Ospemifene Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia. (Chemical Entities of Biological Interest Ontology, CHEBI_73275)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3036505
Similar Terms
Downloads & Tools

Genes

198 proteins with high or low expression in Ospemifene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ZSCAN32 zinc finger and SCAN domain containing 32 2.36
B2M beta-2-microglobulin 1.1
ABHD2 abhydrolase domain containing 2 0.81
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.75
SLF1 SMC5-SMC6 complex localization factor 1 0.73
PER1 period circadian clock 1 0.64
POMP proteasome maturation protein 0.6
LAPTM4A lysosomal protein transmembrane 4 alpha 0.51
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.49
XTBD1 XRN2 binding domain containing 1 0.48
NOTCH3 notch 3 0.47
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 0.46
GATD1 glutamine amidotransferase class 1 domain containing 1 0.46
DDN dendrin 0.46
ZNF12 zinc finger protein 12 0.44
TMSB10 thymosin beta 10 0.44
CCDC57 coiled-coil domain containing 57 0.44
ADCY10 adenylate cyclase 10 (soluble) 0.43
MCTP2 multiple C2 domains, transmembrane 2 0.43
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 0.42
ZNF3 zinc finger protein 3 0.42
ADARB1 adenosine deaminase, RNA-specific, B1 0.41
PIF1 PIF1 5'-to-3' DNA helicase 0.41
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.39
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.38
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.38
TTLL4 tubulin tyrosine ligase-like family member 4 0.38
UNC5B unc-5 homolog B (C. elegans) 0.38
HSBP1 heat shock factor binding protein 1 0.38
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.38
TRIM15 tripartite motif containing 15 0.38
MGLL monoglyceride lipase 0.37
TEN1 TEN1 CST complex subunit 0.37
JPT1 Jupiter microtubule associated homolog 1 0.37
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.37
EGR1 early growth response 1 0.37
ARL13B ADP-ribosylation factor-like 13B 0.36
NRP1 neuropilin 1 0.36
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.35
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.34
HBA1 hemoglobin, alpha 1 0.34
PRKD3 protein kinase D3 0.34
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.34
CUX2 cut-like homeobox 2 0.34
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.34
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.33
LYPLA2 lysophospholipase II 0.33
ZNF503 zinc finger protein 503 0.33
S100A14 S100 calcium binding protein A14 0.33
KMT2B lysine (K)-specific methyltransferase 2B 0.33
RPS7 ribosomal protein S7 0.33
COX5A cytochrome c oxidase subunit Va 0.33
FANCE Fanconi anemia, complementation group E 0.33
TPM4 tropomyosin 4 0.33
FHIT fragile histidine triad 0.33
BANF1 barrier to autointegration factor 1 0.33
COL14A1 collagen, type XIV, alpha 1 0.33
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.32
USP31 ubiquitin specific peptidase 31 0.32
NPHP3 nephronophthisis 3 (adolescent) 0.32
BAG3 BCL2-associated athanogene 3 0.32
GATA2 GATA binding protein 2 0.32
KSR2 kinase suppressor of ras 2 0.32
GLI4 GLI family zinc finger 4 0.31
ATP5PF ATP synthase peripheral stalk subunit F6 0.31
CDCA3 cell division cycle associated 3 0.31
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.31
RPL31 ribosomal protein L31 0.31
S100A6 S100 calcium binding protein A6 0.31
PFDN6 prefoldin subunit 6 0.31
CAPZB capping protein (actin filament) muscle Z-line, beta 0.31
LONP2 lon peptidase 2, peroxisomal 0.3
TULP4 tubby like protein 4 0.3
GLRX glutaredoxin (thioltransferase) 0.3
SPTBN4 spectrin, beta, non-erythrocytic 4 0.29
TMEM200A transmembrane protein 200A 0.29
GON7 GON7 subunit of KEOPS complex 0.29
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.29
PFDN5 prefoldin subunit 5 0.29
C1ORF52 chromosome 1 open reading frame 52 0.29
C2ORF42 chromosome 2 open reading frame 42 0.28
CALU calumenin 0.28
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 0.28
STMN2 stathmin 2 0.28
LMNB2 lamin B2 0.28
FXN frataxin 0.28
CFL1 cofilin 1 (non-muscle) 0.28
ZSCAN25 zinc finger and SCAN domain containing 25 0.28
AKAP12 A kinase (PRKA) anchor protein 12 0.28
MZT2A mitotic spindle organizing protein 2A 0.27
HOXA10 homeobox A10 0.27
SYTL3 synaptotagmin-like 3 0.27
FAM171B family with sequence similarity 171, member B 0.27
ARL4A ADP-ribosylation factor-like 4A 0.27
FN1 fibronectin 1 0.27
ZDHHC12 zinc finger, DHHC-type containing 12 0.27
METTL6 methyltransferase like 6 0.26
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 0.26
MED10 mediator complex subunit 10 0.26

low expression

Symbol Name Standardized Value
SGSH N-sulfoglucosamine sulfohydrolase -0.96
CLSTN3 calsyntenin 3 -0.76
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.63
FAM189B family with sequence similarity 189, member B -0.61
PLIN2 perilipin 2 -0.56
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.55
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.52
TMEM120A transmembrane protein 120A -0.52
C2CD3 C2 calcium-dependent domain containing 3 -0.47
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.45
ZSWIM9 zinc finger SWIM-type containing 9 -0.43
ZNF410 zinc finger protein 410 -0.42
SYT17 synaptotagmin XVII -0.42
SPATA7 spermatogenesis associated 7 -0.41
CCDC150 coiled-coil domain containing 150 -0.4
BCOR BCL6 corepressor -0.38
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.35
SLC25A39 solute carrier family 25, member 39 -0.34
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -0.34
PLK4 polo-like kinase 4 -0.33
ZNF532 zinc finger protein 532 -0.33
SPATA31D1 SPATA31 subfamily D, member 1 -0.32
METTL22 methyltransferase like 22 -0.32
TIMM29 translocase of inner mitochondrial membrane 29 -0.32
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -0.32
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -0.32
PRDM2 PR domain containing 2, with ZNF domain -0.32
ICOSLG inducible T-cell co-stimulator ligand -0.31
NIPSNAP3A nipsnap homolog 3A (C. elegans) -0.31
PXYLP1 2-phosphoxylose phosphatase 1 -0.31
HRH1 histamine receptor H1 -0.31
GORASP1 golgi reassembly stacking protein 1, 65kDa -0.3
BCORL1 BCL6 corepressor-like 1 -0.3
CCDC90B coiled-coil domain containing 90B -0.3
FAT2 FAT atypical cadherin 2 -0.3
DONSON downstream neighbor of SON -0.3
DDT D-dopachrome tautomerase -0.29
DNAL4 dynein, axonemal, light chain 4 -0.29
FAM241A family with sequence similarity 241 member A -0.29
RARG retinoic acid receptor, gamma -0.29
USP22 ubiquitin specific peptidase 22 -0.29
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.28
ANAPC11 anaphase promoting complex subunit 11 -0.28
MBNL2 muscleblind-like splicing regulator 2 -0.28
STOML1 stomatin (EPB72)-like 1 -0.27
ENTR1 endosome associated trafficking regulator 1 -0.27
COMMD5 COMM domain containing 5 -0.26
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -0.26
BICRAL BICRA like chromatin remodeling complex associated protein -0.26
FLNA filamin A, alpha -0.26
HLA-F major histocompatibility complex, class I, F -0.26
RNF4 ring finger protein 4 -0.26
ERVMER34-1 endogenous retrovirus group MER34, member 1 -0.25
AXIN2 axin 2 -0.25
ANKRD39 ankyrin repeat domain 39 -0.25
TMEM104 transmembrane protein 104 -0.25
MR1 major histocompatibility complex, class I-related -0.25
TMEM63A transmembrane protein 63A -0.25
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -0.25
XDH xanthine dehydrogenase -0.25
S100A2 S100 calcium binding protein A2 -0.25
SMIM19 small integral membrane protein 19 -0.25
CEP104 centrosomal protein 104kDa -0.25
PNPLA2 patatin-like phospholipase domain containing 2 -0.24
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -0.24
NECTIN3 nectin cell adhesion molecule 3 -0.24
ITGB8 integrin, beta 8 -0.24
VWA5B2 von Willebrand factor A domain containing 5B2 -0.24
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.24
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -0.24
COA5 cytochrome c oxidase assembly factor 5 -0.23
PIM1 Pim-1 proto-oncogene, serine/threonine kinase -0.23
ALDOA aldolase A, fructose-bisphosphate -0.23
ZNF276 zinc finger protein 276 -0.23
PALB2 partner and localizer of BRCA2 -0.23
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -0.23
FBXO33 F-box protein 33 -0.23
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.23
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -0.23
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.23
CES2 carboxylesterase 2 -0.23
RAB24 RAB24, member RAS oncogene family -0.22
LINS1 lines homolog 1 -0.22
DMAC2L distal membrane arm assembly component 2 like -0.22
FGFR1OP2 FGFR1 oncogene partner 2 -0.22
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.22
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.22
PCLO piccolo presynaptic cytomatrix protein -0.22
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.21
BCAM basal cell adhesion molecule (Lutheran blood group) -0.21
GTDC1 glycosyltransferase-like domain containing 1 -0.21
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 -0.21
PAQR7 progestin and adipoQ receptor family member VII -0.21
ELL3 elongation factor RNA polymerase II-like 3 -0.21
TECPR1 tectonin beta-propeller repeat containing 1 -0.21
GRAMD4 GRAM domain containing 4 -0.21
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -0.21
CXXC5 CXXC finger protein 5 -0.21
ACSF2 acyl-CoA synthetase family member 2 -0.2