| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.120486 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.112823 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.101334 |
| VIM | vimentin | 0.0961702 |
| PGK1 | phosphoglycerate kinase 1 | 0.0816262 |
| B2M | beta-2-microglobulin | 0.0759499 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0756267 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0700913 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.068468 |
| PTMA | prothymosin, alpha | 0.0667079 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.066183 |
| MT2A | metallothionein 2A | 0.0634887 |
| ANXA2 | annexin A2 | 0.0544629 |
| ENO1 | enolase 1, (alpha) | 0.0527111 |
| H1-0 | H1.0 linker histone | 0.0503736 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0498553 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0496624 |
| CALR | calreticulin | 0.0496431 |
| CTSB | cathepsin B | 0.0489465 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0468883 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0445292 |
| ADM | adrenomedullin | 0.0436058 |
| YBX1 | Y box binding protein 1 | 0.0433504 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0405697 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0395305 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0392233 |
| ANGPTL4 | angiopoietin-like 4 | 0.0382602 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0374806 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0372735 |
| PCBP2 | poly(rC) binding protein 2 | 0.0372337 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0366453 |
| MKI67 | marker of proliferation Ki-67 | 0.0364233 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0364183 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0359062 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0354622 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0351832 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0335969 |
| RPS27A | ribosomal protein S27a | 0.0334174 |
| FLNA | filamin A, alpha | 0.0328082 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0327561 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0318358 |
| MMP2 | matrix metallopeptidase 2 | 0.0317567 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0316189 |
| UBC | ubiquitin C | 0.0306164 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0299088 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0297981 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0297917 |
| LDHA | lactate dehydrogenase A | 0.029476 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0291245 |
| RPL12 | ribosomal protein L12 | 0.0287432 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0277663 |
| SFTPA2 | surfactant protein A2 | 0.0276777 |
| ARRDC3 | arrestin domain containing 3 | 0.0275383 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0269725 |
| TMSB4X | thymosin beta 4, X-linked | 0.0265867 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0256822 |
| HMGB2 | high mobility group box 2 | 0.025567 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0254663 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0254633 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0253518 |
| INHBA | inhibin, beta A | 0.0249456 |
| KIF5B | kinesin family member 5B | 0.0244665 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0242173 |
| RPL35A | ribosomal protein L35a | 0.0242054 |
| COL7A1 | collagen, type VII, alpha 1 | 0.024051 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0240251 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0238186 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.023714 |
| FAM162A | family with sequence similarity 162, member A | 0.0236694 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0234484 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.023319 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0230508 |
| APP | amyloid beta (A4) precursor protein | 0.0229542 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0229455 |
| S100A9 | S100 calcium binding protein A9 | 0.0228811 |
| RPS19 | ribosomal protein S19 | 0.0227428 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0223065 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0222311 |
| RPL23 | ribosomal protein L23 | 0.022145 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0220882 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0218634 |
| RPS8 | ribosomal protein S8 | 0.0218283 |
| TMSB10 | thymosin beta 10 | 0.0218168 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.021805 |
| CANX | calnexin | 0.0218023 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0216526 |
| RACK1 | receptor for activated C kinase 1 | 0.0214925 |
| CD164 | CD164 molecule, sialomucin | 0.0212696 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0212263 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0209261 |
| NPTN | neuroplastin | 0.0208848 |
| BRD2 | bromodomain containing 2 | 0.0208393 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0205518 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0205422 |
| SPAG5 | sperm associated antigen 5 | 0.0203763 |
| RNF145 | ring finger protein 145 | 0.0197582 |
| MATR3 | matrin 3 | 0.0197561 |
| RPLP1 | ribosomal protein, large, P1 | 0.019676 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0193233 |
| YTHDC1 | YTH domain containing 1 | 0.0192975 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.197774 |
| FN1 | fibronectin 1 | -0.188582 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131972 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.127768 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.102435 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0967891 |
| COL1A2 | collagen, type I, alpha 2 | -0.0952527 |
| NRP1 | neuropilin 1 | -0.0817048 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0742025 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0620254 |
| USP34 | ubiquitin specific peptidase 34 | -0.061376 |
| EGR1 | early growth response 1 | -0.0610373 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.06084 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0608266 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0588891 |
| ASPH | aspartate beta-hydroxylase | -0.0560696 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0554407 |
| CDH13 | cadherin 13 | -0.0552929 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0537155 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0531341 |
| FHIT | fragile histidine triad | -0.0527486 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0524965 |
| ATXN1 | ataxin 1 | -0.0522224 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0519382 |
| DST | dystonin | -0.051902 |
| NBEAL1 | neurobeachin-like 1 | -0.0501733 |
| PTK2 | protein tyrosine kinase 2 | -0.0501268 |
| SEC24D | SEC24 family member D | -0.0494544 |
| GOLGB1 | golgin B1 | -0.048181 |
| COL1A1 | collagen, type I, alpha 1 | -0.0472321 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0465254 |
| SETD5 | SET domain containing 5 | -0.0450413 |
| NAV1 | neuron navigator 1 | -0.0450281 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0447608 |
| GLIS3 | GLIS family zinc finger 3 | -0.0444214 |
| HM13 | histocompatibility (minor) 13 | -0.0431674 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0429946 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0429929 |
| MAP4 | microtubule-associated protein 4 | -0.0424021 |
| GNAS | GNAS complex locus | -0.0411604 |
| FNIP1 | folliculin interacting protein 1 | -0.0408185 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0399801 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0397343 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0392315 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0390706 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0388606 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0387928 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0384161 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0381298 |
| NBAS | neuroblastoma amplified sequence | -0.0373775 |
| SMYD3 | SET and MYND domain containing 3 | -0.0370852 |
| EXOC4 | exocyst complex component 4 | -0.0364771 |
| NF1 | neurofibromin 1 | -0.036423 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.036293 |
| TXNRD1 | thioredoxin reductase 1 | -0.0362572 |
| CLTC | clathrin, heavy chain (Hc) | -0.0362388 |
| PKM | pyruvate kinase, muscle | -0.0361069 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0359799 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0358816 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.035804 |
| EXOC6B | exocyst complex component 6B | -0.0355717 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0355683 |
| BBX | bobby sox homolog (Drosophila) | -0.0336771 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0330852 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0330193 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0329328 |
| AAK1 | AP2 associated kinase 1 | -0.032886 |
| GOLGA4 | golgin A4 | -0.0328815 |
| BPTF | bromodomain PHD finger transcription factor | -0.0325439 |
| POTEF | POTE ankyrin domain family, member F | -0.0325262 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0323198 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0322475 |
| CLIC4 | chloride intracellular channel 4 | -0.0321352 |
| CDCP1 | CUB domain containing protein 1 | -0.0321202 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0320527 |
| RUNX1 | runt-related transcription factor 1 | -0.0320479 |
| TMEM165 | transmembrane protein 165 | -0.0318527 |
| YEATS2 | YEATS domain containing 2 | -0.0316113 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.0311416 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0311361 |
| FBXO32 | F-box protein 32 | -0.0311143 |
| TPM1 | tropomyosin 1 (alpha) | -0.0309637 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0308506 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0307133 |
| CDK19 | cyclin-dependent kinase 19 | -0.030633 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.030625 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0305486 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0302302 |
| ZNF609 | zinc finger protein 609 | -0.030105 |
| TNS3 | tensin 3 | -0.0300119 |
| SBF2 | SET binding factor 2 | -0.0299527 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0298887 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0298795 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0298242 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0297897 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0297586 |
| HDAC8 | histone deacetylase 8 | -0.0296705 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.029478 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0292772 |
| JMJD1C | jumonji domain containing 1C | -0.0292728 |
