Osimertinib (mesylate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0967189
PTMA prothymosin, alpha 0.0833123
HILPDA hypoxia inducible lipid droplet-associated 0.0812884
NAMPT nicotinamide phosphoribosyltransferase 0.0623412
BHLHE40 basic helix-loop-helix family, member e40 0.0555943
RPS3 ribosomal protein S3 0.0532216
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0489822
RPL23 ribosomal protein L23 0.0488729
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0488721
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0481016
SET SET nuclear proto-oncogene 0.0428458
MT2A metallothionein 2A 0.0427025
XPO1 exportin 1 0.0421098
RPLP1 ribosomal protein, large, P1 0.038386
EIF1 eukaryotic translation initiation factor 1 0.0382669
RPL26 ribosomal protein L26 0.0375677
NUP58 nucleoporin 58 0.0374214
CHD1 chromodomain helicase DNA binding protein 1 0.036943
B2M beta-2-microglobulin 0.0368768
PNISR PNN-interacting serine/arginine-rich protein 0.0359851
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0353827
LOC102724023 ES1 protein homolog, mitochondrial 0.0349444
TRA2A transformer 2 alpha homolog (Drosophila) 0.0346206
RPS12 ribosomal protein S12 0.032802
RPL35A ribosomal protein L35a 0.0324008
KIF5B kinesin family member 5B 0.0322978
PCBP2 poly(rC) binding protein 2 0.0321754
RPL12 ribosomal protein L12 0.0314117
HDGF hepatoma-derived growth factor 0.030575
RNF145 ring finger protein 145 0.0301257
FTL ferritin, light polypeptide 0.030074
SNX14 sorting nexin 14 0.0296795
ADM adrenomedullin 0.0291373
ANKRD37 ankyrin repeat domain 37 0.0290851
SRRM2 serine/arginine repetitive matrix 2 0.0290476
ARRDC3 arrestin domain containing 3 0.0289961
MATR3 matrin 3 0.0285138
NAP1L1 nucleosome assembly protein 1-like 1 0.0283259
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.027838
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0271268
DDIT4 DNA-damage-inducible transcript 4 0.0268589
CIB1 calcium and integrin binding 1 (calmyrin) 0.0265528
WSB1 WD repeat and SOCS box containing 1 0.0263579
BIRC3 baculoviral IAP repeat containing 3 0.0257491
RSRC2 arginine/serine-rich coiled-coil 2 0.0254968
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0254298
RPL37A ribosomal protein L37a 0.0252326
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0251784
TPI1 triosephosphate isomerase 1 0.025127
TMEM41B transmembrane protein 41B 0.0250249
EEF2 eukaryotic translation elongation factor 2 0.0247611
IGFBP3 insulin-like growth factor binding protein 3 0.024549
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0243879
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0243298
PCLO piccolo presynaptic cytomatrix protein 0.0241662
S100A9 S100 calcium binding protein A9 0.0238714
CALR calreticulin 0.0238206
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0237533
RPS17 ribosomal protein S17 0.0233047
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0230841
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0228642
FMNL2 formin-like 2 0.0227919
PFN1 profilin 1 0.0224347
PRPF4B pre-mRNA processing factor 4B 0.0221317
VIM vimentin 0.0220434
RAB6A RAB6A, member RAS oncogene family 0.021898
SYNE2 spectrin repeat containing, nuclear envelope 2 0.021889
EIF4B eukaryotic translation initiation factor 4B 0.0218416
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0218386
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.021718
ERRFI1 ERBB receptor feedback inhibitor 1 0.0216087
TPM3 tropomyosin 3 0.0215653
KMT2E lysine (K)-specific methyltransferase 2E 0.021517
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0214725
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.021424
INSIG1 insulin induced gene 1 0.0214188
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0209802
HSPA4 heat shock 70kDa protein 4 0.020943
SMAP1 small ArfGAP 1 0.0209125
RAD23B RAD23 homolog B (S. cerevisiae) 0.0208922
YAP1 Yes-associated protein 1 0.0207311
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0206777
ZBTB1 zinc finger and BTB domain containing 1 0.0205656
RPL21 ribosomal protein L21 0.0205404
RANBP9 RAN binding protein 9 0.0199443
WDR43 WD repeat domain 43 0.0199403
CCNL1 cyclin L1 0.0199224
RPS2 ribosomal protein S2 0.0198976
LGALS1 lectin, galactoside-binding, soluble, 1 0.019886
RPS8 ribosomal protein S8 0.0198238
STAT1 signal transducer and activator of transcription 1, 91kDa 0.019815
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0197389
ATP5F1E ATP synthase F1 subunit epsilon 0.0196938
RACK1 receptor for activated C kinase 1 0.0196873
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0196382
CEP250 centrosomal protein 250kDa 0.0194853
RAB1A RAB1A, member RAS oncogene family 0.0194647
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0194242
CUL4B cullin 4B 0.0192741
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0192397

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.34193
SMYD3 SET and MYND domain containing 3 -0.109889
TAS2R14 taste receptor, type 2, member 14 -0.10783
FNDC3B fibronectin type III domain containing 3B -0.0949539
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0788608
ATM ATM serine/threonine kinase -0.0676921
OSMR oncostatin M receptor -0.06693
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0663299
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0645552
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0568443
THSD4 thrombospondin, type I, domain containing 4 -0.0565583
LOC112694756 uncharaterized LOC112694756 -0.0561254
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0559676
FMN1 formin 1 -0.0541482
ANKRD28 ankyrin repeat domain 28 -0.0533452
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0522391
MBD5 methyl-CpG binding domain protein 5 -0.0520009
DST dystonin -0.0515473
SMAD3 SMAD family member 3 -0.0500417
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0489977
TRIO trio Rho guanine nucleotide exchange factor -0.0485552
HMGA2 high mobility group AT-hook 2 -0.0483772
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0470359
VCL vinculin -0.0469199
ZBTB20 zinc finger and BTB domain containing 20 -0.046787
FNIP1 folliculin interacting protein 1 -0.0455796
NCEH1 neutral cholesterol ester hydrolase 1 -0.0453158
LDHA lactate dehydrogenase A -0.04499
SLC38A2 solute carrier family 38, member 2 -0.0448852
CD44 CD44 molecule (Indian blood group) -0.0444036
DPYD dihydropyrimidine dehydrogenase -0.0440305
BIRC6 baculoviral IAP repeat containing 6 -0.0432288
DIAPH3 diaphanous-related formin 3 -0.0431677
SMC4 structural maintenance of chromosomes 4 -0.0429244
ACTG1 actin gamma 1 -0.0420533
SVIL supervillin -0.0419669
USP34 ubiquitin specific peptidase 34 -0.0418772
PBX3 pre-B-cell leukemia homeobox 3 -0.0412253
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0410811
KIAA1328 KIAA1328 -0.0406761
EFNA5 ephrin-A5 -0.0405969
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0402253
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0398935
NAV3 neuron navigator 3 -0.0398212
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0397926
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0392926
MBNL1 muscleblind-like splicing regulator 1 -0.0388617
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0386715
EXOC6B exocyst complex component 6B -0.0385867
ATG7 autophagy related 7 -0.0379133
LPP LIM domain containing preferred translocation partner in lipoma -0.0372492
SAMD4A sterile alpha motif domain containing 4A -0.0363713
JMJD1C jumonji domain containing 1C -0.0360787
NALCN sodium leak channel, non selective -0.0360736
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0351842
MKI67 marker of proliferation Ki-67 -0.0350213
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0348894
GPATCH2L G patch domain containing 2-like -0.0348084
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0346194
BCAR3 breast cancer anti-estrogen resistance 3 -0.0346163
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0346028
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0344226
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0341346
RAD51B RAD51 paralog B -0.0339788
PDE8A phosphodiesterase 8A -0.03394
TPT1 tumor protein, translationally-controlled 1 -0.0333712
PHF14 PHD finger protein 14 -0.0329324
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0326905
COMMD10 COMM domain containing 10 -0.0324852
SDCCAG8 serologically defined colon cancer antigen 8 -0.0324521
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.032323
RNF213 ring finger protein 213 -0.0322902
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0322794
FLNB filamin B, beta -0.0321966
CLASP2 cytoplasmic linker associated protein 2 -0.031633
ARB2A ARB2 cotranscriptional regulator A -0.031622
FER fer (fps/fes related) tyrosine kinase -0.0316165
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0315901
IL6ST interleukin 6 signal transducer -0.0312353
CENPF centromere protein F, 350/400kDa -0.0312169
PRH1 proline-rich protein HaeIII subfamily 1 -0.0310173
EXT1 exostosin glycosyltransferase 1 -0.0309258
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0309218
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0308427
INTS6 integrator complex subunit 6 -0.0308197
DLG1 discs, large homolog 1 (Drosophila) -0.0307871
ATF7IP activating transcription factor 7 interacting protein -0.0307482
ELL2 elongation factor, RNA polymerase II, 2 -0.0306571
PCNX4 pecanex 4 -0.0299899
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0297233
AK1 adenylate kinase 1 -0.0296954
AHNAK AHNAK nucleoprotein -0.0293785
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0293105
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0291871
ANO6 anoctamin 6 -0.0289565
BPTF bromodomain PHD finger transcription factor -0.0288617
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0287316
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0286738
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0281015
EXOC4 exocyst complex component 4 -0.0280987