Ouabain (Octahydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0828575
TXNRD1 thioredoxin reductase 1 0.0727826
ERRFI1 ERBB receptor feedback inhibitor 1 0.0701199
TM4SF1 transmembrane 4 L six family member 1 0.0670839
EREG epiregulin 0.0558079
CAPRIN2 caprin family member 2 0.0545557
SPAG9 sperm associated antigen 9 0.0473155
MKI67 marker of proliferation Ki-67 0.0472633
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0452807
TRIP12 thyroid hormone receptor interactor 12 0.0452571
CENPF centromere protein F, 350/400kDa 0.0428266
BIRC3 baculoviral IAP repeat containing 3 0.0421362
JMJD1C jumonji domain containing 1C 0.0418951
APP amyloid beta (A4) precursor protein 0.0411653
FNIP1 folliculin interacting protein 1 0.0401238
TSC22D2 TSC22 domain family, member 2 0.0383732
SLC38A2 solute carrier family 38, member 2 0.0382482
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0369702
ANLN anillin, actin binding protein 0.0367798
GLS2 glutaminase 2 (liver, mitochondrial) 0.0345123
ECT2 epithelial cell transforming 2 0.0335303
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0325123
ATP13A3 ATPase type 13A3 0.0320061
CCNL1 cyclin L1 0.0316307
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0315384
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0307462
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0303405
CKAP5 cytoskeleton associated protein 5 0.0302958
BIRC2 baculoviral IAP repeat containing 2 0.0300973
SFPQ splicing factor proline/glutamine-rich 0.0300309
ARRDC3 arrestin domain containing 3 0.0298869
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0296582
SMC4 structural maintenance of chromosomes 4 0.0293424
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0277564
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0277204
RTN4 reticulon 4 0.0275813
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0275266
ZEB1 zinc finger E-box binding homeobox 1 0.02678
MCTP1 multiple C2 domains, transmembrane 1 0.0262963
NUP58 nucleoporin 58 0.0252222
PLK2 polo-like kinase 2 0.0249577
CHD1 chromodomain helicase DNA binding protein 1 0.0244682
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.024086
ETNK1 ethanolamine kinase 1 0.0238669
USP9X ubiquitin specific peptidase 9, X-linked 0.0237041
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0235169
ANXA1 annexin A1 0.0231846
PUM2 pumilio RNA-binding family member 2 0.022508
CLTC clathrin, heavy chain (Hc) 0.0219509
JUN jun proto-oncogene 0.0214419
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0214035
MCL1 myeloid cell leukemia 1 0.0213568
TPX2 TPX2, microtubule-associated 0.0213008
TOP1 topoisomerase (DNA) I 0.0211475
CRY1 cryptochrome circadian clock 1 0.020467
WDR43 WD repeat domain 43 0.020447
IPO7 importin 7 0.0204427
EZR ezrin 0.0203916
BRD2 bromodomain containing 2 0.0203572
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0203092
NUP153 nucleoporin 153kDa 0.0200165
ADAM9 ADAM metallopeptidase domain 9 0.0196781
DIAPH3 diaphanous-related formin 3 0.0195352
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0195338
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0194826
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0193347
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0192857
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0187655
AHCTF1 AT hook containing transcription factor 1 0.0185862
TFRC transferrin receptor 0.018567
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0183336
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0183305
NAV2 neuron navigator 2 0.0183024
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0180569
USP34 ubiquitin specific peptidase 34 0.017938
NCKAP1 NCK-associated protein 1 0.0173957
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.01739
RBM39 RNA binding motif protein 39 0.0173683
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0172277
ARL5B ADP-ribosylation factor-like 5B 0.0170524
NUP98 nucleoporin 98kDa 0.0169683
KIF14 kinesin family member 14 0.0168835
ZC3H11A zinc finger CCCH-type containing 11A 0.0168552
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0168549
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0168119
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0166825
HSPA8 heat shock 70kDa protein 8 0.0166196
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0163225
SQSTM1 sequestosome 1 0.0161337
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0161202
CAMTA1 calmodulin binding transcription activator 1 0.0160632
GAN gigaxonin 0.0159649
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0158901
CENPE centromere protein E, 312kDa 0.0157829
ZFAND3 zinc finger, AN1-type domain 3 0.0157154
TRA2B transformer 2 beta homolog (Drosophila) 0.0156783
SON SON DNA binding protein 0.015646
ECPAS Ecm29 proteasome adaptor and scaffold 0.01553
WAC WW domain containing adaptor with coiled-coil 0.0152323
MEMO1 mediator of cell motility 1 0.0152171

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.171427
VIM vimentin -0.166088
TMSB10 thymosin beta 10 -0.146564
MT2A metallothionein 2A -0.122001
PSD3 pleckstrin and Sec7 domain containing 3 -0.0929182
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0799699
FTL ferritin, light polypeptide -0.0791823
TP63 tumor protein p63 -0.066759
RPS8 ribosomal protein S8 -0.0654123
PTMA prothymosin, alpha -0.063712
RPL35A ribosomal protein L35a -0.0628256
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0519781
RPS6 ribosomal protein S6 -0.0491845
RPS19 ribosomal protein S19 -0.048811
RPL23 ribosomal protein L23 -0.0471968
TPT1 tumor protein, translationally-controlled 1 -0.0448779
RPL12 ribosomal protein L12 -0.0442346
RPLP1 ribosomal protein, large, P1 -0.0424904
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0393129
ZMYND8 zinc finger, MYND-type containing 8 -0.037965
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0376384
RPL36 ribosomal protein L36 -0.0375691
CADM2 cell adhesion molecule 2 -0.0355168
RPL37A ribosomal protein L37a -0.0340835
RPL26 ribosomal protein L26 -0.0340216
MT1E metallothionein 1E -0.0333234
RPLP2 ribosomal protein, large, P2 -0.0327792
RPS12 ribosomal protein S12 -0.0327184
RPL31 ribosomal protein L31 -0.032483
TMSB4X thymosin beta 4, X-linked -0.0321027
HLA-B major histocompatibility complex, class I, B -0.0319938
RPS29 ribosomal protein S29 -0.030946
RPS3 ribosomal protein S3 -0.0306644
RPL19 ribosomal protein L19 -0.0304538
RPS23 ribosomal protein S23 -0.0303864
RACK1 receptor for activated C kinase 1 -0.0302864
S100A9 S100 calcium binding protein A9 -0.0295274
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0295208
HMGA1 high mobility group AT-hook 1 -0.0291987
RAD51B RAD51 paralog B -0.0291575
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028924
RERE arginine-glutamic acid dipeptide (RE) repeats -0.02888
LOXL2 lysyl oxidase-like 2 -0.0288136
MT1X metallothionein 1X -0.028682
RPL28 ribosomal protein L28 -0.0285068
RPS27A ribosomal protein S27a -0.0274464
RPS14 ribosomal protein S14 -0.0273043
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0272013
RPL37 ribosomal protein L37 -0.0270096
RPL11 ribosomal protein L11 -0.026922
RPS24 ribosomal protein S24 -0.0269071
IFI6 interferon, alpha-inducible protein 6 -0.0268714
EXOC4 exocyst complex component 4 -0.0262668
TSC22D1 TSC22 domain family, member 1 -0.026163
RPL34 ribosomal protein L34 -0.0260268
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0258519
RPS10 ribosomal protein S10 -0.0258014
RPS16 ribosomal protein S16 -0.0256176
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0255385
DLG1 discs, large homolog 1 (Drosophila) -0.0254661
RPL36A ribosomal protein L36a -0.0254645
SMYD3 SET and MYND domain containing 3 -0.0247631
RPL35 ribosomal protein L35 -0.024477
MYOF myoferlin -0.0242848
NPAS2 neuronal PAS domain protein 2 -0.0242045
LOC112694756 uncharaterized LOC112694756 -0.0239864
EHBP1 EH domain binding protein 1 -0.0239544
RNF213 ring finger protein 213 -0.0237955
RPL8 ribosomal protein L8 -0.0234371
RPS27 ribosomal protein S27 -0.023403
RPS25 ribosomal protein S25 -0.0233991
RPS21 ribosomal protein S21 -0.0230787
TNS3 tensin 3 -0.0226692
RPL38 ribosomal protein L38 -0.0220956
EFNA5 ephrin-A5 -0.0220481
PDE10A phosphodiesterase 10A -0.0218072
RPS13 ribosomal protein S13 -0.0215201
PRELID2 PRELI domain containing 2 -0.0213044
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0212627
RPL18 ribosomal protein L18 -0.0211468
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0211006
S100A10 S100 calcium binding protein A10 -0.0210264
MBD5 methyl-CpG binding domain protein 5 -0.0209343
DST dystonin -0.0208323
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0207381
RPLP0 ribosomal protein, large, P0 -0.0202103
RPS15 ribosomal protein S15 -0.020092
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0200194
RPL27 ribosomal protein L27 -0.0198001
NDRG1 N-myc downstream regulated 1 -0.0197912
CFAP299 cilia and flagella associated protein 299 -0.0197856
RUNX1 runt-related transcription factor 1 -0.0197089
WSB1 WD repeat and SOCS box containing 1 -0.0196309
SP100 SP100 nuclear antigen -0.0195278
IFITM1 interferon induced transmembrane protein 1 -0.0195065
S100A6 S100 calcium binding protein A6 -0.0194355
FTH1 ferritin, heavy polypeptide 1 -0.0193414
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.018601
RPS20 ribosomal protein S20 -0.0185648
RPS5 ribosomal protein S5 -0.0185091