Ouabain (Octahydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCTP1 multiple C2 domains, transmembrane 1 0.0730632
TSC22D2 TSC22 domain family, member 2 0.06018
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0551439
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0534488
TXNIP thioredoxin interacting protein 0.0506341
MT2A metallothionein 2A 0.0491666
MCL1 myeloid cell leukemia 1 0.047708
CCNL1 cyclin L1 0.0451486
NRIP1 nuclear receptor interacting protein 1 0.0354831
APLP2 amyloid beta (A4) precursor-like protein 2 0.0345265
BRD2 bromodomain containing 2 0.0331295
ARHGAP26 Rho GTPase activating protein 26 0.033035
TFRC transferrin receptor 0.0319469
ARRDC3 arrestin domain containing 3 0.0310255
SFPQ splicing factor proline/glutamine-rich 0.0310149
CXCL8 chemokine (C-X-C motif) ligand 8 0.0299283
TOP1 topoisomerase (DNA) I 0.028896
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0282574
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0280064
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0276186
CHD1 chromodomain helicase DNA binding protein 1 0.0269489
GPHN gephyrin 0.0256692
SMAD3 SMAD family member 3 0.0255385
RBM25 RNA binding motif protein 25 0.0253561
ADAM9 ADAM metallopeptidase domain 9 0.0247739
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0245821
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0241695
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0241168
FNIP1 folliculin interacting protein 1 0.0239716
GLS2 glutaminase 2 (liver, mitochondrial) 0.0238022
WAC WW domain containing adaptor with coiled-coil 0.0233683
ATP13A3 ATPase type 13A3 0.0230546
RBM39 RNA binding motif protein 39 0.0230139
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0228168
IFRD1 interferon-related developmental regulator 1 0.0219312
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0218765
CD83 CD83 molecule 0.0212
MKI67 marker of proliferation Ki-67 0.0204075
DSCAM Down syndrome cell adhesion molecule 0.0200531
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0199661
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.019505
ARL5B ADP-ribosylation factor-like 5B 0.0192334
YTHDC1 YTH domain containing 1 0.0190861
PUM2 pumilio RNA-binding family member 2 0.0190273
NUP58 nucleoporin 58 0.0188347
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0184244
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0182924
FOSL1 FOS-like antigen 1 0.0182538
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0181695
SIK3 SIK family kinase 3 0.0179315
CENPF centromere protein F, 350/400kDa 0.0177174
MED13 mediator complex subunit 13 0.0176976
ZC3H11A zinc finger CCCH-type containing 11A 0.0176445
THBS1 thrombospondin 1 0.0175599
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0175266
NAMPT nicotinamide phosphoribosyltransferase 0.017507
PCBP2 poly(rC) binding protein 2 0.0174726
MATR3 matrin 3 0.0174591
SON SON DNA binding protein 0.0174578
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0170909
EP300 E1A binding protein p300 0.0170043
PEAK1 pseudopodium-enriched atypical kinase 1 0.0169936
MT1X metallothionein 1X 0.0169564
PEG10 paternally expressed 10 0.0168233
BIRC3 baculoviral IAP repeat containing 3 0.01658
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0165467
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0161525
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0160465
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0157288
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.015651
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0155138
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0153721
KDM6A lysine (K)-specific demethylase 6A 0.015143
MBNL1 muscleblind-like splicing regulator 1 0.0151404
SIRT1 sirtuin 1 0.0151261
SQSTM1 sequestosome 1 0.0149613
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0146518
NUP153 nucleoporin 153kDa 0.0146303
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0144953
PUM1 pumilio RNA-binding family member 1 0.0143397
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0143213
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0142043
FXR1 fragile X mental retardation, autosomal homolog 1 0.014146
CAPRIN2 caprin family member 2 0.0140347
CEMIP2 cell migration inducing hyaluronidase 2 0.0139626
BCLAF1 BCL2-associated transcription factor 1 0.0134218
ATF3 activating transcription factor 3 0.0133523
FUBP1 far upstream element (FUSE) binding protein 1 0.0132592
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0131492
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0130571
MIS18BP1 MIS18 binding protein 1 0.0129528
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0129499
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0129046
TRA2B transformer 2 beta homolog (Drosophila) 0.0128947
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0128311
ZEB1 zinc finger E-box binding homeobox 1 0.012674
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0126001
TRIP12 thyroid hormone receptor interactor 12 0.0125818
NXF1 nuclear RNA export factor 1 0.0125032
RLF rearranged L-myc fusion 0.012448

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.155626
TMSB10 thymosin beta 10 -0.13283
MMP7 matrix metallopeptidase 7 -0.113793
IGFBP3 insulin-like growth factor binding protein 3 -0.109896
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0950986
PTMA prothymosin, alpha -0.0932259
S100A6 S100 calcium binding protein A6 -0.078942
SAMD4A sterile alpha motif domain containing 4A -0.0736944
CP ceruloplasmin (ferroxidase) -0.0712067
F3 coagulation factor III (thromboplastin, tissue factor) -0.071043
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0669075
LMO7 LIM domain 7 -0.0661227
APOL1 apolipoprotein L, 1 -0.0649136
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0646948
B2M beta-2-microglobulin -0.0615682
KRT19 keratin 19, type I -0.0603884
MAML2 mastermind-like 2 (Drosophila) -0.0587987
HLA-B major histocompatibility complex, class I, B -0.0582418
IFI27 interferon, alpha-inducible protein 27 -0.0564563
TMSB4X thymosin beta 4, X-linked -0.0523688
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0514157
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0503891
TPT1 tumor protein, translationally-controlled 1 -0.0499426
PGK1 phosphoglycerate kinase 1 -0.0497728
FNDC3B fibronectin type III domain containing 3B -0.0486324
S100A10 S100 calcium binding protein A10 -0.0477427
EHBP1 EH domain binding protein 1 -0.0473486
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0471465
AHNAK AHNAK nucleoprotein -0.046555
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0453145
DTNA dystrobrevin, alpha -0.0429717
HMGA1 high mobility group AT-hook 1 -0.0429691
TPM4 tropomyosin 4 -0.0427209
RAD51B RAD51 paralog B -0.041919
ISG15 ISG15 ubiquitin-like modifier -0.0418722
DSG2 desmoglein 2 -0.0416544
ANXA2 annexin A2 -0.0407658
AHNAK2 AHNAK nucleoprotein 2 -0.0399863
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0395102
NPEPPS aminopeptidase puromycin sensitive -0.0393196
BACE2 beta-site APP-cleaving enzyme 2 -0.0392697
RRBP1 ribosome binding protein 1 -0.0385153
RPL23 ribosomal protein L23 -0.0381178
PATJ PATJ crumbs cell polarity complex component -0.0375719
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0375635
FLNB filamin B, beta -0.0371153
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0364098
ACTG1 actin gamma 1 -0.0363961
FTL ferritin, light polypeptide -0.0363298
MYO1E myosin IE -0.0361909
VIM vimentin -0.0358496
EFNA5 ephrin-A5 -0.0357709
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.034765
AKAP12 A kinase (PRKA) anchor protein 12 -0.0346645
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0345175
ASPH aspartate beta-hydroxylase -0.034503
LAMC2 laminin, gamma 2 -0.0342997
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0340048
ENO1 enolase 1, (alpha) -0.0339323
EIF1 eukaryotic translation initiation factor 1 -0.0336229
IFI6 interferon, alpha-inducible protein 6 -0.0324672
MACF1 microtubule-actin crosslinking factor 1 -0.032064
PLAT plasminogen activator, tissue -0.031579
LAMA4 laminin, alpha 4 -0.0312654
RPS8 ribosomal protein S8 -0.030717
CD2AP CD2-associated protein -0.0305303
ZBTB20 zinc finger and BTB domain containing 20 -0.0304617
MEF2A myocyte enhancer factor 2A -0.0302218
S100A11 S100 calcium binding protein A11 -0.0300843
ITGA6 integrin, alpha 6 -0.0298856
OSMR oncostatin M receptor -0.0297131
NCKAP5 NCK-associated protein 5 -0.0294496
CSTB cystatin B (stefin B) -0.0294186
PKM pyruvate kinase, muscle -0.0292999
RPLP1 ribosomal protein, large, P1 -0.029146
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0289426
UBE2H ubiquitin-conjugating enzyme E2H -0.0287657
FTH1 ferritin, heavy polypeptide 1 -0.0284219
RPL19 ribosomal protein L19 -0.0282189
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0282042
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0280533
RAI14 retinoic acid induced 14 -0.0278185
IGF1R insulin-like growth factor 1 receptor -0.0276354
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0274565
DST dystonin -0.0271274
ZMYND8 zinc finger, MYND-type containing 8 -0.0268755
PDE4D phosphodiesterase 4D, cAMP-specific -0.0267173
RNF213 ring finger protein 213 -0.0265696
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264118
SP100 SP100 nuclear antigen -0.0263236
HLA-A major histocompatibility complex, class I, A -0.0261347
TBC1D22A TBC1 domain family, member 22A -0.0261347
TM4SF1 transmembrane 4 L six family member 1 -0.0260902
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0260892
LPP LIM domain containing preferred translocation partner in lipoma -0.0260855
PARD3 par-3 family cell polarity regulator -0.0260854
HMGA2 high mobility group AT-hook 2 -0.0259488
RPL37A ribosomal protein L37a -0.0256125
RPL35A ribosomal protein L35a -0.0254948
BTBD9 BTB (POZ) domain containing 9 -0.0253185