Ouabain (Octahydrate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNIP1 folliculin interacting protein 1 0.12597
SQSTM1 sequestosome 1 0.102144
JMJD1C jumonji domain containing 1C 0.0911067
TOP1 topoisomerase (DNA) I 0.0839502
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0714028
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0704555
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0546099
ARRDC3 arrestin domain containing 3 0.054469
SPAG9 sperm associated antigen 9 0.0524182
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0505458
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0502831
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0483095
GLS2 glutaminase 2 (liver, mitochondrial) 0.0478729
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0458789
NUP58 nucleoporin 58 0.045242
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0433926
ZNF217 zinc finger protein 217 0.041824
RLF rearranged L-myc fusion 0.040444
RAB7A RAB7A, member RAS oncogene family 0.0401886
RBM39 RNA binding motif protein 39 0.0397195
NIPBL Nipped-B homolog (Drosophila) 0.0392066
PICALM phosphatidylinositol binding clathrin assembly protein 0.0390562
OGA O-GlcNAcase 0.0373852
KDM6A lysine (K)-specific demethylase 6A 0.0371023
USP9X ubiquitin specific peptidase 9, X-linked 0.0368895
CRY1 cryptochrome circadian clock 1 0.0361831
RICTOR RPTOR independent companion of MTOR, complex 2 0.0361341
CPNE8 copine VIII 0.0353634
PTK2 protein tyrosine kinase 2 0.0350839
APP amyloid beta (A4) precursor protein 0.034404
WDR26 WD repeat domain 26 0.0339775
HDAC9 histone deacetylase 9 0.031844
MBNL1 muscleblind-like splicing regulator 1 0.0310522
DSCAM Down syndrome cell adhesion molecule 0.0308223
OSBPL8 oxysterol binding protein-like 8 0.0295704
AFF4 AF4/FMR2 family, member 4 0.0283368
ARL8B ADP-ribosylation factor-like 8B 0.0282371
MED13 mediator complex subunit 13 0.0278771
RB1CC1 RB1-inducible coiled-coil 1 0.0277935
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0273236
FRMD5 FERM domain containing 5 0.0264506
ERBIN erbb2 interacting protein 0.0261102
ZFAND3 zinc finger, AN1-type domain 3 0.0257227
EP300 E1A binding protein p300 0.0255386
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0254975
TSC22D2 TSC22 domain family, member 2 0.025442
SLMAP sarcolemma associated protein 0.0252497
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0248447
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0247968
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0242671
WAC WW domain containing adaptor with coiled-coil 0.0241447
NF1 neurofibromin 1 0.0240014
OSBPL3 oxysterol binding protein-like 3 0.0238337
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0235555
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0235316
KDM3A lysine (K)-specific demethylase 3A 0.0235017
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0233049
CCNL1 cyclin L1 0.0230422
ANKRD12 ankyrin repeat domain 12 0.0228523
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.022779
UVRAG UV radiation resistance associated 0.0225802
PUM2 pumilio RNA-binding family member 2 0.0223461
ZNFX1 zinc finger, NFX1-type containing 1 0.0223163
ARHGAP26 Rho GTPase activating protein 26 0.0220369
TRIP12 thyroid hormone receptor interactor 12 0.0219326
RABGAP1 RAB GTPase activating protein 1 0.0218898
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0215156
MCL1 myeloid cell leukemia 1 0.0214471
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0214025
NPTN neuroplastin 0.0212995
RLIM ring finger protein, LIM domain interacting 0.0206884
LAMP2 lysosomal-associated membrane protein 2 0.0206082
HBP1 HMG-box transcription factor 1 0.02057
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0203979
DOCK4 dedicator of cytokinesis 4 0.020295
PRRC2C proline-rich coiled-coil 2C 0.0201986
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.020046
ARL5B ADP-ribosylation factor-like 5B 0.0199149
ATP13A3 ATPase type 13A3 0.0197673
CLTC clathrin, heavy chain (Hc) 0.0196669
TANK TRAF family member-associated NFKB activator 0.0196052
MICU1 mitochondrial calcium uptake 1 0.0195787
PER1 period circadian clock 1 0.0194938
FAM91A1 family with sequence similarity 91, member A1 0.019438
ZC3H11A zinc finger CCCH-type containing 11A 0.0193903
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0192871
RAB22A RAB22A, member RAS oncogene family 0.0191843
AVL9 AVL9 homolog (S. cerevisiase) 0.0190425
ATF6 activating transcription factor 6 0.0190344
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0190197
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.018714
ANKHD1 ankyrin repeat and KH domain containing 1 0.0186348
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0185089
NCKAP1 NCK-associated protein 1 0.0183986
MCTP1 multiple C2 domains, transmembrane 1 0.0182469
CNOT4 CCR4-NOT transcription complex, subunit 4 0.018131
YTHDC1 YTH domain containing 1 0.0179105
ANKRD28 ankyrin repeat domain 28 0.0179062
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0177472
ZNF609 zinc finger protein 609 0.0177421

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.169649
MTSS1 metastasis suppressor 1 -0.116194
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0964099
TIMP3 TIMP metallopeptidase inhibitor 3 -0.078385
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0698169
MT2A metallothionein 2A -0.0670352
TMSB10 thymosin beta 10 -0.0618159
SLC35F3 solute carrier family 35, member F3 -0.0614457
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0592805
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0523327
NDRG1 N-myc downstream regulated 1 -0.0487501
PSD3 pleckstrin and Sec7 domain containing 3 -0.0486716
RPS6 ribosomal protein S6 -0.0483343
RAI14 retinoic acid induced 14 -0.0476498
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0476363
MYOF myoferlin -0.0463063
PTMA prothymosin, alpha -0.0461672
S100A10 S100 calcium binding protein A10 -0.0422376
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.042051
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0406143
RPS8 ribosomal protein S8 -0.0405249
B2M beta-2-microglobulin -0.0397729
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0387886
SQLE squalene epoxidase -0.0384651
EZR ezrin -0.0376327
RPS21 ribosomal protein S21 -0.0368503
HM13 histocompatibility (minor) 13 -0.0363448
LMNA lamin A/C -0.0363392
ANXA2 annexin A2 -0.0357246
PDLIM5 PDZ and LIM domain 5 -0.0353889
HSPG2 heparan sulfate proteoglycan 2 -0.035299
LMO7 LIM domain 7 -0.0351709
SULF1 sulfatase 1 -0.0349734
RPS3 ribosomal protein S3 -0.0336518
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0333474
RPL11 ribosomal protein L11 -0.0331694
DOCK5 dedicator of cytokinesis 5 -0.0328252
RPLP2 ribosomal protein, large, P2 -0.0325208
TGM2 transglutaminase 2 -0.032121
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.031572
MEF2A myocyte enhancer factor 2A -0.0302618
CLU clusterin -0.0297741
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0296385
OSMR oncostatin M receptor -0.0295308
RPS13 ribosomal protein S13 -0.0294473
RPS19 ribosomal protein S19 -0.0292053
IFITM3 interferon induced transmembrane protein 3 -0.0288253
EFNA5 ephrin-A5 -0.0285726
S100A9 S100 calcium binding protein A9 -0.0278045
ALCAM activated leukocyte cell adhesion molecule -0.0265673
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0262611
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0258975
FOXO1 forkhead box O1 -0.0258179
PLAT plasminogen activator, tissue -0.0255602
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0249058
FTL ferritin, light polypeptide -0.0248994
ACTN4 actinin, alpha 4 -0.0248425
AMOTL1 angiomotin like 1 -0.0247343
PALLD palladin, cytoskeletal associated protein -0.0244767
PLS3 plastin 3 -0.0243297
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0241753
EMP1 epithelial membrane protein 1 -0.0239754
RPL37 ribosomal protein L37 -0.0236641
S100A2 S100 calcium binding protein A2 -0.0233558
MECOM MDS1 and EVI1 complex locus -0.02332
RPL23 ribosomal protein L23 -0.0232988
S100A11 S100 calcium binding protein A11 -0.0232143
SMYD3 SET and MYND domain containing 3 -0.023125
RPL35A ribosomal protein L35a -0.0230929
GPRC5B G protein-coupled receptor, class C, group 5, member B -0.0229976
RPLP1 ribosomal protein, large, P1 -0.0226683
TRIO trio Rho guanine nucleotide exchange factor -0.0226058
BLCAP bladder cancer associated protein -0.0225718
S100A6 S100 calcium binding protein A6 -0.0225013
GNAS GNAS complex locus -0.0220962
RPL8 ribosomal protein L8 -0.0220167
TNS3 tensin 3 -0.0216471
RPS25 ribosomal protein S25 -0.0215034
ENO1 enolase 1, (alpha) -0.0213482
RAD51B RAD51 paralog B -0.0212352
RABGAP1L RAB GTPase activating protein 1-like -0.021142
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0210448
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0210009
AKAP13 A kinase (PRKA) anchor protein 13 -0.0209876
FN1 fibronectin 1 -0.0208123
POTEF POTE ankyrin domain family, member F -0.0207864
MSN moesin -0.0206374
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0206225
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0205878
IFITM1 interferon induced transmembrane protein 1 -0.0205335
NCOR2 nuclear receptor corepressor 2 -0.0204751
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0203882
RPL37A ribosomal protein L37a -0.0203072
GRB10 growth factor receptor-bound protein 10 -0.0201722
AKAP9 A kinase (PRKA) anchor protein 9 -0.0201026
RPL34 ribosomal protein L34 -0.0200679
RPS27A ribosomal protein S27a -0.0196808
TPT1 tumor protein, translationally-controlled 1 -0.0195738
TPM4 tropomyosin 4 -0.01951
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0194566