Osimertinib (mesylate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0846941
RBM39 RNA binding motif protein 39 0.0751997
MATR3 matrin 3 0.0694973
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0688591
CCNL1 cyclin L1 0.0621315
KMT2E lysine (K)-specific methyltransferase 2E 0.0599514
USP3 ubiquitin specific peptidase 3 0.0564778
H1-0 H1.0 linker histone 0.05457
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0543747
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0520921
MED13L mediator complex subunit 13-like 0.0516856
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0497542
NAMPT nicotinamide phosphoribosyltransferase 0.0491565
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0489072
RAD21 RAD21 homolog (S. pombe) 0.0487351
TRA2A transformer 2 alpha homolog (Drosophila) 0.0484049
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0476522
CTNND1 catenin (cadherin-associated protein), delta 1 0.0468837
FXR1 fragile X mental retardation, autosomal homolog 1 0.045392
KDM3A lysine (K)-specific demethylase 3A 0.0452772
NCKAP1 NCK-associated protein 1 0.0452068
TOP2B topoisomerase (DNA) II beta 180kDa 0.0450477
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0446281
GOLGA4 golgin A4 0.04179
KMT2C lysine (K)-specific methyltransferase 2C 0.0388242
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0387651
EEF2 eukaryotic translation elongation factor 2 0.0385763
PUM2 pumilio RNA-binding family member 2 0.0382718
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0380588
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0378608
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0378516
EPS8 epidermal growth factor receptor pathway substrate 8 0.0376007
TMSB4X thymosin beta 4, X-linked 0.0372519
TSC22D2 TSC22 domain family, member 2 0.03713
MTMR3 myotubularin related protein 3 0.0368698
ZNF292 zinc finger protein 292 0.0362817
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0361767
FNBP1L formin binding protein 1-like 0.0360745
RNF145 ring finger protein 145 0.0359498
FTH1 ferritin, heavy polypeptide 1 0.0358897
NEK7 NIMA-related kinase 7 0.0357138
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0356301
MYH9 myosin, heavy chain 9, non-muscle 0.0350862
BHLHE40 basic helix-loop-helix family, member e40 0.034744
WAC WW domain containing adaptor with coiled-coil 0.0346886
UGCG UDP-glucose ceramide glucosyltransferase 0.034674
AFDN afadin, adherens junction formation factor 0.0341155
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.034063
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0330566
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0329447
PDS5B PDS5 cohesin associated factor B 0.0328959
TFG TRK-fused gene 0.0327069
ANKRD28 ankyrin repeat domain 28 0.0322873
MARCHF6 membrane associated ring-CH-type finger 6 0.032203
NCOA3 nuclear receptor coactivator 3 0.0319314
SUCO SUN domain containing ossification factor 0.0318611
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0317333
EZR ezrin 0.0312618
FLNA filamin A, alpha 0.0312614
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0310999
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.030995
TRA2B transformer 2 beta homolog (Drosophila) 0.0307898
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0306053
ANKRD11 ankyrin repeat domain 11 0.0305853
TOP1 topoisomerase (DNA) I 0.0302006
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0298696
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0297084
DSCAM Down syndrome cell adhesion molecule 0.0293992
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0293184
KIF5B kinesin family member 5B 0.0292038
PICALM phosphatidylinositol binding clathrin assembly protein 0.029132
RBM25 RNA binding motif protein 25 0.0287265
TXNRD1 thioredoxin reductase 1 0.028717
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0284335
KDM6A lysine (K)-specific demethylase 6A 0.0281491
NPTN neuroplastin 0.0280456
ADAM17 ADAM metallopeptidase domain 17 0.0280222
ZFAND3 zinc finger, AN1-type domain 3 0.0278546
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0278306
RHEB Ras homolog enriched in brain 0.0277963
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0274301
AGFG1 ArfGAP with FG repeats 1 0.0273759
RBM33 RNA binding motif protein 33 0.0270217
FAM3C family with sequence similarity 3, member C 0.0270179
EWSR1 EWS RNA-binding protein 1 0.0269591
CUL3 cullin 3 0.0267361
RAD23B RAD23 homolog B (S. cerevisiae) 0.0266923
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0263032
GARS1 glycyl-tRNA synthetase 1 0.0261296
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0258645
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0258346
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0254448
PRRC2C proline-rich coiled-coil 2C 0.0254074
SPAG9 sperm associated antigen 9 0.0252935
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0252093
SNX9 sorting nexin 9 0.0250845
PLAUR plasminogen activator, urokinase receptor 0.0249093
NKTR natural killer cell triggering receptor 0.0248833
NRIP1 nuclear receptor interacting protein 1 0.0246699
FAR1 fatty acyl CoA reductase 1 0.0246219

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.15663
MAML2 mastermind-like 2 (Drosophila) -0.145713
PTMA prothymosin, alpha -0.110511
FTL ferritin, light polypeptide -0.10367
TMSB10 thymosin beta 10 -0.0917044
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0862756
RPS6 ribosomal protein S6 -0.0830293
PCLO piccolo presynaptic cytomatrix protein -0.0799734
ZBTB20 zinc finger and BTB domain containing 20 -0.070665
EHBP1 EH domain binding protein 1 -0.0706215
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.070328
EGR1 early growth response 1 -0.0701553
ZMYND8 zinc finger, MYND-type containing 8 -0.0607509
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0594448
RPL35A ribosomal protein L35a -0.0593402
FNDC3B fibronectin type III domain containing 3B -0.0591726
RPLP1 ribosomal protein, large, P1 -0.0582736
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0570513
GMDS GDP-mannose 4,6-dehydratase -0.0557859
CADPS Ca++-dependent secretion activator -0.0545689
EXOC4 exocyst complex component 4 -0.0526818
TPT1 tumor protein, translationally-controlled 1 -0.0510988
RPS21 ribosomal protein S21 -0.0510962
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0500227
CUX1 cut-like homeobox 1 -0.0497355
SDK1 sidekick cell adhesion molecule 1 -0.0485499
GOLGB1 golgin B1 -0.0485493
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0481016
GNAS GNAS complex locus -0.0471651
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0446673
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0444288
HM13 histocompatibility (minor) 13 -0.0436156
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0436014
MYO1E myosin IE -0.0435506
RPL37A ribosomal protein L37a -0.0426913
RPS25 ribosomal protein S25 -0.0426899
DLG1 discs, large homolog 1 (Drosophila) -0.042259
RPL31 ribosomal protein L31 -0.0420382
ACTG1 actin gamma 1 -0.0420246
PTPRK protein tyrosine phosphatase, receptor type, K -0.0402494
ZBTB38 zinc finger and BTB domain containing 38 -0.0396953
NCEH1 neutral cholesterol ester hydrolase 1 -0.039645
RPL23 ribosomal protein L23 -0.039366
NDRG1 N-myc downstream regulated 1 -0.0388856
RPS13 ribosomal protein S13 -0.0379835
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0378353
RAD51B RAD51 paralog B -0.0374237
RPLP0 ribosomal protein, large, P0 -0.0372726
PKM pyruvate kinase, muscle -0.0368825
BCL2L1 BCL2-like 1 -0.0363406
RPL34 ribosomal protein L34 -0.0361012
PERP PERP, TP53 apoptosis effector -0.0355282
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0348925
NEBL nebulette -0.0342563
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0341677
VCL vinculin -0.0341626
RPL19 ribosomal protein L19 -0.0338647
RPL12 ribosomal protein L12 -0.0336616
ETV6 ets variant 6 -0.0332808
RPS8 ribosomal protein S8 -0.0331266
RPLP2 ribosomal protein, large, P2 -0.0329638
GPHN gephyrin -0.0329355
LDHA lactate dehydrogenase A -0.0327559
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0326438
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0323046
LOC102724023 ES1 protein homolog, mitochondrial -0.0321848
HMGA1 high mobility group AT-hook 1 -0.032128
CEMIP cell migration inducing protein, hyaluronan binding -0.032047
MX2 MX dynamin-like GTPase 2 -0.0319481
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0316979
RPS24 ribosomal protein S24 -0.0316481
BPTF bromodomain PHD finger transcription factor -0.0315529
PATJ PATJ crumbs cell polarity complex component -0.0313358
RPL27A ribosomal protein L27a -0.0311151
TMEM123 transmembrane protein 123 -0.0305051
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0304991
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0301775
KRT8 keratin 8, type II -0.0301711
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0300368
PLSCR1 phospholipid scramblase 1 -0.0299012
INTS6 integrator complex subunit 6 -0.0295723
IFITM1 interferon induced transmembrane protein 1 -0.0292703
RPL26 ribosomal protein L26 -0.0291428
SP100 SP100 nuclear antigen -0.029124
RPS5 ribosomal protein S5 -0.0289595
NFIA nuclear factor I/A -0.0289059
RPL8 ribosomal protein L8 -0.0289049
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0285644
IER3 immediate early response 3 -0.0285086
RPS19 ribosomal protein S19 -0.0283278
B2M beta-2-microglobulin -0.0283047
SERINC5 serine incorporator 5 -0.0282036
FAT1 FAT atypical cadherin 1 -0.0281612
SLC38A2 solute carrier family 38, member 2 -0.0281335
CMIP c-Maf inducing protein -0.028067
CDK13 cyclin-dependent kinase 13 -0.0280494
RPL9 ribosomal protein L9 -0.0280274
RPS12 ribosomal protein S12 -0.0279418
RPS17 ribosomal protein S17 -0.0278567
TAS2R14 taste receptor, type 2, member 14 -0.027706