| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.148808 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132709 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0973586 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0964163 |
| SFTPA2 | surfactant protein A2 | 0.0961928 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.082395 |
| MSN | moesin | 0.0702463 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0663268 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0641224 |
| FLNA | filamin A, alpha | 0.0630479 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0567855 |
| FMNL2 | formin-like 2 | 0.0558098 |
| PCBP2 | poly(rC) binding protein 2 | 0.0551905 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0536119 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0491879 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0465977 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0465495 |
| RPS3 | ribosomal protein S3 | 0.0451134 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0438387 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.043715 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0434301 |
| FLNB | filamin B, beta | 0.0429718 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0428347 |
| ANGPTL4 | angiopoietin-like 4 | 0.0422676 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0411716 |
| TPM3 | tropomyosin 3 | 0.0411216 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0411065 |
| RPL3 | ribosomal protein L3 | 0.0410798 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0398623 |
| VEGFA | vascular endothelial growth factor A | 0.038799 |
| CANX | calnexin | 0.0383193 |
| NLGN1 | neuroligin 1 | 0.0377203 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0363252 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0360889 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0358913 |
| SEPTIN9 | septin 9 | 0.035628 |
| MSI2 | musashi RNA-binding protein 2 | 0.0348564 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0343402 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0333745 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0317447 |
| YEATS2 | YEATS domain containing 2 | 0.0307706 |
| PGK1 | phosphoglycerate kinase 1 | 0.0299375 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0298421 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0295998 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0292237 |
| KLC1 | kinesin light chain 1 | 0.0292139 |
| TLN1 | talin 1 | 0.0288739 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0288087 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0286103 |
| ZNF638 | zinc finger protein 638 | 0.0285017 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0284269 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0283737 |
| BRD2 | bromodomain containing 2 | 0.0281507 |
| ENO1 | enolase 1, (alpha) | 0.0278815 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0276472 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0274286 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0267785 |
| PRELID2 | PRELI domain containing 2 | 0.025242 |
| CYCS | cytochrome c, somatic | 0.0252138 |
| CTSB | cathepsin B | 0.02503 |
| CDK19 | cyclin-dependent kinase 19 | 0.0249744 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0246775 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0245928 |
| CLEC2D | C-type lectin domain family 2, member D | 0.0245193 |
| FAM219A | family with sequence similarity 219, member A | 0.0241162 |
| MCL1 | myeloid cell leukemia 1 | 0.023964 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0238851 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0235797 |
| AATF | apoptosis antagonizing transcription factor | 0.0235568 |
| CADM1 | cell adhesion molecule 1 | 0.0234279 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0232531 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0232498 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0231825 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0231005 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0228936 |
| ATF4 | activating transcription factor 4 | 0.0228629 |
| USP34 | ubiquitin specific peptidase 34 | 0.0225355 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0225332 |
| PYGL | phosphorylase, glycogen, liver | 0.0224765 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0220014 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0218761 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0217449 |
| LSAMP | limbic system-associated membrane protein | 0.021668 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0215519 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0214653 |
| TCF20 | transcription factor 20 (AR1) | 0.0214149 |
| NGLY1 | N-glycanase 1 | 0.0212899 |
| SLC25A17 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | 0.021203 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0211293 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0211 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0210933 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0208634 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.0208331 |
| GOLGA4 | golgin A4 | 0.0206661 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0205793 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0205069 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0204549 |
| PHF21A | PHD finger protein 21A | 0.020405 |
| HLA-A | major histocompatibility complex, class I, A | 0.0203182 |
| COPA | coatomer protein complex, subunit alpha | 0.0202369 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.198332 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.133119 |
| FMN1 | formin 1 | -0.125438 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0775759 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0733257 |
| CCND1 | cyclin D1 | -0.0726813 |
| FRMD5 | FERM domain containing 5 | -0.0718016 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0563599 |
| TXNRD1 | thioredoxin reductase 1 | -0.0545183 |
| ACTG1 | actin gamma 1 | -0.0538591 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0489063 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0440317 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0429229 |
| RPLP1 | ribosomal protein, large, P1 | -0.039469 |
| NRG3 | neuregulin 3 | -0.0393878 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0385571 |
| RPL32 | ribosomal protein L32 | -0.0372078 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0371012 |
| FN1 | fibronectin 1 | -0.0369884 |
| QKI | QKI, KH domain containing, RNA binding | -0.0369191 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0334718 |
| FRMD4A | FERM domain containing 4A | -0.0332972 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0326158 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0323967 |
| RPL34 | ribosomal protein L34 | -0.0318316 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.031159 |
| TMSB10 | thymosin beta 10 | -0.0311326 |
| RPS6 | ribosomal protein S6 | -0.0308168 |
| TUBB | tubulin, beta class I | -0.0296678 |
| PTMA | prothymosin, alpha | -0.0296586 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.029185 |
| VIM | vimentin | -0.0289917 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0285907 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0283184 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0282494 |
| CDK6 | cyclin-dependent kinase 6 | -0.0275318 |
| RPLP0 | ribosomal protein, large, P0 | -0.0274664 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0273016 |
| ANLN | anillin, actin binding protein | -0.027085 |
| CENPF | centromere protein F, 350/400kDa | -0.0270356 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0268827 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0267861 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0263687 |
| RPS24 | ribosomal protein S24 | -0.0263408 |
| ANXA2 | annexin A2 | -0.025948 |
| RPS21 | ribosomal protein S21 | -0.0258254 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0256556 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0256038 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0252561 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.025094 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0242295 |
| TMEM263 | transmembrane protein 263 | -0.024154 |
| MORF4L2 | mortality factor 4 like 2 | -0.0241158 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0234655 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.023302 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0231933 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0230551 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0227654 |
| FTL | ferritin, light polypeptide | -0.0224554 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0224201 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0220802 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0218618 |
| TKT | transketolase | -0.0217478 |
| CD63 | CD63 molecule | -0.0217385 |
| EMP1 | epithelial membrane protein 1 | -0.0216442 |
| SMYD3 | SET and MYND domain containing 3 | -0.0215689 |
| NPR2 | natriuretic peptide receptor 2 | -0.0213867 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0212733 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0212448 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0212427 |
| MT2A | metallothionein 2A | -0.0210794 |
| RPS5 | ribosomal protein S5 | -0.0209789 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0209018 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0208956 |
| RASAL2 | RAS protein activator like 2 | -0.0205667 |
| HMGB1 | high mobility group box 1 | -0.0205473 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0205072 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0204768 |
| OLA1 | Obg-like ATPase 1 | -0.0204767 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0202744 |
| RPL38 | ribosomal protein L38 | -0.0201683 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0199378 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0197174 |
| GNAS | GNAS complex locus | -0.0197133 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0193563 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0192516 |
| FGF13 | fibroblast growth factor 13 | -0.0192355 |
| MAP4 | microtubule-associated protein 4 | -0.0191244 |
| TCF12 | transcription factor 12 | -0.0189264 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.018838 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0187934 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0186948 |
| NOP58 | NOP58 ribonucleoprotein | -0.0186611 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0183721 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0183471 |
| FBXO32 | F-box protein 32 | -0.0183268 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0182825 |
| MKI67 | marker of proliferation Ki-67 | -0.0182125 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0180355 |
| RPL30 | ribosomal protein L30 | -0.017974 |
