| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.0796284 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.063672 |
| PCBP2 | poly(rC) binding protein 2 | 0.0603123 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0568949 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0520635 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.046093 |
| MSN | moesin | 0.0342647 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0340538 |
| TXNIP | thioredoxin interacting protein | 0.0325727 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0316128 |
| ANLN | anillin, actin binding protein | 0.0302216 |
| XPO1 | exportin 1 | 0.0300084 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0280251 |
| RPL3 | ribosomal protein L3 | 0.0268879 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0264523 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0258381 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0256785 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0255546 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0252275 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0250753 |
| RPS3 | ribosomal protein S3 | 0.024164 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0235887 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.023376 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0219459 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0216411 |
| ARRDC3 | arrestin domain containing 3 | 0.0215382 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0211792 |
| NUP58 | nucleoporin 58 | 0.0207273 |
| SET | SET nuclear proto-oncogene | 0.0197713 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0193175 |
| NDRG1 | N-myc downstream regulated 1 | 0.0192573 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0190496 |
| RPL21 | ribosomal protein L21 | 0.0184765 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0184683 |
| RPS2 | ribosomal protein S2 | 0.0178701 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0177257 |
| ENO1 | enolase 1, (alpha) | 0.0176584 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0170482 |
| TMF1 | TATA element modulatory factor 1 | 0.0168327 |
| SSRP1 | structure specific recognition protein 1 | 0.0166663 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.01579 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0152387 |
| VEGFA | vascular endothelial growth factor A | 0.0152231 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0151021 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0149732 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.014904 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0148315 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0148255 |
| GOLGA4 | golgin A4 | 0.0144007 |
| HDGF | hepatoma-derived growth factor | 0.0142799 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0141904 |
| BRD2 | bromodomain containing 2 | 0.0140269 |
| PLIN2 | perilipin 2 | 0.0138895 |
| FLNA | filamin A, alpha | 0.013781 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0135821 |
| RPS17 | ribosomal protein S17 | 0.0134164 |
| RAB6A | RAB6A, member RAS oncogene family | 0.013129 |
| PCM1 | pericentriolar material 1 | 0.0130844 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0129584 |
| PTMS | parathymosin | 0.0129076 |
| TNS4 | tensin 4 | 0.0128964 |
| B2M | beta-2-microglobulin | 0.0128527 |
| MKI67 | marker of proliferation Ki-67 | 0.0127819 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0126901 |
| DSPP | dentin sialophosphoprotein | 0.0126011 |
| PTEN | phosphatase and tensin homolog | 0.0125084 |
| UBC | ubiquitin C | 0.0124893 |
| OPTN | optineurin | 0.0122534 |
| RPS3A | ribosomal protein S3A | 0.0121008 |
| MKRN1 | makorin ring finger protein 1 | 0.0120069 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0119158 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0119049 |
| ZNF292 | zinc finger protein 292 | 0.011889 |
| INSIG2 | insulin induced gene 2 | 0.0118337 |
| RACK1 | receptor for activated C kinase 1 | 0.0116473 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0115986 |
| RPS19 | ribosomal protein S19 | 0.0115695 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0114485 |
| SFTPA2 | surfactant protein A2 | 0.011394 |
| PKM | pyruvate kinase, muscle | 0.0113393 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0113206 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0112724 |
| RPS12 | ribosomal protein S12 | 0.0112221 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0111895 |
| CADM1 | cell adhesion molecule 1 | 0.0111392 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.0110012 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0109411 |
| ZNF160 | zinc finger protein 160 | 0.0109088 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.010874 |
| RPS18 | ribosomal protein S18 | 0.010862 |
| PNN | pinin, desmosome associated protein | 0.0108574 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0106634 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0105887 |
| TPM3 | tropomyosin 3 | 0.0105174 |
| CEP152 | centrosomal protein 152kDa | 0.0104699 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0104667 |
| CTSB | cathepsin B | 0.0104384 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0104126 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.010361 |
| TLN1 | talin 1 | 0.0103455 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.241398 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.108712 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0975006 |
| SYT1 | synaptotagmin I | -0.0958769 |
| VCL | vinculin | -0.0887514 |
| CDH13 | cadherin 13 | -0.0833003 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0728014 |
| ACTG1 | actin gamma 1 | -0.0716208 |
| LMO7 | LIM domain 7 | -0.0710121 |
| EZR | ezrin | -0.0700431 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0691807 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0678666 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0634653 |
| RUNX1 | runt-related transcription factor 1 | -0.0630549 |
| CDK6 | cyclin-dependent kinase 6 | -0.0624033 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0610442 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0582825 |
| TNS3 | tensin 3 | -0.0570476 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0565677 |
| SPATA13 | spermatogenesis associated 13 | -0.0563485 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.056029 |
| ACTN4 | actinin, alpha 4 | -0.054561 |
| WWOX | WW domain containing oxidoreductase | -0.0540927 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.053904 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0527933 |
| NAV2 | neuron navigator 2 | -0.0524766 |
| CCND1 | cyclin D1 | -0.0511869 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0498931 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0498452 |
| SMYD3 | SET and MYND domain containing 3 | -0.0486395 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0471075 |
| RPS24 | ribosomal protein S24 | -0.0469734 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0466336 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0463543 |
| HDAC4 | histone deacetylase 4 | -0.0459166 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0459048 |
| FRMD5 | FERM domain containing 5 | -0.0451767 |
| TCF12 | transcription factor 12 | -0.0443442 |
| COBL | cordon-bleu WH2 repeat protein | -0.0433276 |
| TMEM123 | transmembrane protein 123 | -0.0429006 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0427305 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0420459 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0408032 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0403272 |
| ANXA2 | annexin A2 | -0.0401997 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0400545 |
| ATXN1 | ataxin 1 | -0.0395295 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0385425 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0373631 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0366546 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0365021 |
| BPTF | bromodomain PHD finger transcription factor | -0.0364027 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0363429 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0360583 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0358732 |
| PHF14 | PHD finger protein 14 | -0.0357522 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0353995 |
| DST | dystonin | -0.0353301 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0347907 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0345602 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0343708 |
| MSI2 | musashi RNA-binding protein 2 | -0.0342616 |
| AOPEP | aminopeptidase O (putative) | -0.0342035 |
| THOC2 | THO complex 2 | -0.0341736 |
| AK1 | adenylate kinase 1 | -0.034111 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0338674 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0337625 |
| MTAP | methylthioadenosine phosphorylase | -0.0333368 |
| MED13 | mediator complex subunit 13 | -0.0333258 |
| DIAPH2 | diaphanous-related formin 2 | -0.0333131 |
| NF1 | neurofibromin 1 | -0.0328731 |
| RBM39 | RNA binding motif protein 39 | -0.0321253 |
| BCL2L1 | BCL2-like 1 | -0.0319967 |
| JMJD1C | jumonji domain containing 1C | -0.0318334 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0315792 |
| TMEM163 | transmembrane protein 163 | -0.0315495 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0311229 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0310558 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.030947 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0308576 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0307635 |
| HMGB1 | high mobility group box 1 | -0.0306655 |
| PTMA | prothymosin, alpha | -0.0306561 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0304417 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0302616 |
| TMSB10 | thymosin beta 10 | -0.0302177 |
| EHBP1 | EH domain binding protein 1 | -0.0301725 |
| EXOC4 | exocyst complex component 4 | -0.0301342 |
| ETNK1 | ethanolamine kinase 1 | -0.0298559 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0295369 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0295293 |
| RAD51B | RAD51 paralog B | -0.0293479 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0290847 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.02899 |
| SH3D19 | SH3 domain containing 19 | -0.0288814 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0288438 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0286393 |
| GPHN | gephyrin | -0.0286392 |
| KPNB1 | karyopherin (importin) beta 1 | -0.028512 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.028495 |
