Osteosclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A bone remodeling disease that results_in abnormal elevated bone density or mass. (Human Disease Ontology, DOID_4254)
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Genes

730 genes co-occuring with the disease Osteosclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CLCN7 chloride channel, voltage-sensitive 7 3.674
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3.544
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 3.512
OSTM1 osteopetrosis associated transmembrane protein 1 3.335
CTSK cathepsin K 3.331
ACP5 acid phosphatase 5, tartrate resistant 3.208
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 3.166
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 3.087
LEMD3 LEM domain containing 3 2.975
DCSTAMP dendrocyte expressed seven transmembrane protein 2.975
SNX10 sorting nexin 10 2.956
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 2.952
CA2 carbonic anhydrase II 2.912
SOST sclerostin 2.871
BGLAP bone gamma-carboxyglutamate (gla) protein 2.856
CSF1 colony stimulating factor 1 (macrophage) 2.815
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.795
SP7 Sp7 transcription factor 2.774
RUNX2 runt-related transcription factor 2 2.768
FOS FBJ murine osteosarcoma viral oncogene homolog 2.687
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.682
OSCAR osteoclast associated, immunoglobulin-like receptor 2.675
ANKH ANKH inorganic pyrophosphate transport regulator 2.672
LRP5 low density lipoprotein receptor-related protein 5 2.656
PTH parathyroid hormone 2.643
CSF1R colony stimulating factor 1 receptor 2.616
FERMT3 fermitin family member 3 2.57
FAM20C family with sequence similarity 20, member C 2.541
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.532
TYROBP TYRO protein tyrosine kinase binding protein 2.507
TGFB1 transforming growth factor, beta 1 2.493
IBSP integrin-binding sialoprotein 2.454
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.447
OCSTAMP osteoclast stimulatory transmembrane protein 2.431
SPP1 secreted phosphoprotein 1 2.403
CALCR calcitonin receptor 2.397
AMER1 APC membrane recruitment protein 1 2.352
DNAH8 dynein, axonemal, heavy chain 8 2.349
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.346
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.311
BMP2 bone morphogenetic protein 2 2.308
LRRK1 leucine-rich repeat kinase 1 2.307
CLCN5 chloride channel, voltage-sensitive 5 2.298
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.275
SPI1 Spi-1 proto-oncogene 2.257
COL1A1 collagen, type I, alpha 1 2.252
TNF tumor necrosis factor 2.246
DMP1 dentin matrix acidic phosphoprotein 1 2.226
MITF microphthalmia-associated transcription factor 2.213
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.207
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.205
CLCN4 chloride channel, voltage-sensitive 4 2.194
ALPL alkaline phosphatase, liver/bone/kidney 2.188
IL1B interleukin 1, beta 2.187
CLCN3 chloride channel, voltage-sensitive 3 2.187
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.18
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.162
CD1E CD1e molecule 2.158
CLCN6 chloride channel, voltage-sensitive 6 2.155
FGF23 fibroblast growth factor 23 2.154
CD1A CD1a molecule 2.15
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.145
CD1B CD1b molecule 2.142
PTHLH parathyroid hormone-like hormone 2.136
PHEX phosphate regulating endopeptidase homolog, X-linked 2.132
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.128
IL6 interleukin 6 2.107
MMP9 matrix metallopeptidase 9 2.106
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.106
IL1A interleukin 1, alpha 2.089
CD1C CD1c molecule 2.082
PTH1R parathyroid hormone 1 receptor 2.077
MEPE matrix extracellular phosphoglycoprotein 2.065
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.057
JUN jun proto-oncogene 2.051
JAK2 Janus kinase 2 2.049
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.035
MMP13 matrix metallopeptidase 13 2.032
IL34 interleukin 34 2.031
CD1D CD1d molecule 2.031
COL1A2 collagen, type I, alpha 2 2.018
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.017
CD68 CD68 molecule 2.008
CD34 CD34 molecule 2.006
ACAN aggrecan 1.997
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.993
TREM2 triggering receptor expressed on myeloid cells 2 1.987
CLCN1 chloride channel, voltage-sensitive 1 1.983
IFNG interferon, gamma 1.979
PTK2B protein tyrosine kinase 2 beta 1.976
IGF1 insulin-like growth factor 1 (somatomedin C) 1.97
LRP6 low density lipoprotein receptor-related protein 6 1.965
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.965
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.957
FAM20B family with sequence similarity 20, member B 1.954
FOSL1 FOS-like antigen 1 1.949
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.945
SIRPB1 signal-regulatory protein beta 1 1.915
IL11 interleukin 11 1.912
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.911
ACTB actin, beta 1.91
PTPRC protein tyrosine phosphatase, receptor type, C 1.908
ITGAV integrin, alpha V 1.906
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.901
SOX9 SRY (sex determining region Y)-box 9 1.899
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 1.89
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.877
CALR calreticulin 1.868
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 1.861
IHH indian hedgehog 1.86
CXCL12 chemokine (C-X-C motif) ligand 12 1.856
THPO thrombopoietin 1.852
TLN1 talin 1 1.852
BMP4 bone morphogenetic protein 4 1.85
WNT10B wingless-type MMTV integration site family, member 10B 1.849
CHUK conserved helix-loop-helix ubiquitous kinase 1.848
MSX2 msh homeobox 2 1.846
SYK spleen tyrosine kinase 1.836
FAM20A family with sequence similarity 20, member A 1.836
VAV3 vav 3 guanine nucleotide exchange factor 1.832
BMP7 bone morphogenetic protein 7 1.832
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.831
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.828
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.817
COL2A1 collagen, type II, alpha 1 1.815
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.805
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.804
TLN2 talin 2 1.804
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 1.799
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.796
CSK c-src tyrosine kinase 1.795
SIGLEC15 sialic acid binding Ig-like lectin 15 1.789
WNT16 wingless-type MMTV integration site family, member 16 1.789
WNT3A wingless-type MMTV integration site family, member 3A 1.782
IL3 interleukin 3 1.781
FOSL2 FOS-like antigen 2 1.772
PPARG peroxisome proliferator-activated receptor gamma 1.771
MATK megakaryocyte-associated tyrosine kinase 1.771
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 1.77
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.77
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.769
BMP6 bone morphogenetic protein 6 1.767
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.767
WNT1 wingless-type MMTV integration site family, member 1 1.764
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 1.761
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.761
COL10A1 collagen, type X, alpha 1 1.76
PXDNL peroxidasin-like 1.749
PXDN peroxidasin 1.747
LTBP3 latent transforming growth factor beta binding protein 3 1.743
FN1 fibronectin 1 1.742
IRF8 interferon regulatory factor 8 1.739
IL17A interleukin 17A 1.736
CRTAP cartilage associated protein 1.736
CTSS cathepsin S 1.735
MAPK3 mitogen-activated protein kinase 3 1.735
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.734
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.731
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.73
FGF2 fibroblast growth factor 2 (basic) 1.727
CA3 carbonic anhydrase III 1.727
FERMT1 fermitin family member 1 1.726
SMAD2 SMAD family member 2 1.725
IFNA1 interferon, alpha 1 1.718
SMAD3 SMAD family member 3 1.717
FDPS farnesyl diphosphate synthase 1.714
MPL MPL proto-oncogene, thrombopoietin receptor 1.714
NOG noggin 1.707
SMAD5 SMAD family member 5 1.707
DLX5 distal-less homeobox 5 1.706
PTDSS1 phosphatidylserine synthase 1 1.704
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.701
BMP1 bone morphogenetic protein 1 1.698
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.697
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.696
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1.695
CSF3 colony stimulating factor 3 (granulocyte) 1.692
TFEC transcription factor EC 1.692
FGF18 fibroblast growth factor 18 1.691
ALB albumin 1.69
EMCN endomucin 1.689
WNT5A wingless-type MMTV integration site family, member 5A 1.689
KITLG KIT ligand 1.687
FERMT2 fermitin family member 2 1.683
LCK LCK proto-oncogene, Src family tyrosine kinase 1.682
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.678
MAP2K1 mitogen-activated protein kinase kinase 1 1.668
JAG1 jagged 1 1.667
ASXL1 additional sex combs like transcriptional regulator 1 1.66
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.66
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.659
SH3BP2 SH3-domain binding protein 2 1.655
TGFB3 transforming growth factor, beta 3 1.654
TRAF5 TNF receptor-associated factor 5 1.653
TGFB2 transforming growth factor, beta 2 1.652
HCK HCK proto-oncogene, Src family tyrosine kinase 1.65
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.648
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.644
TGFBR1 transforming growth factor, beta receptor 1 1.643
IL4 interleukin 4 1.643
RGS10 regulator of G-protein signaling 10 1.639
CD4 CD4 molecule 1.639
CA14 carbonic anhydrase XIV 1.639
IFITM5 interferon induced transmembrane protein 5 1.638
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.637
IL10 interleukin 10 1.637
ESR1 estrogen receptor 1 1.637
FGF8 fibroblast growth factor 8 (androgen-induced) 1.637
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 1.631
PLEK2 pleckstrin 2 1.629
FGF10 fibroblast growth factor 10 1.629
GJA1 gap junction protein, alpha 1, 43kDa 1.627
FGF4 fibroblast growth factor 4 1.623
FGF3 fibroblast growth factor 3 1.622
CLEC5A C-type lectin domain family 5, member A 1.621
VTN vitronectin 1.621
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.62
CXCR4 chemokine (C-X-C motif) receptor 4 1.62
LTBP2 latent transforming growth factor beta binding protein 2 1.619
FGF9 fibroblast growth factor 9 1.618
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.617
PLEK pleckstrin 1.608
FGF7 fibroblast growth factor 7 1.608
IL7 interleukin 7 1.604
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 1.602
FGF16 fibroblast growth factor 16 1.6
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.597
CA1 carbonic anhydrase I 1.597
FGF20 fibroblast growth factor 20 1.597
FGF22 fibroblast growth factor 22 1.597
AXIN1 axin 1 1.596
FGF6 fibroblast growth factor 6 1.596
FGF17 fibroblast growth factor 17 1.595
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 1.593
TMEM53 transmembrane protein 53 1.593
FGF5 fibroblast growth factor 5 1.592
CRP C-reactive protein, pentraxin-related 1.591
CD207 CD207 molecule, langerin 1.591
CDC42 cell division cycle 42 1.589
PLS3 plastin 3 1.587
STAT1 signal transducer and activator of transcription 1, 91kDa 1.587
OSM oncostatin M 1.587
BMP3 bone morphogenetic protein 3 1.586
VCL vinculin 1.586
SMAD9 SMAD family member 9 1.586
IFNA2 interferon, alpha 2 1.586
ACVR1 activin A receptor, type I 1.585
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.584
LEP leptin 1.582
SFRP4 secreted frizzled-related protein 4 1.576
CCDC154 coiled-coil domain containing 154 1.575
GSK3B glycogen synthase kinase 3 beta 1.572
MAPK8 mitogen-activated protein kinase 8 1.572
TFE3 transcription factor binding to IGHM enhancer 3 1.57
LYN LYN proto-oncogene, Src family tyrosine kinase 1.569
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 1.568
KL klotho 1.561
BCAR1 breast cancer anti-estrogen resistance 1 1.56
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.559
CASR calcium-sensing receptor 1.559
FGFR3 fibroblast growth factor receptor 3 1.558
DLX3 distal-less homeobox 3 1.557
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 1.55
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.548
CA5B carbonic anhydrase VB, mitochondrial 1.545
CA5A carbonic anhydrase VA, mitochondrial 1.541
SMAD4 SMAD family member 4 1.536
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.536
MGP matrix Gla protein 1.533
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.533
CD40 CD40 molecule, TNF receptor superfamily member 5 1.531
PXN paxillin 1.531
KREMEN2 kringle containing transmembrane protein 2 1.531
RHOA ras homolog family member A 1.529
GDF5 growth differentiation factor 5 1.528
CXCL8 chemokine (C-X-C motif) ligand 8 1.527
TRAF3 TNF receptor-associated factor 3 1.523
CD163 CD163 molecule 1.523
CA8 carbonic anhydrase VIII 1.52
ALPG alkaline phosphatase, germ cell 1.519
DSPP dentin sialophosphoprotein 1.517
JAK1 Janus kinase 1 1.515
PECAM1 platelet/endothelial cell adhesion molecule 1 1.51
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.507
FYN FYN proto-oncogene, Src family tyrosine kinase 1.507
CA13 carbonic anhydrase XIII 1.507
CD8A CD8a molecule 1.504
CALML3 calmodulin-like 3 1.504
CALML5 calmodulin-like 5 1.503
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.502
CALML4 calmodulin-like 4 1.501
CALML6 calmodulin-like 6 1.501
FGF13 fibroblast growth factor 13 1.499
CD44 CD44 molecule (Indian blood group) 1.498
INS insulin 1.496
EPHB4 EPH receptor B4 1.495
MMP3 matrix metallopeptidase 3 1.493
CCL2 chemokine (C-C motif) ligand 2 1.492
CA7 carbonic anhydrase VII 1.49
GRB2 growth factor receptor-bound protein 2 1.489
EFNB2 ephrin-B2 1.489
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.487
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.484
CA6 carbonic anhydrase VI 1.477
SLAMF1 signaling lymphocytic activation molecule family member 1 1.477
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.477
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.475
EGF epidermal growth factor 1.475
SMAD6 SMAD family member 6 1.474
TET2 tet methylcytosine dioxygenase 2 1.473
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.472
ALPI alkaline phosphatase, intestinal 1.471
TP53 tumor protein p53 1.47
CD40LG CD40 ligand 1.468
CREB1 cAMP responsive element binding protein 1 1.461
ALPP alkaline phosphatase, placental 1.46
IFNA17 interferon, alpha 17 1.459
CA12 carbonic anhydrase XII 1.456
SRSF2 serine/arginine-rich splicing factor 2 1.454
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 1.454
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.453
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 1.451
ELN elastin 1.45
MCOLN1 mucolipin 1 1.45
HCLS1 hematopoietic cell-specific Lyn substrate 1 1.449
EPO erythropoietin 1.445
PLXNA1 plexin A1 1.445
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.437
MX1 MX dynamin-like GTPase 1 1.431
BSND barttin CLCNK-type chloride channel accessory beta subunit 1.431
BLNK B-cell linker 1.43
JUND jun D proto-oncogene 1.43
NES nestin 1.43
IFNA7 interferon, alpha 7 1.426
BMPR1A bone morphogenetic protein receptor, type IA 1.425
RAB3D RAB3D, member RAS oncogene family 1.423
GGPS1 geranylgeranyl diphosphate synthase 1 1.422
IFNB1 interferon, beta 1, fibroblast 1.422
POSTN periostin, osteoblast specific factor 1.42
GDF2 growth differentiation factor 2 1.42
CTTN cortactin 1.418
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 1.416
IFNA4 interferon, alpha 4 1.415
BCR breakpoint cluster region 1.414
SQSTM1 sequestosome 1 1.413
VAV1 vav 1 guanine nucleotide exchange factor 1.413
IFNA16 interferon, alpha 16 1.41
TFEB transcription factor EB 1.41
AMBN ameloblastin (enamel matrix protein) 1.41
IFNA21 interferon, alpha 21 1.409
IFNA14 interferon, alpha 14 1.409
IFNA8 interferon, alpha 8 1.408
DEF8 differentially expressed in FDCP 8 homolog (mouse) 1.408
IFNA5 interferon, alpha 5 1.407
FBN1 fibrillin 1 1.407
IFNA13 interferon, alpha 13 1.406
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.405
CKB creatine kinase, brain 1.404
IGSF23 immunoglobulin superfamily, member 23 1.404
IFNA10 interferon, alpha 10 1.403
IFNA6 interferon, alpha 6 1.402
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 1.4
WWP1 WW domain containing E3 ubiquitin protein ligase 1 1.398
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.398
CKMT1B creatine kinase, mitochondrial 1B 1.397
ENAM enamelin 1.395
ANO5 anoctamin 5 1.394
CKM creatine kinase, muscle 1.393
BTK Bruton agammaglobulinemia tyrosine kinase 1.392
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 1.392
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.392
LEPR leptin receptor 1.392
TLR4 toll-like receptor 4 1.391
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 1.389
BCL2 B-cell CLL/lymphoma 2 1.388
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.385
WNT7B wingless-type MMTV integration site family, member 7B 1.385
GPNMB glycoprotein (transmembrane) nmb 1.384
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.382
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.381
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.381
FLT3 fms-related tyrosine kinase 3 1.379
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.374
GNAS GNAS complex locus 1.372
ATF4 activating transcription factor 4 1.368
CD19 CD19 molecule 1.367
CCL3 chemokine (C-C motif) ligand 3 1.365
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.365
HNF4A hepatocyte nuclear factor 4, alpha 1.364
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.364
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.364
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.361
RUNX1 runt-related transcription factor 1 1.36
BGN biglycan 1.36
WAS Wiskott-Aldrich syndrome 1.359
DKK4 dickkopf WNT signaling pathway inhibitor 4 1.356
TRAPPC10 trafficking protein particle complex 10 1.35
THY1 Thy-1 cell surface antigen 1.35
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.349
DVL1 dishevelled segment polarity protein 1 1.345
NOTCH2 notch 2 1.344
FGR FGR proto-oncogene, Src family tyrosine kinase 1.342
CSF3R colony stimulating factor 3 receptor (granulocyte) 1.337
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.336
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.336
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.335
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.331
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.329
WIF1 WNT inhibitory factor 1 1.328
MANEAL mannosidase, endo-alpha-like 1.327
FGFR1 fibroblast growth factor receptor 1 1.326
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.323
ENG endoglin 1.321
IGF2 insulin-like growth factor 2 1.32
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.319
FEN1 flap structure-specific endonuclease 1 1.317
PLXNB1 plexin B1 1.314
LEF1 lymphoid enhancer-binding factor 1 1.312
USB1 U6 snRNA biogenesis 1 1.312
ADIPOQ adiponectin, C1Q and collagen domain containing 1.312
NT5E 5'-nucleotidase, ecto (CD73) 1.309
EDAR ectodysplasin A receptor 1.308
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.306
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.304
TMEM64 transmembrane protein 64 1.304
LTBP1 latent transforming growth factor beta binding protein 1 1.3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.298
P3H1 prolyl 3-hydroxylase 1 1.298
LAMP1 lysosomal-associated membrane protein 1 1.296
EMD emerin 1.295
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 1.294
LOX lysyl oxidase 1.293
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.293
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.291
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.29
IL2 interleukin 2 1.288
SMAD7 SMAD family member 7 1.287
MSX1 msh homeobox 1 1.287
NOTCH1 notch 1 1.285
CA4 carbonic anhydrase IV 1.282
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.281
EDN1 endothelin 1 1.281
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 1.281
VCAM1 vascular cell adhesion molecule 1 1.28
RSPO2 R-spondin 2 1.28
SH2B3 SH2B adaptor protein 3 1.279
IL18 interleukin 18 1.279
MPLKIP M-phase specific PLK1 interacting protein 1.279
LAMP2 lysosomal-associated membrane protein 2 1.278
LIF leukemia inhibitory factor 1.276
TEK TEK tyrosine kinase, endothelial 1.276
IL13 interleukin 13 1.275
CLCNKB chloride channel, voltage-sensitive Kb 1.274
SCIN scinderin 1.273
CCN2 cellular communication network factor 2 1.272
GC group-specific component (vitamin D binding protein) 1.272
IFNGR1 interferon gamma receptor 1 1.271
GLI1 GLI family zinc finger 1 1.27
RGS12 regulator of G-protein signaling 12 1.269
SH3PXD2A SH3 and PX domains 2A 1.266
HDAC4 histone deacetylase 4 1.264
MAP2K6 mitogen-activated protein kinase kinase 6 1.262
PTK2 protein tyrosine kinase 2 1.261
FRZB frizzled-related protein 1.26
IL1R1 interleukin 1 receptor, type I 1.26
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.26
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.258
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.257
CCR2 chemokine (C-C motif) receptor 2 1.256
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.255
ASXL2 additional sex combs like transcriptional regulator 2 1.253
SDC1 syndecan 1 1.252
ALYREF Aly/REF export factor 1.252
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.251
CCK cholecystokinin 1.247
STAT5A signal transducer and activator of transcription 5A 1.246
SYT7 synaptotagmin VII 1.246
AXIN2 axin 2 1.244
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.244
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.243
FASLG Fas ligand (TNF superfamily, member 6) 1.238
TMEM199 transmembrane protein 199 1.237
PRRX1 paired related homeobox 1 1.235
STAT5B signal transducer and activator of transcription 5B 1.231
AMTN amelotin 1.228
S1PR2 sphingosine-1-phosphate receptor 2 1.227
HCST hematopoietic cell signal transducer 1.227
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.225
RAG1 recombination activating gene 1 1.224
CCN3 cellular communication network factor 3 1.224
ROR2 receptor tyrosine kinase-like orphan receptor 2 1.221
ACVR2A activin A receptor, type IIA 1.221
DCN decorin 1.221
BMP5 bone morphogenetic protein 5 1.221
CBS cystathionine-beta-synthase 1.218
SFRP1 secreted frizzled-related protein 1 1.216
GREM1 gremlin 1, DAN family BMP antagonist 1.215
MAPK14 mitogen-activated protein kinase 14 1.213
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.213
CHRD chordin 1.212
GATA2 GATA binding protein 2 1.212
WNT10A wingless-type MMTV integration site family, member 10A 1.207
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.206
IL15 interleukin 15 1.206
GLB1 galactosidase, beta 1 1.206
CD47 CD47 molecule 1.204
COL9A2 collagen, type IX, alpha 2 1.204
RDX radixin 1.201
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.198
GREM2 gremlin 2, DAN family BMP antagonist 1.197
FGFR2 fibroblast growth factor receptor 2 1.195
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.195
GSN gelsolin 1.194
WNT5B wingless-type MMTV integration site family, member 5B 1.193
BMPR1B bone morphogenetic protein receptor, type IB 1.191
EZR ezrin 1.191
CCL5 chemokine (C-C motif) ligand 5 1.19
ERCC2 excision repair cross-complementation group 2 1.19
JAK3 Janus kinase 3 1.189
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.187
CCND1 cyclin D1 1.187
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.186
CCN4 cellular communication network factor 4 1.186
TRAF1 TNF receptor-associated factor 1 1.182
CLCNKA chloride channel, voltage-sensitive Ka 1.182
TBC1D25 TBC1 domain family, member 25 1.182
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 1.18
MSTN myostatin 1.18
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.18
WLS wntless Wnt ligand secretion mediator 1.18
SGPL1 sphingosine-1-phosphate lyase 1 1.18
CD48 CD48 molecule 1.179
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 1.179
ESRRA estrogen-related receptor alpha 1.174
MMP1 matrix metallopeptidase 1 1.172
ICAM1 intercellular adhesion molecule 1 1.171
FOXO1 forkhead box O1 1.171
VWF von Willebrand factor 1.168
ZBTB40 zinc finger and BTB domain containing 40 1.168
LTBP4 latent transforming growth factor beta binding protein 4 1.167
TSLIG3A tRNA splicing ligase complex subunit 3A 1.164
SHH sonic hedgehog 1.163
RABIF RAB interacting factor 1.162
FAM47B family with sequence similarity 47, member B 1.159
MESD mesoderm development LRP chaperone 1.159
MYD88 myeloid differentiation primary response 88 1.159
KREMEN1 kringle containing transmembrane protein 1 1.158
ANXA5 annexin A5 1.157
ERVW-1 endogenous retrovirus group W, member 1 1.155
GTF2H5 general transcription factor IIH, polypeptide 5 1.152
TWIST2 twist family bHLH transcription factor 2 1.151
KRAS Kirsten rat sarcoma viral oncogene homolog 1.148
CTSD cathepsin D 1.147
NGF nerve growth factor (beta polypeptide) 1.146
CXCL10 chemokine (C-X-C motif) ligand 10 1.146
NFIA nuclear factor I/A 1.143
SPHK1 sphingosine kinase 1 1.142
SIRPA signal-regulatory protein alpha 1.141
IRAK1 interleukin-1 receptor-associated kinase 1 1.141
TBXAS1 thromboxane A synthase 1 (platelet) 1.141
PRG4 proteoglycan 4 1.14
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 1.14
EDARADD EDAR-associated death domain 1.14
TFRC transferrin receptor 1.14
MEF2C myocyte enhancer factor 2C 1.139
WNT9A wingless-type MMTV integration site family, member 9A 1.136
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 1.135
SOX6 SRY (sex determining region Y)-box 6 1.135
THNSL2 threonine synthase-like 2 (S. cerevisiae) 1.132
WNT4 wingless-type MMTV integration site family, member 4 1.132
H3-3B H3.3 histone B 1.132
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.132
IL1RN interleukin 1 receptor antagonist 1.131
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 1.13
RAB44 RAB44, member RAS oncogene family 1.13
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.129
DICER1 dicer 1, ribonuclease type III 1.128
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.125
BCL6 B-cell CLL/lymphoma 6 1.124
CTSB cathepsin B 1.124
ATG5 autophagy related 5 1.124
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 1.123
SEC24D SEC24 family member D 1.121
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.119
CD200 CD200 molecule 1.114
GAB2 GRB2-associated binding protein 2 1.113
CEP57L1 centrosomal protein 57kDa-like 1 1.112
LMNB1 lamin B1 1.112
MMP2 matrix metallopeptidase 2 1.111
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.111
TBCE tubulin folding cofactor E 1.111
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.108
POMC proopiomelanocortin 1.108
WNT6 wingless-type MMTV integration site family, member 6 1.107
JDP2 Jun dimerization protein 2 1.104
LDLR low density lipoprotein receptor 1.103
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.102
PHOSPHO1 phosphatase, orphan 1 1.099
SCARB2 scavenger receptor class B, member 2 1.099
MYOD1 myogenic differentiation 1 1.099
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 1.097
MSN moesin 1.096
EXT1 exostosin glycosyltransferase 1 1.095
SLIT1 slit homolog 1 (Drosophila) 1.094
NKX3-2 NK3 homeobox 2 1.092
MAML2 mastermind-like 2 (Drosophila) 1.091
MAML1 mastermind-like 1 (Drosophila) 1.091
PF4 platelet factor 4 1.09
MYH14 myosin, heavy chain 14, non-muscle 1.09
CD38 CD38 molecule 1.09
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.087
GPRC6A G protein-coupled receptor, class C, group 6, member A 1.084
RAG2 recombination activating gene 2 1.083
STIM1 stromal interaction molecule 1 1.082
HMGA2 high mobility group AT-hook 2 1.082
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 1.082
PTEN phosphatase and tensin homolog 1.081
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.081
MSRB2 methionine sulfoxide reductase B2 1.08
CPED1 cadherin-like and PC-esterase domain containing 1 1.08
CLCN2 chloride channel, voltage-sensitive 2 1.079
CD86 CD86 molecule 1.079
NLRP3 NLR family, pyrin domain containing 3 1.079
MPO myeloperoxidase 1.079
EGFR epidermal growth factor receptor 1.079
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.078
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.077
CAV1 caveolin 1, caveolae protein, 22kDa 1.074
HEYL hes-related family bHLH transcription factor with YRPW motif-like 1.074
CYLD cylindromatosis (turban tumor syndrome) 1.072
CD36 CD36 molecule (thrombospondin receptor) 1.069
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 1.069
CA9 carbonic anhydrase IX 1.068
CCL4 chemokine (C-C motif) ligand 4 1.068
SCARB1 scavenger receptor class B, member 1 1.067
ANGPT1 angiopoietin 1 1.066
CAVIN1 caveolae associated protein 1 1.066
FLNA filamin A, alpha 1.066
FZD9 frizzled class receptor 9 1.065
FCRLB Fc receptor-like B 1.063
TYK2 tyrosine kinase 2 1.062
MAP2K3 mitogen-activated protein kinase kinase 3 1.061
BANF1 barrier to autointegration factor 1 1.06
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.06
ACVR1B activin A receptor, type IB 1.06
BECN1 beclin 1, autophagy related 1.059
LRRC8A leucine rich repeat containing 8 family, member A 1.058
LIFR leukemia inhibitory factor receptor alpha 1.058
SLC4A3 solute carrier family 4 (anion exchanger), member 3 1.057
NF1 neurofibromin 1 1.056
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 1.056
FABP4 fatty acid binding protein 4, adipocyte 1.056
DIAPH3 diaphanous-related formin 3 1.056
TBC1D2 TBC1 domain family, member 2 1.055
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.055
TPCN2 two pore segment channel 2 1.054
SATB2 SATB homeobox 2 1.054
GJA3 gap junction protein, alpha 3, 46kDa 1.053
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.051
COL11A2 collagen, type XI, alpha 2 1.051
APOE apolipoprotein E 1.049
FURIN furin (paired basic amino acid cleaving enzyme) 1.049
HBEGF heparin-binding EGF-like growth factor 1.047
RSPO1 R-spondin 1 1.047
SIRT1 sirtuin 1 1.046
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.044
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 1.044
CHRDL1 chordin-like 1 1.044
FOXP3 forkhead box P3 1.044
DLL1 delta-like 1 (Drosophila) 1.043
LMNA lamin A/C 1.042
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.041
MAML3 mastermind-like 3 (Drosophila) 1.04
EPOR erythropoietin receptor 1.039
LTB lymphotoxin beta (TNF superfamily, member 3) 1.039
GJC1 gap junction protein, gamma 1, 45kDa 1.039
PRDM1 PR domain containing 1, with ZNF domain 1.037
TSPEAR thrombospondin-type laminin G domain and EAR repeats 1.035
CCDC115 coiled-coil domain containing 115 1.035
CD80 CD80 molecule 1.034
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 1.033
ARSB arylsulfatase B 1.033
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.033
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 1.032
TLR2 toll-like receptor 2 1.032
GJA4 gap junction protein, alpha 4, 37kDa 1.032
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.031
H3C13 H3 clustered histone 13 1.031
H3-5 H3.5 histone 1.031
H3-4 H3.4 histone, cluster member 1.03
C16ORF46 chromosome 16 open reading frame 46 1.03
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.03
SPATA32 spermatogenesis associated 32 1.03
CD9 CD9 molecule 1.028
CD33 CD33 molecule 1.028
H3C12 H3 clustered histone 12 1.027
RUBCN rubicon autophagy regulator 1.027
ACP4 acid phosphatase 4 1.025
NDEL1 nudE neurodevelopment protein 1-like 1 1.025
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.024
TSC1 tuberous sclerosis 1 1.024
CD5 CD5 molecule 1.023
TIFA TRAF-interacting protein with forkhead-associated domain 1.022
CTSL cathepsin L 1.021
POTEF POTE ankyrin domain family, member F 1.02
FLT3LG fms-related tyrosine kinase 3 ligand 1.018
BANF2 barrier to autointegration factor 2 1.018
CTF1 cardiotrophin 1 1.018
ARF6 ADP-ribosylation factor 6 1.018
GPR4 G protein-coupled receptor 4 1.015
NRP1 neuropilin 1 1.014
RIN3 Ras and Rab interactor 3 1.013
CCL20 chemokine (C-C motif) ligand 20 1.012
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 1.012
FBN2 fibrillin 2 1.011
PLCG1 phospholipase C, gamma 1 1.01
OMD osteomodulin 1.01
RSPO3 R-spondin 3 1.009
MSRB3 methionine sulfoxide reductase B3 1.008
SPN sialophorin 1.006
EEA1 early endosome antigen 1 1.006
SOX5 SRY (sex determining region Y)-box 5 1.005
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 1.005
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.004
B2M beta-2-microglobulin 1.003
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.002
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.001
BCL2L1 BCL2-like 1 1.0
CCR1 chemokine (C-C motif) receptor 1 1.0
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.0