Osteonecrosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Death of a bone or part of a bone, either atraumatic or posttraumatic. (Experimental Factor Ontology, EFO_0004259)
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Genes

562 genes co-occuring with the disease Osteonecrosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3.518
BGLAP bone gamma-carboxyglutamate (gla) protein 3.191
RUNX2 runt-related transcription factor 2 3.109
BMP2 bone morphogenetic protein 2 3.067
ACP5 acid phosphatase 5, tartrate resistant 3.045
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 3.005
PTH parathyroid hormone 2.931
CTSK cathepsin K 2.894
SOST sclerostin 2.889
FDPS farnesyl diphosphate synthase 2.832
SP7 Sp7 transcription factor 2.755
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 2.648
SPP1 secreted phosphoprotein 1 2.564
IL6 interleukin 6 2.506
TNF tumor necrosis factor 2.488
IL1B interleukin 1, beta 2.466
TGFB1 transforming growth factor, beta 1 2.464
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.456
DCSTAMP dendrocyte expressed seven transmembrane protein 2.406
BMP7 bone morphogenetic protein 7 2.39
IBSP integrin-binding sialoprotein 2.365
ESR1 estrogen receptor 1 2.361
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.35
PTHLH parathyroid hormone-like hormone 2.299
FGF2 fibroblast growth factor 2 (basic) 2.276
COL1A1 collagen, type I, alpha 1 2.25
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.232
GGPS1 geranylgeranyl diphosphate synthase 1 2.216
CRP C-reactive protein, pentraxin-related 2.209
ALPL alkaline phosphatase, liver/bone/kidney 2.209
LRP5 low density lipoprotein receptor-related protein 5 2.206
IL1A interleukin 1, alpha 2.204
ACAN aggrecan 2.196
IGF1 insulin-like growth factor 1 (somatomedin C) 2.178
PECAM1 platelet/endothelial cell adhesion molecule 1 2.171
ENG endoglin 2.169
MMP13 matrix metallopeptidase 13 2.15
ALB albumin 2.146
CD34 CD34 molecule 2.144
THY1 Thy-1 cell surface antigen 2.14
CSF1 colony stimulating factor 1 (macrophage) 2.134
PPARG peroxisome proliferator-activated receptor gamma 2.133
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.127
FGF7 fibroblast growth factor 7 2.106
COL2A1 collagen, type II, alpha 1 2.104
NGF nerve growth factor (beta polypeptide) 2.103
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.102
CCK cholecystokinin 2.082
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.081
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.071
FGF18 fibroblast growth factor 18 2.064
BMP4 bone morphogenetic protein 4 2.063
NT5E 5'-nucleotidase, ecto (CD73) 2.062
FOS FBJ murine osteosarcoma viral oncogene homolog 2.059
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.057
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.054
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.054
MMP9 matrix metallopeptidase 9 2.049
IL10 interleukin 10 2.049
CALCR calcitonin receptor 2.043
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.042
PTPRC protein tyrosine phosphatase, receptor type, C 2.038
FGF5 fibroblast growth factor 5 2.038
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.036
FGF16 fibroblast growth factor 16 2.034
FGF9 fibroblast growth factor 9 2.034
FGF22 fibroblast growth factor 22 2.033
FGF20 fibroblast growth factor 20 2.033
FGF6 fibroblast growth factor 6 2.032
FGF4 fibroblast growth factor 4 2.031
FGF3 fibroblast growth factor 3 2.031
FGF17 fibroblast growth factor 17 2.029
CXCL12 chemokine (C-X-C motif) ligand 12 2.025
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.022
FGF8 fibroblast growth factor 8 (androgen-induced) 2.018
FGF10 fibroblast growth factor 10 2.009
ASPG asparaginase 1.999
ACTB actin, beta 1.986
IL17A interleukin 17A 1.985
EMCN endomucin 1.985
BMP6 bone morphogenetic protein 6 1.983
CXCL8 chemokine (C-X-C motif) ligand 8 1.966
SOX9 SRY (sex determining region Y)-box 9 1.963
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.956
IFNG interferon, gamma 1.949
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.945
BCL2 B-cell CLL/lymphoma 2 1.943
CD4 CD4 molecule 1.926
COL1A2 collagen, type I, alpha 2 1.921
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.9
JUN jun proto-oncogene 1.892
ALPG alkaline phosphatase, germ cell 1.877
F2 coagulation factor II (thrombin) 1.877
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.85
SMAD7 SMAD family member 7 1.847
WNT3A wingless-type MMTV integration site family, member 3A 1.847
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.844
PTH1R parathyroid hormone 1 receptor 1.841
OCSTAMP osteoclast stimulatory transmembrane protein 1.833
PXDN peroxidasin 1.827
CLCN7 chloride channel, voltage-sensitive 7 1.824
FGF13 fibroblast growth factor 13 1.822
PXDNL peroxidasin-like 1.822
CCL2 chemokine (C-C motif) ligand 2 1.821
ALPI alkaline phosphatase, intestinal 1.82
VWF von Willebrand factor 1.816
CD44 CD44 molecule (Indian blood group) 1.814
IL4 interleukin 4 1.811
DLX5 distal-less homeobox 5 1.809
PLG plasminogen 1.807
FN1 fibronectin 1 1.806
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.805
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.805
SMAD5 SMAD family member 5 1.796
ANXA5 annexin A5 1.794
HBB hemoglobin, beta 1.789
GSK3B glycogen synthase kinase 3 beta 1.789
CHIT1 chitinase 1 (chitotriosidase) 1.789
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 1.786
ALPP alkaline phosphatase, placental 1.777
TLR4 toll-like receptor 4 1.774
FGF23 fibroblast growth factor 23 1.773
MMP3 matrix metallopeptidase 3 1.77
IL11 interleukin 11 1.765
CXCR4 chemokine (C-X-C motif) receptor 4 1.764
WNT5B wingless-type MMTV integration site family, member 5B 1.761
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.76
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.756
KDR kinase insert domain receptor 1.756
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.752
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.741
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.74
INS insulin 1.737
CSF3 colony stimulating factor 3 (granulocyte) 1.736
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.735
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.725
CSF1R colony stimulating factor 1 receptor 1.725
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.723
OSCAR osteoclast associated, immunoglobulin-like receptor 1.722
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.708
WNT10B wingless-type MMTV integration site family, member 10B 1.705
SATB2 SATB homeobox 2 1.704
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.703
CD68 CD68 molecule 1.701
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.698
GDF2 growth differentiation factor 2 1.696
TGFB3 transforming growth factor, beta 3 1.691
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.69
CCL3 chemokine (C-C motif) ligand 3 1.689
CD9 CD9 molecule 1.689
EGF epidermal growth factor 1.68
DMP1 dentin matrix acidic phosphoprotein 1 1.676
CD19 CD19 molecule 1.672
IL2 interleukin 2 1.671
TP53 tumor protein p53 1.667
CD8A CD8a molecule 1.661
VCAM1 vascular cell adhesion molecule 1 1.656
NOG noggin 1.65
MAPK3 mitogen-activated protein kinase 3 1.65
NOS3 nitric oxide synthase 3 (endothelial cell) 1.642
POMC proopiomelanocortin 1.641
MMP2 matrix metallopeptidase 2 1.64
CD63 CD63 molecule 1.64
CCL5 chemokine (C-C motif) ligand 5 1.639
SIRT1 sirtuin 1 1.638
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.637
ANGPT1 angiopoietin 1 1.637
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.637
F3 coagulation factor III (thromboplastin, tissue factor) 1.633
GDF5 growth differentiation factor 5 1.624
BAX BCL2-associated X protein 1.619
HMOX1 heme oxygenase 1 1.614
LRP6 low density lipoprotein receptor-related protein 6 1.606
EPO erythropoietin 1.599
PTEN phosphatase and tensin homolog 1.597
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.596
RBMS3 RNA binding motif, single stranded interacting protein 3 1.587
CASR calcium-sensing receptor 1.586
SMAD3 SMAD family member 3 1.58
TAC1 tachykinin, precursor 1 1.576
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.574
WNT5A wingless-type MMTV integration site family, member 5A 1.569
CA2 carbonic anhydrase II 1.568
PLAT plasminogen activator, tissue 1.567
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.557
IL7 interleukin 7 1.552
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 1.542
SMAD2 SMAD family member 2 1.538
MEPE matrix extracellular phosphoglycoprotein 1.535
IFNA1 interferon, alpha 1 1.53
TPMT thiopurine S-methyltransferase 1.529
NELL1 NEL-like 1 (chicken) 1.529
MCAM melanoma cell adhesion molecule 1.526
COMP cartilage oligomeric matrix protein 1.52
MMP8 matrix metallopeptidase 8 1.519
ACE angiotensin I converting enzyme 1.515
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 1.511
ICAM1 intercellular adhesion molecule 1 1.506
IHH indian hedgehog 1.501
GJA1 gap junction protein, alpha 1, 43kDa 1.501
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.501
EDN1 endothelin 1 1.498
TMEM235 transmembrane protein 235 1.497
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.496
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.494
DNTT DNA nucleotidylexotransferase 1.488
LEP leptin 1.48
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.476
KLK3 kallikrein-related peptidase 3 1.469
CCN2 cellular communication network factor 2 1.465
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.464
SPRY2 sprouty homolog 2 (Drosophila) 1.458
IL3 interleukin 3 1.455
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.453
IL1RN interleukin 1 receptor antagonist 1.45
IL18 interleukin 18 1.448
CXCL10 chemokine (C-X-C motif) ligand 10 1.445
MRC1 mannose receptor, C type 1 1.445
ERBB2 erb-b2 receptor tyrosine kinase 2 1.443
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.44
RHOA ras homolog family member A 1.44
PHEX phosphate regulating endopeptidase homolog, X-linked 1.438
COL10A1 collagen, type X, alpha 1 1.433
TSG101 tumor susceptibility 101 1.433
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.43
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.429
SMAD4 SMAD family member 4 1.427
CD81 CD81 molecule 1.422
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.422
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.422
OGN osteoglycin 1.421
FLT1 fms-related tyrosine kinase 1 1.419
GLB1 galactosidase, beta 1 1.418
IL13 interleukin 13 1.412
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.412
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 1.409
APOB apolipoprotein B 1.405
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.405
EGFR epidermal growth factor receptor 1.403
NLRP3 NLR family, pyrin domain containing 3 1.402
WNT1 wingless-type MMTV integration site family, member 1 1.401
FOXO1 forkhead box O1 1.4
SH3YL1 SH3 and SYLF domain containing 1 1.4
MMP1 matrix metallopeptidase 1 1.398
POSTN periostin, osteoblast specific factor 1.397
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.396
OSTM1 osteopetrosis associated transmembrane protein 1 1.392
ACE2 angiotensin I converting enzyme 2 1.39
CRTAP cartilage associated protein 1.389
ANXA2 annexin A2 1.387
APOA1 apolipoprotein A-I 1.381
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.38
CEP72 centrosomal protein 72kDa 1.38
NOTCH1 notch 1 1.379
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.379
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 1.378
CCND1 cyclin D1 1.378
BDNF brain-derived neurotrophic factor 1.376
CCL4 chemokine (C-C motif) ligand 4 1.375
TIMP1 TIMP metallopeptidase inhibitor 1 1.371
KITLG KIT ligand 1.368
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.367
ADIPOQ adiponectin, C1Q and collagen domain containing 1.364
IL33 interleukin 33 1.359
BMP1 bone morphogenetic protein 1 1.358
CD163 CD163 molecule 1.357
FOXP3 forkhead box P3 1.357
IFNA2 interferon, alpha 2 1.353
BECN1 beclin 1, autophagy related 1.352
LRRK1 leucine-rich repeat kinase 1 1.352
FABP4 fatty acid binding protein 4, adipocyte 1.35
ESR2 estrogen receptor 2 (ER beta) 1.348
PRR4 proline rich 4 (lacrimal) 1.345
ITGAV integrin, alpha V 1.345
CYCS cytochrome c, somatic 1.344
FASLG Fas ligand (TNF superfamily, member 6) 1.342
EGFL6 EGF-like-domain, multiple 6 1.34
PTK2 protein tyrosine kinase 2 1.339
TGFB2 transforming growth factor, beta 2 1.339
NGFR nerve growth factor receptor 1.336
KL klotho 1.335
SFRP1 secreted frizzled-related protein 1 1.334
AXIN1 axin 1 1.334
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.334
UGCG UDP-glucose ceramide glucosyltransferase 1.333
ALCAM activated leukocyte cell adhesion molecule 1.325
CKM creatine kinase, muscle 1.322
STAT1 signal transducer and activator of transcription 1, 91kDa 1.322
JAG1 jagged 1 1.32
ARG1 arginase 1 1.319
MAPK8 mitogen-activated protein kinase 8 1.319
PSAP prosaposin 1.318
MSX2 msh homeobox 2 1.318
FOXO3 forkhead box O3 1.318
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.315
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.314
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.314
DCN decorin 1.311
ATRAID all-trans retinoic acid-induced differentiation factor 1.306
VEGFC vascular endothelial growth factor C 1.306
WNT16 wingless-type MMTV integration site family, member 16 1.306
PRG4 proteoglycan 4 1.305
IFNB1 interferon, beta 1, fibroblast 1.299
NFE2L2 nuclear factor, erythroid 2-like 2 1.298
CD86 CD86 molecule 1.292
JAK2 Janus kinase 2 1.291
PCNA proliferating cell nuclear antigen 1.289
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.289
CTSS cathepsin S 1.286
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.284
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.284
CKB creatine kinase, brain 1.283
ARG2 arginase 2 1.282
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.281
CKMT1B creatine kinase, mitochondrial 1B 1.28
SELE selectin E 1.276
FGF1 fibroblast growth factor 1 (acidic) 1.268
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.267
MYD88 myeloid differentiation primary response 88 1.267
WNT11 wingless-type MMTV integration site family, member 11 1.266
HBG2 hemoglobin, gamma G 1.265
TLR2 toll-like receptor 2 1.263
VTN vitronectin 1.262
PGF placental growth factor 1.259
GPX4 glutathione peroxidase 4 1.259
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.257
RAP1A RAP1A, member of RAS oncogene family 1.255
BMP3 bone morphogenetic protein 3 1.255
KNG1 kininogen 1 1.251
GREM1 gremlin 1, DAN family BMP antagonist 1.25
CD38 CD38 molecule 1.249
LTF lactotransferrin 1.249
MPO myeloperoxidase 1.249
B2M beta-2-microglobulin 1.248
ELN elastin 1.248
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.248
SFRP2 secreted frizzled-related protein 2 1.247
IGFBP3 insulin-like growth factor binding protein 3 1.247
DKK4 dickkopf WNT signaling pathway inhibitor 4 1.246
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.246
RUNX1 runt-related transcription factor 1 1.245
ACP1 acid phosphatase 1, soluble 1.239
DNAH8 dynein, axonemal, heavy chain 8 1.238
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 1.237
ATF4 activating transcription factor 4 1.232
HNF4A hepatocyte nuclear factor 4, alpha 1.231
IFNA5 interferon, alpha 5 1.23
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.224
GYPA glycophorin A (MNS blood group) 1.224
HDAC4 histone deacetylase 4 1.219
BGN biglycan 1.218
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.218
PDGFB platelet-derived growth factor beta polypeptide 1.217
SMAD6 SMAD family member 6 1.217
JAK1 Janus kinase 1 1.215
SDC1 syndecan 1 1.212
IFNA4 interferon, alpha 4 1.211
NES nestin 1.21
IFNA21 interferon, alpha 21 1.209
IFNA7 interferon, alpha 7 1.209
IFNA14 interferon, alpha 14 1.209
IFNA6 interferon, alpha 6 1.208
POU5F1 POU class 5 homeobox 1 1.207
CDKN2A cyclin-dependent kinase inhibitor 2A 1.205
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.205
CD80 CD80 molecule 1.205
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.204
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.203
IFNA16 interferon, alpha 16 1.202
AR androgen receptor 1.202
IFNA8 interferon, alpha 8 1.201
IFNA10 interferon, alpha 10 1.201
TEK TEK tyrosine kinase, endothelial 1.2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.199
IFNA13 interferon, alpha 13 1.198
HBD hemoglobin, delta 1.197
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.195
DSPP dentin sialophosphoprotein 1.193
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.191
CHUK conserved helix-loop-helix ubiquitous kinase 1.191
THBD thrombomodulin 1.189
THBS1 thrombospondin 1 1.189
LIF leukemia inhibitory factor 1.188
SLIT1 slit homolog 1 (Drosophila) 1.188
IFNA17 interferon, alpha 17 1.187
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.187
MSX1 msh homeobox 1 1.186
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.185
AFF4 AF4/FMR2 family, member 4 1.185
BCR breakpoint cluster region 1.185
PLXNB1 plexin B1 1.183
MMUT methylmalonyl-CoA mutase 1.173
SLIT3 slit homolog 3 (Drosophila) 1.172
TNMD tenomodulin 1.171
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.171
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.171
ANXA8 annexin A8 1.169
WNT4 wingless-type MMTV integration site family, member 4 1.168
ZNF667 zinc finger protein 667 1.168
SOX2 SRY (sex determining region Y)-box 2 1.167
ETV6 ets variant 6 1.167
TGFBR1 transforming growth factor, beta receptor 1 1.166
FRZB frizzled-related protein 1.165
ASPN asporin 1.165
KDM6B lysine (K)-specific demethylase 6B 1.162
HDAC9 histone deacetylase 9 1.162
BMPR1B bone morphogenetic protein receptor, type IB 1.162
SPI1 Spi-1 proto-oncogene 1.161
APOH apolipoprotein H (beta-2-glycoprotein I) 1.161
CREB1 cAMP responsive element binding protein 1 1.161
PGR progesterone receptor 1.158
EPAS1 endothelial PAS domain protein 1 1.157
OSM oncostatin M 1.156
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.154
CD1A CD1a molecule 1.154
TSC22D3 TSC22 domain family, member 3 1.153
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.152
CCR2 chemokine (C-C motif) receptor 2 1.15
CDK4 cyclin-dependent kinase 4 1.149
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.149
CLEC4E C-type lectin domain family 4, member E 1.146
CCR1 chemokine (C-C motif) receptor 1 1.145
TIMP2 TIMP metallopeptidase inhibitor 2 1.144
BCL2L1 BCL2-like 1 1.144
CALML3 calmodulin-like 3 1.143
AXIN2 axin 2 1.141
CD274 CD274 molecule 1.139
IDO1 indoleamine 2,3-dioxygenase 1 1.136
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.135
RET ret proto-oncogene 1.135
CD40 CD40 molecule, TNF receptor superfamily member 5 1.135
CD1B CD1b molecule 1.135
NANOG Nanog homeobox 1.135
WNT3 wingless-type MMTV integration site family, member 3 1.135
VCL vinculin 1.133
EFNB2 ephrin-B2 1.132
VEGFB vascular endothelial growth factor B 1.131
IL15 interleukin 15 1.128
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.128
HBS1L HBS1-like translational GTPase 1.128
ANKH ANKH inorganic pyrophosphate transport regulator 1.127
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.125
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.125
CD40LG CD40 ligand 1.122
SLC37A3 solute carrier family 37, member 3 1.121
SHH sonic hedgehog 1.12
CALML4 calmodulin-like 4 1.119
CALML6 calmodulin-like 6 1.119
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.119
KEAP1 kelch-like ECH-associated protein 1 1.117
CALML5 calmodulin-like 5 1.116
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.114
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.112
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.111
IGF2 insulin-like growth factor 2 1.111
CD1C CD1c molecule 1.111
IL1R1 interleukin 1 receptor, type I 1.109
REN renin 1.108
HMGB1 high mobility group box 1 1.107
HBG1 hemoglobin, gamma A 1.107
CD1D CD1d molecule 1.106
CD1E CD1e molecule 1.103
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 1.103
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.101
SLC39A1 solute carrier family 39 (zinc transporter), member 1 1.101
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.098
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.097
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.097
SOX5 SRY (sex determining region Y)-box 5 1.096
MITF microphthalmia-associated transcription factor 1.095
MAPK1 mitogen-activated protein kinase 1 1.092
SFRP4 secreted frizzled-related protein 4 1.091
PAX5 paired box 5 1.091
DLL4 delta-like 4 (Drosophila) 1.09
PARP1 poly (ADP-ribose) polymerase 1 1.089
GDF6 growth differentiation factor 6 1.089
CANX calnexin 1.089
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.086
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.086
HEMGN hemogen 1.083
MYOM2 myomesin 2 1.081
TLR9 toll-like receptor 9 1.078
PROM1 prominin 1 1.077
LRRC17 leucine rich repeat containing 17 1.076
FNDC5 fibronectin type III domain containing 5 1.076
IL5 interleukin 5 1.076
KLF4 Kruppel-like factor 4 (gut) 1.075
CDH5 cadherin 5, type 2 (vascular endothelium) 1.074
MSTN myostatin 1.074
LEF1 lymphoid enhancer-binding factor 1 1.074
A2M alpha-2-macroglobulin 1.073
UBXN11 UBX domain protein 11 1.071
PTK2B protein tyrosine kinase 2 beta 1.069
SOD2 superoxide dismutase 2, mitochondrial 1.068
IL6R interleukin 6 receptor 1.068
SMAD9 SMAD family member 9 1.064
SIRT3 sirtuin 3 1.064
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.064
KREMEN2 kringle containing transmembrane protein 2 1.064
MEF2C myocyte enhancer factor 2C 1.062
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 1.055
DHFR2 dihydrofolate reductase 2 1.054
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.054
TGIF2 TGFB-induced factor homeobox 2 1.053
HSPA4 heat shock 70kDa protein 4 1.052
C20ORF203 chromosome 20 open reading frame 203 1.051
SNX10 sorting nexin 10 1.05
MMP7 matrix metallopeptidase 7 1.049
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 1.047
CD79A CD79a molecule, immunoglobulin-associated alpha 1.045
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.045
ARNT aryl hydrocarbon receptor nuclear translocator 1.045
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.044
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.043
BMP5 bone morphogenetic protein 5 1.042
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.041
CDC42 cell division cycle 42 1.04
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.04
EPHB4 EPH receptor B4 1.038
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.038
SQSTM1 sequestosome 1 1.036
DHFR dihydrofolate reductase 1.035
NOX4 NADPH oxidase 4 1.034
GPX7 glutathione peroxidase 7 1.034
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.032
CARD16 caspase recruitment domain family, member 16 1.032
H3-3B H3.3 histone B 1.031
MMP10 matrix metallopeptidase 10 1.031
GPX6 glutathione peroxidase 6 1.029
TMCC2 transmembrane and coiled-coil domain family 2 1.029
TYROBP TYRO protein tyrosine kinase binding protein 1.028
FGFR1 fibroblast growth factor receptor 1 1.027
SIRT6 sirtuin 6 1.024
GDF7 growth differentiation factor 7 1.022
HP haptoglobin 1.02
WNT10A wingless-type MMTV integration site family, member 10A 1.02
IRF8 interferon regulatory factor 8 1.02
GPX8 glutathione peroxidase 8 (putative) 1.019
GPX5 glutathione peroxidase 5 1.019
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.018
GPX2 glutathione peroxidase 2 1.015
GPX3 glutathione peroxidase 3 1.015
CAMP cathelicidin antimicrobial peptide 1.013
FLT4 fms-related tyrosine kinase 4 1.012
TLR7 toll-like receptor 7 1.012
BMPR1A bone morphogenetic protein receptor, type IA 1.01
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.01
MET MET proto-oncogene, receptor tyrosine kinase 1.009
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.009
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.009
SPRED1 sprouty-related, EVH1 domain containing 1 1.008
FOSL2 FOS-like antigen 2 1.007
RHAG Rh-associated glycoprotein 1.007
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.006
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.006
ZSWIM9 zinc finger SWIM-type containing 9 1.006
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.005
WIF1 WNT inhibitory factor 1 1.005
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 1.004
XYLT2 xylosyltransferase II 1.003
AGO2 argonaute RISC catalytic component 2 1.001
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 1.0