Osteopetrosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones. (Human Disease Ontology, DOID_13533)
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Genes

544 genes co-occuring with the disease Osteopetrosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CLCN7 chloride channel, voltage-sensitive 7 3.757
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 3.591
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3.535
OSTM1 osteopetrosis associated transmembrane protein 1 3.419
CTSK cathepsin K 3.303
ACP5 acid phosphatase 5, tartrate resistant 3.212
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 3.196
SNX10 sorting nexin 10 3.039
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 3.032
DCSTAMP dendrocyte expressed seven transmembrane protein 3.017
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 3.003
CA2 carbonic anhydrase II 2.986
CSF1 colony stimulating factor 1 (macrophage) 2.857
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.822
OSCAR osteoclast associated, immunoglobulin-like receptor 2.748
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.72
FOS FBJ murine osteosarcoma viral oncogene homolog 2.706
BGLAP bone gamma-carboxyglutamate (gla) protein 2.672
CSF1R colony stimulating factor 1 receptor 2.672
FERMT3 fermitin family member 3 2.647
SOST sclerostin 2.645
TYROBP TYRO protein tyrosine kinase binding protein 2.582
SP7 Sp7 transcription factor 2.574
LRP5 low density lipoprotein receptor-related protein 5 2.548
RUNX2 runt-related transcription factor 2 2.543
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.541
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.5
OCSTAMP osteoclast stimulatory transmembrane protein 2.479
CALCR calcitonin receptor 2.427
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.421
PTH parathyroid hormone 2.419
DNAH8 dynein, axonemal, heavy chain 8 2.409
LRRK1 leucine-rich repeat kinase 1 2.369
CLCN5 chloride channel, voltage-sensitive 5 2.349
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.343
SPI1 Spi-1 proto-oncogene 2.315
IBSP integrin-binding sialoprotein 2.286
CLCN4 chloride channel, voltage-sensitive 4 2.277
MITF microphthalmia-associated transcription factor 2.272
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.268
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.267
CLCN3 chloride channel, voltage-sensitive 3 2.264
CLCN6 chloride channel, voltage-sensitive 6 2.247
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.242
SPP1 secreted phosphoprotein 1 2.221
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.212
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.191
TNF tumor necrosis factor 2.14
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.126
IL34 interleukin 34 2.119
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.086
COL1A1 collagen, type I, alpha 1 2.071
BMP2 bone morphogenetic protein 2 2.067
TREM2 triggering receptor expressed on myeloid cells 2 2.063
CLCN1 chloride channel, voltage-sensitive 1 2.061
TGFB1 transforming growth factor, beta 1 2.048
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.045
MMP9 matrix metallopeptidase 9 2.04
PTK2B protein tyrosine kinase 2 beta 2.015
IL1B interleukin 1, beta 2.013
JUN jun proto-oncogene 2.004
SIRPB1 signal-regulatory protein beta 1 1.992
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.973
IL1A interleukin 1, alpha 1.964
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.957
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.953
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.953
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.952
ALPL alkaline phosphatase, liver/bone/kidney 1.949
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 1.942
IFNG interferon, gamma 1.939
PTHLH parathyroid hormone-like hormone 1.939
IL6 interleukin 6 1.934
VAV3 vav 3 guanine nucleotide exchange factor 1.924
PTH1R parathyroid hormone 1 receptor 1.913
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.912
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.908
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.904
SYK spleen tyrosine kinase 1.899
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.895
TLN1 talin 1 1.891
CHUK conserved helix-loop-helix ubiquitous kinase 1.883
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 1.88
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 1.862
CSK c-src tyrosine kinase 1.861
ACTB actin, beta 1.86
SIGLEC15 sialic acid binding Ig-like lectin 15 1.855
ITGAV integrin, alpha V 1.85
MEPE matrix extracellular phosphoglycoprotein 1.843
TLN2 talin 2 1.84
PHEX phosphate regulating endopeptidase homolog, X-linked 1.836
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 1.835
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.828
COL1A2 collagen, type I, alpha 2 1.828
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.821
FERMT1 fermitin family member 1 1.818
DMP1 dentin matrix acidic phosphoprotein 1 1.811
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.809
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.802
IRF8 interferon regulatory factor 8 1.798
IL11 interleukin 11 1.796
CA3 carbonic anhydrase III 1.79
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.778
MSX2 msh homeobox 2 1.773
PTPRC protein tyrosine phosphatase, receptor type, C 1.769
TFEC transcription factor EC 1.769
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.749
IGF1 insulin-like growth factor 1 (somatomedin C) 1.743
LRP6 low density lipoprotein receptor-related protein 6 1.736
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.736
TRAF5 TNF receptor-associated factor 5 1.734
HCK HCK proto-oncogene, Src family tyrosine kinase 1.733
CA14 carbonic anhydrase XIV 1.731
CTSS cathepsin S 1.726
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1.725
FOSL1 FOS-like antigen 1 1.722
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.722
RGS10 regulator of G-protein signaling 10 1.717
SH3BP2 SH3-domain binding protein 2 1.717
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.713
FERMT2 fermitin family member 2 1.705
PLEK2 pleckstrin 2 1.703
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1.701
IL3 interleukin 3 1.701
WNT10B wingless-type MMTV integration site family, member 10B 1.698
CLEC5A C-type lectin domain family 5, member A 1.697
PPARG peroxisome proliferator-activated receptor gamma 1.694
PLEK pleckstrin 1.694
IL17A interleukin 17A 1.691
CA1 carbonic anhydrase I 1.689
FOSL2 FOS-like antigen 2 1.686
ANKH ANKH inorganic pyrophosphate transport regulator 1.681
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 1.671
CCDC154 coiled-coil domain containing 154 1.666
CD34 CD34 molecule 1.663
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.651
PXDNL peroxidasin-like 1.65
PXDN peroxidasin 1.649
FGF23 fibroblast growth factor 23 1.642
CA5B carbonic anhydrase VB, mitochondrial 1.637
FDPS farnesyl diphosphate synthase 1.633
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 1.629
BCAR1 breast cancer anti-estrogen resistance 1 1.622
LCK LCK proto-oncogene, Src family tyrosine kinase 1.621
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.619
CA5A carbonic anhydrase VA, mitochondrial 1.618
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 1.617
LYN LYN proto-oncogene, Src family tyrosine kinase 1.616
WNT16 wingless-type MMTV integration site family, member 16 1.614
CA8 carbonic anhydrase VIII 1.611
MAPK3 mitogen-activated protein kinase 3 1.611
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.61
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.61
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.608
CRTAP cartilage associated protein 1.607
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.602
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.602
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.602
CA13 carbonic anhydrase XIII 1.598
TFE3 transcription factor binding to IGHM enhancer 3 1.597
CSF3 colony stimulating factor 3 (granulocyte) 1.597
VTN vitronectin 1.594
WNT3A wingless-type MMTV integration site family, member 3A 1.593
IL4 interleukin 4 1.592
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.591
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.59
MATK megakaryocyte-associated tyrosine kinase 1.589
PLS3 plastin 3 1.584
SOX9 SRY (sex determining region Y)-box 9 1.583
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.582
FYN FYN proto-oncogene, Src family tyrosine kinase 1.579
MMP13 matrix metallopeptidase 13 1.578
CXCL12 chemokine (C-X-C motif) ligand 12 1.576
CDC42 cell division cycle 42 1.573
CD40 CD40 molecule, TNF receptor superfamily member 5 1.57
VCL vinculin 1.57
BMP7 bone morphogenetic protein 7 1.569
CA7 carbonic anhydrase VII 1.566
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.566
PXN paxillin 1.564
DLX5 distal-less homeobox 5 1.563
MAPK8 mitogen-activated protein kinase 8 1.557
IHH indian hedgehog 1.554
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.547
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 1.543
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.542
HCLS1 hematopoietic cell-specific Lyn substrate 1 1.541
IL10 interleukin 10 1.537
CA12 carbonic anhydrase XII 1.535
TRAF3 TNF receptor-associated factor 3 1.532
BMP4 bone morphogenetic protein 4 1.532
CD4 CD4 molecule 1.53
COL10A1 collagen, type X, alpha 1 1.53
MCOLN1 mucolipin 1 1.528
CA6 carbonic anhydrase VI 1.524
CALML5 calmodulin-like 5 1.522
CALML3 calmodulin-like 3 1.522
CALML4 calmodulin-like 4 1.519
CALML6 calmodulin-like 6 1.519
ESR1 estrogen receptor 1 1.513
BMP6 bone morphogenetic protein 6 1.512
CTTN cortactin 1.509
ACAN aggrecan 1.509
FN1 fibronectin 1 1.506
GRB2 growth factor receptor-bound protein 2 1.504
CD40LG CD40 ligand 1.503
IL7 interleukin 7 1.501
DEF8 differentially expressed in FDCP 8 homolog (mouse) 1.5
BSND barttin CLCNK-type chloride channel accessory beta subunit 1.5
PLXNA1 plexin A1 1.499
IGSF23 immunoglobulin superfamily, member 23 1.496
BLNK B-cell linker 1.492
ALB albumin 1.487
STAT1 signal transducer and activator of transcription 1, 91kDa 1.486
RHOA ras homolog family member A 1.479
WNT5A wingless-type MMTV integration site family, member 5A 1.476
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.474
COL2A1 collagen, type II, alpha 1 1.47
KITLG KIT ligand 1.468
IFNB1 interferon, beta 1, fibroblast 1.466
LTBP3 latent transforming growth factor beta binding protein 3 1.462
VAV1 vav 1 guanine nucleotide exchange factor 1.461
TFEB transcription factor EB 1.46
EFNB2 ephrin-B2 1.457
RAB3D RAB3D, member RAS oncogene family 1.457
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 1.454
WNT1 wingless-type MMTV integration site family, member 1 1.454
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.452
FGF18 fibroblast growth factor 18 1.449
TRAPPC10 trafficking protein particle complex 10 1.441
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.441
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.439
LEMD3 LEM domain containing 3 1.438
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.436
FGR FGR proto-oncogene, Src family tyrosine kinase 1.433
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.43
WAS Wiskott-Aldrich syndrome 1.429
SFRP4 secreted frizzled-related protein 4 1.426
CASR calcium-sensing receptor 1.426
EPHB4 EPH receptor B4 1.425
IFITM5 interferon induced transmembrane protein 5 1.422
MANEAL mannosidase, endo-alpha-like 1.419
LEP leptin 1.417
CD8A CD8a molecule 1.416
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 1.412
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.411
GPNMB glycoprotein (transmembrane) nmb 1.408
GGPS1 geranylgeranyl diphosphate synthase 1 1.406
BTK Bruton agammaglobulinemia tyrosine kinase 1.403
FAM20C family with sequence similarity 20, member C 1.402
TMEM64 transmembrane protein 64 1.396
CREB1 cAMP responsive element binding protein 1 1.395
GSK3B glycogen synthase kinase 3 beta 1.393
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.393
FGF2 fibroblast growth factor 2 (basic) 1.392
FGF3 fibroblast growth factor 3 1.392
FGF10 fibroblast growth factor 10 1.389
SQSTM1 sequestosome 1 1.387
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 1.386
CKB creatine kinase, brain 1.383
EMCN endomucin 1.38
EDAR ectodysplasin A receptor 1.377
FGF8 fibroblast growth factor 8 (androgen-induced) 1.376
CKMT1B creatine kinase, mitochondrial 1B 1.374
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.37
CKM creatine kinase, muscle 1.37
FGF4 fibroblast growth factor 4 1.369
CD44 CD44 molecule (Indian blood group) 1.368
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.367
USB1 U6 snRNA biogenesis 1 1.367
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.364
MX1 MX dynamin-like GTPase 1 1.361
CA4 carbonic anhydrase IV 1.361
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.361
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.36
SH3PXD2A SH3 and PX domains 2A 1.358
FGF9 fibroblast growth factor 9 1.357
ENAM enamelin 1.356
LAMP1 lysosomal-associated membrane protein 1 1.356
EGF epidermal growth factor 1.355
CXCR4 chemokine (C-X-C motif) receptor 4 1.355
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.354
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 1.348
TLR4 toll-like receptor 4 1.348
FGF7 fibroblast growth factor 7 1.347
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.346
FGF22 fibroblast growth factor 22 1.344
ASXL2 additional sex combs like transcriptional regulator 2 1.344
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.343
JUND jun D proto-oncogene 1.342
AMER1 APC membrane recruitment protein 1 1.341
FGF20 fibroblast growth factor 20 1.34
OSM oncostatin M 1.34
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.338
CLCNKB chloride channel, voltage-sensitive Kb 1.338
SCIN scinderin 1.337
FGF17 fibroblast growth factor 17 1.337
FGF6 fibroblast growth factor 6 1.335
FGF16 fibroblast growth factor 16 1.335
FGF5 fibroblast growth factor 5 1.334
RGS12 regulator of G-protein signaling 12 1.333
TMEM199 transmembrane protein 199 1.328
ALPG alkaline phosphatase, germ cell 1.328
DLX3 distal-less homeobox 3 1.327
INS insulin 1.326
JAG1 jagged 1 1.326
NOG noggin 1.326
BMP1 bone morphogenetic protein 1 1.321
HCST hematopoietic cell signal transducer 1.319
AMBN ameloblastin (enamel matrix protein) 1.318
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.314
MAP2K6 mitogen-activated protein kinase kinase 6 1.314
CCL2 chemokine (C-C motif) ligand 2 1.313
SMAD2 SMAD family member 2 1.312
LAMP2 lysosomal-associated membrane protein 2 1.31
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.31
CD68 CD68 molecule 1.309
SYT7 synaptotagmin VII 1.307
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.306
SMAD5 SMAD family member 5 1.306
ALPI alkaline phosphatase, intestinal 1.302
IFNGR1 interferon gamma receptor 1 1.296
LTBP2 latent transforming growth factor beta binding protein 2 1.294
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.291
FGF13 fibroblast growth factor 13 1.291
S1PR2 sphingosine-1-phosphate receptor 2 1.287
CBS cystathionine-beta-synthase 1.286
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.285
ALPP alkaline phosphatase, placental 1.284
ALYREF Aly/REF export factor 1.278
SMAD9 SMAD family member 9 1.278
CCL3 chemokine (C-C motif) ligand 3 1.278
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.278
TBC1D25 TBC1 domain family, member 25 1.274
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.274
CLCNKA chloride channel, voltage-sensitive Ka 1.273
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.273
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.273
SGPL1 sphingosine-1-phosphate lyase 1 1.272
TEK TEK tyrosine kinase, endothelial 1.271
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 1.271
FGFR3 fibroblast growth factor receptor 3 1.27
KREMEN2 kringle containing transmembrane protein 2 1.269
WNT7B wingless-type MMTV integration site family, member 7B 1.268
PTK2 protein tyrosine kinase 2 1.263
RDX radixin 1.262
SLAMF1 signaling lymphocytic activation molecule family member 1 1.26
CXCL8 chemokine (C-X-C motif) ligand 8 1.259
TSLIG3A tRNA splicing ligase complex subunit 3A 1.256
TRAF1 TNF receptor-associated factor 1 1.255
KL klotho 1.252
FAM47B family with sequence similarity 47, member B 1.251
CD47 CD47 molecule 1.25
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.245
CD19 CD19 molecule 1.244
GSN gelsolin 1.243
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.242
EZR ezrin 1.242
IFNA1 interferon, alpha 1 1.242
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.241
AXIN1 axin 1 1.237
GC group-specific component (vitamin D binding protein) 1.235
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 1.233
EDARADD EDAR-associated death domain 1.232
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.232
DKK4 dickkopf WNT signaling pathway inhibitor 4 1.23
MSX1 msh homeobox 1 1.228
THNSL2 threonine synthase-like 2 (S. cerevisiae) 1.224
ATF4 activating transcription factor 4 1.224
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 1.222
SIRPA signal-regulatory protein alpha 1.22
RAG1 recombination activating gene 1 1.219
IL2 interleukin 2 1.219
MAPK14 mitogen-activated protein kinase 14 1.217
HNF4A hepatocyte nuclear factor 4, alpha 1.217
ERVW-1 endogenous retrovirus group W, member 1 1.212
SMAD4 SMAD family member 4 1.208
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.208
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.206
IL1R1 interleukin 1 receptor, type I 1.205
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.204
CTSD cathepsin D 1.204
CEP57L1 centrosomal protein 57kDa-like 1 1.203
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.202
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.197
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 1.188
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.188
FASLG Fas ligand (TNF superfamily, member 6) 1.187
SMAD3 SMAD family member 3 1.187
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.185
IL18 interleukin 18 1.185
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.179
IL13 interleukin 13 1.178
CCR2 chemokine (C-C motif) receptor 2 1.175
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 1.174
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.173
MSRB2 methionine sulfoxide reductase B2 1.172
CLCN2 chloride channel, voltage-sensitive 2 1.171
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 1.169
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.167
BGN biglycan 1.165
FLT3 fms-related tyrosine kinase 3 1.163
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 1.161
LIF leukemia inhibitory factor 1.161
BMP3 bone morphogenetic protein 3 1.16
MGP matrix Gla protein 1.157
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.157
P3H1 prolyl 3-hydroxylase 1 1.154
SLC4A3 solute carrier family 4 (anion exchanger), member 3 1.149
TP53 tumor protein p53 1.149
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 1.147
THY1 Thy-1 cell surface antigen 1.147
TBC1D2 TBC1 domain family, member 2 1.146
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.146
TPCN2 two pore segment channel 2 1.146
BCL2 B-cell CLL/lymphoma 2 1.145
GJA1 gap junction protein, alpha 1, 43kDa 1.144
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.142
TGFB3 transforming growth factor, beta 3 1.142
LOX lysyl oxidase 1.142
DSPP dentin sialophosphoprotein 1.142
RABIF RAB interacting factor 1.14
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.14
MESD mesoderm development LRP chaperone 1.14
LEF1 lymphoid enhancer-binding factor 1 1.139
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.138
DICER1 dicer 1, ribonuclease type III 1.137
MSN moesin 1.136
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 1.135
POSTN periostin, osteoblast specific factor 1.135
VCAM1 vascular cell adhesion molecule 1 1.134
BMPR1A bone morphogenetic protein receptor, type IA 1.133
PECAM1 platelet/endothelial cell adhesion molecule 1 1.131
LTB lymphotoxin beta (TNF superfamily, member 3) 1.13
CYLD cylindromatosis (turban tumor syndrome) 1.128
CCDC115 coiled-coil domain containing 115 1.126
LDLR low density lipoprotein receptor 1.125
ICAM1 intercellular adhesion molecule 1 1.124
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 1.124
SPHK1 sphingosine kinase 1 1.123
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 1.123
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 1.123
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 1.123
ESRRA estrogen-related receptor alpha 1.122
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.122
SPATA32 spermatogenesis associated 32 1.122
GAB2 GRB2-associated binding protein 2 1.12
NDEL1 nudE neurodevelopment protein 1-like 1 1.117
CTSB cathepsin B 1.116
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 1.114
MMP3 matrix metallopeptidase 3 1.113
TIFA TRAF-interacting protein with forkhead-associated domain 1.113
DIAPH3 diaphanous-related formin 3 1.111
BCL6 B-cell CLL/lymphoma 6 1.11
CSF3R colony stimulating factor 3 receptor (granulocyte) 1.109
NFIA nuclear factor I/A 1.105
CD86 CD86 molecule 1.104
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 1.104
IL15 interleukin 15 1.101
CA9 carbonic anhydrase IX 1.097
RUNX1 runt-related transcription factor 1 1.095
PTDSS1 phosphatidylserine synthase 1 1.093
SFRP1 secreted frizzled-related protein 1 1.092
CPED1 cadherin-like and PC-esterase domain containing 1 1.09
ADIPOQ adiponectin, C1Q and collagen domain containing 1.088
ARF6 ADP-ribosylation factor 6 1.087
GLB1 galactosidase, beta 1 1.084
PRRX1 paired related homeobox 1 1.081
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.077
STIM1 stromal interaction molecule 1 1.076
LRRC8A leucine rich repeat containing 8 family, member A 1.074
ATG5 autophagy related 5 1.071
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 1.07
NOTCH1 notch 1 1.067
HDAC4 histone deacetylase 4 1.066
ROR2 receptor tyrosine kinase-like orphan receptor 2 1.065
PLXNB1 plexin B1 1.064
CXCL10 chemokine (C-X-C motif) ligand 10 1.064
JDP2 Jun dimerization protein 2 1.063
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 1.062
GNAS GNAS complex locus 1.061
CD80 CD80 molecule 1.06
LEPR leptin receptor 1.059
WLS wntless Wnt ligand secretion mediator 1.059
RUBCN rubicon autophagy regulator 1.058
FRZB frizzled-related protein 1.055
JAK1 Janus kinase 1 1.054
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 1.052
SEC24D SEC24 family member D 1.052
RIN3 Ras and Rab interactor 3 1.052
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.051
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.049
GPRC6A G protein-coupled receptor, class C, group 6, member A 1.049
FCRLB Fc receptor-like B 1.048
ADAM8 ADAM metallopeptidase domain 8 1.048
EEA1 early endosome antigen 1 1.047
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 1.045
LTBP1 latent transforming growth factor beta binding protein 1 1.045
TLR2 toll-like receptor 2 1.043
MYD88 myeloid differentiation primary response 88 1.041
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.037
RAB38 RAB38, member RAS oncogene family 1.037
ACP4 acid phosphatase 4 1.037
GDF2 growth differentiation factor 2 1.037
GATA2 GATA binding protein 2 1.036
CCN3 cellular communication network factor 3 1.036
TSPEAR thrombospondin-type laminin G domain and EAR repeats 1.035
TGFB2 transforming growth factor, beta 2 1.034
SRPRB signal recognition particle receptor, B subunit 1.03
CYBB cytochrome b-245, beta polypeptide 1.029
WNT10A wingless-type MMTV integration site family, member 10A 1.029
JAK2 Janus kinase 2 1.027
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 1.027
FOXO1 forkhead box O1 1.027
SPNS2 spinster homolog 2 (Drosophila) 1.026
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.026
SCARB2 scavenger receptor class B, member 2 1.026
CCN2 cellular communication network factor 2 1.024
RAG2 recombination activating gene 2 1.024
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 1.024
CLIP1 CAP-GLY domain containing linker protein 1 1.023
TANK TRAF family member-associated NFKB activator 1.02
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.019
FOXP3 forkhead box P3 1.018
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.018
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.018
HEYL hes-related family bHLH transcription factor with YRPW motif-like 1.013
GPR4 G protein-coupled receptor 4 1.013
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.013
ATRAID all-trans retinoic acid-induced differentiation factor 1.013
GPR68 G protein-coupled receptor 68 1.013
SLIT1 slit homolog 1 (Drosophila) 1.012
MAP2K3 mitogen-activated protein kinase kinase 3 1.011
ODAM odontogenic, ameloblast asssociated 1.011
NT5E 5'-nucleotidase, ecto (CD73) 1.011
RAB33B RAB33B, member RAS oncogene family 1.006
EPO erythropoietin 1.003
LRRC8C leucine rich repeat containing 8 family, member C 1.002
ARL8B ADP-ribosylation factor-like 8B 1.001
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 1.001
CD200 CD200 molecule 1.0
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 1.0
TMEM175 transmembrane protein 175 1.0
ANXA5 annexin A5 1.0