| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.146957 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.145158 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.107032 |
| FN1 | fibronectin 1 | 0.10623 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.104447 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0955718 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0845141 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0828156 |
| CADM1 | cell adhesion molecule 1 | 0.0719111 |
| SFTPA2 | surfactant protein A2 | 0.0645064 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0634493 |
| ZNF292 | zinc finger protein 292 | 0.0632767 |
| SPAG9 | sperm associated antigen 9 | 0.0625776 |
| ATP13A3 | ATPase type 13A3 | 0.061123 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0569147 |
| ARRDC3 | arrestin domain containing 3 | 0.0545861 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0525174 |
| HELZ | helicase with zinc finger | 0.0518844 |
| OGA | O-GlcNAcase | 0.0507077 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0495427 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0494111 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0488233 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0481614 |
| ADM | adrenomedullin | 0.0478316 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0475294 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.046881 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0460742 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0449526 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0439355 |
| MSN | moesin | 0.0436225 |
| PCBP2 | poly(rC) binding protein 2 | 0.0430455 |
| PDE10A | phosphodiesterase 10A | 0.0427474 |
| VEGFA | vascular endothelial growth factor A | 0.0422674 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.039646 |
| FLNA | filamin A, alpha | 0.0383938 |
| MYOF | myoferlin | 0.0380609 |
| ANLN | anillin, actin binding protein | 0.0369066 |
| GOLGA4 | golgin A4 | 0.0368192 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0364087 |
| CENPF | centromere protein F, 350/400kDa | 0.036389 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0335986 |
| MKI67 | marker of proliferation Ki-67 | 0.0326257 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0323339 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0317443 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0311841 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0311282 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0306544 |
| ANXA2 | annexin A2 | 0.0306 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0305996 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0304925 |
| APP | amyloid beta (A4) precursor protein | 0.0304528 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0304148 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0298498 |
| CCNL1 | cyclin L1 | 0.0298425 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0292676 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0290875 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0284984 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0284066 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0269274 |
| NAV2 | neuron navigator 2 | 0.0252494 |
| USP37 | ubiquitin specific peptidase 37 | 0.0247399 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0242289 |
| FLNB | filamin B, beta | 0.0238804 |
| NUP153 | nucleoporin 153kDa | 0.0237609 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0236878 |
| TMSB4X | thymosin beta 4, X-linked | 0.0234697 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0234563 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0232675 |
| SNX9 | sorting nexin 9 | 0.0232357 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0230967 |
| AFDN | afadin, adherens junction formation factor | 0.0230392 |
| PGK1 | phosphoglycerate kinase 1 | 0.0229569 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0227804 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.022655 |
| DENND5A | DENN/MADD domain containing 5A | 0.0225901 |
| CORO1C | coronin, actin binding protein, 1C | 0.022489 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0220724 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0220132 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0219655 |
| RNF145 | ring finger protein 145 | 0.0218922 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0218172 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0216962 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0213882 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0213095 |
| FOXO3 | forkhead box O3 | 0.0212362 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0211856 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0211635 |
| AHR | aryl hydrocarbon receptor | 0.0211219 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0209513 |
| OPTN | optineurin | 0.0202877 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0201191 |
| MATR3 | matrin 3 | 0.0200851 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0200761 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0199275 |
| KIF13A | kinesin family member 13A | 0.0198886 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0197826 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0196489 |
| TPX2 | TPX2, microtubule-associated | 0.0196221 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0193841 |
| TTK | TTK protein kinase | 0.0193736 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.224603 |
| VIM | vimentin | -0.205476 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.133034 |
| HLA-B | major histocompatibility complex, class I, B | -0.124702 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.111962 |
| IER3 | immediate early response 3 | -0.111451 |
| HMGA2 | high mobility group AT-hook 2 | -0.101648 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101067 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0984362 |
| GLIS3 | GLIS family zinc finger 3 | -0.0935489 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0839231 |
| FTL | ferritin, light polypeptide | -0.0838314 |
| TMSB10 | thymosin beta 10 | -0.0829717 |
| CDH13 | cadherin 13 | -0.0787402 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0776519 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0741982 |
| RPS6 | ribosomal protein S6 | -0.0619694 |
| MT2A | metallothionein 2A | -0.0610652 |
| RPS24 | ribosomal protein S24 | -0.0568561 |
| FRMD4A | FERM domain containing 4A | -0.0556249 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0552128 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0540737 |
| ACTG1 | actin gamma 1 | -0.0537747 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0531959 |
| ASPH | aspartate beta-hydroxylase | -0.051975 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.051033 |
| NAV1 | neuron navigator 1 | -0.0503241 |
| RPS8 | ribosomal protein S8 | -0.0502327 |
| SMYD3 | SET and MYND domain containing 3 | -0.0495927 |
| RPL35A | ribosomal protein L35a | -0.0486553 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0482282 |
| VCL | vinculin | -0.0477498 |
| NDRG1 | N-myc downstream regulated 1 | -0.0468563 |
| RPS23 | ribosomal protein S23 | -0.0468108 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0457971 |
| DIAPH2 | diaphanous-related formin 2 | -0.0456678 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0453505 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0450916 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0450459 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.044252 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0439615 |
| HLA-A | major histocompatibility complex, class I, A | -0.0439118 |
| ENO1 | enolase 1, (alpha) | -0.0420215 |
| EGR1 | early growth response 1 | -0.0414036 |
| AFF3 | AF4/FMR2 family, member 3 | -0.041309 |
| RPLP1 | ribosomal protein, large, P1 | -0.0407683 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0402587 |
| RPL23 | ribosomal protein L23 | -0.040247 |
| RPLP2 | ribosomal protein, large, P2 | -0.0402428 |
| GOLGB1 | golgin B1 | -0.0398718 |
| INTS6 | integrator complex subunit 6 | -0.0389354 |
| SQSTM1 | sequestosome 1 | -0.0386684 |
| HDAC9 | histone deacetylase 9 | -0.0385293 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0380694 |
| CTSD | cathepsin D | -0.0374997 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.03715 |
| TMEM132D | transmembrane protein 132D | -0.0370945 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0367119 |
| GNAS | GNAS complex locus | -0.0366163 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.036231 |
| BICC1 | BicC family RNA binding protein 1 | -0.0360909 |
| RND3 | Rho family GTPase 3 | -0.0360378 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0352411 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0345039 |
| RPL19 | ribosomal protein L19 | -0.0344976 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0342081 |
| RPS19 | ribosomal protein S19 | -0.0340925 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0340552 |
| EFNA5 | ephrin-A5 | -0.0339044 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0336847 |
| RPL32 | ribosomal protein L32 | -0.033433 |
| LDHA | lactate dehydrogenase A | -0.0334323 |
| ATXN1 | ataxin 1 | -0.0331261 |
| RPS12 | ribosomal protein S12 | -0.0330869 |
| NABP1 | nucleic acid binding protein 1 | -0.0325938 |
| RPL34 | ribosomal protein L34 | -0.0319447 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0317555 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0315165 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0314425 |
| RPS21 | ribosomal protein S21 | -0.0310436 |
| RPS13 | ribosomal protein S13 | -0.0307381 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0307089 |
| RAI14 | retinoic acid induced 14 | -0.0302484 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0296776 |
| RPL9 | ribosomal protein L9 | -0.0294104 |
| RAD51B | RAD51 paralog B | -0.0291887 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0289133 |
| RPL36A | ribosomal protein L36a | -0.0286254 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0285203 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0279941 |
| FNIP1 | folliculin interacting protein 1 | -0.0279212 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.027679 |
| RPL37A | ribosomal protein L37a | -0.0266345 |
| RPL38 | ribosomal protein L38 | -0.0266139 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0265226 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0262631 |
| EXOC4 | exocyst complex component 4 | -0.0261509 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0261442 |
| RPS10 | ribosomal protein S10 | -0.0260909 |
| COL5A1 | collagen, type V, alpha 1 | -0.0257722 |
