| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.166535 |
| B2M | beta-2-microglobulin | 0.130061 |
| MT2A | metallothionein 2A | 0.11227 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0819511 |
| FTL | ferritin, light polypeptide | 0.0628822 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0555014 |
| ADM | adrenomedullin | 0.0521081 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.051486 |
| GOLGA4 | golgin A4 | 0.0469011 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0461685 |
| ARRDC3 | arrestin domain containing 3 | 0.0439119 |
| FAM13A | family with sequence similarity 13, member A | 0.0417999 |
| VEGFA | vascular endothelial growth factor A | 0.0383991 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0383355 |
| PTMA | prothymosin, alpha | 0.0381721 |
| CALR | calreticulin | 0.0372578 |
| CANX | calnexin | 0.0367586 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0366972 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0362505 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0357938 |
| RNF145 | ring finger protein 145 | 0.0356736 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0350347 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.034705 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0339445 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0338683 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.032673 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0326613 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.032642 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0323012 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0314843 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0313879 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.031149 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0310902 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0305836 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0300142 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0299628 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0299235 |
| XPO1 | exportin 1 | 0.0294884 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0292999 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0284831 |
| RPL12 | ribosomal protein L12 | 0.027903 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.027315 |
| RYBP | RING1 and YY1 binding protein | 0.0266252 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0261291 |
| YBX1 | Y box binding protein 1 | 0.0260722 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0259259 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0258772 |
| INSIG2 | insulin induced gene 2 | 0.0257715 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0256899 |
| RPL11 | ribosomal protein L11 | 0.0252918 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0252513 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0251628 |
| FAM13B | family with sequence similarity 13, member B | 0.0250742 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0250379 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.024775 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0244975 |
| PHF21A | PHD finger protein 21A | 0.0244467 |
| TMEM167A | transmembrane protein 167A | 0.0243935 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0241764 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0241593 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0236187 |
| CTSB | cathepsin B | 0.0234311 |
| RHEB | Ras homolog enriched in brain | 0.0233582 |
| ATP13A3 | ATPase type 13A3 | 0.023242 |
| RPS12 | ribosomal protein S12 | 0.0228483 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0227196 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0226356 |
| RPL37A | ribosomal protein L37a | 0.022481 |
| HMGB2 | high mobility group box 2 | 0.0220954 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0220657 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0220361 |
| CDC27 | cell division cycle 27 | 0.0217361 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0214645 |
| IL6 | interleukin 6 | 0.021378 |
| SEM1 | SEM1 26S proteasome subunit | 0.0212254 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0211836 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0209473 |
| PTN | pleiotrophin | 0.0208545 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0206894 |
| BRD2 | bromodomain containing 2 | 0.0206123 |
| RACK1 | receptor for activated C kinase 1 | 0.0205473 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0204026 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.0201973 |
| DSTN | destrin (actin depolymerizing factor) | 0.0199066 |
| MAGT1 | magnesium transporter 1 | 0.0198591 |
| CXXC5 | CXXC finger protein 5 | 0.0198222 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0197897 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0197694 |
| FAM162A | family with sequence similarity 162, member A | 0.0195967 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0195928 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0195816 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0195612 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0193661 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0193069 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0192164 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0191664 |
| MSN | moesin | 0.01907 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0190411 |
| QKI | QKI, KH domain containing, RNA binding | 0.018928 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0188872 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.172796 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.151697 |
| FN1 | fibronectin 1 | -0.0921559 |
| HLA-B | major histocompatibility complex, class I, B | -0.0901256 |
| HMGA2 | high mobility group AT-hook 2 | -0.0840576 |
| GLIS3 | GLIS family zinc finger 3 | -0.0756043 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0744763 |
| LOX | lysyl oxidase | -0.0680666 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0655414 |
| LOXL2 | lysyl oxidase-like 2 | -0.0595942 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0563139 |
| CDK6 | cyclin-dependent kinase 6 | -0.0559556 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0499243 |
| TMSB10 | thymosin beta 10 | -0.0495937 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0490732 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0490459 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.048667 |
| VCL | vinculin | -0.0469929 |
| CALD1 | caldesmon 1 | -0.045628 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0452029 |
| CLTC | clathrin, heavy chain (Hc) | -0.0422892 |
| SMAD3 | SMAD family member 3 | -0.042122 |
| NRP1 | neuropilin 1 | -0.0417246 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0405998 |
| MAP1B | microtubule-associated protein 1B | -0.0401305 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0394191 |
| EFNA5 | ephrin-A5 | -0.0379837 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0368887 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.036837 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.036386 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0363696 |
| AOPEP | aminopeptidase O (putative) | -0.0361648 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0361141 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0358327 |
| SRPK2 | SRSF protein kinase 2 | -0.0356733 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0353313 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0351702 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0349904 |
| USP34 | ubiquitin specific peptidase 34 | -0.0346541 |
| EXOC4 | exocyst complex component 4 | -0.0338472 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.0332427 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.033102 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0329481 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0321878 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0321512 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0320557 |
| OSMR | oncostatin M receptor | -0.03114 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0310302 |
| MAP4 | microtubule-associated protein 4 | -0.0305468 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0305309 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0300061 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0296307 |
| FUS | FUS RNA binding protein | -0.0296295 |
| ANXA2 | annexin A2 | -0.0295083 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0293236 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0289523 |
| TAGLN2 | transgelin 2 | -0.0284278 |
| HIP1 | huntingtin interacting protein 1 | -0.0281514 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0279797 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0279062 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0277549 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.027722 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0275458 |
| PTK2 | protein tyrosine kinase 2 | -0.0275316 |
| COL5A1 | collagen, type V, alpha 1 | -0.0273881 |
| ASPH | aspartate beta-hydroxylase | -0.0273161 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.027157 |
| RASAL2 | RAS protein activator like 2 | -0.0265789 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0264843 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0263871 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0261782 |
| STK17A | serine/threonine kinase 17a | -0.0260665 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0259781 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0258492 |
| CUL3 | cullin 3 | -0.0256961 |
| PCM1 | pericentriolar material 1 | -0.0256738 |
| AK1 | adenylate kinase 1 | -0.0254525 |
| TNNC1 | troponin C type 1 (slow) | -0.025263 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0251781 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0251527 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.025125 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0250506 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0250097 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0250064 |
| ZNF644 | zinc finger protein 644 | -0.0244785 |
| SETBP1 | SET binding protein 1 | -0.0241936 |
| NKTR | natural killer cell triggering receptor | -0.0241202 |
| CFDP1 | craniofacial development protein 1 | -0.0240732 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.024038 |
| AHNAK | AHNAK nucleoprotein | -0.023995 |
| FAM20C | family with sequence similarity 20, member C | -0.0239242 |
| SYNPO | synaptopodin | -0.0239048 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0238296 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0237443 |
| EHBP1 | EH domain binding protein 1 | -0.023651 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0232844 |
| PMM2 | phosphomannomutase 2 | -0.0230256 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0228315 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0227575 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0225378 |
