Osteoarthritis Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. (Experimental Factor Ontology, EFO_0002506)
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Genes

217 genes associated with the disease Osteoarthritis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
GDF5 growth differentiation factor 5 1.965
CEP250 centrosomal protein 250kDa 1.965
C20ORF173 chromosome 20 open reading frame 173 1.965
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 1.965
RANGAP1 Ran GTPase activating protein 1 1.936
EP300 E1A binding protein p300 1.936
L3MBTL2 l(3)mbt-like 2 (Drosophila) 1.936
CHADL chondroadherin-like 1.936
COL11A1 collagen, type XI, alpha 1 1.89
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 1.871
NEK4 NIMA-related kinase 4 1.871
GLT8D1 glycosyltransferase 8 domain containing 1 1.871
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 1.871
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 1.871
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 1.871
TGFA transforming growth factor, alpha 1.863
ADD2 adducin 2 (beta) 1.863
MUSTN1 musculoskeletal, embryonic nuclear protein 1 1.844
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 1.844
STIMATE STIM activating enhancer 1.844
PBRM1 polybromo 1 1.844
TRIM32 tripartite motif containing 32 1.833
ASTN2 astrotactin 2 1.833
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 1.814
LTBP1 latent transforming growth factor beta binding protein 1 1.812
OLFM3 olfactomedin 3 1.804
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 1.794
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 1.794
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.786
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 1.786
MGP matrix Gla protein 1.786
ERP27 endoplasmic reticulum protein 27 1.786
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 1.786
SMCO3 single-pass membrane protein with coiled-coil domains 3 1.786
C12ORF60 chromosome 12 open reading frame 60 1.786
H4C2 H4 clustered histone 2 1.778
B4GAT1-DT B4GAT1 divergent transcript 1.778
H2BC3 H2B clustered histone 3 1.778
H4C3 H4 clustered histone 3 1.778
H2AC4 H2A clustered histone 4 1.778
HFE hemochromatosis 1.778
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.778
H1-2 H1.2 linker histone, cluster member 1.778
H2BC4 H2B clustered histone 4 1.778
H1-4 H1.4 linker histone, cluster member 1.778
H2BC5 H2B clustered histone 5 1.778
H1-6 H1.6 linker histone, cluster member 1.778
H4C4 H4 clustered histone 4 1.778
H2AC6 H2A clustered histone 6 1.778
RUNX2 runt-related transcription factor 2 1.706
FILIP1 filamin A interacting protein 1 1.699
LMX1B LIM homeobox transcription factor 1, beta 1.689
ZBTB43 zinc finger and BTB domain containing 43 1.689
JMJD4 jumonji domain containing 4 1.666
SNAP47 synaptosomal-associated protein, 47kDa 1.666
ZNF678 zinc finger protein 678 1.666
WWP2 WW domain containing E3 ubiquitin protein ligase 2 1.664
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 1.654
TNC tenascin C 1.654
WBP11 WW domain binding protein 11 1.619
AAGAB alpha- and gamma-adaptin binding protein 1.602
SMAD3 SMAD family member 3 1.602
SBNO1 strawberry notch homolog 1 (Drosophila) 1.561
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.561
RILPL2 Rab interacting lysosomal protein-like 2 1.561
KMT5A lysine methyltransferase 5A 1.561
ZNF618 zinc finger protein 618 1.556
COL27A1 collagen, type XXVII, alpha 1 1.556
KIF12 kinesin family member 12 1.556
AMBP alpha-1-microglobulin/bikunin precursor 1.556
H3C1 H3 clustered histone 1 1.549
H1-1 H1.1 linker histone, cluster member 1.549
TRIM38 tripartite motif containing 38 1.549
H4C1 H4 clustered histone 1 1.549
KMT5C lysine methyltransferase 5C 1.495
C19ORF85 chromosome 19 open reading frame 85 1.495
BRSK1 BR serine/threonine kinase 1 1.495
SHISA7 shisa family member 7 1.495
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 1.495
RPL28 ribosomal protein L28 1.495
TMEM190 transmembrane protein 190 1.495
TMEM238 transmembrane protein 238 1.495
ISOC2 isochorismatase domain containing 2 1.495
UBE2S ubiquitin-conjugating enzyme E2S 1.495
IL11 interleukin 11 1.495
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 1.495
TMEM150B transmembrane protein 150B 1.495
GSDMC gasdermin C 1.459
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 1.458
CLEC18A C-type lectin domain family 18, member A 1.438
TACC3 transforming, acidic coiled-coil containing protein 3 1.433
FGFR3 fibroblast growth factor receptor 3 1.433
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase 1.433
FAM53A family with sequence similarity 53, member A 1.433
SLBP stem-loop binding protein 1.433
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 1.41
SMO smoothened, frizzled class receptor 1.391
TSPAN33 tetraspanin 33 1.391
AHCYL2 adenosylhomocysteinase-like 2 1.391
MAPT microtubule-associated protein tau 1.383
NQO1 NAD(P)H dehydrogenase, quinone 1 1.383
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 1.383
STH saitohin 1.383
KANSL1 KAT8 regulatory NSL complex subunit 1 1.383
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.383
COL11A2 collagen, type XI, alpha 2 1.346
HLA-DOA major histocompatibility complex, class II, DO alpha 1.346
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.346
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.346
GLIS3 GLIS family zinc finger 3 1.337
PRSS38 protease, serine, 38 1.298
CDC5L cell division cycle 5-like 1.296
BCL7A B-cell CLL/lymphoma 7A 1.277
MLXIP MLX interacting protein 1.277
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 1.277
LRRC43 leucine rich repeat containing 43 1.277
IL31 interleukin 31 1.277
DIABLO diablo, IAP-binding mitochondrial protein 1.277
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 1.261
MAP2K6 mitogen-activated protein kinase kinase 6 1.261
NF1 neurofibromin 1 1.256
OMG oligodendrocyte myelin glycoprotein 1.256
EPPK1 epiplakin 1 1.235
PLEC plectin 1.235
PARP10 poly (ADP-ribose) polymerase family, member 10 1.235
SPATC1 spermatogenesis and centriole associated 1 1.235
OPLAH 5-oxoprolinase (ATP-hydrolysing) 1.235
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 1.235
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.23
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.23
KCNK7 potassium channel, two pore domain subfamily K, member 7 1.23
SCYL1 SCY1-like 1 (S. cerevisiae) 1.23
LTBP3 latent transforming growth factor beta binding protein 3 1.23
FAM89B family with sequence similarity 89, member B 1.23
SIPA1 signal-induced proliferation-associated 1 1.23
ZNRD2 zinc ribbon domain containing 2 1.23
PCNX3 pecanex 3 1.23
EHBP1L1 EH domain binding protein 1-like 1 1.23
HIC1 hypermethylated in cancer 1 1.224
SMG6 SMG6 nonsense mediated mRNA decay factor 1.224
BTNL2 butyrophilin-like 2 1.214
TSBP1 testis expressed basic protein 1 1.214
HLA-DRA major histocompatibility complex, class II, DR alpha 1.214
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 1.189
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 1.182
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 1.182
RGL1 ral guanine nucleotide dissociation stimulator-like 1 1.173
TSEN15 TSEN15 tRNA splicing endonuclease subunit 1.173
COLGALT2 collagen beta(1-O)galactosyltransferase 2 1.173
RNF32 ring finger protein 32 1.172
KLHL42 kelch-like family member 42 1.164
PTHLH parathyroid hormone-like hormone 1.164
MANSC4 MANSC domain containing 4 1.164
RPGRIP1L RPGRIP1-like 1.156
FTO fat mass and obesity associated 1.156
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1.143
HDAC9 histone deacetylase 9 1.143
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 1.127
EXOSC5 exosome component 5 1.127
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 1.127
TMEM91 transmembrane protein 91 1.127
B9D2 B9 protein domain 2 1.127
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 1.127
CCDC97 coiled-coil domain containing 97 1.127
TGFB1 transforming growth factor, beta 1 1.127
AXL AXL receptor tyrosine kinase 1.127
CCDC91 coiled-coil domain containing 91 1.12
NCOR2 nuclear receptor corepressor 2 1.112
RFLNA refilin A 1.112
ZNF664 zinc finger protein 664 1.112
MPHOSPH9 M-phase phosphoprotein 9 1.089
PPP1R3B protein phosphatase 1, regulatory subunit 3B 1.086
BMP5 bone morphogenetic protein 5 1.086
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 1.086
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 1.086
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.074
TBCA tubulin folding cofactor A 1.074
SMIM23 small integral membrane protein 23 1.054
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.054
FGF18 fibroblast growth factor 18 1.054
GABPB1 GA binding protein transcription factor, beta subunit 1 1.043
USP8 ubiquitin specific peptidase 8 1.043
USP50 ubiquitin specific peptidase 50 1.043
STRA6 stimulated by retinoic acid 6 1.005
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 1.005
CCDC33 coiled-coil domain containing 33 1.005
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.005
F2 coagulation factor II (thrombin) 0.988
ATG13 autophagy related 13 0.988
ARHGAP1 Rho GTPase activating protein 1 0.988
ZNF408 zinc finger protein 408 0.988
CKAP5 cytoskeleton associated protein 5 0.988
H2AC8 H2A clustered histone 8 0.961
HIST1H2BF histone cluster 1, H2bf 0.961
H3C4 H3 clustered histone 4 0.961
RBM4 RNA binding motif protein 4 0.961
H2AC7 H2A clustered histone 7 0.961
RBM4B RNA binding motif protein 4B 0.961
SPTBN2 spectrin, beta, non-erythrocytic 2 0.961
H4C5 H4 clustered histone 5 0.961
H2BC8 H2B clustered histone 8 0.961
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.923
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.923
ADAMTSL4 ADAMTS-like 4 0.923
PRPF3 pre-mRNA processing factor 3 0.923
MCL1 myeloid cell leukemia 1 0.923
ECM1 extracellular matrix protein 1 0.923
SPP1 secreted phosphoprotein 1 0.908
MEPE matrix extracellular phosphoglycoprotein 0.908
IBSP integrin-binding sialoprotein 0.908
SENP6 SUMO1/sentrin specific peptidase 6 0.748
NACA2 nascent polypeptide-associated complex alpha subunit 2 0.65
TBX4 T-box 4 0.65
CLDN23 claudin 23 0.586
LYPLAL1 lysophospholipase-like 1 0.574
NABP1 nucleic acid binding protein 1 0.547
CAVIN2 caveolae associated protein 2 0.547