Osteoarthritis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. (Experimental Factor Ontology, EFO_0002506)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D010003
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Genes

141 genes/proteins associated with the disease Osteoarthritis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TGM2 transglutaminase 2 2.88009
CXCL6 chemokine (C-X-C motif) ligand 6 2.88009
SDCBP syndecan binding protein (syntenin) 2.88009
ASPN asporin 2.88009
AKR1C1 aldo-keto reductase family 1, member C1 2.88009
TFPI2 tissue factor pathway inhibitor 2 2.88009
MSN moesin 2.88009
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.88009
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 2.88009
SEC23A Sec23 homolog A (S. cerevisiae) 2.88009
AKR1C2 aldo-keto reductase family 1, member C2 2.88009
CXCL2 chemokine (C-X-C motif) ligand 2 2.88009
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.88009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.88009
PLS3 plastin 3 2.88009
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.88009
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.88009
ESD esterase D 2.88009
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.88009
COL2A1 collagen, type II, alpha 1 2.88009
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.88009
DPYSL2 dihydropyrimidinase-like 2 2.88009
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.88009
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.88009
PPARG peroxisome proliferator-activated receptor gamma 2.88009
CLU clusterin 2.88009
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.88009
GLS glutaminase 2.88009
MYH13 myosin, heavy chain 13, skeletal muscle 2.88009
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.88009
GSTK1 glutathione S-transferase kappa 1 2.88009
GDF5 growth differentiation factor 5 2.88009
TXNRD1 thioredoxin reductase 1 2.88009
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 2.88009
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.88009
PDCD6IP programmed cell death 6 interacting protein 2.88009
VDAC2 voltage-dependent anion channel 2 2.88009
CALCA calcitonin-related polypeptide alpha 2.88009
VIM vimentin 2.88009
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.88009
IMMT inner membrane protein, mitochondrial 2.88009
MVP major vault protein 2.88009
P3H3 prolyl 3-hydroxylase 3 2.88009
TRAP1 TNF receptor-associated protein 1 2.88009
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.88009
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.88009
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.88009
EEF2 eukaryotic translation elongation factor 2 2.88009
LTBP3 latent transforming growth factor beta binding protein 3 2.88009
ISOC2 isochorismatase domain containing 2 2.88009
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.88009
ACO1 aconitase 1, soluble 2.88009
AK4 adenylate kinase 4 2.88009
RAN RAN, member RAS oncogene family 2.88009
COL1A2 collagen, type I, alpha 2 2.88009
COL6A2 collagen, type VI, alpha 2 2.88009
ACAA2 acetyl-CoA acyltransferase 2 2.88009
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.88009
COMP cartilage oligomeric matrix protein 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
FRZB frizzled-related protein 2.88009
MATN3 matrilin 3 2.88009
CLIC1 chloride intracellular channel 1 2.88009
CLIC4 chloride intracellular channel 4 2.88009
SMAD3 SMAD family member 3 2.88009
OS4 Osteoarthritis, generalized, without dysplasia, susceptibility to 2.88009
OS6 Osteoarthritis susceptibility 6 2.88009
SCRN1 secernin 1 2.88009
POU3F3 POU class 3 homeobox 3 2.88009
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 2.88009
CTSD cathepsin D 2.88009
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.88009
OPA1 optic atrophy 1 (autosomal dominant) 2.88009
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.88009
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.88009
ENO1 enolase 1, (alpha) 2.88009
EZR ezrin 2.88009
TRIM2 tripartite motif containing 2 2.88009
EDIL3 EGF-like repeats and discoidin I-like domains 3 2.88009
FTL ferritin, light polypeptide 2.88009
ACTB actin, beta 2.88009
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.88009
PLCD1 phospholipase C, delta 1 2.88009
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.917
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.7681
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.74601
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.73838
SELL selectin L 1.65731
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.58607
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.54086
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.53061
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.52693
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.48479
ALB albumin 1.4351
IL1B interleukin 1, beta 1.42347
TNF tumor necrosis factor 1.41667
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.41313
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.39702
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.34082
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.32339
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.31506
IL6 interleukin 6 1.30543
MPO myeloperoxidase 1.26514
CHUK conserved helix-loop-helix ubiquitous kinase 1.26483
DDIT3 DNA-damage-inducible transcript 3 1.25338
GCLC glutamate-cysteine ligase, catalytic subunit 1.20622
CCND1 cyclin D1 1.20394
IL1A interleukin 1, alpha 1.19179
MMP3 matrix metallopeptidase 3 1.1908
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.18718
PPARD peroxisome proliferator-activated receptor delta 1.18059
BIRC5 baculoviral IAP repeat containing 5 1.17268
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.16866
BID BH3 interacting domain death agonist 1.1607
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.15797
CCL3 chemokine (C-C motif) ligand 3 1.15458
ICAM1 intercellular adhesion molecule 1 1.14336
PTGES prostaglandin E synthase 1.13862
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.12771
VEGFA vascular endothelial growth factor A 1.12668
HSF1 heat shock transcription factor 1 1.12391
MMP1 matrix metallopeptidase 1 1.12391
BAK1 BCL2-antagonist/killer 1 1.11707
MMP9 matrix metallopeptidase 9 1.10596
NOS2 nitric oxide synthase 2, inducible 1.09332
GSK3B glycogen synthase kinase 3 beta 1.0894
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.08797
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.08161
IL10 interleukin 10 1.06406
LTA lymphotoxin alpha 1.06044
PDGFA platelet-derived growth factor alpha polypeptide 1.06044
JUND jun D proto-oncogene 1.05573
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.05573
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.05015
NGFR nerve growth factor receptor 1.04014
FOS FBJ murine osteosarcoma viral oncogene homolog 1.03976
GCLM glutamate-cysteine ligase, modifier subunit 1.03604
MAPK14 mitogen-activated protein kinase 14 1.02373
NGF nerve growth factor (beta polypeptide) 1.01512
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.01361
CFLAR CASP8 and FADD-like apoptosis regulator 1.01174