| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.147332 |
| PTMA | prothymosin, alpha | 0.099827 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0843343 |
| ENO1 | enolase 1, (alpha) | 0.0816232 |
| PEG10 | paternally expressed 10 | 0.080679 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0660507 |
| CENPF | centromere protein F, 350/400kDa | 0.0658548 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0639989 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0614599 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0533017 |
| VGF | VGF nerve growth factor inducible | 0.0529589 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0516452 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0492601 |
| CALCA | calcitonin-related polypeptide alpha | 0.0487226 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0468762 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.046875 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0463139 |
| TMSB4X | thymosin beta 4, X-linked | 0.0450978 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0424067 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0408216 |
| ZNF292 | zinc finger protein 292 | 0.0403908 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0379332 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0376683 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0372645 |
| PGK1 | phosphoglycerate kinase 1 | 0.0367498 |
| HMGB3 | high mobility group box 3 | 0.0359127 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0351625 |
| CPE | carboxypeptidase E | 0.0340594 |
| MATR3 | matrin 3 | 0.0338545 |
| MKI67 | marker of proliferation Ki-67 | 0.0338326 |
| CHGB | chromogranin B | 0.033742 |
| MAP1B | microtubule-associated protein 1B | 0.0336797 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0325757 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0321675 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.031957 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0314518 |
| H1-0 | H1.0 linker histone | 0.0311327 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0306298 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0306065 |
| INHBA | inhibin, beta A | 0.0305871 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0298108 |
| IRS2 | insulin receptor substrate 2 | 0.0294076 |
| XPO1 | exportin 1 | 0.0288933 |
| TENM1 | teneurin transmembrane protein 1 | 0.0288205 |
| MT2A | metallothionein 2A | 0.0286777 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0283456 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0281875 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0280027 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0278495 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.027149 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0271057 |
| LDHA | lactate dehydrogenase A | 0.026981 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0269651 |
| RPS3 | ribosomal protein S3 | 0.0264917 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0262115 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0258328 |
| SCG3 | secretogranin III | 0.0258077 |
| RTN4 | reticulon 4 | 0.0257526 |
| FAT1 | FAT atypical cadherin 1 | 0.0256992 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0256706 |
| RIT2 | Ras-like without CAAX 2 | 0.0253607 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0252954 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0250883 |
| PCM1 | pericentriolar material 1 | 0.0250258 |
| TPM3 | tropomyosin 3 | 0.024958 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0248939 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0248582 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0247909 |
| SET | SET nuclear proto-oncogene | 0.0246732 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0245258 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0244752 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0243222 |
| FOXC1 | forkhead box C1 | 0.0243069 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0241888 |
| MTMR7 | myotubularin related protein 7 | 0.0237391 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0237022 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0236703 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0234442 |
| KIF5B | kinesin family member 5B | 0.0233247 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0232094 |
| STC1 | stanniocalcin 1 | 0.0230258 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0228858 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.021937 |
| YBX1 | Y box binding protein 1 | 0.0217632 |
| SCG2 | secretogranin II | 0.0215874 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0215618 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0214977 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.021385 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0212709 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0211287 |
| TPX2 | TPX2, microtubule-associated | 0.0207447 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0206832 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.020558 |
| DSTN | destrin (actin depolymerizing factor) | 0.0203234 |
| ADAR | adenosine deaminase, RNA-specific | 0.0203201 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0202214 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0201761 |
| NSD3 | nuclear receptor binding SET domain protein 3 | 0.0200445 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0200322 |
| AOPEP | aminopeptidase O (putative) | 0.0195557 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.0839969 |
| NRG1 | neuregulin 1 | -0.0822024 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0597488 |
| MCL1 | myeloid cell leukemia 1 | -0.0564382 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0551324 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0542188 |
| RORA | RAR-related orphan receptor A | -0.0531768 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0445335 |
| ESRRG | estrogen-related receptor gamma | -0.0440644 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.042416 |
| SNTG1 | syntrophin, gamma 1 | -0.0369551 |
| NDRG1 | N-myc downstream regulated 1 | -0.0356068 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0341766 |
| ASPH | aspartate beta-hydroxylase | -0.0339107 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0327296 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0327005 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0321674 |
| PTCHD4 | patched domain containing 4 | -0.0306881 |
| SETX | senataxin | -0.0305861 |
| SMYD3 | SET and MYND domain containing 3 | -0.0302741 |
| EFNA5 | ephrin-A5 | -0.0296187 |
| DTNA | dystrobrevin, alpha | -0.0290332 |
| KIF26B | kinesin family member 26B | -0.0290125 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0286176 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0284 |
| GOLGB1 | golgin B1 | -0.028224 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0276863 |
| EPHA6 | EPH receptor A6 | -0.0270054 |
| ACTG1 | actin gamma 1 | -0.0266332 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0264677 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0262208 |
| KLHL29 | kelch-like family member 29 | -0.0261396 |
| EGR1 | early growth response 1 | -0.0251928 |
| NCKAP5 | NCK-associated protein 5 | -0.0242814 |
| DOCK5 | dedicator of cytokinesis 5 | -0.024226 |
| SCFD1 | sec1 family domain containing 1 | -0.0237765 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0236231 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0235699 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0224256 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0220218 |
| GPC5 | glypican 5 | -0.0219951 |
| HOMER1 | homer scaffolding protein 1 | -0.0219581 |
| ZFHX3 | zinc finger homeobox 3 | -0.0218617 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0217592 |
| MYT1L | myelin transcription factor 1-like | -0.021372 |
| NELL1 | NEL-like 1 (chicken) | -0.0212851 |
| IGF2 | insulin-like growth factor 2 | -0.0210868 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0207567 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0204333 |
| LSAMP | limbic system-associated membrane protein | -0.0204213 |
| SCFD2 | sec1 family domain containing 2 | -0.020368 |
| INTS6 | integrator complex subunit 6 | -0.0199897 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0199372 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0196352 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0193596 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0192413 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0189457 |
| TOP1 | topoisomerase (DNA) I | -0.0185881 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0183277 |
| CDK13 | cyclin-dependent kinase 13 | -0.0181732 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0181223 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0179919 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0179004 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0178356 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0177607 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0176155 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0176079 |
| FHIT | fragile histidine triad | -0.0172663 |
| SP100 | SP100 nuclear antigen | -0.0167519 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0165177 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0164699 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.016349 |
| DENND1A | DENN/MADD domain containing 1A | -0.016086 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0160832 |
| ZNF804A | zinc finger protein 804A | -0.0160337 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0159216 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0158534 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0157079 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0157007 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0156681 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0151341 |
| FRY | furry homolog (Drosophila) | -0.0149041 |
| EGFR | epidermal growth factor receptor | -0.0148603 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0147559 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0147058 |
| VCL | vinculin | -0.0146658 |
| NCOR2 | nuclear receptor corepressor 2 | -0.01462 |
| FN1 | fibronectin 1 | -0.0144246 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0143689 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0143469 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0141634 |
| RNF213 | ring finger protein 213 | -0.0140275 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0140274 |
| ONECUT2 | one cut homeobox 2 | -0.0138681 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0137056 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0136952 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0136527 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0135626 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.0134304 |
| GOLGA3 | golgin A3 | -0.013398 |
