| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Osimertinib (mesylate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.181251 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0996724 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.085815 |
| B2M | beta-2-microglobulin | 0.0687222 |
| PTMA | prothymosin, alpha | 0.0626924 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0609338 |
| ADM | adrenomedullin | 0.0536905 |
| TMSB4X | thymosin beta 4, X-linked | 0.0535996 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0507706 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0493822 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0451662 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0448271 |
| CALR | calreticulin | 0.0418258 |
| RPS3 | ribosomal protein S3 | 0.0408832 |
| FLNA | filamin A, alpha | 0.0397093 |
| ATP13A3 | ATPase type 13A3 | 0.0396586 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0378885 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0368454 |
| CAVIN1 | caveolae associated protein 1 | 0.0359718 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0345881 |
| MMP1 | matrix metallopeptidase 1 | 0.0344574 |
| TNS1 | tensin 1 | 0.0341882 |
| NUP58 | nucleoporin 58 | 0.0339433 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0333514 |
| HMGA2 | high mobility group AT-hook 2 | 0.0329534 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0327476 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.032417 |
| RRBP1 | ribosome binding protein 1 | 0.0322039 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0319544 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0318857 |
| CTSB | cathepsin B | 0.0310779 |
| TMF1 | TATA element modulatory factor 1 | 0.0310224 |
| COPA | coatomer protein complex, subunit alpha | 0.0306766 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0303237 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0301937 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0297449 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0292997 |
| EXT1 | exostosin glycosyltransferase 1 | 0.029238 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0289985 |
| FBN1 | fibrillin 1 | 0.0280547 |
| SFTPA2 | surfactant protein A2 | 0.0277468 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0273785 |
| RPL26 | ribosomal protein L26 | 0.0271988 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0271756 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0270123 |
| SMAD3 | SMAD family member 3 | 0.02691 |
| WDR43 | WD repeat domain 43 | 0.0268472 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0264721 |
| HDLBP | high density lipoprotein binding protein | 0.0264202 |
| RPL11 | ribosomal protein L11 | 0.0262407 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0259658 |
| CD44 | CD44 molecule (Indian blood group) | 0.0259089 |
| MT2A | metallothionein 2A | 0.0257843 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.025737 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.025716 |
| GDI2 | GDP dissociation inhibitor 2 | 0.025355 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0249681 |
| SPAG9 | sperm associated antigen 9 | 0.0249523 |
| RPL3 | ribosomal protein L3 | 0.0245654 |
| PMM2 | phosphomannomutase 2 | 0.0245648 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0243402 |
| DUSP10 | dual specificity phosphatase 10 | 0.0241235 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0240072 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0237196 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0237157 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0235821 |
| AFF3 | AF4/FMR2 family, member 3 | 0.023307 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0231739 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0231026 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0228202 |
| TMSB10 | thymosin beta 10 | 0.0228066 |
| RACK1 | receptor for activated C kinase 1 | 0.0225891 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0223094 |
| BRD2 | bromodomain containing 2 | 0.0221362 |
| RPS7 | ribosomal protein S7 | 0.0220564 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0218537 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0218527 |
| HLA-E | major histocompatibility complex, class I, E | 0.0217777 |
| RPL35 | ribosomal protein L35 | 0.0215286 |
| SPAG5 | sperm associated antigen 5 | 0.0213674 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0212379 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0212277 |
| ATF4 | activating transcription factor 4 | 0.021209 |
| RPS12 | ribosomal protein S12 | 0.0210932 |
| RPL37A | ribosomal protein L37a | 0.0209474 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0208432 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0208359 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0206852 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0204463 |
| TCEAL9 | transcription elongation factor A like 9 | 0.0204093 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0203296 |
| RAB13 | RAB13, member RAS oncogene family | 0.0203218 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0202773 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0202573 |
| RPS8 | ribosomal protein S8 | 0.0200954 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.02006 |
| GOLGA4 | golgin A4 | 0.0197847 |
| YBX1 | Y box binding protein 1 | 0.0196983 |
| RPL23 | ribosomal protein L23 | 0.0196959 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0194836 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.470995 |
| FN1 | fibronectin 1 | -0.123179 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0984154 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0927241 |
| COL1A2 | collagen, type I, alpha 2 | -0.0781509 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0761903 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0736673 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0715576 |
| COL1A1 | collagen, type I, alpha 1 | -0.0706618 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0687197 |
| PKM | pyruvate kinase, muscle | -0.0684639 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0659663 |
| NDRG1 | N-myc downstream regulated 1 | -0.0646912 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0633124 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0625513 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0619817 |
| MYO10 | myosin X | -0.0568306 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0516445 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0502106 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.049393 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0484694 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0477236 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0475202 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0474039 |
| EMP1 | epithelial membrane protein 1 | -0.0472717 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0469733 |
| POTEF | POTE ankyrin domain family, member F | -0.0460815 |
| PFN1 | profilin 1 | -0.0453866 |
| ASPH | aspartate beta-hydroxylase | -0.0451455 |
| ACTG1 | actin gamma 1 | -0.0449101 |
| FTL | ferritin, light polypeptide | -0.0444019 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.042421 |
| INHBA | inhibin, beta A | -0.0415956 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0415799 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0412272 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0408457 |
| PTK2 | protein tyrosine kinase 2 | -0.0403767 |
| CD99 | CD99 molecule | -0.039831 |
| CALD1 | caldesmon 1 | -0.039785 |
| IER3 | immediate early response 3 | -0.0387587 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0381923 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0370045 |
| RTN4 | reticulon 4 | -0.0369025 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0364972 |
| INSIG1 | insulin induced gene 1 | -0.03612 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0357214 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0354754 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0349268 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.033916 |
| GPHN | gephyrin | -0.0334612 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0333889 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0332266 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0326518 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0321798 |
| MED13L | mediator complex subunit 13-like | -0.0321158 |
| TMEM263 | transmembrane protein 263 | -0.0319566 |
| DST | dystonin | -0.0316938 |
| SNX9 | sorting nexin 9 | -0.0313969 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0309865 |
| NAV1 | neuron navigator 1 | -0.0308108 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0305396 |
| JMJD1C | jumonji domain containing 1C | -0.0298643 |
| IKBIP | IKBKB interacting protein | -0.0293448 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0292077 |
| OXR1 | oxidation resistance 1 | -0.0289726 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0288914 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0286485 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0284866 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0283817 |
| S100A10 | S100 calcium binding protein A10 | -0.0283189 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0280415 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0278932 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0278861 |
| PRR16 | proline rich 16 | -0.0277904 |
| RPS5 | ribosomal protein S5 | -0.0276908 |
| CDK6 | cyclin-dependent kinase 6 | -0.027305 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.027196 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0269715 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0265898 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0264892 |
| OSMR | oncostatin M receptor | -0.0258249 |
| GPATCH2L | G patch domain containing 2-like | -0.0258024 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0254788 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0254426 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0253576 |
| TMEM123 | transmembrane protein 123 | -0.0252899 |
| LDHA | lactate dehydrogenase A | -0.0252799 |
| HLA-A | major histocompatibility complex, class I, A | -0.0252569 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0248249 |
| FGF5 | fibroblast growth factor 5 | -0.0247893 |
| RPS25 | ribosomal protein S25 | -0.0247535 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0246818 |
| WASF2 | WAS protein family, member 2 | -0.0245932 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0245227 |
| UBC | ubiquitin C | -0.0244233 |
| PRSS23 | protease, serine, 23 | -0.0242394 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0241765 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0241627 |
| NRP1 | neuropilin 1 | -0.0240083 |
| TAPBP | TAP binding protein (tapasin) | -0.0239937 |
