Osteoporosis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. (Experimental Factor Ontology, EFO_0003882)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D010024
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Genes

334 genes/proteins associated with the disease Osteoporosis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
VCL vinculin 2.88009
COL1A2 collagen, type I, alpha 2 2.88009
PRDX3 peroxiredoxin 3 2.88009
COL1A1 collagen, type I, alpha 1 2.88009
CALCR calcitonin receptor 2.88009
TLN1 talin 1 2.88009
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 2.88009
ANTXR2 anthrax toxin receptor 2 2.88009
LRP5 low density lipoprotein receptor-related protein 5 2.88009
ANXA2 annexin A2 2.88009
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.88009
FGB fibrinogen beta chain 2.88009
FGA fibrinogen alpha chain 2.88009
RAB7B RAB7B, member RAS oncogene family 2.88009
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.88009
PDLIM4 PDZ and LIM domain 4 2.88009
PARK7 parkinson protein 7 2.88009
ACTG1 actin gamma 1 2.88009
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.88009
PLEK pleckstrin 2.88009
PNP purine nucleoside phosphorylase 2.88009
GSN gelsolin 2.88009
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 2.88009
ZDHHC13 zinc finger, DHHC-type containing 13 2.88009
WDR1 WD repeat domain 1 2.88009
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
BMND7 bone mineral density quantiative trait locus 7 2.88009
POMC proopiomelanocortin 2.88009
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.88009
CCT2 chaperonin containing TCP1, subunit 2 (beta) 2.88009
IL6 interleukin 6 2.88009
TUBA1B tubulin, alpha 1b 2.88009
TUBA1C tubulin, alpha 1c 2.88009
KL klotho 2.88009
TPM4 tropomyosin 4 2.88009
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.88009
ADCY5 adenylate cyclase 5 2.88009
RSU1 Ras suppressor protein 1 2.88009
PGLS 6-phosphogluconolactonase 2.88009
P4HB prolyl 4-hydroxylase, beta polypeptide 2.88009
GORAB golgin, RAB6-interacting 2.88009
ENO1 enolase 1, (alpha) 2.88009
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.88009
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.88009
OXCT1 3-oxoacid CoA transferase 1 2.88009
BMND8 bone mineral density quantiative trait locus 8 2.88009
GPX1 glutathione peroxidase 1 2.88009
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.88009
TGFB1 transforming growth factor, beta 1 2.88009
REN renin 2.88009
IL6R interleukin 6 receptor 2.88009
CA2 carbonic anhydrase II 2.88009
PTH parathyroid hormone 2.88009
TPI1 triosephosphate isomerase 1 2.88009
MGLL monoglyceride lipase 2.88009
PKM pyruvate kinase, muscle 2.88009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.88009
LTF lactotransferrin 2.88009
BGLAP bone gamma-carboxyglutamate (gla) protein 2.0382
TNF tumor necrosis factor 1.8716
VEGFA vascular endothelial growth factor A 1.74903
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.74341
BCL2 B-cell CLL/lymphoma 2 1.73434
IGF1 insulin-like growth factor 1 (somatomedin C) 1.69405
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.69189
JUN jun proto-oncogene 1.6857
MAPK1 mitogen-activated protein kinase 1 1.66403
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.62379
MAPK3 mitogen-activated protein kinase 3 1.61874
FOS FBJ murine osteosarcoma viral oncogene homolog 1.60501
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.60407
NFE2L2 nuclear factor, erythroid 2-like 2 1.56435
NOS2 nitric oxide synthase 2, inducible 1.56337
MAP2K1 mitogen-activated protein kinase kinase 1 1.55723
MKI67 marker of proliferation Ki-67 1.5555
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.55206
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.54742
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.54742
PPARG peroxisome proliferator-activated receptor gamma 1.5284
SOD1 superoxide dismutase 1, soluble 1.52767
TFRC transferrin receptor 1.52464
TP53 tumor protein p53 1.51759
MMP2 matrix metallopeptidase 2 1.51506
PGR progesterone receptor 1.51481
TH tyrosine hydroxylase 1.49839
BAX BCL2-associated X protein 1.49711
GSK3B glycogen synthase kinase 3 beta 1.49686
EDN1 endothelin 1 1.47426
CCND1 cyclin D1 1.4727
MMP9 matrix metallopeptidase 9 1.47064
PARP1 poly (ADP-ribose) polymerase 1 1.45962
CCL2 chemokine (C-C motif) ligand 2 1.4583
PLAT plasminogen activator, tissue 1.45036
CAT catalase 1.44273
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.43892
NOS3 nitric oxide synthase 3 (endothelial cell) 1.43646
IL4 interleukin 4 1.43455
ICAM1 intercellular adhesion molecule 1 1.42913
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.42831
CYCS cytochrome c, somatic 1.42669
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.42129
RUNX2 runt-related transcription factor 2 1.41532
EGR1 early growth response 1 1.40787
FAS Fas cell surface death receptor 1.40568
NOS1 nitric oxide synthase 1 (neuronal) 1.39897
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.3973
IL1B interleukin 1, beta 1.39563
IGFBP3 insulin-like growth factor binding protein 3 1.3917
GH1 growth hormone 1 1.3878
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.38412
LDLR low density lipoprotein receptor 1.38298
CKB creatine kinase, brain 1.38015
NCOA1 nuclear receptor coactivator 1 1.37733
COL3A1 collagen, type III, alpha 1 1.37246
BCL2L1 BCL2-like 1 1.3716
CRP C-reactive protein, pentraxin-related 1.36905
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.36677
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.3639
MAOA monoamine oxidase A 1.3639
ALPL alkaline phosphatase, liver/bone/kidney 1.36161
FDPS farnesyl diphosphate synthase 1.36047
FN1 fibronectin 1 1.35962
TOP2A topoisomerase (DNA) II alpha 170kDa 1.35213
IFNG interferon, gamma 1.35041
BDNF brain-derived neurotrophic factor 1.34459
STAT1 signal transducer and activator of transcription 1, 91kDa 1.34401
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.34314
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.33523
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.32428
ADIPOQ adiponectin, C1Q and collagen domain containing 1.32162
CTSD cathepsin D 1.32132
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.32044
SQSTM1 sequestosome 1 1.31956
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.31927
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.31297
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.31237
LEP leptin 1.31178
IL2 interleukin 2 1.30819
LPL lipoprotein lipase 1.30635
SPP1 secreted phosphoprotein 1 1.30543
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.30543
HMOX1 heme oxygenase 1 1.3039
CXCL8 chemokine (C-X-C motif) ligand 8 1.30208
CSF1 colony stimulating factor 1 (macrophage) 1.29379
CCL3 chemokine (C-C motif) ligand 3 1.28241
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.28241
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.28149
PRL prolactin 1.27966
IL10 interleukin 10 1.2744
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.27009
IGF2 insulin-like growth factor 2 1.27009
FSHB follicle stimulating hormone, beta polypeptide 1.26483
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.2639
NGF nerve growth factor (beta polypeptide) 1.26329
IL12B interleukin 12B 1.26267
VCAM1 vascular cell adhesion molecule 1 1.26052
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.25929
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.25682
MMP1 matrix metallopeptidase 1 1.25651
JUNB jun B proto-oncogene 1.25307
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 1.2475
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.2475
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.24718
BAD BCL2-associated agonist of cell death 1.24655
IL12A interleukin 12A 1.2368
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.2368
FASLG Fas ligand (TNF superfamily, member 6) 1.2336
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.23233
INHBA inhibin, beta A 1.23137
ESR2 estrogen receptor 2 (ER beta) 1.23011
SREBF1 sterol regulatory element binding transcription factor 1 1.22727
CD14 CD14 molecule 1.2208
BMP2 bone morphogenetic protein 2 1.21855
MIR146A microRNA 146a 1.21727
ACP5 acid phosphatase 5, tartrate resistant 1.21534
FABP4 fatty acid binding protein 4, adipocyte 1.21501
RGS4 regulator of G-protein signaling 4 1.21173
RAP1A RAP1A, member of RAS oncogene family 1.20946
IGFBP5 insulin-like growth factor binding protein 5 1.20816
FASN fatty acid synthase 1.20394
CXCL12 chemokine (C-X-C motif) ligand 12 1.20328
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.20163
AR androgen receptor 1.19704
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.19607
LHB luteinizing hormone beta polypeptide 1.19509
PECAM1 platelet/endothelial cell adhesion molecule 1 1.19477
UBB ubiquitin B 1.19445
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.19146
PTHLH parathyroid hormone-like hormone 1.18521
BID BH3 interacting domain death agonist 1.18489
GSTP1 glutathione S-transferase pi 1 1.18489
PRKCE protein kinase C, epsilon 1.18424
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.18026
MT2A metallothionein 2A 1.17761
RARA retinoic acid receptor, alpha 1.17497
RHOA ras homolog family member A 1.17497
SIRT1 sirtuin 1 1.17431
OXTR oxytocin receptor 1.17101
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.17034
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.16967
PER2 period circadian clock 2 1.16967
CCNB1 cyclin B1 1.16766
GREB1 growth regulation by estrogen in breast cancer 1 1.16666
CDC42 cell division cycle 42 1.16666
APOB apolipoprotein B 1.166
PRKCA protein kinase C, alpha 1.16368
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.16335
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.16203
MAPK14 mitogen-activated protein kinase 14 1.15661
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.15189
GSR glutathione reductase 1.15022
IRAK1 interleukin-1 receptor-associated kinase 1 1.14954
CTGF connective tissue growth factor 1.14678
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.14302
CHEK2 checkpoint kinase 2 1.142
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.14098
APP amyloid beta (A4) precursor protein 1.1403
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.1403
IL18 interleukin 18 1.13862
IL5 interleukin 5 1.13862
BAK1 BCL2-antagonist/killer 1 1.13793
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.13793
APOE apolipoprotein E 1.13381
SOCS3 suppressor of cytokine signaling 3 1.13381
ADAM17 ADAM metallopeptidase domain 17 1.13313
SELE selectin E 1.13177
KLF4 Kruppel-like factor 4 (gut) 1.13177
MMP13 matrix metallopeptidase 13 1.12564
F3 coagulation factor III (thromboplastin, tissue factor) 1.12357
MGP matrix Gla protein 1.12357
IL1A interleukin 1, alpha 1.12185
TFF1 trefoil factor 1 1.12151
HRAS Harvey rat sarcoma viral oncogene homolog 1.12117
MAP2K3 mitogen-activated protein kinase kinase 3 1.12117
HOMER1 homer scaffolding protein 1 1.12117
BCL3 B-cell CLL/lymphoma 3 1.12117
ESR1 estrogen receptor 1 1.12082
NQO1 NAD(P)H dehydrogenase, quinone 1 1.12048
MCM2 minichromosome maintenance complex component 2 1.11809
MUC1 mucin 1, cell surface associated 1.11741
FGF9 fibroblast growth factor 9 1.11396
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.1136
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.1129
CXCL2 chemokine (C-X-C motif) ligand 2 1.10734
C3 complement component 3 1.10596
CAV1 caveolin 1, caveolae protein, 22kDa 1.10596
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.10596
STAR steroidogenic acute regulatory protein 1.10562
DUSP1 dual specificity phosphatase 1 1.10562
TF transferrin 1.10388
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.10282
F2R coagulation factor II (thrombin) receptor 1.10246
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.09998
IGF1R insulin-like growth factor 1 receptor 1.09998
CISH cytokine inducible SH2-containing protein 1.09892
MMP3 matrix metallopeptidase 3 1.09646
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.09611
HSPA1A heat shock 70kDa protein 1A 1.09366
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.09366
SOD3 superoxide dismutase 3, extracellular 1.09262
DDIT3 DNA-damage-inducible transcript 3 1.0919
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.08904
RACGAP1 Rac GTPase activating protein 1 1.08833
SQLE squalene epoxidase 1.08762
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.08762
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.08655
CXCL10 chemokine (C-X-C motif) ligand 10 1.08619
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.08513
LBP lipopolysaccharide binding protein 1.08478
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.08019
CTSK cathepsin K 1.07804
PLAU plasminogen activator, urokinase 1.07768
GFAP glial fibrillary acidic protein 1.07768
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.07696
F2 coagulation factor II (thrombin) 1.07411
RPS6 ribosomal protein S6 1.07305
EGFR epidermal growth factor receptor 1.07269
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.07128
COL2A1 collagen, type II, alpha 1 1.07093
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.06808
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.06771
PDGFB platelet-derived growth factor beta polypeptide 1.06588
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.06588
MYF5 myogenic factor 5 1.06225
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.06152
RGS2 regulator of G-protein signaling 2 1.06152
RXRA retinoid X receptor, alpha 1.06008
KDR kinase insert domain receptor 1.06008
GLUL glutamate-ammonia ligase 1.059
S100A8 S100 calcium binding protein A8 1.05685
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.05237
IGFBP4 insulin-like growth factor binding protein 4 1.04868
CALCA calcitonin-related polypeptide alpha 1.04794
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.04794
CYBA cytochrome b-245, alpha polypeptide 1.04757
GSTM1 glutathione S-transferase mu 1 1.04611
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.04574
CYBB cytochrome b-245, beta polypeptide 1.04538
TGFA transforming growth factor, alpha 1.04314
CHUK conserved helix-loop-helix ubiquitous kinase 1.04314
ALB albumin 1.04051
IRS2 insulin receptor substrate 2 1.03939
PCNA proliferating cell nuclear antigen 1.03715
TGFBR1 transforming growth factor, beta receptor 1 1.03641
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.03641
MYLK myosin light chain kinase 1.03641
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.03419
RBP1 retinol binding protein 1, cellular 1.03308
CRH corticotropin releasing hormone 1.03235
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.03084
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.03046
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.03009
INS insulin 1.02821
CREB1 cAMP responsive element binding protein 1 1.02821
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.02783
CD36 CD36 molecule (thrombospondin receptor) 1.02596
ANXA1 annexin A1 1.02559
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.02522
EPOR erythropoietin receptor 1.02485
H2AFX H2A histone family, member X 1.02299
CDK1 cyclin-dependent kinase 1 1.02299
PTGES prostaglandin E synthase 1.02151
FST follistatin 1.02151
CCL5 chemokine (C-C motif) ligand 5 1.02151
EDN3 endothelin 3 1.02077
TLR4 toll-like receptor 4 1.01814
INSIG1 insulin induced gene 1 1.01739
GPX3 glutathione peroxidase 3 1.01739
GJA1 gap junction protein, alpha 1, 43kDa 1.01474
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.01286
CLU clusterin 1.01174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.01099
FGF2 fibroblast growth factor 2 (basic) 1.01025