Osimertinib (mesylate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.106409
EEF2 eukaryotic translation elongation factor 2 0.0936338
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0753208
LAMB3 laminin, beta 3 0.0741456
BHLHE40 basic helix-loop-helix family, member e40 0.0595601
KDM3A lysine (K)-specific demethylase 3A 0.052439
SRRM2 serine/arginine repetitive matrix 2 0.0522022
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0518572
ELL2 elongation factor, RNA polymerase II, 2 0.0473679
CORO1C coronin, actin binding protein, 1C 0.044164
MYH9 myosin, heavy chain 9, non-muscle 0.0431458
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0430224
USP9X ubiquitin specific peptidase 9, X-linked 0.0428277
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0419951
RAD21 RAD21 homolog (S. pombe) 0.0418642
WDR43 WD repeat domain 43 0.0413985
NUP58 nucleoporin 58 0.0410804
RB1CC1 RB1-inducible coiled-coil 1 0.0407996
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0385684
CKAP5 cytoskeleton associated protein 5 0.0382867
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0366719
PRRC2C proline-rich coiled-coil 2C 0.0356514
TPD52 tumor protein D52 0.0346772
ATP13A3 ATPase type 13A3 0.0346473
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0345339
RPL3 ribosomal protein L3 0.0339674
PSME4 proteasome (prosome, macropain) activator subunit 4 0.033817
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.033513
UBA6 ubiquitin-like modifier activating enzyme 6 0.0332098
CHD1 chromodomain helicase DNA binding protein 1 0.0326411
TOP2B topoisomerase (DNA) II beta 180kDa 0.0322619
RBM39 RNA binding motif protein 39 0.0321341
SET SET nuclear proto-oncogene 0.0321252
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0320703
USP3 ubiquitin specific peptidase 3 0.0318746
NCKAP1 NCK-associated protein 1 0.0318573
ZNF292 zinc finger protein 292 0.0310059
RNF145 ring finger protein 145 0.030768
RLF rearranged L-myc fusion 0.0306817
STC1 stanniocalcin 1 0.0305706
KAT6A K(lysine) acetyltransferase 6A 0.0303248
NAMPT nicotinamide phosphoribosyltransferase 0.0302674
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0301637
RASA2 RAS p21 protein activator 2 0.0299598
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0297185
EIF4B eukaryotic translation initiation factor 4B 0.0296277
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0290207
MATR3 matrin 3 0.0289858
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.028545
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0284447
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0283514
AKAP12 A kinase (PRKA) anchor protein 12 0.0283391
PGK1 phosphoglycerate kinase 1 0.028205
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.028194
HELZ helicase with zinc finger 0.0281186
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0275191
KDM6A lysine (K)-specific demethylase 6A 0.0273979
MKI67 marker of proliferation Ki-67 0.0271636
ADAM9 ADAM metallopeptidase domain 9 0.0270854
KMT2C lysine (K)-specific methyltransferase 2C 0.0264715
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0264045
FOXO3 forkhead box O3 0.0263569
WAC WW domain containing adaptor with coiled-coil 0.0263139
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.026052
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0260098
KDM5C lysine (K)-specific demethylase 5C 0.0257097
OGA O-GlcNAcase 0.0255202
KMT2E lysine (K)-specific methyltransferase 2E 0.0255199
ANXA5 annexin A5 0.0249541
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0248176
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0248166
MTF2 metal response element binding transcription factor 2 0.0244236
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0243967
ADAM17 ADAM metallopeptidase domain 17 0.0241346
TOP2A topoisomerase (DNA) II alpha 170kDa 0.024051
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0234672
TRIO trio Rho guanine nucleotide exchange factor 0.0229381
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0228593
MAST4 microtubule associated serine/threonine kinase family member 4 0.0225968
RAB6A RAB6A, member RAS oncogene family 0.022477
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0224489
TRIM33 tripartite motif containing 33 0.0223466
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0222389
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0221413
CHIC2 cysteine-rich hydrophobic domain 2 0.0219667
FLNA filamin A, alpha 0.0219566
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0218866
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0218625
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0217175
YTHDC1 YTH domain containing 1 0.0217076
SRRM1 serine/arginine repetitive matrix 1 0.0216602
ZNF654 zinc finger protein 654 0.021652
PNISR PNN-interacting serine/arginine-rich protein 0.0215597
PICALM phosphatidylinositol binding clathrin assembly protein 0.0215364
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.02141
RAD23B RAD23 homolog B (S. cerevisiae) 0.0213551
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0213549
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0212405
KDM2A lysine (K)-specific demethylase 2A 0.021168
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0211413

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.216375
ZNF438 zinc finger protein 438 -0.136436
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116491
FRMD6 FERM domain containing 6 -0.111412
DLC1 DLC1 Rho GTPase activating protein -0.107732
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0980729
NAV3 neuron navigator 3 -0.0944666
HDAC9 histone deacetylase 9 -0.087429
HMGA2 high mobility group AT-hook 2 -0.0866381
NABP1 nucleic acid binding protein 1 -0.0822877
RPS6 ribosomal protein S6 -0.0764225
SLC38A2 solute carrier family 38, member 2 -0.0684252
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0666444
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0662969
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0607541
IFI16 interferon, gamma-inducible protein 16 -0.0559384
IARS1 isoleucyl-tRNA synthetase 1 -0.0529434
ARHGAP22 Rho GTPase activating protein 22 -0.0506302
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0504985
FRMD4A FERM domain containing 4A -0.0492868
ACTG1 actin gamma 1 -0.0477525
TPT1 tumor protein, translationally-controlled 1 -0.0465419
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0447973
PCNX4 pecanex 4 -0.0439896
EGR1 early growth response 1 -0.0432385
BNC2 basonuclin 2 -0.04277
PTPRG protein tyrosine phosphatase, receptor type, G -0.0419759
EXOC4 exocyst complex component 4 -0.0395717
EXT1 exostosin glycosyltransferase 1 -0.0395593
MTAP methylthioadenosine phosphorylase -0.0389975
RPLP1 ribosomal protein, large, P1 -0.0389023
RPS8 ribosomal protein S8 -0.0388929
SP100 SP100 nuclear antigen -0.0387971
MCTP1 multiple C2 domains, transmembrane 1 -0.0384218
RPL34 ribosomal protein L34 -0.037997
TCF12 transcription factor 12 -0.0371548
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0365154
RPS21 ribosomal protein S21 -0.0360947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0360462
LPP LIM domain containing preferred translocation partner in lipoma -0.0358132
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0357825
RPL8 ribosomal protein L8 -0.0350453
GPHN gephyrin -0.0340027
CUX1 cut-like homeobox 1 -0.0333015
RPL23 ribosomal protein L23 -0.0328136
TMSB10 thymosin beta 10 -0.0323356
ALCAM activated leukocyte cell adhesion molecule -0.0314936
FTL ferritin, light polypeptide -0.0313266
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0312272
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0310039
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0309413
ANKRD17 ankyrin repeat domain 17 -0.0308133
MT2A metallothionein 2A -0.0308121
FHIT fragile histidine triad -0.0304106
INTS6 integrator complex subunit 6 -0.0299795
DGKI diacylglycerol kinase, iota -0.0299329
RPS24 ribosomal protein S24 -0.029822
RPLP2 ribosomal protein, large, P2 -0.0296848
RPS20 ribosomal protein S20 -0.0295549
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0295488
EFNB2 ephrin-B2 -0.0293329
RAB7A RAB7A, member RAS oncogene family -0.0293117
HMGA1 high mobility group AT-hook 1 -0.0289962
TM4SF1 transmembrane 4 L six family member 1 -0.0283345
RPLP0 ribosomal protein, large, P0 -0.0282825
WNT2B wingless-type MMTV integration site family, member 2B -0.0281783
RPL9 ribosomal protein L9 -0.0281601
RIGI RNA sensor RIG-I -0.0278196
PDIA3 protein disulfide isomerase family A, member 3 -0.0274856
TAS2R14 taste receptor, type 2, member 14 -0.0271948
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0271422
RPS29 ribosomal protein S29 -0.0271367
RPL35A ribosomal protein L35a -0.0267491
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0266659
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0266269
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0264737
POTEF POTE ankyrin domain family, member F -0.0263468
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0262205
RAD51B RAD51 paralog B -0.02586
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.025722
ANTXR2 anthrax toxin receptor 2 -0.0257204
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0256632
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0256579
BPTF bromodomain PHD finger transcription factor -0.0256531
RPS15 ribosomal protein S15 -0.0254207
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0251434
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0250897
RPL5 ribosomal protein L5 -0.0248935
SPIDR scaffolding protein involved in DNA repair -0.0248797
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0246396
ZBTB20 zinc finger and BTB domain containing 20 -0.0244488
RPS25 ribosomal protein S25 -0.0241813
FNIP1 folliculin interacting protein 1 -0.0239702
AK1 adenylate kinase 1 -0.0238438
ASPH aspartate beta-hydroxylase -0.0234862
SAMD12 sterile alpha motif domain containing 12 -0.0232446
RPL19 ribosomal protein L19 -0.0231669
CAST calpastatin -0.0230265
AOPEP aminopeptidase O (putative) -0.0228135
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0226825