Ouabain (Octahydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.166231
ENO1 enolase 1, (alpha) 0.0970223
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0941965
TMSB10 thymosin beta 10 0.0735602
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0689885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0614713
MT2A metallothionein 2A 0.0499799
TPT1 tumor protein, translationally-controlled 1 0.0477117
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0460061
EEF2 eukaryotic translation elongation factor 2 0.0443274
FAT1 FAT atypical cadherin 1 0.0442729
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0412973
ARF4 ADP-ribosylation factor 4 0.0390116
TUBA1B tubulin, alpha 1b 0.0358042
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0352594
RAB7A RAB7A, member RAS oncogene family 0.0313774
FTL ferritin, light polypeptide 0.030993
SRRM2 serine/arginine repetitive matrix 2 0.0307586
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0300896
POTEF POTE ankyrin domain family, member F 0.0299435
EGR1 early growth response 1 0.0289769
S100A9 S100 calcium binding protein A9 0.027179
FTH1 ferritin, heavy polypeptide 1 0.0268982
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0264197
PKM pyruvate kinase, muscle 0.0258001
MKI67 marker of proliferation Ki-67 0.0247161
EIF4A1 eukaryotic translation initiation factor 4A1 0.0241353
ACTG1 actin gamma 1 0.0235843
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0224708
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0222262
KRT18 keratin 18, type I 0.0220323
PFN1 profilin 1 0.0215671
LOC102724023 ES1 protein homolog, mitochondrial 0.0212464
GOLGA4 golgin A4 0.0211267
TUBB tubulin, beta class I 0.0209252
ZCCHC7 zinc finger, CCHC domain containing 7 0.0208708
YBX1 Y box binding protein 1 0.0204678
SCFD2 sec1 family domain containing 2 0.0203636
HLA-A major histocompatibility complex, class I, A 0.0195867
EPCAM epithelial cell adhesion molecule 0.0195407
FOS FBJ murine osteosarcoma viral oncogene homolog 0.019301
RPL35A ribosomal protein L35a 0.0191169
RPL8 ribosomal protein L8 0.0190481
EZR ezrin 0.0187119
PA2G4 proliferation-associated 2G4, 38kDa 0.0186767
HSPH1 heat shock 105kDa/110kDa protein 1 0.0185236
CCND1 cyclin D1 0.0183674
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0176358
SRP54 signal recognition particle 54kDa 0.0174708
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0174683
UBC ubiquitin C 0.0171537
KPNB1 karyopherin (importin) beta 1 0.0168377
S100A6 S100 calcium binding protein A6 0.0166677
H1-0 H1.0 linker histone 0.016357
NOP58 NOP58 ribonucleoprotein 0.01629
HMGA2 high mobility group AT-hook 2 0.0160843
TTC3 tetratricopeptide repeat domain 3 0.015817
GNAS GNAS complex locus 0.0157317
WDR45B WD repeat domain 45B 0.0156994
BRD2 bromodomain containing 2 0.0156345
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0155932
EIF1 eukaryotic translation initiation factor 1 0.0155288
JUN jun proto-oncogene 0.0154335
LDHB lactate dehydrogenase B 0.015138
RSL1D1 ribosomal L1 domain containing 1 0.0145697
HMGA1 high mobility group AT-hook 1 0.0145358
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0145175
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.014253
PER1 period circadian clock 1 0.0142329
RPS4X ribosomal protein S4, X-linked 0.0139812
TIMP1 TIMP metallopeptidase inhibitor 1 0.0137732
ARF1 ADP-ribosylation factor 1 0.0137658
PTBP1 polypyrimidine tract binding protein 1 0.0137523
DIAPH1 diaphanous-related formin 1 0.013544
KRT8 keratin 8, type II 0.0134236
RHOA ras homolog family member A 0.0134164
SRPRA SRP receptor subunit alpha 0.0132552
FRMD5 FERM domain containing 5 0.0130467
SUCO SUN domain containing ossification factor 0.012859
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0128262
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0127724
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0127438
SERBP1 SERPINE1 mRNA binding protein 1 0.0127259
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0126638
DEK DEK proto-oncogene 0.012641
CBX5 chromobox homolog 5 0.0126283
OSBP oxysterol binding protein 0.01262
TLN1 talin 1 0.0125477
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0125332
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0124826
IFITM3 interferon induced transmembrane protein 3 0.0124814
WDR43 WD repeat domain 43 0.0124757
PRC1 protein regulator of cytokinesis 1 0.0124598
SRRM1 serine/arginine repetitive matrix 1 0.0124209
PRDX2 peroxiredoxin 2 0.0124164
NOP56 NOP56 ribonucleoprotein 0.012391
BSG basigin (Ok blood group) 0.012379
EIF5B eukaryotic translation initiation factor 5B 0.0123667
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0123577
MYL12B myosin, light chain 12B, regulatory 0.0121242

decreased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.145425
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142483
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.104829
PRELID2 PRELI domain containing 2 -0.0920219
RAD51B RAD51 paralog B -0.087362
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0704478
KDM4C lysine (K)-specific demethylase 4C -0.0596114
FHIT fragile histidine triad -0.0504382
RPS2 ribosomal protein S2 -0.0493233
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0492947
NEBL nebulette -0.0488738
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0462337
ZNF638 zinc finger protein 638 -0.0451505
SMYD3 SET and MYND domain containing 3 -0.0446037
ANKRD12 ankyrin repeat domain 12 -0.0441331
TBC1D22A TBC1 domain family, member 22A -0.0440127
OGA O-GlcNAcase -0.0433666
YEATS2 YEATS domain containing 2 -0.0423841
MBD5 methyl-CpG binding domain protein 5 -0.0418652
ZNF292 zinc finger protein 292 -0.0416657
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0398635
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0398406
AKAP9 A kinase (PRKA) anchor protein 9 -0.0378795
ZBTB20 zinc finger and BTB domain containing 20 -0.036923
BBX bobby sox homolog (Drosophila) -0.0366709
KIAA1217 KIAA1217 -0.0361828
AHNAK AHNAK nucleoprotein -0.0361548
NF1 neurofibromin 1 -0.0354898
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0354189
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0350059
DSCAM Down syndrome cell adhesion molecule -0.0346006
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0345931
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0343818
PATJ PATJ crumbs cell polarity complex component -0.034179
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.033942
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0334164
RBM39 RNA binding motif protein 39 -0.0333024
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0325603
HELZ helicase with zinc finger -0.0317778
ATXN1 ataxin 1 -0.0317094
WWC2 WW and C2 domain containing 2 -0.0308103
KMT2C lysine (K)-specific methyltransferase 2C -0.0304748
PLAUR plasminogen activator, urokinase receptor -0.0301334
TENM3 teneurin transmembrane protein 3 -0.0292912
WDR26 WD repeat domain 26 -0.0290722
MYO9A myosin IXA -0.0290166
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0289328
WSB1 WD repeat and SOCS box containing 1 -0.0289112
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0277332
MYH9 myosin, heavy chain 9, non-muscle -0.0276977
CSNK1A1 casein kinase 1, alpha 1 -0.0276313
UTRN utrophin -0.027512
EXOC6B exocyst complex component 6B -0.0272583
RNF24 ring finger protein 24 -0.0269055
CDK19 cyclin-dependent kinase 19 -0.026778
CLTC clathrin, heavy chain (Hc) -0.0267418
LOC112694756 uncharaterized LOC112694756 -0.0266703
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.026519
ZC3H12B zinc finger CCCH-type containing 12B -0.0263861
TOR1AIP2 torsin A interacting protein 2 -0.0262898
BABAM2 BRISC and BRCA1 A complex member 2 -0.0262743
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0259023
GPHN gephyrin -0.025616
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0254613
ATG10 autophagy related 10 -0.0253806
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0253242
ZFAND3 zinc finger, AN1-type domain 3 -0.0253032
METTL15 methyltransferase like 15 -0.0248902
TNRC6A trinucleotide repeat containing 6A -0.0247803
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0247383
ZFC3H1 zinc finger, C3H1-type containing -0.0246439
ANKRD36 ankyrin repeat domain 36 -0.0245689
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0245187
KMT2E lysine (K)-specific methyltransferase 2E -0.0242674
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0241363
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0237124
BCAS3 breast carcinoma amplified sequence 3 -0.0235565
DOCK7 dedicator of cytokinesis 7 -0.023279
VMP1 vacuole membrane protein 1 -0.0231447
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0231005
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0229199
DSPP dentin sialophosphoprotein -0.0229037
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0228568
ZNF654 zinc finger protein 654 -0.0226748
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0225733
SETD5 SET domain containing 5 -0.0225649
RPS18 ribosomal protein S18 -0.0221677
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0220699
DARS1 aspartyl-tRNA synthetase 1 -0.0220186
BRWD3 bromodomain and WD repeat domain containing 3 -0.0219701
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0218549
MATR3 matrin 3 -0.0218404
R3HDM2 R3H domain containing 2 -0.0215238
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0213831
RBM33 RNA binding motif protein 33 -0.0211058
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0210579
EXOC4 exocyst complex component 4 -0.0209335
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0209096
DDIT4 DNA-damage-inducible transcript 4 -0.0208058
NCKAP1 NCK-associated protein 1 -0.0207318