| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ANXA1 | annexin A1 | 0.111442 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.111165 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0686101 |
| DSPP | dentin sialophosphoprotein | 0.0626003 |
| RPS3 | ribosomal protein S3 | 0.0534063 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.048091 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0472749 |
| RPL3 | ribosomal protein L3 | 0.0466207 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0427183 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0420232 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0416565 |
| RNF145 | ring finger protein 145 | 0.0391419 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0389035 |
| RPS2 | ribosomal protein S2 | 0.0378034 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0375852 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0366871 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0362358 |
| WDR43 | WD repeat domain 43 | 0.034191 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0337689 |
| AREG | amphiregulin | 0.0333559 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0324637 |
| CPOX | coproporphyrinogen oxidase | 0.0316613 |
| CTSB | cathepsin B | 0.0314698 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0312603 |
| PCBP2 | poly(rC) binding protein 2 | 0.0307018 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0298316 |
| BRD2 | bromodomain containing 2 | 0.028579 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0282364 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0280326 |
| YTHDC1 | YTH domain containing 1 | 0.0277484 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0271591 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0269162 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0268991 |
| NUP58 | nucleoporin 58 | 0.0265383 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0264387 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0263093 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0261567 |
| TXNIP | thioredoxin interacting protein | 0.0260816 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0256127 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0255993 |
| RPS18 | ribosomal protein S18 | 0.0254829 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0254093 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0246449 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.024429 |
| RPS3A | ribosomal protein S3A | 0.0242228 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.023995 |
| HDAC2 | histone deacetylase 2 | 0.0239721 |
| CCNL1 | cyclin L1 | 0.0238495 |
| GOLGA4 | golgin A4 | 0.0236239 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0235843 |
| PNN | pinin, desmosome associated protein | 0.0230156 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0228315 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0228277 |
| RBM39 | RNA binding motif protein 39 | 0.0226094 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0224607 |
| INSIG2 | insulin induced gene 2 | 0.0223701 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0219469 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.021865 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0218096 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0217872 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.021433 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0213993 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0212123 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0209007 |
| CLDND1 | claudin domain containing 1 | 0.0208993 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0208792 |
| SETD5 | SET domain containing 5 | 0.020648 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0201665 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.02009 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0199459 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0198119 |
| FMNL2 | formin-like 2 | 0.0197665 |
| TPR | translocated promoter region, nuclear basket protein | 0.0197564 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0197203 |
| SFTPA2 | surfactant protein A2 | 0.019701 |
| RPS7 | ribosomal protein S7 | 0.0195649 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0193259 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0191734 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.0191323 |
| DENR | density-regulated protein | 0.0188865 |
| YBX1 | Y box binding protein 1 | 0.0187288 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.018616 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.018509 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0185006 |
| APP | amyloid beta (A4) precursor protein | 0.0184685 |
| FAM13B | family with sequence similarity 13, member B | 0.0183746 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0180173 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0178163 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0176601 |
| NFXL1 | nuclear transcription factor, X-box binding-like 1 | 0.0176165 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0174993 |
| MATR3 | matrin 3 | 0.0174943 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0174667 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0170611 |
| SET | SET nuclear proto-oncogene | 0.0170316 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0170152 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0169863 |
| MPZL3 | myelin protein zero-like 3 | 0.01682 |
| H1-10 | H1.10 linker histone | 0.0167802 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0166061 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | -0.167586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154056 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.14716 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.114681 |
| ACTG1 | actin gamma 1 | -0.110824 |
| IER3 | immediate early response 3 | -0.107574 |
| EGFR | epidermal growth factor receptor | -0.087427 |
| RAD51B | RAD51 paralog B | -0.0812603 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0752619 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0683827 |
| ATXN1 | ataxin 1 | -0.0682911 |
| EGR1 | early growth response 1 | -0.0648315 |
| RPS24 | ribosomal protein S24 | -0.0636308 |
| SMYD3 | SET and MYND domain containing 3 | -0.0620955 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0618786 |
| GPHN | gephyrin | -0.0605727 |
| FERMT1 | fermitin family member 1 | -0.0585664 |
| ACTN4 | actinin, alpha 4 | -0.0578063 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0568674 |
| FHIT | fragile histidine triad | -0.0561389 |
| RNF43 | ring finger protein 43 | -0.0517876 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0504706 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0502269 |
| CUX1 | cut-like homeobox 1 | -0.0498273 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0495383 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0481339 |
| FLOT1 | flotillin 1 | -0.0471445 |
| EXOC4 | exocyst complex component 4 | -0.0446397 |
| NDRG1 | N-myc downstream regulated 1 | -0.0433112 |
| TXNRD1 | thioredoxin reductase 1 | -0.0411184 |
| RPL34 | ribosomal protein L34 | -0.0407214 |
| S100A10 | S100 calcium binding protein A10 | -0.0400794 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0399496 |
| SERINC5 | serine incorporator 5 | -0.0384414 |
| RPLP1 | ribosomal protein, large, P1 | -0.0377429 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0373862 |
| TOP1 | topoisomerase (DNA) I | -0.0365748 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0356148 |
| RPS6 | ribosomal protein S6 | -0.0354494 |
| MTAP | methylthioadenosine phosphorylase | -0.0350878 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.033994 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0336811 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.0334991 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0333521 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0326069 |
| FOSL1 | FOS-like antigen 1 | -0.0319149 |
| TCF12 | transcription factor 12 | -0.0313625 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0312993 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0307502 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0303798 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0299543 |
| SEPTIN9 | septin 9 | -0.0297292 |
| TUBB | tubulin, beta class I | -0.0295767 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -0.0292411 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0289728 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0283515 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0283065 |
| RPLP0 | ribosomal protein, large, P0 | -0.0282305 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0282169 |
| BPTF | bromodomain PHD finger transcription factor | -0.028148 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0279217 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0278416 |
| RPL4 | ribosomal protein L4 | -0.0277632 |
| PKM | pyruvate kinase, muscle | -0.027657 |
| TENM3 | teneurin transmembrane protein 3 | -0.027627 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.027492 |
| JMJD1C | jumonji domain containing 1C | -0.0274657 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0274114 |
| PFKP | phosphofructokinase, platelet | -0.0270306 |
| KIAA0040 | KIAA0040 | -0.0270297 |
| YAP1 | Yes-associated protein 1 | -0.0268492 |
| DEK | DEK proto-oncogene | -0.0266453 |
| DIAPH2 | diaphanous-related formin 2 | -0.0265921 |
| VCL | vinculin | -0.0264273 |
| WWOX | WW domain containing oxidoreductase | -0.0259722 |
| RPS23 | ribosomal protein S23 | -0.0259177 |
| EHBP1 | EH domain binding protein 1 | -0.025915 |
| RPS21 | ribosomal protein S21 | -0.0258367 |
| TMSB10 | thymosin beta 10 | -0.025765 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0257412 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0257063 |
| TMEM123 | transmembrane protein 123 | -0.0256724 |
| ZNRF3 | zinc and ring finger 3 | -0.0255886 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0253139 |
| R3HDM1 | R3H domain containing 1 | -0.0253124 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0252445 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0251647 |
| RAB10 | RAB10, member RAS oncogene family | -0.0251334 |
| HMGA1 | high mobility group AT-hook 1 | -0.0249631 |
| RPL38 | ribosomal protein L38 | -0.0249467 |
| RPS29 | ribosomal protein S29 | -0.0244764 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0244202 |
| RPL5 | ribosomal protein L5 | -0.0243267 |
| TNS3 | tensin 3 | -0.0242543 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0242209 |
| MSI2 | musashi RNA-binding protein 2 | -0.0241857 |
| CDK13 | cyclin-dependent kinase 13 | -0.0241255 |
| FHL2 | four and a half LIM domains 2 | -0.0238572 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0238559 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0237612 |
