Ouabain (Octahydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.282032
FNDC3B fibronectin type III domain containing 3B 0.15929
SMAD3 SMAD family member 3 0.118827
CD44 CD44 molecule (Indian blood group) 0.117302
SOD2 superoxide dismutase 2, mitochondrial 0.0958483
ATP13A3 ATPase type 13A3 0.0852168
MYH9 myosin, heavy chain 9, non-muscle 0.0841727
RUNX1 runt-related transcription factor 1 0.0829693
EXT1 exostosin glycosyltransferase 1 0.0804547
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0803479
GLS2 glutaminase 2 (liver, mitochondrial) 0.0786734
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0773344
FMNL2 formin-like 2 0.0770084
NAV2 neuron navigator 2 0.0722056
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0721977
NDRG1 N-myc downstream regulated 1 0.0713866
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0681507
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0671364
ZFAND3 zinc finger, AN1-type domain 3 0.0659936
RTN4 reticulon 4 0.0647654
CSF1 colony stimulating factor 1 (macrophage) 0.0642969
INSIG1 insulin induced gene 1 0.0635009
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0634583
FAT1 FAT atypical cadherin 1 0.0632141
NRIP1 nuclear receptor interacting protein 1 0.0630898
KYNU kynureninase 0.0624425
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0620967
TXNRD1 thioredoxin reductase 1 0.0594676
NAMPT nicotinamide phosphoribosyltransferase 0.0593874
PTK2 protein tyrosine kinase 2 0.0558768
IGFBP3 insulin-like growth factor binding protein 3 0.0541666
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0534852
DOCK5 dedicator of cytokinesis 5 0.0523614
CADM1 cell adhesion molecule 1 0.0511534
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0509949
SPAG9 sperm associated antigen 9 0.0496466
MSN moesin 0.0492471
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0491447
EFNA5 ephrin-A5 0.0478126
MYO1B myosin IB 0.0473222
RBM39 RNA binding motif protein 39 0.0470283
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0467883
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0466847
ARRDC3 arrestin domain containing 3 0.0465119
SAMD4A sterile alpha motif domain containing 4A 0.0451135
RB1CC1 RB1-inducible coiled-coil 1 0.0442602
OSBPL3 oxysterol binding protein-like 3 0.0439205
ALCAM activated leukocyte cell adhesion molecule 0.0433937
ADAM9 ADAM metallopeptidase domain 9 0.0432376
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0431482
UBA6 ubiquitin-like modifier activating enzyme 6 0.0427903
ANXA5 annexin A5 0.0427053
UBE2H ubiquitin-conjugating enzyme E2H 0.0426297
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0423175
JAK1 Janus kinase 1 0.0422469
ICAM1 intercellular adhesion molecule 1 0.0421692
ANKRD33B ankyrin repeat domain 33B 0.0413986
EGFR epidermal growth factor receptor 0.0410909
KMT2E lysine (K)-specific methyltransferase 2E 0.0408522
ADAM17 ADAM metallopeptidase domain 17 0.0403928
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0401746
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0401427
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0399881
RICTOR RPTOR independent companion of MTOR, complex 2 0.0392688
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0384869
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0382551
CREB5 cAMP responsive element binding protein 5 0.0382108
SHB Src homology 2 domain containing adaptor protein B 0.0381453
EPAS1 endothelial PAS domain protein 1 0.0381368
SEPTIN9 septin 9 0.0379948
MGST1 microsomal glutathione S-transferase 1 0.0378793
TRIO trio Rho guanine nucleotide exchange factor 0.0377216
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0374971
CDK6 cyclin-dependent kinase 6 0.0370008
APP amyloid beta (A4) precursor protein 0.0369819
FTH1 ferritin, heavy polypeptide 1 0.0366083
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0363763
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0363483
TUSC3 tumor suppressor candidate 3 0.0359062
DENND4A DENN/MADD domain containing 4A 0.0354214
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0353844
MSR1 macrophage scavenger receptor 1 0.0353616
IFRD1 interferon-related developmental regulator 1 0.0352869
CRY1 cryptochrome circadian clock 1 0.0351586
TLE4 transducin-like enhancer of split 4 0.03513
DDIT4 DNA-damage-inducible transcript 4 0.0351125
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0343465
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0342757
OSMR oncostatin M receptor 0.034254
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.033985
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0339651
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0335513
RND3 Rho family GTPase 3 0.0335334
POTEF POTE ankyrin domain family, member F 0.0331063
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.032714
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0324578
MBNL1 muscleblind-like splicing regulator 1 0.0324245
MCTP1 multiple C2 domains, transmembrane 1 0.0321526
DOCK4 dedicator of cytokinesis 4 0.0320954
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0319724

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.0871746
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0671412
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0539249
FTL ferritin, light polypeptide -0.0393326
RRBP1 ribosome binding protein 1 -0.0368519
TPT1 tumor protein, translationally-controlled 1 -0.0364998
TTC3 tetratricopeptide repeat domain 3 -0.0333228
PTMA prothymosin, alpha -0.0317305
CAVIN1 caveolae associated protein 1 -0.0287128
RPL23 ribosomal protein L23 -0.0286737
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0284901
SMYD3 SET and MYND domain containing 3 -0.0279928
RPS8 ribosomal protein S8 -0.0256109
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0255017
RPS27A ribosomal protein S27a -0.0253343
RPL34 ribosomal protein L34 -0.0246609
RPL26 ribosomal protein L26 -0.0244473
S100A10 S100 calcium binding protein A10 -0.0241993
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0240234
FN1 fibronectin 1 -0.0236785
GOLGA4 golgin A4 -0.0235119
CENPF centromere protein F, 350/400kDa -0.0234266
RPS21 ribosomal protein S21 -0.0231655
RSL1D1 ribosomal L1 domain containing 1 -0.0230959
CP ceruloplasmin (ferroxidase) -0.0227516
TMSB10 thymosin beta 10 -0.0224974
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0222676
RPS16 ribosomal protein S16 -0.0220531
GMCL1 germ cell-less, spermatogenesis associated 1 -0.0219305
PBX1 pre-B-cell leukemia homeobox 1 -0.0216662
RPS12 ribosomal protein S12 -0.0209606
MTDH metadherin -0.0208381
SCFD2 sec1 family domain containing 2 -0.0206691
EHBP1 EH domain binding protein 1 -0.0204432
S100A6 S100 calcium binding protein A6 -0.0201135
TPM4 tropomyosin 4 -0.0200836
PTH2R parathyroid hormone 2 receptor -0.0197513
RPL8 ribosomal protein L8 -0.0194534
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0194417
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0192351
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0190723
SERF2 small EDRK-rich factor 2 -0.0189546
RPS2 ribosomal protein S2 -0.0186489
SPDYA speedy/RINGO cell cycle regulator family member A -0.0183935
RAI14 retinoic acid induced 14 -0.0183179
RIGI RNA sensor RIG-I -0.0180608
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0175243
RPS6 ribosomal protein S6 -0.0174549
PDIA5 protein disulfide isomerase family A, member 5 -0.0173973
DIAPH3 diaphanous-related formin 3 -0.0173821
RPLP2 ribosomal protein, large, P2 -0.0169551
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0168299
ARHGAP29 Rho GTPase activating protein 29 -0.0167961
RPL13A ribosomal protein L13a -0.0167299
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0164551
CSTB cystatin B (stefin B) -0.0164297
KRT10 keratin 10, type I -0.0164173
EIF1 eukaryotic translation initiation factor 1 -0.0159719
RPL36 ribosomal protein L36 -0.0159598
GOLGA2 golgin A2 -0.0158432
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0157557
ARB2A ARB2 cotranscriptional regulator A -0.015713
CANX calnexin -0.015691
BICD1 bicaudal D homolog 1 (Drosophila) -0.0156777
NBEAL1 neurobeachin-like 1 -0.0152394
SRGN serglycin -0.0152033
RPL35 ribosomal protein L35 -0.0151849
INTS10 integrator complex subunit 10 -0.0151538
RAD51B RAD51 paralog B -0.0151356
LMAN1 lectin, mannose-binding, 1 -0.0149726
RPL38 ribosomal protein L38 -0.0148218
ANXA4 annexin A4 -0.014779
ARF1 ADP-ribosylation factor 1 -0.0147672
LAMB3 laminin, beta 3 -0.0145931
RPS13 ribosomal protein S13 -0.014547
SPIDR scaffolding protein involved in DNA repair -0.0144676
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.01421
CALR calreticulin -0.0141878
RPLP1 ribosomal protein, large, P1 -0.0141074
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0140027
SEC61G Sec61 gamma subunit -0.0139657
NUCB2 nucleobindin 2 -0.0139284
RPL19 ribosomal protein L19 -0.0137828
KANK1 KN motif and ankyrin repeat domains 1 -0.0137134
MLEC malectin -0.0136696
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0136421
VDAC1 voltage-dependent anion channel 1 -0.0134461
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.013313
RNF220 ring finger protein 220 -0.0132323
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0132167
S100A11 S100 calcium binding protein A11 -0.0132162
RRM2 ribonucleotide reductase M2 -0.0130584
OXR1 oxidation resistance 1 -0.0129909
CHSY3 chondroitin sulfate synthase 3 -0.012981
RPL18 ribosomal protein L18 -0.0129325
RABGAP1L RAB GTPase activating protein 1-like -0.012908
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0128673
G0S2 G0/G1 switch 2 -0.0128634
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.012847
CDK13 cyclin-dependent kinase 13 -0.012825