Ouabain (Octahydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.199478
DSCAM Down syndrome cell adhesion molecule 0.108232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105913
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0797947
PTMA prothymosin, alpha 0.074716
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0664042
HSPH1 heat shock 105kDa/110kDa protein 1 0.0627833
PRRC2C proline-rich coiled-coil 2C 0.0617707
WAC WW domain containing adaptor with coiled-coil 0.0614012
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0562645
VIM vimentin 0.0556999
CENPF centromere protein F, 350/400kDa 0.0551941
CLTC clathrin, heavy chain (Hc) 0.0524521
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0520076
MED13 mediator complex subunit 13 0.0518184
PICALM phosphatidylinositol binding clathrin assembly protein 0.0517197
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.051514
GOLGA4 golgin A4 0.0485165
ARID4B AT rich interactive domain 4B (RBP1-like) 0.047845
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0476804
ZFAND3 zinc finger, AN1-type domain 3 0.0472662
LCORL ligand dependent nuclear receptor corepressor-like 0.0465926
SQSTM1 sequestosome 1 0.0463477
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0440159
SPAG9 sperm associated antigen 9 0.0433523
TOP1 topoisomerase (DNA) I 0.043007
GNAS GNAS complex locus 0.042767
PABPC1 poly(A) binding protein, cytoplasmic 1 0.042357
COL1A1 collagen, type I, alpha 1 0.0422589
PKM pyruvate kinase, muscle 0.0417549
APP amyloid beta (A4) precursor protein 0.0408647
LPIN1 lipin 1 0.0407
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0404917
BIRC6 baculoviral IAP repeat containing 6 0.0395826
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0390016
CHD1 chromodomain helicase DNA binding protein 1 0.0379528
MAP1B microtubule-associated protein 1B 0.0379332
KDM6A lysine (K)-specific demethylase 6A 0.0373494
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0372984
CDC27 cell division cycle 27 0.0367057
EIF1 eukaryotic translation initiation factor 1 0.0365606
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0364632
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0363323
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0359155
RB1CC1 RB1-inducible coiled-coil 1 0.03568
PTK2 protein tyrosine kinase 2 0.0353834
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0353739
CCNL1 cyclin L1 0.0352044
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0351769
RSRC2 arginine/serine-rich coiled-coil 2 0.0348627
ENAH enabled homolog (Drosophila) 0.0346211
NAP1L1 nucleosome assembly protein 1-like 1 0.0338104
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0337088
EIF3A eukaryotic translation initiation factor 3, subunit A 0.033705
PUM2 pumilio RNA-binding family member 2 0.0334218
AFF4 AF4/FMR2 family, member 4 0.0333879
PNISR PNN-interacting serine/arginine-rich protein 0.0328597
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0325166
OGA O-GlcNAcase 0.0322157
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0320959
MATR3 matrin 3 0.0319945
QKI QKI, KH domain containing, RNA binding 0.031991
NUP58 nucleoporin 58 0.0315894
MSMO1 methylsterol monooxygenase 1 0.0310765
NUP153 nucleoporin 153kDa 0.0309198
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0308636
SREBF2 sterol regulatory element binding transcription factor 2 0.0306014
SETD5 SET domain containing 5 0.0305668
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0305341
GATAD2B GATA zinc finger domain containing 2B 0.0304094
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0302865
KDM3A lysine (K)-specific demethylase 3A 0.0302498
ZNF654 zinc finger protein 654 0.0302213
CSDE1 cold shock domain containing E1, RNA-binding 0.0300742
YTHDC1 YTH domain containing 1 0.0298792
USP36 ubiquitin specific peptidase 36 0.0296029
KPNB1 karyopherin (importin) beta 1 0.0290359
KDM2A lysine (K)-specific demethylase 2A 0.0285512
FXR1 fragile X mental retardation, autosomal homolog 1 0.0285435
CYLD cylindromatosis (turban tumor syndrome) 0.0284953
HELZ helicase with zinc finger 0.028442
NPEPPS aminopeptidase puromycin sensitive 0.0284011
PHIP pleckstrin homology domain interacting protein 0.028175
RFX7 regulatory factor X, 7 0.0281061
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0278914
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0273312
TCERG1 transcription elongation regulator 1 0.0272515
PAPOLA poly(A) polymerase alpha 0.0272275
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0270633
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0270526
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0270327
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0268966
GLG1 golgi glycoprotein 1 0.0267542
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0267263
SUCO SUN domain containing ossification factor 0.0267048
UBA6 ubiquitin-like modifier activating enzyme 6 0.0266648
B2M beta-2-microglobulin 0.0265191
SSBP2 single-stranded DNA binding protein 2 0.0264155
MEMO1 mediator of cell motility 1 0.0263871
KIF5B kinesin family member 5B 0.0263786

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.230191
LSAMP limbic system-associated membrane protein -0.228866
PTPRD protein tyrosine phosphatase, receptor type, D -0.154078
NRG1 neuregulin 1 -0.149124
NALF1 NALCN channel auxiliary factor 1 -0.115831
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.102503
EXT1 exostosin glycosyltransferase 1 -0.0957746
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0888623
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0845006
SMYD3 SET and MYND domain containing 3 -0.0760762
ANTXR1 anthrax toxin receptor 1 -0.0723947
THSD4 thrombospondin, type I, domain containing 4 -0.0713061
TRIB2 tribbles pseudokinase 2 -0.0695811
NPAS2 neuronal PAS domain protein 2 -0.065932
MAPK10 mitogen-activated protein kinase 10 -0.0655779
BCAS3 breast carcinoma amplified sequence 3 -0.0646387
AKAP12 A kinase (PRKA) anchor protein 12 -0.0641487
FMN1 formin 1 -0.0629849
RAD51B RAD51 paralog B -0.0628115
RPTOR regulatory associated protein of MTOR, complex 1 -0.0620928
TPM1 tropomyosin 1 (alpha) -0.0618579
NREP neuronal regeneration related protein -0.0613478
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0585644
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0578167
RNF213 ring finger protein 213 -0.0554177
FRMD4A FERM domain containing 4A -0.0533557
PLAT plasminogen activator, tissue -0.0532037
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0522836
VMP1 vacuole membrane protein 1 -0.0499239
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0484457
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0480701
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0468681
PDE4D phosphodiesterase 4D, cAMP-specific -0.0463027
MYO1E myosin IE -0.0456326
DIAPH2 diaphanous-related formin 2 -0.0441797
FNDC3A fibronectin type III domain containing 3A -0.0436867
ZBTB20 zinc finger and BTB domain containing 20 -0.0432617
RNF150 ring finger protein 150 -0.0431279
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0427718
TLE4 transducin-like enhancer of split 4 -0.0421098
PTPRM protein tyrosine phosphatase, receptor type, M -0.0410589
STK38L serine/threonine kinase 38 like -0.0407097
SYT1 synaptotagmin I -0.0406598
PBX1 pre-B-cell leukemia homeobox 1 -0.0397431
MCL1 myeloid cell leukemia 1 -0.039647
AEBP2 AE binding protein 2 -0.0390248
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0382846
CALD1 caldesmon 1 -0.0380266
PCBP3 poly(rC) binding protein 3 -0.0377405
GSE1 Gse1 coiled-coil protein -0.0376791
MSI2 musashi RNA-binding protein 2 -0.0373078
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0358699
LIMCH1 LIM and calponin homology domains 1 -0.0351276
IGF1R insulin-like growth factor 1 receptor -0.0350334
UNC5C unc-5 homolog C (C. elegans) -0.0349501
PSD3 pleckstrin and Sec7 domain containing 3 -0.0348718
ANK2 ankyrin 2, neuronal -0.0348199
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0344332
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0342492
EXOC4 exocyst complex component 4 -0.0340079
DACH2 dachshund family transcription factor 2 -0.0339834
KDM4C lysine (K)-specific demethylase 4C -0.033517
PDLIM5 PDZ and LIM domain 5 -0.0334671
MAML2 mastermind-like 2 (Drosophila) -0.0334444
ASPH aspartate beta-hydroxylase -0.0333564
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0324869
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0321414
NCAM2 neural cell adhesion molecule 2 -0.0320924
GREM2 gremlin 2, DAN family BMP antagonist -0.0314626
KIAA1217 KIAA1217 -0.0314152
ADGRB3 adhesion G protein-coupled receptor B3 -0.0312822
FAM107B family with sequence similarity 107, member B -0.0312613
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0311638
CNTN4 contactin 4 -0.0311497
DTNA dystrobrevin, alpha -0.0310647
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0305303
KLHL13 kelch-like family member 13 -0.0300154
TPM4 tropomyosin 4 -0.0299584
PRKG1 protein kinase, cGMP-dependent, type I -0.0299079
FERMT2 fermitin family member 2 -0.0298637
MYH9 myosin, heavy chain 9, non-muscle -0.0297173
COL4A6 collagen, type IV, alpha 6 -0.0293714
GPC6 glypican 6 -0.0293602
LPP LIM domain containing preferred translocation partner in lipoma -0.0290767
EFNA5 ephrin-A5 -0.0290539
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0289978
GMDS GDP-mannose 4,6-dehydratase -0.0286288
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0285998
ZNF804A zinc finger protein 804A -0.0285475
ACTG1 actin gamma 1 -0.0285014
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0282957
TENM4 teneurin transmembrane protein 4 -0.0282234
SIK2 salt-inducible kinase 2 -0.0276705
SEPTIN9 septin 9 -0.0276099
TAS2R14 taste receptor, type 2, member 14 -0.0274653
PRKCA protein kinase C, alpha -0.0274393
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0270174
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0268299
ATRNL1 attractin-like 1 -0.0268237
FNDC3B fibronectin type III domain containing 3B -0.0265931