Ouabain (Octahydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.187308
MCTP1 multiple C2 domains, transmembrane 1 0.0960275
FTL ferritin, light polypeptide 0.0720626
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0606746
NUP58 nucleoporin 58 0.0601406
TSC22D2 TSC22 domain family, member 2 0.0530317
RPS6 ribosomal protein S6 0.0527199
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0503695
MT2A metallothionein 2A 0.0481834
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0476618
PTMA prothymosin, alpha 0.0466507
EIF1 eukaryotic translation initiation factor 1 0.0466423
JUN jun proto-oncogene 0.0455077
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.043844
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.043398
OSBPL8 oxysterol binding protein-like 8 0.0431963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0427222
WAC WW domain containing adaptor with coiled-coil 0.0417327
SPAG9 sperm associated antigen 9 0.0391094
TXNIP thioredoxin interacting protein 0.0381883
RLF rearranged L-myc fusion 0.0378838
QKI QKI, KH domain containing, RNA binding 0.037522
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0371091
GLS2 glutaminase 2 (liver, mitochondrial) 0.0367647
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0363769
CCNL1 cyclin L1 0.0363356
ADAM9 ADAM metallopeptidase domain 9 0.0358079
RBM39 RNA binding motif protein 39 0.0339535
PRRC2C proline-rich coiled-coil 2C 0.0337796
VIM vimentin 0.0331755
WDR43 WD repeat domain 43 0.0323501
EEF2 eukaryotic translation elongation factor 2 0.0320585
BRD2 bromodomain containing 2 0.0320339
KDM3A lysine (K)-specific demethylase 3A 0.0315829
TFRC transferrin receptor 0.031466
PKM pyruvate kinase, muscle 0.0314185
YBX3 Y box binding protein 3 0.0310795
UGCG UDP-glucose ceramide glucosyltransferase 0.0310214
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0305443
PNISR PNN-interacting serine/arginine-rich protein 0.030263
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0301938
APP amyloid beta (A4) precursor protein 0.0298823
JMJD1C jumonji domain containing 1C 0.0296608
PUM1 pumilio RNA-binding family member 1 0.0295393
CRY1 cryptochrome circadian clock 1 0.0292418
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0288759
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0285944
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0285816
MED13L mediator complex subunit 13-like 0.0285587
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0285241
PUM2 pumilio RNA-binding family member 2 0.0283816
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.028126
KIF5B kinesin family member 5B 0.0280152
GOLGA4 golgin A4 0.0277407
CHD1 chromodomain helicase DNA binding protein 1 0.0274523
PHIP pleckstrin homology domain interacting protein 0.0273973
NAP1L1 nucleosome assembly protein 1-like 1 0.0270756
RND3 Rho family GTPase 3 0.0269838
RPS12 ribosomal protein S12 0.0267479
RSRC2 arginine/serine-rich coiled-coil 2 0.0267251
NAMPT nicotinamide phosphoribosyltransferase 0.0265343
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0263104
USP15 ubiquitin specific peptidase 15 0.0262226
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02614
ZNF292 zinc finger protein 292 0.025885
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0256487
NUP153 nucleoporin 153kDa 0.0256014
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.025495
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0254391
BCLAF1 BCL2-associated transcription factor 1 0.025421
KTN1 kinectin 1 (kinesin receptor) 0.0253901
KMT2E lysine (K)-specific methyltransferase 2E 0.0252116
RNF145 ring finger protein 145 0.0250881
FUBP1 far upstream element (FUSE) binding protein 1 0.0248627
RPL23 ribosomal protein L23 0.0248616
CUL3 cullin 3 0.0248129
PEAK1 pseudopodium-enriched atypical kinase 1 0.0247573
TOP2A topoisomerase (DNA) II alpha 170kDa 0.024629
RAD21 RAD21 homolog (S. pombe) 0.0245785
MED13 mediator complex subunit 13 0.0244553
RAB7A RAB7A, member RAS oncogene family 0.0244093
RTN4 reticulon 4 0.0242686
ZNF207 zinc finger protein 207 0.0239155
EIF4A1 eukaryotic translation initiation factor 4A1 0.0239066
RPS19 ribosomal protein S19 0.0238556
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0237475
MARCHF6 membrane associated ring-CH-type finger 6 0.0237036
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0235685
POTEF POTE ankyrin domain family, member F 0.0234237
RPLP2 ribosomal protein, large, P2 0.0232071
LDHA lactate dehydrogenase A 0.0230905
NCKAP1 NCK-associated protein 1 0.0226146
NOP58 NOP58 ribonucleoprotein 0.0225593
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0225277
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0223132
ZFAND3 zinc finger, AN1-type domain 3 0.0219937
TOP1 topoisomerase (DNA) I 0.0216859
RPS8 ribosomal protein S8 0.0216802
TMSB10 thymosin beta 10 0.021607
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0215424

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.107
EFNA5 ephrin-A5 -0.102918
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0711361
EXT1 exostosin glycosyltransferase 1 -0.0694435
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0593679
SAMD3 sterile alpha motif domain containing 3 -0.0558727
PRKG1 protein kinase, cGMP-dependent, type I -0.0557118
GPC6 glypican 6 -0.051375
NTM neurotrimin -0.050037
MMP12 matrix metallopeptidase 12 -0.044948
KIAA1549L KIAA1549-like -0.0449015
NALF1 NALCN channel auxiliary factor 1 -0.0442052
NAV1 neuron navigator 1 -0.0435988
PBX3 pre-B-cell leukemia homeobox 3 -0.0417248
PHACTR1 phosphatase and actin regulator 1 -0.0415926
CALD1 caldesmon 1 -0.0408328
PTPRG protein tyrosine phosphatase, receptor type, G -0.0388698
SDCCAG8 serologically defined colon cancer antigen 8 -0.0382615
TRIO trio Rho guanine nucleotide exchange factor -0.036178
CDH13 cadherin 13 -0.0361585
ENKUR enkurin, TRPC channel interacting protein -0.0330587
AHNAK AHNAK nucleoprotein -0.0321677
VCL vinculin -0.0314228
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0310665
DTNA dystrobrevin, alpha -0.0309058
KIAA1217 KIAA1217 -0.0296075
ADAM19 ADAM metallopeptidase domain 19 -0.027971
LIMCH1 LIM and calponin homology domains 1 -0.0269027
HMGA2 high mobility group AT-hook 2 -0.0268633
RAD51B RAD51 paralog B -0.0264755
MACF1 microtubule-actin crosslinking factor 1 -0.0259011
FOXP1 forkhead box P1 -0.0255878
SAMD4A sterile alpha motif domain containing 4A -0.0253534
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0248642
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0240297
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0238639
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0236183
PTPRD protein tyrosine phosphatase, receptor type, D -0.0235672
LPP LIM domain containing preferred translocation partner in lipoma -0.0231403
DST dystonin -0.0230759
PTCHD4 patched domain containing 4 -0.0228339
MYO10 myosin X -0.0224567
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0216969
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0216345
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0215737
ASPH aspartate beta-hydroxylase -0.0214456
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0213301
MAML2 mastermind-like 2 (Drosophila) -0.0208405
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0206497
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0204921
ANO6 anoctamin 6 -0.0191413
EXOC4 exocyst complex component 4 -0.0190559
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.019055
SMYD3 SET and MYND domain containing 3 -0.018784
RNF213 ring finger protein 213 -0.0186967
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0185406
KDM4C lysine (K)-specific demethylase 4C -0.0183322
SBF2 SET binding factor 2 -0.0181548
SASH1 SAM and SH3 domain containing 1 -0.0180462
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0177868
NABP1 nucleic acid binding protein 1 -0.0177506
RAI14 retinoic acid induced 14 -0.0173772
RIGI RNA sensor RIG-I -0.0172478
ANTXR2 anthrax toxin receptor 2 -0.0170359
PRKCE protein kinase C, epsilon -0.01677
ZBTB20 zinc finger and BTB domain containing 20 -0.0167632
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0164336
AEBP2 AE binding protein 2 -0.0163667
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0163171
ETV6 ets variant 6 -0.016226
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0160996
C2CD2 C2 calcium-dependent domain containing 2 -0.016008
MYO9A myosin IXA -0.0158087
KLF7 Kruppel-like factor 7 (ubiquitous) -0.015612
MBD5 methyl-CpG binding domain protein 5 -0.0153008
TRPS1 trichorhinophalangeal syndrome I -0.0152821
RABGAP1L RAB GTPase activating protein 1-like -0.0150189
ATXN1 ataxin 1 -0.0149952
CFAP251 cilia and flagella associated protein 251 -0.0147875
CUX1 cut-like homeobox 1 -0.0147075
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0146888
NLGN1 neuroligin 1 -0.0146818
SMAD3 SMAD family member 3 -0.0144761
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0143763
PRELID2 PRELI domain containing 2 -0.0143597
ZNF804A zinc finger protein 804A -0.0143332
RUNX1 runt-related transcription factor 1 -0.0141977
FMN1 formin 1 -0.0140776
BMAL2 basic helix-loop-helix ARNT like 2 -0.0139985
DOCK1 dedicator of cytokinesis 1 -0.0137551
RIMS2 regulating synaptic membrane exocytosis 2 -0.0137442
DOCK5 dedicator of cytokinesis 5 -0.013741
EGFR epidermal growth factor receptor -0.0135904
PDE4D phosphodiesterase 4D, cAMP-specific -0.0135846
INTS6 integrator complex subunit 6 -0.0131084
FMNL2 formin-like 2 -0.0130624
CD109 CD109 molecule -0.0126793
TENM2 teneurin transmembrane protein 2 -0.0126737
TBC1D5 TBC1 domain family, member 5 -0.0126369
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -0.0124498