Ouabain (Octahydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.179055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.168267
MCTP1 multiple C2 domains, transmembrane 1 0.0704097
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0605271
SPAG9 sperm associated antigen 9 0.05826
RAB7A RAB7A, member RAS oncogene family 0.0570732
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0463165
CCNL1 cyclin L1 0.0454349
HILPDA hypoxia inducible lipid droplet-associated 0.0452136
CADM1 cell adhesion molecule 1 0.0443267
ATP13A3 ATPase type 13A3 0.0441902
KDM3A lysine (K)-specific demethylase 3A 0.04364
RLF rearranged L-myc fusion 0.0426939
TSC22D2 TSC22 domain family, member 2 0.0426374
ZFAND3 zinc finger, AN1-type domain 3 0.0406961
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0392605
NAMPT nicotinamide phosphoribosyltransferase 0.0391818
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0388241
TFRC transferrin receptor 0.0381781
GLS2 glutaminase 2 (liver, mitochondrial) 0.036682
ANLN anillin, actin binding protein 0.036617
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0360242
CRY1 cryptochrome circadian clock 1 0.0348682
CHD1 chromodomain helicase DNA binding protein 1 0.0345612
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0345564
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336926
NUP58 nucleoporin 58 0.0330544
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0329952
CUL3 cullin 3 0.0325532
TRA2A transformer 2 alpha homolog (Drosophila) 0.0325359
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0312656
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0302952
APP amyloid beta (A4) precursor protein 0.0300308
KDM6A lysine (K)-specific demethylase 6A 0.0290243
NAP1L1 nucleosome assembly protein 1-like 1 0.0285613
LCORL ligand dependent nuclear receptor corepressor-like 0.0284536
PUM1 pumilio RNA-binding family member 1 0.027473
SCAF4 SR-related CTD-associated factor 4 0.0271634
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0270798
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0270559
QKI QKI, KH domain containing, RNA binding 0.0269626
HSPH1 heat shock 105kDa/110kDa protein 1 0.0265624
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0264636
MARCHF6 membrane associated ring-CH-type finger 6 0.0264594
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0263563
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0262049
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0261965
AFF4 AF4/FMR2 family, member 4 0.0259639
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0259455
POU2F1 POU class 2 homeobox 1 0.0255742
CYLD cylindromatosis (turban tumor syndrome) 0.0254443
RHEB Ras homolog enriched in brain 0.0253964
SOD2 superoxide dismutase 2, mitochondrial 0.0253125
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0251615
ECT2 epithelial cell transforming 2 0.024605
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0245114
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0241805
IFRD1 interferon-related developmental regulator 1 0.0240846
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0235993
OSBPL9 oxysterol binding protein-like 9 0.0234777
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0234479
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0234187
RB1CC1 RB1-inducible coiled-coil 1 0.0232854
EIF4A3 eukaryotic translation initiation factor 4A3 0.0231486
NCKAP1 NCK-associated protein 1 0.0231267
NPTN neuroplastin 0.0224797
GAS2L3 growth arrest-specific 2 like 3 0.0224537
TRA2B transformer 2 beta homolog (Drosophila) 0.0221369
OSBPL8 oxysterol binding protein-like 8 0.0220778
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.022056
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0215998
USP3 ubiquitin specific peptidase 3 0.0214394
CDC73 cell division cycle 73 0.0213277
BIRC3 baculoviral IAP repeat containing 3 0.0213261
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0212511
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0212083
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0212006
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0211709
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.021112
NUP98 nucleoporin 98kDa 0.0210967
MIMS1 mitochondrial inner membrane scaffold 1 0.0210513
NIPBL Nipped-B homolog (Drosophila) 0.0210144
COLEC11 collectin sub-family member 11 0.0209781
HSPA8 heat shock 70kDa protein 8 0.0209099
KYNU kynureninase 0.02076
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0204037
CAMTA1 calmodulin binding transcription activator 1 0.0203549
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0201933
SNX13 sorting nexin 13 0.0201111
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.019984
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0199186
FXR1 fragile X mental retardation, autosomal homolog 1 0.019803
ERBIN erbb2 interacting protein 0.01966
DIAPH1 diaphanous-related formin 1 0.0196457
WAC WW domain containing adaptor with coiled-coil 0.0195771
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0195268
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0192899
YTHDC1 YTH domain containing 1 0.0192599
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0191676
PUM2 pumilio RNA-binding family member 2 0.0190797

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.220392
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163566
COL6A3 collagen, type VI, alpha 3 -0.101018
VIM vimentin -0.0838079
TMSB10 thymosin beta 10 -0.080199
FTL ferritin, light polypeptide -0.0687983
NALF1 NALCN channel auxiliary factor 1 -0.0667942
NDRG1 N-myc downstream regulated 1 -0.0630358
MT2A metallothionein 2A -0.059437
TGFBI transforming growth factor, beta-induced, 68kDa -0.0513636
FN1 fibronectin 1 -0.0500262
EGFR epidermal growth factor receptor -0.0498202
ASPH aspartate beta-hydroxylase -0.0491184
PDE4D phosphodiesterase 4D, cAMP-specific -0.0470636
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0468336
LOX lysyl oxidase -0.0464842
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442973
P4HB prolyl 4-hydroxylase, beta polypeptide -0.043816
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0418151
IGFBP5 insulin-like growth factor binding protein 5 -0.0416344
ENO1 enolase 1, (alpha) -0.0411727
CALD1 caldesmon 1 -0.0407073
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0401745
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.036904
AKAP12 A kinase (PRKA) anchor protein 12 -0.0366244
RPS19 ribosomal protein S19 -0.0365455
TPM4 tropomyosin 4 -0.0355643
B2M beta-2-microglobulin -0.034088
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0337233
PKM pyruvate kinase, muscle -0.0332396
ZBTB20 zinc finger and BTB domain containing 20 -0.032943
RPLP1 ribosomal protein, large, P1 -0.0325951
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0322792
NAV1 neuron navigator 1 -0.0318564
TNS3 tensin 3 -0.0310072
AHNAK AHNAK nucleoprotein -0.0309594
COL5A1 collagen, type V, alpha 1 -0.0308885
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0304083
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0303769
HLA-B major histocompatibility complex, class I, B -0.0294458
TTC3 tetratricopeptide repeat domain 3 -0.0278124
LOXL2 lysyl oxidase-like 2 -0.026771
DST dystonin -0.0267136
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0266883
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0257543
NLGN1 neuroligin 1 -0.0254316
CALR calreticulin -0.0254031
RPLP2 ribosomal protein, large, P2 -0.0253482
RPL28 ribosomal protein L28 -0.0253427
GLIS3 GLIS family zinc finger 3 -0.0238712
RPL37A ribosomal protein L37a -0.0233822
RPS27A ribosomal protein S27a -0.0232145
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0231235
ZNF395 zinc finger protein 395 -0.022975
S100A10 S100 calcium binding protein A10 -0.0226735
CD44 CD44 molecule (Indian blood group) -0.0222945
PGK1 phosphoglycerate kinase 1 -0.0221433
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0221225
EGR1 early growth response 1 -0.0221139
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0220307
PTPRD protein tyrosine phosphatase, receptor type, D -0.0219221
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0218308
RPS6 ribosomal protein S6 -0.0217061
RPL23 ribosomal protein L23 -0.0215609
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0212443
MACF1 microtubule-actin crosslinking factor 1 -0.0209418
OSMR oncostatin M receptor -0.0206126
RPL35A ribosomal protein L35a -0.0205103
RPS13 ribosomal protein S13 -0.0204861
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0204835
ANXA2 annexin A2 -0.0204389
BPTF bromodomain PHD finger transcription factor -0.0203729
PHF14 PHD finger protein 14 -0.0201561
MBD5 methyl-CpG binding domain protein 5 -0.0198153
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0196648
STC1 stanniocalcin 1 -0.0196521
ATXN1 ataxin 1 -0.0195211
FLNB filamin B, beta -0.0193287
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0192088
DOCK5 dedicator of cytokinesis 5 -0.0191644
RPS8 ribosomal protein S8 -0.0191511
VEGFA vascular endothelial growth factor A -0.0190721
BBS9 Bardet-Biedl syndrome 9 -0.0189985
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0189348
SMYD3 SET and MYND domain containing 3 -0.0188694
SKAP2 src kinase associated phosphoprotein 2 -0.0187717
RPS3 ribosomal protein S3 -0.0186974
GOLGB1 golgin B1 -0.0184948
SEC61G Sec61 gamma subunit -0.0184654
LOC112694756 uncharaterized LOC112694756 -0.0182654
HLA-A major histocompatibility complex, class I, A -0.0182387
NFE2L1 nuclear factor, erythroid 2-like 1 -0.017961
PRELID2 PRELI domain containing 2 -0.0179277
MYOF myoferlin -0.0176297
RPS16 ribosomal protein S16 -0.0176067
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0175854
CANX calnexin -0.017547
RPL9 ribosomal protein L9 -0.0175375
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0174154
SH3KBP1 SH3-domain kinase binding protein 1 -0.0172577