Osimertinib (mesylate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.275389
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.115013
PTMA prothymosin, alpha 0.112157
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0948309
FTL ferritin, light polypeptide 0.0632198
TMSB4X thymosin beta 4, X-linked 0.056578
SFTPA2 surfactant protein A2 0.0504437
TMSB10 thymosin beta 10 0.0503844
CANX calnexin 0.0471248
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0407174
CALR calreticulin 0.0383316
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0381596
HILPDA hypoxia inducible lipid droplet-associated 0.0370414
PLIN2 perilipin 2 0.0365902
BHLHE40 basic helix-loop-helix family, member e40 0.0340664
RPL35A ribosomal protein L35a 0.0324885
B2M beta-2-microglobulin 0.0309119
RACK1 receptor for activated C kinase 1 0.0293498
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0277572
CXCL8 chemokine (C-X-C motif) ligand 8 0.0250311
KDM3A lysine (K)-specific demethylase 3A 0.0248779
RNF145 ring finger protein 145 0.0247726
DDIT4 DNA-damage-inducible transcript 4 0.0245817
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.023003
TPI1 triosephosphate isomerase 1 0.0221096
HMGB3 high mobility group box 3 0.0215383
RPL37A ribosomal protein L37a 0.0213728
VIM vimentin 0.02027
HLA-B major histocompatibility complex, class I, B 0.0198978
TCIM transcriptional and immune response regulator 0.0197374
TMED9 transmembrane emp24 protein transport domain containing 9 0.0196329
RPS27 ribosomal protein S27 0.0191557
RPL23 ribosomal protein L23 0.0190755
LGALS1 lectin, galactoside-binding, soluble, 1 0.018857
CTSB cathepsin B 0.0185974
EEF2 eukaryotic translation elongation factor 2 0.0184098
S100A6 S100 calcium binding protein A6 0.01791
RPL26 ribosomal protein L26 0.0177065
RPLP1 ribosomal protein, large, P1 0.0176086
BASP1 brain abundant, membrane attached signal protein 1 0.0175459
RPS3 ribosomal protein S3 0.0166843
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0162508
PGK1 phosphoglycerate kinase 1 0.0161644
IGFBP3 insulin-like growth factor binding protein 3 0.0160263
RPS19 ribosomal protein S19 0.0160256
SOX4 SRY (sex determining region Y)-box 4 0.0159425
H1-0 H1.0 linker histone 0.0158617
RPS8 ribosomal protein S8 0.0157401
HLA-A major histocompatibility complex, class I, A 0.0157208
RPL12 ribosomal protein L12 0.0156804
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0156355
FDPS farnesyl diphosphate synthase 0.0152253
ZFP36L1 ZFP36 ring finger protein-like 1 0.0151903
WDR43 WD repeat domain 43 0.0150291
CIB1 calcium and integrin binding 1 (calmyrin) 0.0149431
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0147939
RPL31 ribosomal protein L31 0.0144419
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0143943
IFI27 interferon, alpha-inducible protein 27 0.0138807
RPL37 ribosomal protein L37 0.0136909
EIF1 eukaryotic translation initiation factor 1 0.0135498
RPL36 ribosomal protein L36 0.0133086
RPS14 ribosomal protein S14 0.0132254
PDIA6 protein disulfide isomerase family A, member 6 0.013224
YBX1 Y box binding protein 1 0.0130674
SQSTM1 sequestosome 1 0.0127876
RPL36AL ribosomal protein L36a-like 0.012752
PELO pelota homolog (Drosophila) 0.0125003
RAD21 RAD21 homolog (S. pombe) 0.0124386
TPT1 tumor protein, translationally-controlled 1 0.0122004
ENO1 enolase 1, (alpha) 0.0121964
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.0120136
FAM13A family with sequence similarity 13, member A 0.0119739
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0117052
LOC102724023 ES1 protein homolog, mitochondrial 0.0116953
MLEC malectin 0.0116337
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0111932
AHNAK2 AHNAK nucleoprotein 2 0.0111497
SEC61G Sec61 gamma subunit 0.0110977
CST3 cystatin C 0.0110663
STC2 stanniocalcin 2 0.0110386
SRRM2 serine/arginine repetitive matrix 2 0.0110344
INSIG2 insulin induced gene 2 0.0109858
ZC3H15 zinc finger CCCH-type containing 15 0.0105883
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0103704
C15ORF48 chromosome 15 open reading frame 48 0.0103158
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0102108
ENO2 enolase 2 (gamma, neuronal) 0.0101374
ATF4 activating transcription factor 4 0.010114
RAB7A RAB7A, member RAS oncogene family 0.0100499
LMAN1 lectin, mannose-binding, 1 0.010008
ADM adrenomedullin 0.00999123
MT2A metallothionein 2A 0.0099078
FAM162A family with sequence similarity 162, member A 0.009851
RPS7 ribosomal protein S7 0.00979352
ADIPOR2 adiponectin receptor 2 0.00966097
CREBRF CREB3 regulatory factor 0.00958874
RPS27A ribosomal protein S27a 0.00952651
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00941208
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.00923802

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.295731
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.175828
FNDC3B fibronectin type III domain containing 3B -0.113019
NRG1 neuregulin 1 -0.108709
ASPH aspartate beta-hydroxylase -0.107533
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.102532
HMGA2 high mobility group AT-hook 2 -0.0955124
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0872937
EXT1 exostosin glycosyltransferase 1 -0.0716316
TRIO trio Rho guanine nucleotide exchange factor -0.069523
EFNA5 ephrin-A5 -0.0663159
NDRG1 N-myc downstream regulated 1 -0.0614575
TMEM156 transmembrane protein 156 -0.0610923
FN1 fibronectin 1 -0.0603746
GLIS3 GLIS family zinc finger 3 -0.0600689
PTK2 protein tyrosine kinase 2 -0.0596328
SMYD3 SET and MYND domain containing 3 -0.0582331
CENPF centromere protein F, 350/400kDa -0.0580994
SMAD3 SMAD family member 3 -0.0549366
ITGA1 integrin, alpha 1 -0.0493301
TAS2R14 taste receptor, type 2, member 14 -0.0491033
DOCK5 dedicator of cytokinesis 5 -0.0482338
MBD5 methyl-CpG binding domain protein 5 -0.0457948
NRP1 neuropilin 1 -0.0456946
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0456363
OSMR oncostatin M receptor -0.0455022
DST dystonin -0.044746
NAMPT nicotinamide phosphoribosyltransferase -0.0445357
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0440575
PDE4D phosphodiesterase 4D, cAMP-specific -0.043576
JMJD1C jumonji domain containing 1C -0.0400093
MAML2 mastermind-like 2 (Drosophila) -0.0393924
GPC6 glypican 6 -0.0392587
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.038764
IL6ST interleukin 6 signal transducer -0.0384581
MCTP2 multiple C2 domains, transmembrane 2 -0.0383019
ATXN1 ataxin 1 -0.0378082
FNBP1 formin binding protein 1 -0.0376493
CDCP1 CUB domain containing protein 1 -0.037467
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0369321
ZBTB20 zinc finger and BTB domain containing 20 -0.0368072
LRMDA leucine rich melanocyte differentiation associated -0.0364773
LOXL2 lysyl oxidase-like 2 -0.0360979
SVIL supervillin -0.0356089
HIPK2 homeodomain interacting protein kinase 2 -0.0352382
FOXP1 forkhead box P1 -0.0344602
MAP1B microtubule-associated protein 1B -0.0341393
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0336391
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0334924
AHR aryl hydrocarbon receptor -0.0333468
VCL vinculin -0.0328462
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0322554
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0318946
ETV6 ets variant 6 -0.031746
NAV2 neuron navigator 2 -0.0317196
NRIP1 nuclear receptor interacting protein 1 -0.0316414
SEPTIN9 septin 9 -0.03135
RUNX1 runt-related transcription factor 1 -0.0311942
USP34 ubiquitin specific peptidase 34 -0.030963
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0301472
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0300858
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0300856
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0297451
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0295965
PRKCA protein kinase C, alpha -0.0293774
KMT2E lysine (K)-specific methyltransferase 2E -0.029296
EXOC4 exocyst complex component 4 -0.0291565
FRY furry homolog (Drosophila) -0.0290397
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0289937
RAD51B RAD51 paralog B -0.0288467
APLP2 amyloid beta (A4) precursor-like protein 2 -0.028666
GRB10 growth factor receptor-bound protein 10 -0.0285996
RTN4 reticulon 4 -0.028449
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0282152
POTEF POTE ankyrin domain family, member F -0.0281089
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0280269
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0278708
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0275495
CLTC clathrin, heavy chain (Hc) -0.0274333
NPAS2 neuronal PAS domain protein 2 -0.0273849
TMEM165 transmembrane protein 165 -0.0271558
ELL2 elongation factor, RNA polymerase II, 2 -0.0269183
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.026591
DENND5B DENN/MADD domain containing 5B -0.026505
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.026449
ZC3H12C zinc finger CCCH-type containing 12C -0.0260565
PKM pyruvate kinase, muscle -0.0258006
BABAM2 BRISC and BRCA1 A complex member 2 -0.0257035
BPTF bromodomain PHD finger transcription factor -0.0256575
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.025581
P4HB prolyl 4-hydroxylase, beta polypeptide -0.025553
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0253894
PARD3 par-3 family cell polarity regulator -0.0252981
ZMYND8 zinc finger, MYND-type containing 8 -0.0251997
TTC28 tetratricopeptide repeat domain 28 -0.0251633
RANBP17 RAN binding protein 17 -0.0249406
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0249194
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0249049
VEGFC vascular endothelial growth factor C -0.0246232
RABGAP1L RAB GTPase activating protein 1-like -0.0245657