Ouabain (Octahydrate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KYNU kynureninase 0.153343
SMAD3 SMAD family member 3 0.127498
TM4SF1 transmembrane 4 L six family member 1 0.0779887
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0685073
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.067511
TXNRD1 thioredoxin reductase 1 0.0671925
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0610509
TRIO trio Rho guanine nucleotide exchange factor 0.0578581
ASPH aspartate beta-hydroxylase 0.0555401
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0510677
DSCAM Down syndrome cell adhesion molecule 0.0503867
FAT1 FAT atypical cadherin 1 0.0477336
MCTP1 multiple C2 domains, transmembrane 1 0.0469968
CXCL5 chemokine (C-X-C motif) ligand 5 0.0438854
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0419613
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0401796
GLS2 glutaminase 2 (liver, mitochondrial) 0.0391397
MED13 mediator complex subunit 13 0.0390706
BIRC3 baculoviral IAP repeat containing 3 0.0388955
PTK2 protein tyrosine kinase 2 0.0369791
JMJD1C jumonji domain containing 1C 0.036512
ALCAM activated leukocyte cell adhesion molecule 0.0364032
NF1 neurofibromin 1 0.0325948
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0323505
EREG epiregulin 0.0322458
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0312479
NRIP1 nuclear receptor interacting protein 1 0.0302755
SQSTM1 sequestosome 1 0.0285488
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0279604
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0279382
TCF12 transcription factor 12 0.0277301
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0274926
USP9X ubiquitin specific peptidase 9, X-linked 0.0273996
SOD2 superoxide dismutase 2, mitochondrial 0.0270609
FNIP1 folliculin interacting protein 1 0.0267329
CDK6 cyclin-dependent kinase 6 0.0267275
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0264589
NIPBL Nipped-B homolog (Drosophila) 0.0264447
SLC35F3 solute carrier family 35, member F3 0.0263215
ECT2 epithelial cell transforming 2 0.0260723
JAK1 Janus kinase 1 0.0258777
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0254674
CAMTA1 calmodulin binding transcription activator 1 0.0253889
ZFAND3 zinc finger, AN1-type domain 3 0.0251619
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0249148
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0240232
SETX senataxin 0.0236345
ADAM9 ADAM metallopeptidase domain 9 0.0234174
MAP2K4 mitogen-activated protein kinase kinase 4 0.0228221
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0228024
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0226693
SAMD4A sterile alpha motif domain containing 4A 0.0224057
KLF6 Kruppel-like factor 6 0.0222528
GPHN gephyrin 0.02148
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0214497
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.021409
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0213999
EGFR epidermal growth factor receptor 0.0213493
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0211697
DOCK5 dedicator of cytokinesis 5 0.0211485
ARL5B ADP-ribosylation factor-like 5B 0.0210607
LPP LIM domain containing preferred translocation partner in lipoma 0.0208955
ADGRG6 adhesion G protein-coupled receptor G6 0.0208015
ZC3H11A zinc finger CCCH-type containing 11A 0.0205219
CEP95 centrosomal protein 95kDa 0.0199463
DST dystonin 0.0198939
CXCL8 chemokine (C-X-C motif) ligand 8 0.019867
NAV3 neuron navigator 3 0.0198463
CD59 CD59 molecule, complement regulatory protein 0.0195068
PRKCA protein kinase C, alpha 0.0192557
MED13L mediator complex subunit 13-like 0.0192248
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0189403
RASAL2 RAS protein activator like 2 0.0189354
SMC4 structural maintenance of chromosomes 4 0.0188574
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0187834
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0187447
ANO6 anoctamin 6 0.0187055
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0185683
PICALM phosphatidylinositol binding clathrin assembly protein 0.0184232
TFPI2 tissue factor pathway inhibitor 2 0.0182162
FAF1 Fas (TNFRSF6) associated factor 1 0.0181164
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0181097
KDM6A lysine (K)-specific demethylase 6A 0.0180479
TRIP12 thyroid hormone receptor interactor 12 0.0179673
USP34 ubiquitin specific peptidase 34 0.0175871
PTPRM protein tyrosine phosphatase, receptor type, M 0.0173982
PCNX1 pecanex 1 0.0173912
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0173522
BIRC6 baculoviral IAP repeat containing 6 0.0172983
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0171227
ERBIN erbb2 interacting protein 0.0171061
RBMS3 RNA binding motif, single stranded interacting protein 3 0.017005
IL6ST interleukin 6 signal transducer 0.0168306
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0165537
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0165085
FRMD6 FERM domain containing 6 0.0163149
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0162606
MCL1 myeloid cell leukemia 1 0.0162335
UBASH3B ubiquitin associated and SH3 domain containing B 0.0161719
PEAK1 pseudopodium-enriched atypical kinase 1 0.0160604

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174756
FTL ferritin, light polypeptide -0.127976
TMSB10 thymosin beta 10 -0.117221
RPS6 ribosomal protein S6 -0.0915991
VIM vimentin -0.0911625
AKAP12 A kinase (PRKA) anchor protein 12 -0.0860286
NDRG1 N-myc downstream regulated 1 -0.0817712
RPS19 ribosomal protein S19 -0.0756711
IGFBP3 insulin-like growth factor binding protein 3 -0.0755985
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0739359
PTMA prothymosin, alpha -0.0714657
IGFBP4 insulin-like growth factor binding protein 4 -0.0653156
RPLP1 ribosomal protein, large, P1 -0.0600122
MT2A metallothionein 2A -0.0600073
FTH1 ferritin, heavy polypeptide 1 -0.0594663
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0578516
CA12 carbonic anhydrase XII -0.0548138
PDE4D phosphodiesterase 4D, cAMP-specific -0.0547718
ANXA2 annexin A2 -0.0531048
BASP1 brain abundant, membrane attached signal protein 1 -0.0513544
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0496697
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0474429
RPL23 ribosomal protein L23 -0.0469087
RPS16 ribosomal protein S16 -0.046741
STC1 stanniocalcin 1 -0.046668
ACTG1 actin gamma 1 -0.0460021
USP3 ubiquitin specific peptidase 3 -0.0452007
EIF1 eukaryotic translation initiation factor 1 -0.0436763
RPS8 ribosomal protein S8 -0.0424695
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0419806
KCTD9 potassium channel tetramerization domain containing 9 -0.0415458
S100A6 S100 calcium binding protein A6 -0.0398067
RPL19 ribosomal protein L19 -0.03963
RPL26 ribosomal protein L26 -0.0392282
UBC ubiquitin C -0.0380814
RPL12 ribosomal protein L12 -0.0380445
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0338819
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0338271
HMGA1 high mobility group AT-hook 1 -0.0335372
RPLP0 ribosomal protein, large, P0 -0.033274
LDHA lactate dehydrogenase A -0.0327715
RPL8 ribosomal protein L8 -0.0326754
RPL28 ribosomal protein L28 -0.0323176
RPS3 ribosomal protein S3 -0.0318174
KRT81 keratin 81, type II -0.0312875
FA2H fatty acid 2-hydroxylase -0.0312455
FLNB filamin B, beta -0.0311583
PKM pyruvate kinase, muscle -0.0302805
RPL37A ribosomal protein L37a -0.0299992
RACK1 receptor for activated C kinase 1 -0.0299921
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0298943
RPS27A ribosomal protein S27a -0.0298032
S100A10 S100 calcium binding protein A10 -0.029801
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0288656
PFN1 profilin 1 -0.0286006
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0282978
TKT transketolase -0.0281069
RPS13 ribosomal protein S13 -0.0280633
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0280142
RPL13A ribosomal protein L13a -0.0278551
AUTS2 autism susceptibility candidate 2 -0.0278324
RPLP2 ribosomal protein, large, P2 -0.0277585
MT1X metallothionein 1X -0.0273558
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0271274
RPS12 ribosomal protein S12 -0.0268909
GOLGA4 golgin A4 -0.0265363
HELZ helicase with zinc finger -0.0264069
RPS5 ribosomal protein S5 -0.0261955
MYO1E myosin IE -0.0260568
TPT1 tumor protein, translationally-controlled 1 -0.0259845
RPL18 ribosomal protein L18 -0.0253891
DSTN destrin (actin depolymerizing factor) -0.0253555
LOC112694756 uncharaterized LOC112694756 -0.0251973
KRT7 keratin 7, type II -0.0248605
HIP1 huntingtin interacting protein 1 -0.0247376
RPS14 ribosomal protein S14 -0.0246017
RPS23 ribosomal protein S23 -0.0245721
BHLHE40 basic helix-loop-helix family, member e40 -0.0244462
RPS17 ribosomal protein S17 -0.0244366
RPL11 ribosomal protein L11 -0.0241563
EEF2 eukaryotic translation elongation factor 2 -0.0241509
ACBD3 acyl-CoA binding domain containing 3 -0.0237452
RPS2 ribosomal protein S2 -0.0235367
RPL31 ribosomal protein L31 -0.0235328
FNDC3B fibronectin type III domain containing 3B -0.0233537
RRBP1 ribosome binding protein 1 -0.0230448
RPS4X ribosomal protein S4, X-linked -0.0228884
HILPDA hypoxia inducible lipid droplet-associated -0.0227813
PCBP2 poly(rC) binding protein 2 -0.0223829
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0219602
RPL35A ribosomal protein L35a -0.0217902
RPL32 ribosomal protein L32 -0.0215966
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0213196
EPAS1 endothelial PAS domain protein 1 -0.0211024
RPS29 ribosomal protein S29 -0.0210809
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0210255
WASF2 WAS protein family, member 2 -0.0210249
RPS27 ribosomal protein S27 -0.020912
RPS11 ribosomal protein S11 -0.0209108
RPL7A ribosomal protein L7a -0.0205641