Osteosarcoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)|A malignant mesenchymal tumor arising from the bone.|A usually aggressive malignant bone-forming mesenchymal tumor, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs. (Experimental Factor Ontology, EFO_0000637)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D012516
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Genes

554 genes/proteins associated with the disease Osteosarcoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
DHFR dihydrofolate reductase 2.88009
ZW10 zw10 kinetochore protein 2.88009
GRM4 glutamate receptor, metabotropic 4 2.88009
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.88009
MIR302B microRNA 302b 2.88009
MIR130B microRNA 130b 2.88009
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.88009
MET MET proto-oncogene, receptor tyrosine kinase 2.88009
LOX lysyl oxidase 2.88009
MIR93 microRNA 93 2.88009
EGFR epidermal growth factor receptor 2.88009
RGS1 regulator of G-protein signaling 1 2.88009
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.88009
JUN jun proto-oncogene 2.88009
MIR106B microRNA 106b 2.88009
BCOR BCL6 corepressor 2.88009
CHEK2 checkpoint kinase 2 2.88009
TP53 tumor protein p53 2.88009
MST1R macrophage stimulating 1 receptor 2.88009
RB1 retinoblastoma 1 2.88009
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.88009
GSTP1 glutathione S-transferase pi 1 2.88009
CCNB3 cyclin B3 2.88009
BMI1 BMI1 proto-oncogene, polycomb ring finger 2.88009
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.88009
FOLR1 folate receptor 1 (adult) 2.88009
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.88009
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.88009
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.88009
RFC1 replication factor C (activator 1) 1, 145kDa 2.88009
BCL2 B-cell CLL/lymphoma 2 2.06647
MCL1 myeloid cell leukemia 1 1.98453
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.98324
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.96224
BAX BCL2-associated X protein 1.96193
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.93322
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.9296
SOD2 superoxide dismutase 2, mitochondrial 1.91234
FAS Fas cell surface death receptor 1.90392
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.892
BIRC3 baculoviral IAP repeat containing 3 1.87958
TYMP thymidine phosphorylase 1.8545
PARP1 poly (ADP-ribose) polymerase 1 1.84481
FASLG Fas ligand (TNF superfamily, member 6) 1.84233
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.83378
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.81484
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.8051
MAPK1 mitogen-activated protein kinase 1 1.80303
IL6 interleukin 6 1.79904
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.78606
BAK1 BCL2-antagonist/killer 1 1.77724
IL1B interleukin 1, beta 1.77218
ERBB2 erb-b2 receptor tyrosine kinase 2 1.7621
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.74341
BIRC5 baculoviral IAP repeat containing 5 1.73434
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.72281
BBC3 BCL2 binding component 3 1.71379
CDK2 cyclin-dependent kinase 2 1.70347
MAPK3 mitogen-activated protein kinase 3 1.68253
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.67376
TNF tumor necrosis factor 1.66986
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.66555
BCL2L1 BCL2-like 1 1.6649
GSK3B glycogen synthase kinase 3 beta 1.66382
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.66102
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.64955
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.63966
PRKCD protein kinase C, delta 1.63653
BID BH3 interacting domain death agonist 1.63005
TYMS thymidylate synthetase 1.62601
CYCS cytochrome c, somatic 1.60641
BIRC2 baculoviral IAP repeat containing 2 1.60058
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.59661
CFLAR CASP8 and FADD-like apoptosis regulator 1.59661
TOP2A topoisomerase (DNA) II alpha 170kDa 1.58537
GPX3 glutathione peroxidase 3 1.58398
CAT catalase 1.579
STAT1 signal transducer and activator of transcription 1, 91kDa 1.57853
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.57641
SGK1 serum/glucocorticoid regulated kinase 1 1.57162
F3 coagulation factor III (thromboplastin, tissue factor) 1.56804
VEGFA vascular endothelial growth factor A 1.56361
DDIT3 DNA-damage-inducible transcript 3 1.56092
SP1 Sp1 transcription factor 1.55946
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.55896
DPYD dihydropyrimidine dehydrogenase 1.55896
GADD45A growth arrest and DNA-damage-inducible, alpha 1.54693
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.53627
MAPK9 mitogen-activated protein kinase 9 1.53012
EGF epidermal growth factor 1.52889
MAPK8 mitogen-activated protein kinase 8 1.52693
VCAM1 vascular cell adhesion molecule 1 1.52667
CCNA2 cyclin A2 1.52642
NQO1 NAD(P)H dehydrogenase, quinone 1 1.51886
GSTM1 glutathione S-transferase mu 1 1.51456
MAPK14 mitogen-activated protein kinase 14 1.50877
PCNA proliferating cell nuclear antigen 1.507
GCLC glutamate-cysteine ligase, catalytic subunit 1.50448
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.49967
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.49711
BUB3 BUB3 mitotic checkpoint protein 1.48967
CDK1 cyclin-dependent kinase 1 1.48761
GDF15 growth differentiation factor 15 1.4817
H2AFX H2A histone family, member X 1.4817
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.48119
BAD BCL2-associated agonist of cell death 1.48017
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.4727
BRCA1 breast cancer 1, early onset 1.47167
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.46674
TIMP1 TIMP metallopeptidase inhibitor 1 1.46436
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.46409
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.45484
HMGA2 high mobility group AT-hook 2 1.45115
MGMT O-6-methylguanine-DNA methyltransferase 1.44872
IL23A interleukin 23, alpha subunit p19 1.44382
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.44327
MMP9 matrix metallopeptidase 9 1.44273
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.44029
LHB luteinizing hormone beta polypeptide 1.437
IFNG interferon, gamma 1.43428
CCNE1 cyclin E1 1.43184
ATF5 activating transcription factor 5 1.42669
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.42293
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.42074
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.41451
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.41396
XAF1 XIAP associated factor 1 1.41202
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.40288
CYLD cylindromatosis (turban tumor syndrome) 1.40176
PRC1 protein regulator of cytokinesis 1 1.4012
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.40064
SFN stratifin 1.39813
CXCL8 chemokine (C-X-C motif) ligand 8 1.39535
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.39451
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.39226
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.39198
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.3903
IL2 interleukin 2 1.3903
EPO erythropoietin 1.38441
EDN1 endothelin 1 1.38412
FANCG Fanconi anemia, complementation group G 1.3827
THBS1 thrombospondin 1 1.38242
CCND1 cyclin D1 1.38242
ICAM1 intercellular adhesion molecule 1 1.37874
LGALS8 lectin, galactoside-binding, soluble, 8 1.37817
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.37817
MMP1 matrix metallopeptidase 1 1.37733
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 1.36905
G6PD glucose-6-phosphate dehydrogenase 1.36876
IER3 immediate early response 3 1.36706
BCL2A1 BCL2-related protein A1 1.36648
RRM2 ribonucleotide reductase M2 1.36504
DUSP2 dual specificity phosphatase 2 1.36476
TXNIP thioredoxin interacting protein 1.36304
SESN2 sestrin 2 1.36104
PSPC1 paraspeckle component 1 1.36076
RBM17 RNA binding motif protein 17 1.36076
TOP2B topoisomerase (DNA) II beta 180kDa 1.36047
KAT2B K(lysine) acetyltransferase 2B 1.36047
ZNF552 zinc finger protein 552 1.35705
EMP3 epithelial membrane protein 3 1.35618
HRAS Harvey rat sarcoma viral oncogene homolog 1.35531
EDNRB endothelin receptor type B 1.35386
TP73 tumor protein p73 1.35213
HSPA1B heat shock 70kDa protein 1B 1.35213
MMP2 matrix metallopeptidase 2 1.35098
BIRC7 baculoviral IAP repeat containing 7 1.34082
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.33966
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.33761
HMOX1 heme oxygenase 1 1.33553
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 1.33199
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.32935
CHEK1 checkpoint kinase 1 1.32935
TGFB1 transforming growth factor, beta 1 1.32786
CCNB1 cyclin B1 1.32726
BECN1 beclin 1, autophagy related 1.32518
ATM ATM serine/threonine kinase 1.32428
ATF2 activating transcription factor 2 1.32044
CDC6 cell division cycle 6 1.32044
NOS2 nitric oxide synthase 2, inducible 1.31985
FOS FBJ murine osteosarcoma viral oncogene homolog 1.31867
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 1.31686
NRP1 neuropilin 1 1.31327
ERCC2 excision repair cross-complementation group 2 1.31327
C5ORF28 chromosome 5 open reading frame 28 1.31178
SQSTM1 sequestosome 1 1.31119
CCL2 chemokine (C-C motif) ligand 2 1.31089
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.30788
PSAP prosaposin 1.30604
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.30238
MIR21 microRNA 21 1.29564
EGR1 early growth response 1 1.2941
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.28858
RPL6 ribosomal protein L6 1.28858
MT2A metallothionein 2A 1.28425
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.28272
BIK BCL2-interacting killer (apoptosis-inducing) 1.2821
UROD uroporphyrinogen decarboxylase 1.2818
PRNP prion protein 1.27966
IL15 interleukin 15 1.27875
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.27813
GPX1 glutathione peroxidase 1 1.27347
MPO myeloperoxidase 1.27286
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.26947
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.26607
FSHB follicle stimulating hormone, beta polypeptide 1.26483
NFE2L2 nuclear factor, erythroid 2-like 2 1.26483
MAP2K1 mitogen-activated protein kinase kinase 1 1.26359
CDC25C cell division cycle 25C 1.26113
MACF1 microtubule-actin crosslinking factor 1 1.26021
CDKN2A cyclin-dependent kinase inhibitor 2A 1.25929
NKAIN1 Na+/K+ transporting ATPase interacting 1 1.25338
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.24812
JAK2 Janus kinase 2 1.24781
NOS3 nitric oxide synthase 3 (endothelial cell) 1.2475
STIP1 stress-induced phosphoprotein 1 1.24528
FTH1 ferritin, heavy polypeptide 1 1.24401
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.24213
VIM vimentin 1.2415
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 1.24056
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.24056
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.23962
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.2368
IRS1 insulin receptor substrate 1 1.23648
BCR breakpoint cluster region 1.23584
CAPN2 calpain 2, (m/II) large subunit 1.23424
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.23424
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.23137
IGFBP4 insulin-like growth factor binding protein 4 1.23137
TMPO thymopoietin 1.23137
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.22599
ODC1 ornithine decarboxylase 1 1.22436
RUNX3 runt-related transcription factor 3 1.22209
BIN1 bridging integrator 1 1.22209
SAT1 spermidine/spermine N1-acetyltransferase 1 1.22048
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.21984
SOCS3 suppressor of cytokine signaling 3 1.21823
RAP1A RAP1A, member of RAS oncogene family 1.21791
E2F3 E2F transcription factor 3 1.21759
PDS5B PDS5 cohesin associated factor B 1.21599
ERBB4 erb-b2 receptor tyrosine kinase 4 1.21337
DBF4 DBF4 zinc finger 1.21337
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.21271
GSTA1 glutathione S-transferase alpha 1 1.21141
BRCA2 breast cancer 2, early onset 1.20978
SPATA18 spermatogenesis associated 18 1.20784
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.20654
DBN1 drebrin 1 1.2046
TPI1 triosephosphate isomerase 1 1.20229
BTG2 BTG family, member 2 1.20097
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 1.20064
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.20064
KCMF1 potassium channel modulatory factor 1 1.19933
ATF4 activating transcription factor 4 1.19933
CCNG2 cyclin G2 1.19737
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.19737
NBN nibrin 1.19639
RAD23B RAD23 homolog B (S. cerevisiae) 1.19639
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.19246
CD14 CD14 molecule 1.19246
OSBPL10 oxysterol binding protein-like 10 1.19179
SOD1 superoxide dismutase 1, soluble 1.19146
DDIT4 DNA-damage-inducible transcript 4 1.18915
DST dystonin 1.18849
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.18849
EPOR erythropoietin receptor 1.18816
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.18751
TIMP2 TIMP metallopeptidase inhibitor 2 1.18751
PDE4B phosphodiesterase 4B, cAMP-specific 1.18751
BCL2L2 BCL2-like 2 1.18456
IL10 interleukin 10 1.18424
TXNRD1 thioredoxin reductase 1 1.18359
FOSL1 FOS-like antigen 1 1.18293
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.18293
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.18226
CXCL12 chemokine (C-X-C motif) ligand 12 1.17794
IGFBP7 insulin-like growth factor binding protein 7 1.17695
IL27RA interleukin 27 receptor, alpha 1.17662
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.17596
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.1753
ATF3 activating transcription factor 3 1.1753
UBE2C ubiquitin-conjugating enzyme E2C 1.17366
PLAU plasminogen activator, urokinase 1.17034
ZNRD1 zinc ribbon domain containing 1 1.17
AURKA aurora kinase A 1.169
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.169
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.16666
PROCR protein C receptor, endothelial 1.166
SRM spermidine synthase 1.16567
PHLDA1 pleckstrin homology-like domain, family A, member 1 1.16467
FAM219A family with sequence similarity 219, member A 1.16434
KIAA0368 KIAA0368 1.16401
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 1.16269
TRAF1 TNF receptor-associated factor 1 1.16236
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.16236
IGF1 insulin-like growth factor 1 (somatomedin C) 1.16035
NRG1 neuregulin 1 1.16035
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.16035
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.15865
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.15797
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.15797
NCKAP1 NCK-associated protein 1 1.15593
ANGPT1 angiopoietin 1 1.15526
CTH cystathionine gamma-lyase 1.15357
S100P S100 calcium binding protein P 1.15189
CCL5 chemokine (C-C motif) ligand 5 1.15189
POSTN periostin, osteoblast specific factor 1.15189
ATR ATR serine/threonine kinase 1.15189
GEM GTP binding protein overexpressed in skeletal muscle 1.15156
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.15156
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 1.14954
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.14954
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.14954
ZNF32 zinc finger protein 32 1.14919
TFPI2 tissue factor pathway inhibitor 2 1.1485
MAP2K4 mitogen-activated protein kinase kinase 4 1.14816
DUSP10 dual specificity phosphatase 10 1.14816
CA9 carbonic anhydrase IX 1.14816
GAMT guanidinoacetate N-methyltransferase 1.14816
EGR2 early growth response 2 1.14507
AXL AXL receptor tyrosine kinase 1.14507
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.14473
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 1.14166
RELN reelin 1.14166
MAP2K3 mitogen-activated protein kinase kinase 3 1.14166
TNNI3 troponin I type 3 (cardiac) 1.14166
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.14098
ALB albumin 1.14064
RGL1 ral guanine nucleotide dissociation stimulator-like 1 1.13724
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.13724
BBS4 Bardet-Biedl syndrome 4 1.13689
TBL1X transducin (beta)-like 1X-linked 1.13689
RPS6 ribosomal protein S6 1.13484
XPA xeroderma pigmentosum, complementation group A 1.13484
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 1.13484
HBEGF heparin-binding EGF-like growth factor 1.13279
AHCYL1 adenosylhomocysteinase-like 1 1.13109
MR1 major histocompatibility complex, class I-related 1.13109
SPP1 secreted phosphoprotein 1 1.13075
CALR calreticulin 1.12872
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.12838
FGF1 fibroblast growth factor 1 (acidic) 1.12668
STK4 serine/threonine kinase 4 1.12599
FHL1 four and a half LIM domains 1 1.12564
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.12564
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.12564
STK17A serine/threonine kinase 17a 1.1253
CIDEB cell death-inducing DFFA-like effector b 1.1253
KDM4B lysine (K)-specific demethylase 4B 1.1253
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.12495
LDHA lactate dehydrogenase A 1.12495
PTEN phosphatase and tensin homolog 1.12391
ITGAV integrin, alpha V 1.12219
STMN1 stathmin 1 1.12082
GSR glutathione reductase 1.12082
RAD51 RAD51 recombinase 1.12082
CCAR1 cell division cycle and apoptosis regulator 1 1.1198
TLR4 toll-like receptor 4 1.1198
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.11911
DUSP4 dual specificity phosphatase 4 1.11911
SDC1 syndecan 1 1.11606
NPPA natriuretic peptide A 1.11466
CLU clusterin 1.11431
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 1.11396
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.11325
CLDN4 claudin 4 1.11325
FGF2 fibroblast growth factor 2 (basic) 1.11325
PROM1 prominin 1 1.11325
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.11151
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 1.11011
CHUK conserved helix-loop-helix ubiquitous kinase 1.10942
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.10872
CD70 CD70 molecule 1.10838
MFN1 mitofusin 1 1.10838
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.10734
ISG15 ISG15 ubiquitin-like modifier 1.10734
KITLG KIT ligand 1.10734
SETD1B SET domain containing 1B 1.10699
FGF7 fibroblast growth factor 7 1.10459
SNAI1 snail family zinc finger 1 1.10459
MAP2K2 mitogen-activated protein kinase kinase 2 1.10388
CDC27 cell division cycle 27 1.10317
SESN1 sestrin 1 1.1014
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.09892
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 1.09857
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.09857
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.09857
TCF4 transcription factor 4 1.09857
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.09822
WISP1 WNT1 inducible signaling pathway protein 1 1.09786
PCCA propionyl CoA carboxylase, alpha polypeptide 1.09786
SRXN1 sulfiredoxin 1 1.09646
COL1A1 collagen, type I, alpha 1 1.09611
EIF2A eukaryotic translation initiation factor 2A, 65kDa 1.09576
CCNB2 cyclin B2 1.09471
CCND3 cyclin D3 1.09471
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 1.09332
MAPK7 mitogen-activated protein kinase 7 1.09297
WEE1 WEE1 G2 checkpoint kinase 1.09297
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 1.09297
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.09011
SLC19A1 solute carrier family 19 (folate transporter), member 1 1.09011
LMNB1 lamin B1 1.09011
CDK4 cyclin-dependent kinase 4 1.08868
GPR137B G protein-coupled receptor 137B 1.08797
CSTA cystatin A (stefin A) 1.08797
ANKRD10 ankyrin repeat domain 10 1.08797
IL1RN interleukin 1 receptor antagonist 1.08762
EMP1 epithelial membrane protein 1 1.08726
HSPB1 heat shock 27kDa protein 1 1.08513
TOP1 topoisomerase (DNA) I 1.08478
SPHK1 sphingosine kinase 1 1.08442
SHANK2 SH3 and multiple ankyrin repeat domains 2 1.08301
C21ORF91 chromosome 21 open reading frame 91 1.08266
TAT tyrosine aminotransferase 1.08196
POR P450 (cytochrome) oxidoreductase 1.08126
ERBB3 erb-b2 receptor tyrosine kinase 3 1.07947
AREG amphiregulin 1.07732
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.0766
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.0766
CDC25A cell division cycle 25A 1.0766
NUPR1 nuclear protein, transcriptional regulator, 1 1.07553
SLC22A18 solute carrier family 22, member 18 1.0734
FUBP1 far upstream element (FUSE) binding protein 1 1.0734
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 1.07305
PRR3 proline rich 3 1.07234
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 1.07234
COL4A1 collagen, type IV, alpha 1 1.07128
CCND2 cyclin D2 1.07057
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.07057
TFF1 trefoil factor 1 1.07057
E2F1 E2F transcription factor 1 1.06881
NUSAP1 nucleolar and spindle associated protein 1 1.06625
GRN granulin 1.06625
PCOLCE procollagen C-endopeptidase enhancer 1.06479
TRIB2 tribbles pseudokinase 2 1.06442
SULF1 sulfatase 1 1.06442
DKK3 dickkopf WNT signaling pathway inhibitor 3 1.06442
RSRP1 arginine/serine-rich protein 1 1.06406
PDCD5 programmed cell death 5 1.06406
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.0637
MCM4 minichromosome maintenance complex component 4 1.0637
VDAC1 voltage-dependent anion channel 1 1.0637
MMP12 matrix metallopeptidase 12 1.0637
PMP22 peripheral myelin protein 22 1.0637
CD1D CD1d molecule 1.06261
UPK3A uroplakin 3A 1.06225
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.06116
BAG3 BCL2-associated athanogene 3 1.06116
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.06116
MAP2K6 mitogen-activated protein kinase kinase 6 1.06116
PPAP2A phosphatidic acid phosphatase type 2A 1.06044
IL1A interleukin 1, alpha 1.06044
DPYSL4 dihydropyrimidinase-like 4 1.06008
GBP1 guanylate binding protein 1, interferon-inducible 1.06008
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 1.05972
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 1.05972
ABHD2 abhydrolase domain containing 2 1.05972
UBE2L6 ubiquitin-conjugating enzyme E2L 6 1.05972
NFE2L1 nuclear factor, erythroid 2-like 1 1.05972
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.059
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.05864
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 1.05864
GCLM glutamate-cysteine ligase, modifier subunit 1.05864
PERP PERP, TP53 apoptosis effector 1.0561
HDAC4 histone deacetylase 4 1.05573
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.05573
TRAP1 TNF receptor-associated protein 1 1.05498
CD44 CD44 molecule (Indian blood group) 1.05386
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.05349
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 1.05237
EDA2R ectodysplasin A2 receptor 1.05237
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 1.052
AAMDC adipogenesis associated, Mth938 domain containing 1.052
COL7A1 collagen, type VII, alpha 1 1.05089
FSCN1 fascin actin-bundling protein 1 1.05089
FN1 fibronectin 1 1.04941
MMP3 matrix metallopeptidase 3 1.04904
VLDLR very low density lipoprotein receptor 1.04868
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.04868
CTSD cathepsin D 1.04757
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.04684
FANCI Fanconi anemia, complementation group I 1.04647
UNG uracil-DNA glycosylase 1.04611
CDKN3 cyclin-dependent kinase inhibitor 3 1.04611
PLK1 polo-like kinase 1 1.04611
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.04389
GHR growth hormone receptor 1.04352
GSK3A glycogen synthase kinase 3 alpha 1.04276
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.04276
CASP10 caspase 10, apoptosis-related cysteine peptidase 1.04276
COL1A2 collagen, type I, alpha 2 1.04276
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 1.04239
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.04239
MKNK2 MAP kinase interacting serine/threonine kinase 2 1.04239
GLIPR1 GLI pathogenesis-related 1 1.04239
DIABLO diablo, IAP-binding mitochondrial protein 1.04163
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.04051
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.03864
APLP2 amyloid beta (A4) precursor-like protein 2 1.03789
CP ceruloplasmin (ferroxidase) 1.03789
SMAD2 SMAD family member 2 1.03678
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 1.03641
GOLGA8A golgin A8 family, member A 1.03567
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.03419
CREM cAMP responsive element modulator 1.03419
COL4A4 collagen, type IV, alpha 4 1.03419
DENND4A DENN/MADD domain containing 4A 1.03419
KLF4 Kruppel-like factor 4 (gut) 1.03419
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 1.03419
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.03235
ERCC1 excision repair cross-complementation group 1 1.03197
TSC22D3 TSC22 domain family, member 3 1.03197
SRGN serglycin 1.03009
TRIM2 tripartite motif containing 2 1.03009
RBPMS RNA binding protein with multiple splicing 1.03009
GSTA4 glutathione S-transferase alpha 4 1.02896
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 1.02634
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 1.02634
FAM171A1 family with sequence similarity 171, member A1 1.02559
ZBTB24 zinc finger and BTB domain containing 24 1.02559
TICAM2 toll-like receptor adaptor molecule 2 1.02522
HELQ helicase, POLQ-like 1.02522
RBM34 RNA binding motif protein 34 1.02522
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 1.02522
CHML choroideremia-like (Rab escort protein 2) 1.02485
PTRH2 peptidyl-tRNA hydrolase 2 1.02485
CCDC28B coiled-coil domain containing 28B 1.02485
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.02447
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 1.02225
BDH1 3-hydroxybutyrate dehydrogenase, type 1 1.02225
MCM6 minichromosome maintenance complex component 6 1.0204
IGFBP3 insulin-like growth factor binding protein 3 1.02003
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.0189
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.0189
GFRA1 GDNF family receptor alpha 1 1.01852
LY6E lymphocyte antigen 6 complex, locus E 1.01852
BAMBI BMP and activin membrane-bound inhibitor 1.01852
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.01852
IL4 interleukin 4 1.01814
WRN Werner syndrome, RecQ helicase-like 1.01776
CCDC82 coiled-coil domain containing 82 1.01739
EPB41L2 erythrocyte membrane protein band 4.1-like 2 1.01701
SIRT1 sirtuin 1 1.01701
HSPE1 heat shock 10kDa protein 1 1.01625
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.01625
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.01625
ZFP36L2 ZFP36 ring finger protein-like 2 1.01474
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.01361
LDLR low density lipoprotein receptor 1.01286
AURKB aurora kinase B 1.01212
PPIF peptidylprolyl isomerase F 1.01137
IER5 immediate early response 5 1.01137
IFITM1 interferon induced transmembrane protein 1 1.01137