BCL2L1 | BCL2-like 1 | -0.0265586 |
| NAV2 | neuron navigator 2 | -0.0263274 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.025833 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0257922 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0257415 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0256726 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0255807 |
| RNF213 | ring finger protein 213 | -0.0255781 |
| RAD51B | RAD51 paralog B | -0.0255235 |
| NCOA7 | nuclear receptor coactivator 7 | -0.025385 |
