Ouabain (Octahydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.2431
NAMPT nicotinamide phosphoribosyltransferase 0.122081
NDRG1 N-myc downstream regulated 1 0.105935
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0985178
ELL2 elongation factor, RNA polymerase II, 2 0.09221
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0881786
ASPH aspartate beta-hydroxylase 0.075642
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0746464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0691405
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0646621
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0639678
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0607107
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0595026
IL6ST interleukin 6 signal transducer 0.0590532
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0584215
CCNL1 cyclin L1 0.0581076
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0527012
TFG TRK-fused gene 0.0504741
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0496359
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0496089
DSCAM Down syndrome cell adhesion molecule 0.0488634
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0487012
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.048158
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0476811
CD83 CD83 molecule 0.04595
TXNRD1 thioredoxin reductase 1 0.0459168
FAM3C family with sequence similarity 3, member C 0.0456811
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0454717
FXR1 fragile X mental retardation, autosomal homolog 1 0.0450505
MARCHF6 membrane associated ring-CH-type finger 6 0.0440634
ADAM9 ADAM metallopeptidase domain 9 0.0435109
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0431718
MATR3 matrin 3 0.0430284
PAPOLA poly(A) polymerase alpha 0.0429342
FNDC3B fibronectin type III domain containing 3B 0.0421074
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0413124
KDM6A lysine (K)-specific demethylase 6A 0.0407379
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0400014
CDK17 cyclin-dependent kinase 17 0.0378254
UBA6 ubiquitin-like modifier activating enzyme 6 0.0376667
NPEPPS aminopeptidase puromycin sensitive 0.0366001
RBM39 RNA binding motif protein 39 0.0363624
TMEM131L transmembrane 131 like 0.0356784
CD46 CD46 molecule, complement regulatory protein 0.0345796
GOLGA4 golgin A4 0.0344646
KMT2E lysine (K)-specific methyltransferase 2E 0.0340449
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0339599
PELI1 pellino E3 ubiquitin protein ligase 1 0.0337314
EEF2 eukaryotic translation elongation factor 2 0.0333451
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0331703
ANXA5 annexin A5 0.0327931
USP9X ubiquitin specific peptidase 9, X-linked 0.0327593
SLC38A1 solute carrier family 38, member 1 0.0327511
MSMO1 methylsterol monooxygenase 1 0.0327201
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0324155
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0321258
CXCL8 chemokine (C-X-C motif) ligand 8 0.0320946
BIRC3 baculoviral IAP repeat containing 3 0.0318761
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0317192
STRN3 striatin, calmodulin binding protein 3 0.0316706
ARRDC3 arrestin domain containing 3 0.0316246
RAD21 RAD21 homolog (S. pombe) 0.030916
NRIP1 nuclear receptor interacting protein 1 0.0308196
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.030622
RTN4 reticulon 4 0.0305884
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0302207
CDC73 cell division cycle 73 0.0299859
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0293632
RNF145 ring finger protein 145 0.029091
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0290774
TM9SF3 transmembrane 9 superfamily member 3 0.0290691
ZFAND3 zinc finger, AN1-type domain 3 0.0290416
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.028876
MTMR3 myotubularin related protein 3 0.0287358
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0286762
DENND4A DENN/MADD domain containing 4A 0.0284252
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0279245
CLINT1 clathrin interactor 1 0.0278577
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0278205
WDFY3 WD repeat and FYVE domain containing 3 0.0277855
ALCAM activated leukocyte cell adhesion molecule 0.0277539
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0277165
TRA2B transformer 2 beta homolog (Drosophila) 0.0276846
TOP1 topoisomerase (DNA) I 0.0275977
NCKAP1 NCK-associated protein 1 0.0275579
SETD5 SET domain containing 5 0.0275561
ARL5B ADP-ribosylation factor-like 5B 0.0273444
ANKRD28 ankyrin repeat domain 28 0.0271988
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0271774
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0271631
CPNE8 copine VIII 0.0271455
ATP13A3 ATPase type 13A3 0.0270511
TNIP1 TNFAIP3 interacting protein 1 0.0269602
NUP58 nucleoporin 58 0.0268934
NEK7 NIMA-related kinase 7 0.0268615
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0268341
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.026613
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0259546
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0258603
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0257487

decreased expression

Symbol Name Standardized Value
LPP LIM domain containing preferred translocation partner in lipoma -0.155411
SAMD4A sterile alpha motif domain containing 4A -0.141752
PTMA prothymosin, alpha -0.132834
FTL ferritin, light polypeptide -0.121032
TMSB10 thymosin beta 10 -0.10886
ZSWIM6 zinc finger, SWIM-type containing 6 -0.106944
ACTG1 actin gamma 1 -0.100565
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0894966
FBXO32 F-box protein 32 -0.0878839
LIMCH1 LIM and calponin homology domains 1 -0.0786453
EXT1 exostosin glycosyltransferase 1 -0.075737
RNF213 ring finger protein 213 -0.0695964
GRB10 growth factor receptor-bound protein 10 -0.0642437
AHNAK AHNAK nucleoprotein -0.0596043
S100A10 S100 calcium binding protein A10 -0.058746
ISG15 ISG15 ubiquitin-like modifier -0.0583211
RPLP1 ribosomal protein, large, P1 -0.0579161
IFI27 interferon, alpha-inducible protein 27 -0.0559517
ZBTB20 zinc finger and BTB domain containing 20 -0.0537166
RAI14 retinoic acid induced 14 -0.0532174
IFI16 interferon, gamma-inducible protein 16 -0.0511481
RIGI RNA sensor RIG-I -0.0502999
MX2 MX dynamin-like GTPase 2 -0.0471011
KRT7 keratin 7, type II -0.0463515
GOLGB1 golgin B1 -0.0461228
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0448295
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0443553
TPT1 tumor protein, translationally-controlled 1 -0.0441308
SQSTM1 sequestosome 1 -0.0438184
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0434083
IFI6 interferon, alpha-inducible protein 6 -0.0420113
SP100 SP100 nuclear antigen -0.0420008
PGBD5 piggyBac transposable element derived 5 -0.041813
EFNA5 ephrin-A5 -0.0411952
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0406648
CTBP2 C-terminal binding protein 2 -0.0405847
INTS6 integrator complex subunit 6 -0.0403493
CCND1 cyclin D1 -0.0399177
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0395603
ARHGAP20 Rho GTPase activating protein 20 -0.0389071
RPL8 ribosomal protein L8 -0.0388609
RPS29 ribosomal protein S29 -0.0388541
WSB1 WD repeat and SOCS box containing 1 -0.0387784
PLEC plectin -0.0387023
SOX4 SRY (sex determining region Y)-box 4 -0.037208
IFITM3 interferon induced transmembrane protein 3 -0.0370311
MX1 MX dynamin-like GTPase 1 -0.0367465
ATXN1 ataxin 1 -0.0360256
RPS3 ribosomal protein S3 -0.0359663
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0354758
KDM5B lysine (K)-specific demethylase 5B -0.0353516
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.035272
CUX1 cut-like homeobox 1 -0.0350993
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0350756
MAML2 mastermind-like 2 (Drosophila) -0.0345384
G0S2 G0/G1 switch 2 -0.0342935
ETV6 ets variant 6 -0.0342227
RAB7A RAB7A, member RAS oncogene family -0.0341206
AHNAK2 AHNAK nucleoprotein 2 -0.0340003
RPLP2 ribosomal protein, large, P2 -0.033493
RPL35A ribosomal protein L35a -0.0330077
PDLIM5 PDZ and LIM domain 5 -0.0325967
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0321582
RAD51B RAD51 paralog B -0.032101
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0320235
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0319339
RBM47 RNA binding motif protein 47 -0.0311094
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0310432
FHIT fragile histidine triad -0.0306697
SVIL supervillin -0.0306401
EXOC4 exocyst complex component 4 -0.0300744
ATP11A ATPase, class VI, type 11A -0.0299787
RPS8 ribosomal protein S8 -0.0298104
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0295238
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0294881
RRBP1 ribosome binding protein 1 -0.0294058
MCU mitochondrial calcium uniporter -0.028941
RPS14 ribosomal protein S14 -0.0289033
IFITM1 interferon induced transmembrane protein 1 -0.0286315
PRKCA protein kinase C, alpha -0.028628
RPL28 ribosomal protein L28 -0.0284623
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0282603
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.028136
VCL vinculin -0.0280388
CAVIN1 caveolae associated protein 1 -0.0278205
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0277857
TBC1D22A TBC1 domain family, member 22A -0.0274721
AEBP2 AE binding protein 2 -0.027467
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0273769
RPL34 ribosomal protein L34 -0.0271801
MACF1 microtubule-actin crosslinking factor 1 -0.0271496
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0270364
DSPP dentin sialophosphoprotein -0.0270324
MYO1E myosin IE -0.0269716
SAMD12 sterile alpha motif domain containing 12 -0.0269171
S100A9 S100 calcium binding protein A9 -0.0268256
TTC3 tetratricopeptide repeat domain 3 -0.0267792
CSTB cystatin B (stefin B) -0.0267285
RPS19 ribosomal protein S19 -0.0264042
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0259902