Ouabain (Octahydrate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.074864
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0508842
GMDS GDP-mannose 4,6-dehydratase 0.0503011
ALCAM activated leukocyte cell adhesion molecule 0.0432634
PDLIM5 PDZ and LIM domain 5 0.0420804
MBNL1 muscleblind-like splicing regulator 1 0.0410781
MYO1E myosin IE 0.0380189
LAMA4 laminin, alpha 4 0.0356354
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.035218
NPSR1 neuropeptide S receptor 1 0.0344878
PTPRK protein tyrosine phosphatase, receptor type, K 0.0308462
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0307966
EXT1 exostosin glycosyltransferase 1 0.030079
ANTXR2 anthrax toxin receptor 2 0.028961
POF1B premature ovarian failure, 1B 0.0286622
EMP1 epithelial membrane protein 1 0.0280773
USP53 ubiquitin specific peptidase 53 0.0268578
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0259396
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0237078
ANXA1 annexin A1 0.0222316
NALF1 NALCN channel auxiliary factor 1 0.0222247
GLS2 glutaminase 2 (liver, mitochondrial) 0.0217986
RIGI RNA sensor RIG-I 0.0215006
IFRD1 interferon-related developmental regulator 1 0.0212065
SLC38A2 solute carrier family 38, member 2 0.0206579
GRB10 growth factor receptor-bound protein 10 0.0203152
EPS8 epidermal growth factor receptor pathway substrate 8 0.0191867
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.018979
PSD3 pleckstrin and Sec7 domain containing 3 0.0173593
ECT2 epithelial cell transforming 2 0.0170237
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0164005
INTS6 integrator complex subunit 6 0.0162946
MRPS6 mitochondrial ribosomal protein S6 0.0161287
EGFR epidermal growth factor receptor 0.0158419
FBXO11 F-box protein 11 0.015813
PALLD palladin, cytoskeletal associated protein 0.0154991
MARCHF3 membrane associated ring-CH-type finger 3 0.0152524
ONECUT3 one cut homeobox 3 0.0151541
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0150039
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0146769
RAP1B RAP1B, member of RAS oncogene family 0.0145163
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0143345
MAML3 mastermind-like 3 (Drosophila) 0.0143149
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.014044
SLC35F3 solute carrier family 35, member F3 0.0137918
TRPS1 trichorhinophalangeal syndrome I 0.013704
JUN jun proto-oncogene 0.0133987
SPATA13 spermatogenesis associated 13 0.0131927
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0128857
ANXA3 annexin A3 0.0127097
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0126898
MYH14 myosin, heavy chain 14, non-muscle 0.0126842
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0126659
IGFL2 IGF-like family member 2 0.0123973
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.0122337
OSBPL8 oxysterol binding protein-like 8 0.0120747
HSPH1 heat shock 105kDa/110kDa protein 1 0.0120076
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0119725
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.011936
SATB2 SATB homeobox 2 0.0117693
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0114801
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0114689
FMNL2 formin-like 2 0.0114651
PIGR polymeric immunoglobulin receptor 0.0113703
MED13 mediator complex subunit 13 0.0112881
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0110534
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0110387
TSC22D2 TSC22 domain family, member 2 0.0109499
LAMB3 laminin, beta 3 0.0108022
KLF6 Kruppel-like factor 6 0.0106105
CRACD capping protein inhibiting regulator of actin dynamics 0.010592
USP15 ubiquitin specific peptidase 15 0.010464
FAM107B family with sequence similarity 107, member B 0.0103849
HDAC2 histone deacetylase 2 0.0103803
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0103761
DGKH diacylglycerol kinase, eta 0.0103002
OSBPL3 oxysterol binding protein-like 3 0.0102907
CLOCK clock circadian regulator 0.0101695
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0100976
PTPRB protein tyrosine phosphatase, receptor type, B 0.0100949
PCDH9 protocadherin 9 0.0100937
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.00998276
ABR active BCR-related 0.00982892
WAC WW domain containing adaptor with coiled-coil 0.00982744
CXCL8 chemokine (C-X-C motif) ligand 8 0.00976483
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.009752
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0097291
MRTFA myocardin related transcription factor A 0.00969225
PUM1 pumilio RNA-binding family member 1 0.0096403
TRIB1 tribbles pseudokinase 1 0.00960009
C3ORF52 chromosome 3 open reading frame 52 0.00959918
JMJD1C jumonji domain containing 1C 0.0095029
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.00941006
KDM6A lysine (K)-specific demethylase 6A 0.00940096
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.00938877
GK glycerol kinase 0.00923936
MTAP methylthioadenosine phosphorylase 0.00920379
ANXA2 annexin A2 0.00918168
CATSPERB catsper channel auxiliary subunit beta 0.00911179
RORA RAR-related orphan receptor A 0.0091001

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.23569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165966
RPS6 ribosomal protein S6 -0.144716
PTMA prothymosin, alpha -0.136213
RPS2 ribosomal protein S2 -0.0938208
TMSB10 thymosin beta 10 -0.076033
RPS8 ribosomal protein S8 -0.0730893
NDRG1 N-myc downstream regulated 1 -0.0706025
RPS12 ribosomal protein S12 -0.0703981
RPS19 ribosomal protein S19 -0.0647369
GOLGA4 golgin A4 -0.0646589
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0641791
VEGFA vascular endothelial growth factor A -0.0613911
RPLP1 ribosomal protein, large, P1 -0.0586168
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0575289
DSPP dentin sialophosphoprotein -0.0559419
RPL23 ribosomal protein L23 -0.0551224
CEMIP cell migration inducing protein, hyaluronan binding -0.0550469
TXNIP thioredoxin interacting protein -0.0541972
RPLP2 ribosomal protein, large, P2 -0.0538688
RPL37A ribosomal protein L37a -0.0521951
LDHA lactate dehydrogenase A -0.0513011
RPL26 ribosomal protein L26 -0.0509053
RPL12 ribosomal protein L12 -0.0503206
AREG amphiregulin -0.0495877
RPS3 ribosomal protein S3 -0.0490978
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0482652
TNS4 tensin 4 -0.0472187
FTL ferritin, light polypeptide -0.0471794
KRT18 keratin 18, type I -0.0465078
PKM pyruvate kinase, muscle -0.0455405
RPL11 ribosomal protein L11 -0.0455049
EIF1 eukaryotic translation initiation factor 1 -0.0454956
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0453641
RPL7 ribosomal protein L7 -0.0433974
RPS23 ribosomal protein S23 -0.0430428
RPL36 ribosomal protein L36 -0.0429433
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0419046
RPL35A ribosomal protein L35a -0.0412524
RNF43 ring finger protein 43 -0.0405046
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0404842
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0397805
RPL34 ribosomal protein L34 -0.0395784
CALR calreticulin -0.0389361
PDIA3 protein disulfide isomerase family A, member 3 -0.0389213
RPL19 ribosomal protein L19 -0.0387242
RPL9 ribosomal protein L9 -0.037072
FAM13A family with sequence similarity 13, member A -0.0368511
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0366824
RPS29 ribosomal protein S29 -0.0362824
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0361992
S100A9 S100 calcium binding protein A9 -0.0358254
ENO1 enolase 1, (alpha) -0.0354963
RPS17 ribosomal protein S17 -0.0347806
DSG2 desmoglein 2 -0.0343909
KTN1 kinectin 1 (kinesin receptor) -0.0341991
MUC6 mucin 6, oligomeric mucus/gel-forming -0.034196
ZNF292 zinc finger protein 292 -0.0341094
CENPF centromere protein F, 350/400kDa -0.0337342
TPT1 tumor protein, translationally-controlled 1 -0.0337225
RPS13 ribosomal protein S13 -0.0336511
ISG15 ISG15 ubiquitin-like modifier -0.0333527
RPL5 ribosomal protein L5 -0.0332984
RPL18 ribosomal protein L18 -0.0332102
PRELID2 PRELI domain containing 2 -0.0316271
RPS27 ribosomal protein S27 -0.0313592
PGK1 phosphoglycerate kinase 1 -0.0311864
RPS27A ribosomal protein S27a -0.0310628
RPS24 ribosomal protein S24 -0.0309035
RBM39 RNA binding motif protein 39 -0.0306937
RPS16 ribosomal protein S16 -0.0305776
RPS25 ribosomal protein S25 -0.030232
RPL31 ribosomal protein L31 -0.030045
RPL37 ribosomal protein L37 -0.0298367
POTEF POTE ankyrin domain family, member F -0.0297638
KRT19 keratin 19, type I -0.0297144
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0296195
PTEN phosphatase and tensin homolog -0.0295113
RPL8 ribosomal protein L8 -0.029484
RPL32 ribosomal protein L32 -0.0293153
CANX calnexin -0.028908
HMGA1 high mobility group AT-hook 1 -0.0287267
RPL27A ribosomal protein L27a -0.0286832
LOC112694756 uncharaterized LOC112694756 -0.0286635
AKAP9 A kinase (PRKA) anchor protein 9 -0.0285613
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0284428
RPS14 ribosomal protein S14 -0.0284059
RPS11 ribosomal protein S11 -0.0283278
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0279832
B2M beta-2-microglobulin -0.0276724
RREB1 ras responsive element binding protein 1 -0.0274628
GOLGB1 golgin B1 -0.0271887
TPM3 tropomyosin 3 -0.0266849
ACTG1 actin gamma 1 -0.0266518
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0262824
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0260735
SBF2 SET binding factor 2 -0.0259976
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.025596
SSR1 signal sequence receptor, alpha -0.0254923
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0254454