| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB4X | thymosin beta 4, X-linked | 0.103079 |
| GOLGA4 | golgin A4 | 0.0827717 |
| XPO1 | exportin 1 | 0.0721437 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0670824 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.063285 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0603863 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0589603 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0584763 |
| ZNF292 | zinc finger protein 292 | 0.0575819 |
| TXNIP | thioredoxin interacting protein | 0.0554853 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0517829 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0459249 |
| NUP58 | nucleoporin 58 | 0.0456855 |
| CCNL1 | cyclin L1 | 0.045667 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0451863 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0438389 |
| QKI | QKI, KH domain containing, RNA binding | 0.0417756 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0404782 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0402311 |
| MATR3 | matrin 3 | 0.0388674 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0386896 |
| PCBP2 | poly(rC) binding protein 2 | 0.0362428 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0357906 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0352253 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0347461 |
| CDC73 | cell division cycle 73 | 0.0342084 |
| RPS2 | ribosomal protein S2 | 0.034089 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.03353 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0329137 |
| RNF145 | ring finger protein 145 | 0.0327039 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0319401 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0318208 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0316675 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.03111 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0309852 |
| HMGB2 | high mobility group box 2 | 0.0306874 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0302397 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0299946 |
| ECT2 | epithelial cell transforming 2 | 0.0298155 |
| MEF2A | myocyte enhancer factor 2A | 0.0296352 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0293256 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0288539 |
| HDAC9 | histone deacetylase 9 | 0.0286445 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0285272 |
| TXNRD1 | thioredoxin reductase 1 | 0.0278462 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0277152 |
| SET | SET nuclear proto-oncogene | 0.0270351 |
| SMC3 | structural maintenance of chromosomes 3 | 0.026868 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0267679 |
| TFG | TRK-fused gene | 0.0264709 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.026441 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0262749 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0261803 |
| NCKAP1 | NCK-associated protein 1 | 0.0261498 |
| B2M | beta-2-microglobulin | 0.025943 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.025553 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0254758 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0251372 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250817 |
| MT2A | metallothionein 2A | 0.0248518 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0245359 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0243878 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0242741 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.0236339 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0234579 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0233629 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0229639 |
| ANK2 | ankyrin 2, neuronal | 0.0229241 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0229061 |
| RPL3 | ribosomal protein L3 | 0.0227724 |
| SFTPA2 | surfactant protein A2 | 0.0227509 |
| KIF5B | kinesin family member 5B | 0.0226757 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0222182 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0218857 |
| FAM13A | family with sequence similarity 13, member A | 0.0218481 |
| USP24 | ubiquitin specific peptidase 24 | 0.0217187 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0216449 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0214991 |
| PREPL | prolyl endopeptidase-like | 0.0211838 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0211155 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0211051 |
| MIS18BP1 | MIS18 binding protein 1 | 0.021084 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.020832 |
| EVI5 | ecotropic viral integration site 5 | 0.0203816 |
| OGA | O-GlcNAcase | 0.0203066 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0202032 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0200404 |
| EZR | ezrin | 0.0199645 |
| RYBP | RING1 and YY1 binding protein | 0.0198942 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0198369 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0198185 |
| PTMS | parathymosin | 0.019662 |
| RHEB | Ras homolog enriched in brain | 0.0191441 |
| ARRDC3 | arrestin domain containing 3 | 0.0191253 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0190987 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0190416 |
| CASC3 | cancer susceptibility candidate 3 | 0.0189566 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0189168 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0188203 |
| PAQR3 | progestin and adipoQ receptor family member III | 0.0187566 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.34611 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.121475 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.112152 |
| FOXP1 | forkhead box P1 | -0.0803217 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0737923 |
| RPL31 | ribosomal protein L31 | -0.0731716 |
| RPS23 | ribosomal protein S23 | -0.0695663 |
| BMP10 | bone morphogenetic protein 10 | -0.0672171 |
| RPS13 | ribosomal protein S13 | -0.0633471 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0621734 |
| EGFR | epidermal growth factor receptor | -0.0620501 |
| VCL | vinculin | -0.0619692 |
| PTMA | prothymosin, alpha | -0.0606715 |
| ACTG1 | actin gamma 1 | -0.0602691 |
| PKM | pyruvate kinase, muscle | -0.0590264 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0572433 |
| RPLP1 | ribosomal protein, large, P1 | -0.0569795 |
| RPL34 | ribosomal protein L34 | -0.0554222 |
| RPS6 | ribosomal protein S6 | -0.0489878 |
| RPL9 | ribosomal protein L9 | -0.0482136 |
| RPS29 | ribosomal protein S29 | -0.0472279 |
| RPL19 | ribosomal protein L19 | -0.0461919 |
| RPS25 | ribosomal protein S25 | -0.0450953 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0450428 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0435777 |
| RPS8 | ribosomal protein S8 | -0.0422798 |
| RPLP2 | ribosomal protein, large, P2 | -0.0421658 |
| RPL38 | ribosomal protein L38 | -0.0419876 |
| CCND1 | cyclin D1 | -0.0413971 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0412579 |
| RPL35A | ribosomal protein L35a | -0.0409526 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0391821 |
| RPL37A | ribosomal protein L37a | -0.0390762 |
| RPS24 | ribosomal protein S24 | -0.0378662 |
| RPS21 | ribosomal protein S21 | -0.0373445 |
| RPS27A | ribosomal protein S27a | -0.0368658 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0360542 |
| GLI3 | GLI family zinc finger 3 | -0.0358105 |
| S100A10 | S100 calcium binding protein A10 | -0.0356721 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0355182 |
| S100A9 | S100 calcium binding protein A9 | -0.034429 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0330606 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0329533 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0323558 |
| RPS15 | ribosomal protein S15 | -0.0319055 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0308593 |
| RPL8 | ribosomal protein L8 | -0.0305973 |
| SMYD3 | SET and MYND domain containing 3 | -0.0302895 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0302857 |
| EFNA5 | ephrin-A5 | -0.0302573 |
| RPS11 | ribosomal protein S11 | -0.0300512 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0298175 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0296136 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0293933 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0290774 |
| NBEA | neurobeachin | -0.0288238 |
| VIM | vimentin | -0.0287622 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0287541 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0285438 |
| RPL7A | ribosomal protein L7a | -0.0280167 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0279836 |
| RPS16 | ribosomal protein S16 | -0.0279329 |
| CUX1 | cut-like homeobox 1 | -0.0278142 |
| INTS6 | integrator complex subunit 6 | -0.0277991 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0277633 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0277304 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0276606 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0274326 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0268068 |
| SEPTIN9 | septin 9 | -0.0267212 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0264556 |
| OSMR | oncostatin M receptor | -0.0264475 |
| ASPH | aspartate beta-hydroxylase | -0.0259011 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0258757 |
| NOP56 | NOP56 ribonucleoprotein | -0.0253687 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0252634 |
| HLA-B | major histocompatibility complex, class I, B | -0.02519 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0250688 |
| RPLP0 | ribosomal protein, large, P0 | -0.0248835 |
| RPL27A | ribosomal protein L27a | -0.0248772 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0248411 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0247608 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0244202 |
| RPL15 | ribosomal protein L15 | -0.0243711 |
| RPS3 | ribosomal protein S3 | -0.0239117 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.0237022 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0236873 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0236588 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0235349 |
| RPL36A | ribosomal protein L36a | -0.0234412 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0232744 |
| RPL30 | ribosomal protein L30 | -0.0232134 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0230924 |
| BPTF | bromodomain PHD finger transcription factor | -0.0230595 |
| TBCA | tubulin folding cofactor A | -0.0230436 |
| GPATCH8 | G patch domain containing 8 | -0.0229232 |
| FUS | FUS RNA binding protein | -0.022835 |
| MYO5C | myosin VC | -0.022715 |
| AHNAK | AHNAK nucleoprotein | -0.0226348 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0223616 |
