Osteoporosis Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. (Experimental Factor Ontology, EFO_0003882)
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Genes

31 genes associated with the trait Osteoporosis in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
CD38 CD38 molecule 0.948569
FAM135B family with sequence similarity 135, member B 0.894264
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.836775
CDC73 cell division cycle 73 0.813287
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.813287
DMD dystrophin 0.675202
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.64828
RPL26P32 ribosomal protein L26 pseudogene 32 0.629193
CHM choroideremia (Rab escort protein 1) 0.618235
WIF1 WNT inhibitory factor 1 0.614288
OSBPL1A oxysterol binding protein-like 1A 0.567219
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.537919
DOK6 docking protein 6 0.50886
OR4D10 olfactory receptor, family 4, subfamily D, member 10 0.47636
CCDC148 coiled-coil domain containing 148 0.46572
LRP1B low density lipoprotein receptor-related protein 1B 0.447043
UMOD uromodulin 0.443956
CNTNAP2 contactin associated protein-like 2 0.416324
HK2 hexokinase 2 0.406869
HSPA4L heat shock 70kDa protein 4-like 0.389899
CLINT1 clathrin interactor 1 0.374231
PIBF1 progesterone immunomodulatory binding factor 1 0.34888
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.289047
ZCCHC6 zinc finger, CCHC domain containing 6 0.259951
SLIT3 slit homolog 3 (Drosophila) 0.195142
CNOT6 CCR4-NOT transcription complex, subunit 6 0.144687
AKAP7 A kinase (PRKA) anchor protein 7 0.137336
NRG1 neuregulin 1 0.121529
USO1 USO1 vesicle transport factor 0.082505
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.077409
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.061362