Ouabain (Octahydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.217814
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.170953
CXCL8 chemokine (C-X-C motif) ligand 8 0.14414
SPAG9 sperm associated antigen 9 0.133482
MCTP1 multiple C2 domains, transmembrane 1 0.0742319
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0674181
CRY1 cryptochrome circadian clock 1 0.0608439
CCNL1 cyclin L1 0.058719
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0563641
RAB7A RAB7A, member RAS oncogene family 0.0559642
CHD1 chromodomain helicase DNA binding protein 1 0.0519839
TSC22D2 TSC22 domain family, member 2 0.0512365
EIF4A3 eukaryotic translation initiation factor 4A3 0.0478174
UBAP2L ubiquitin associated protein 2-like 0.0458479
USP9X ubiquitin specific peptidase 9, X-linked 0.04538
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0451858
KDM6A lysine (K)-specific demethylase 6A 0.0436118
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0432606
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.043103
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0420951
DDIT4 DNA-damage-inducible transcript 4 0.0416536
PER1 period circadian clock 1 0.0410208
WAC WW domain containing adaptor with coiled-coil 0.0397256
USP36 ubiquitin specific peptidase 36 0.039604
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0393214
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0383513
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0382731
NUP58 nucleoporin 58 0.0381316
QKI QKI, KH domain containing, RNA binding 0.0370391
PNPLA8 patatin-like phospholipase domain containing 8 0.0356366
ATP13A3 ATPase type 13A3 0.035016
CAMTA1 calmodulin binding transcription activator 1 0.0343807
KYNU kynureninase 0.034103
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0338999
SOD2 superoxide dismutase 2, mitochondrial 0.033848
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0330346
ELL2 elongation factor, RNA polymerase II, 2 0.0321429
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0316993
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.031109
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0309439
RLF rearranged L-myc fusion 0.0307066
TOP1 topoisomerase (DNA) I 0.0306091
TFRC transferrin receptor 0.0306075
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0303557
KMT2E lysine (K)-specific methyltransferase 2E 0.0299746
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0299417
DUSP5 dual specificity phosphatase 5 0.0287413
AHR aryl hydrocarbon receptor 0.0282891
HSPA8 heat shock 70kDa protein 8 0.0282557
LOC102724023 ES1 protein homolog, mitochondrial 0.0282158
USP3 ubiquitin specific peptidase 3 0.0281815
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0279353
KDM3A lysine (K)-specific demethylase 3A 0.0278507
HSPH1 heat shock 105kDa/110kDa protein 1 0.0277688
GARS1 glycyl-tRNA synthetase 1 0.0276691
CUL3 cullin 3 0.0272209
MCL1 myeloid cell leukemia 1 0.0270816
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0264285
ARL5B ADP-ribosylation factor-like 5B 0.0264059
ZFP36 ZFP36 ring finger protein 0.0263212
PTK2 protein tyrosine kinase 2 0.0259723
ECT2 epithelial cell transforming 2 0.0258727
RTN4 reticulon 4 0.0257512
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0255647
SNAP25 synaptosomal-associated protein, 25kDa 0.0254121
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0253965
TEX10 testis expressed 10 0.0252526
RBM39 RNA binding motif protein 39 0.0245033
IFRD1 interferon-related developmental regulator 1 0.0241679
EIF4A1 eukaryotic translation initiation factor 4A1 0.0241075
RHEB Ras homolog enriched in brain 0.0239101
NCKAP1 NCK-associated protein 1 0.0238767
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.023754
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0234979
GLS2 glutaminase 2 (liver, mitochondrial) 0.0228635
RNF145 ring finger protein 145 0.0226274
ANXA5 annexin A5 0.0225682
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0222274
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0219447
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0215365
ETV3 ets variant 3 0.0213206
ARRDC3 arrestin domain containing 3 0.021102
BCLAF1 BCL2-associated transcription factor 1 0.0208761
LCORL ligand dependent nuclear receptor corepressor-like 0.0207697
CDC73 cell division cycle 73 0.0206826
PUM2 pumilio RNA-binding family member 2 0.0204549
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0203319
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0202347
INSIG1 insulin induced gene 1 0.0200996
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0199272
WDR43 WD repeat domain 43 0.0199195
TFPI2 tissue factor pathway inhibitor 2 0.0198878
ADAM9 ADAM metallopeptidase domain 9 0.0198008
SIRT1 sirtuin 1 0.0197506
SLC38A1 solute carrier family 38, member 1 0.0195337
DSCAM Down syndrome cell adhesion molecule 0.0193687
CXCL5 chemokine (C-X-C motif) ligand 5 0.019334
TM4SF1 transmembrane 4 L six family member 1 0.0189673
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.018698
ADAM17 ADAM metallopeptidase domain 17 0.01795

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.28364
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151542
EFNA5 ephrin-A5 -0.13574
PSD3 pleckstrin and Sec7 domain containing 3 -0.12334
VIM vimentin -0.118765
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.101969
TMSB10 thymosin beta 10 -0.101567
PDE10A phosphodiesterase 10A -0.0987965
COL5A2 collagen, type V, alpha 2 -0.0938389
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0898694
FN1 fibronectin 1 -0.0864033
RPLP1 ribosomal protein, large, P1 -0.0744498
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0741607
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0734856
NALF1 NALCN channel auxiliary factor 1 -0.072298
RPS6 ribosomal protein S6 -0.0714352
CDH13 cadherin 13 -0.0650607
PTMA prothymosin, alpha -0.0645617
RPS8 ribosomal protein S8 -0.0624627
LIMCH1 LIM and calponin homology domains 1 -0.0605864
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0593611
SMYD3 SET and MYND domain containing 3 -0.05924
MAML3 mastermind-like 3 (Drosophila) -0.0592041
ASPH aspartate beta-hydroxylase -0.0589895
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0547918
RPS27A ribosomal protein S27a -0.0544324
P3H2 prolyl 3-hydroxylase 2 -0.0533309
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0527134
DST dystonin -0.0524398
RPL26 ribosomal protein L26 -0.0515442
RPL12 ribosomal protein L12 -0.051273
TPT1 tumor protein, translationally-controlled 1 -0.0507117
RPS24 ribosomal protein S24 -0.0494334
RPS19 ribosomal protein S19 -0.0492579
RPL23 ribosomal protein L23 -0.04921
RPS12 ribosomal protein S12 -0.0488133
RPL37A ribosomal protein L37a -0.0470296
SH3KBP1 SH3-domain kinase binding protein 1 -0.0467405
BASP1 brain abundant, membrane attached signal protein 1 -0.0464909
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0459065
RPL31 ribosomal protein L31 -0.0453205
MYOF myoferlin -0.0441454
ENO1 enolase 1, (alpha) -0.043862
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0429716
RPL19 ribosomal protein L19 -0.0426766
GDA guanine deaminase -0.0425469
RPL35A ribosomal protein L35a -0.0422888
GRAMD1B GRAM domain containing 1B -0.041799
NRCAM neuronal cell adhesion molecule -0.0416793
PRKN parkin RBR E3 ubiquitin protein ligase -0.0415971
FTL ferritin, light polypeptide -0.0411997
PCBP3 poly(rC) binding protein 3 -0.039802
RPS23 ribosomal protein S23 -0.0395053
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0393991
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0393422
S100A6 S100 calcium binding protein A6 -0.0385792
RPL34 ribosomal protein L34 -0.0381821
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0373517
IGFBP3 insulin-like growth factor binding protein 3 -0.0360413
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0358468
RPS3 ribosomal protein S3 -0.0357332
RPS14 ribosomal protein S14 -0.0356134
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0353002
NPAS2 neuronal PAS domain protein 2 -0.0350538
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0348066
DOCK5 dedicator of cytokinesis 5 -0.0343164
INHBA inhibin, beta A -0.0341244
RPLP2 ribosomal protein, large, P2 -0.0337024
RPS27 ribosomal protein S27 -0.0329228
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0325089
RPL36A ribosomal protein L36a -0.0323086
RPS29 ribosomal protein S29 -0.0316867
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0312905
COL8A1 collagen, type VIII, alpha 1 -0.0312553
RPLP0 ribosomal protein, large, P0 -0.030859
ISG15 ISG15 ubiquitin-like modifier -0.0303251
LSAMP limbic system-associated membrane protein -0.0302911
PGK1 phosphoglycerate kinase 1 -0.0300177
RPL9 ribosomal protein L9 -0.0299526
SOX4 SRY (sex determining region Y)-box 4 -0.0297898
RPL7A ribosomal protein L7a -0.0296929
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0293405
RPL37 ribosomal protein L37 -0.029158
S100A10 S100 calcium binding protein A10 -0.0290079
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.028973
RPS25 ribosomal protein S25 -0.0286547
RGS2 regulator of G-protein signaling 2 -0.0285508
HLA-B major histocompatibility complex, class I, B -0.0285368
COL4A5 collagen, type IV, alpha 5 -0.0284326
RPL36 ribosomal protein L36 -0.0281195
PRELID2 PRELI domain containing 2 -0.02793
PYGL phosphorylase, glycogen, liver -0.02775
CANX calnexin -0.027718
EXT1 exostosin glycosyltransferase 1 -0.0273918
RPS21 ribosomal protein S21 -0.0273225
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0269606
NCOA7 nuclear receptor coactivator 7 -0.0267549
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.026683
RPL38 ribosomal protein L38 -0.0266149
PALLD palladin, cytoskeletal associated protein -0.0261881