Ouabain (Octahydrate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZFP36 ZFP36 ring finger protein 0.127165
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.121642
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.119071
TM4SF1 transmembrane 4 L six family member 1 0.064226
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0597439
SPAG9 sperm associated antigen 9 0.0596729
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0568482
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0488052
AHNAK AHNAK nucleoprotein 0.0480441
UBC ubiquitin C 0.045655
NUP98 nucleoporin 98kDa 0.0427659
GARS1 glycyl-tRNA synthetase 1 0.0425234
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0423464
ZFAND3 zinc finger, AN1-type domain 3 0.0413824
NAV2 neuron navigator 2 0.0402377
TXNRD1 thioredoxin reductase 1 0.0365716
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0359293
SUCO SUN domain containing ossification factor 0.0335782
CANX calnexin 0.0335059
FXR1 fragile X mental retardation, autosomal homolog 1 0.0329808
CDK13 cyclin-dependent kinase 13 0.0326405
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320574
ECT2 epithelial cell transforming 2 0.0318473
ANKRD11 ankyrin repeat domain 11 0.0316588
ZCCHC7 zinc finger, CCHC domain containing 7 0.0306631
BRD2 bromodomain containing 2 0.0306173
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0303865
ACTN4 actinin, alpha 4 0.0302147
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0292803
COPA coatomer protein complex, subunit alpha 0.0292803
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0290024
SLC35F3 solute carrier family 35, member F3 0.028999
DSCAM Down syndrome cell adhesion molecule 0.0283464
ATP13A3 ATPase type 13A3 0.0281563
CTBP2 C-terminal binding protein 2 0.0280492
MYH9 myosin, heavy chain 9, non-muscle 0.0276693
RRM2 ribonucleotide reductase M2 0.0273931
CARS1 cysteinyl-tRNA synthetase 1 0.0273049
UPP1 uridine phosphorylase 1 0.0270483
ATF6 activating transcription factor 6 0.026955
PMM2 phosphomannomutase 2 0.0266813
WDR43 WD repeat domain 43 0.0259546
CRY1 cryptochrome circadian clock 1 0.0258582
IARS1 isoleucyl-tRNA synthetase 1 0.02538
PTGES2 prostaglandin E synthase 2 0.0252234
THSD4 thrombospondin, type I, domain containing 4 0.0250137
KDM3A lysine (K)-specific demethylase 3A 0.0249852
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0248226
SEC63 SEC63 homolog (S. cerevisiae) 0.024722
SAMD4B sterile alpha motif domain containing 4B 0.0244816
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0244499
HSPA8 heat shock 70kDa protein 8 0.0238212
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.023657
MCL1 myeloid cell leukemia 1 0.0235643
ZEB1 zinc finger E-box binding homeobox 1 0.0229426
USP34 ubiquitin specific peptidase 34 0.0228779
COG5 component of oligomeric golgi complex 5 0.0227388
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.022551
EXT1 exostosin glycosyltransferase 1 0.0225379
RLF rearranged L-myc fusion 0.0225048
NUP153 nucleoporin 153kDa 0.0224187
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0220935
MACF1 microtubule-actin crosslinking factor 1 0.0219515
COPB1 coatomer protein complex, subunit beta 1 0.0219367
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0217406
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0216201
TMEM39A transmembrane protein 39A 0.0215349
APP amyloid beta (A4) precursor protein 0.0215263
SAMD4A sterile alpha motif domain containing 4A 0.0214983
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0214069
VCL vinculin 0.0212968
CAMTA1 calmodulin binding transcription activator 1 0.0209962
BMP6 bone morphogenetic protein 6 0.0207947
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0206265
GOLGB1 golgin B1 0.0205404
MARS1 methionyl-tRNA synthetase 1 0.020539
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0202131
FLNA filamin A, alpha 0.0202125
SFPQ splicing factor proline/glutamine-rich 0.0200777
ATG7 autophagy related 7 0.0200475
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0198834
SOD2 superoxide dismutase 2, mitochondrial 0.0198065
ELOVL5 ELOVL fatty acid elongase 5 0.0197935
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0197811
PUM1 pumilio RNA-binding family member 1 0.0196783
PDIA4 protein disulfide isomerase family A, member 4 0.0195783
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0195467
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0192603
HJURP Holliday junction recognition protein 0.019256
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.019119
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0190368
TARS1 threonyl-tRNA synthetase 1 0.0189269
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0188732
AFDN afadin, adherens junction formation factor 0.0187182
DENND5A DENN/MADD domain containing 5A 0.0187124
PLEC plectin 0.0186818
SRSF1 serine/arginine-rich splicing factor 1 0.0186803
RPL3 ribosomal protein L3 0.0185101
TRIP12 thyroid hormone receptor interactor 12 0.0184083
KIF5B kinesin family member 5B 0.018396

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.380598
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.258372
VIM vimentin -0.150664
TMSB10 thymosin beta 10 -0.127702
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.101167
RPL35A ribosomal protein L35a -0.0970019
MT2A metallothionein 2A -0.0909834
RPLP2 ribosomal protein, large, P2 -0.0889481
RPLP0 ribosomal protein, large, P0 -0.0773688
PTMA prothymosin, alpha -0.0749917
AKAP12 A kinase (PRKA) anchor protein 12 -0.0719572
RPLP1 ribosomal protein, large, P1 -0.070987
FOSL1 FOS-like antigen 1 -0.0646569
FTL ferritin, light polypeptide -0.0636211
S100A6 S100 calcium binding protein A6 -0.0624832
ADM adrenomedullin -0.0560667
TMEM123 transmembrane protein 123 -0.0549169
S100A10 S100 calcium binding protein A10 -0.0542275
RPS19 ribosomal protein S19 -0.0530692
SQSTM1 sequestosome 1 -0.0522229
DEPP1 DEPP autophagy regulator 1 -0.0506915
B2M beta-2-microglobulin -0.0499383
SEPTIN9 septin 9 -0.0496063
RPS25 ribosomal protein S25 -0.0489269
RPS6 ribosomal protein S6 -0.0487243
RPL28 ribosomal protein L28 -0.0485723
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.048349
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0482976
ANXA2 annexin A2 -0.0467595
JMJD1C jumonji domain containing 1C -0.0456335
IFITM3 interferon induced transmembrane protein 3 -0.0455246
RPS3 ribosomal protein S3 -0.045513
RPL23 ribosomal protein L23 -0.0454611
RPS24 ribosomal protein S24 -0.0454571
MED13L mediator complex subunit 13-like -0.0449356
KLF6 Kruppel-like factor 6 -0.0443528
RPS14 ribosomal protein S14 -0.0433853
RPL11 ribosomal protein L11 -0.0433408
RPL27A ribosomal protein L27a -0.0432358
YBX1 Y box binding protein 1 -0.0429357
RPS5 ribosomal protein S5 -0.042557
RPL12 ribosomal protein L12 -0.0420417
RPS8 ribosomal protein S8 -0.0414911
HMGA1 high mobility group AT-hook 1 -0.0413454
SDK1 sidekick cell adhesion molecule 1 -0.0412647
PFN1 profilin 1 -0.0404643
CD59 CD59 molecule, complement regulatory protein -0.0394938
ZNF292 zinc finger protein 292 -0.0394935
SBF2 SET binding factor 2 -0.038846
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0382676
RTN4 reticulon 4 -0.0376576
TRIO trio Rho guanine nucleotide exchange factor -0.0375881
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0368987
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0360272
LOC112694756 uncharaterized LOC112694756 -0.0358361
TPT1 tumor protein, translationally-controlled 1 -0.0351457
KTN1 kinectin 1 (kinesin receptor) -0.0348491
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0333011
CARD18 caspase recruitment domain family, member 18 -0.0327458
DLG1 discs, large homolog 1 (Drosophila) -0.0326677
RHOBTB3 Rho-related BTB domain containing 3 -0.0322874
RAP1B RAP1B, member of RAS oncogene family -0.0322868
BBX bobby sox homolog (Drosophila) -0.0322523
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0321784
WASF2 WAS protein family, member 2 -0.0319833
S100A9 S100 calcium binding protein A9 -0.0318652
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0314865
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0311698
ACTG1 actin gamma 1 -0.0311296
FRMD5 FERM domain containing 5 -0.0310845
RPS21 ribosomal protein S21 -0.0310054
RPL8 ribosomal protein L8 -0.0307323
RPS23 ribosomal protein S23 -0.0303498
RPL36 ribosomal protein L36 -0.0298481
TSC22D2 TSC22 domain family, member 2 -0.029846
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0297227
UGCG UDP-glucose ceramide glucosyltransferase -0.0296084
RPL36A ribosomal protein L36a -0.0291774
RPS13 ribosomal protein S13 -0.028933
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0289028
SERF2 small EDRK-rich factor 2 -0.0287547
RPL37A ribosomal protein L37a -0.0284989
SNX14 sorting nexin 14 -0.0282278
RACK1 receptor for activated C kinase 1 -0.0280638
DEK DEK proto-oncogene -0.028007
HLA-B major histocompatibility complex, class I, B -0.0276427
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0275333
LDHA lactate dehydrogenase A -0.0274744
ATP5F1E ATP synthase F1 subunit epsilon -0.0273088
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0270957
C15ORF48 chromosome 15 open reading frame 48 -0.026961
RAB7A RAB7A, member RAS oncogene family -0.0267955
RPL32 ribosomal protein L32 -0.0263458
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0262775
RPL31 ribosomal protein L31 -0.0260359
RPL34 ribosomal protein L34 -0.0259855
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0258541
ANGPTL4 angiopoietin-like 4 -0.0257
NF1 neurofibromin 1 -0.0256878
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0253779