Ouabain (Octahydrate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNIP thioredoxin interacting protein 0.167177
THBS1 thrombospondin 1 0.106488
BIRC3 baculoviral IAP repeat containing 3 0.0868561
ZFAND3 zinc finger, AN1-type domain 3 0.0867657
JMJD1C jumonji domain containing 1C 0.0727774
RBM39 RNA binding motif protein 39 0.0667979
RASAL2 RAS protein activator like 2 0.0621077
CCNL1 cyclin L1 0.0598096
ARRDC3 arrestin domain containing 3 0.0581996
TSC22D2 TSC22 domain family, member 2 0.0558478
SQSTM1 sequestosome 1 0.0552343
MYO6 myosin VI 0.0507638
NIPBL Nipped-B homolog (Drosophila) 0.048182
EPS8 epidermal growth factor receptor pathway substrate 8 0.046318
MED13 mediator complex subunit 13 0.0451189
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0449283
SPAG9 sperm associated antigen 9 0.0448181
IL6ST interleukin 6 signal transducer 0.0447288
FRMD6 FERM domain containing 6 0.043522
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0426656
ARHGAP26 Rho GTPase activating protein 26 0.0426606
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0424134
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.041948
CXCL8 chemokine (C-X-C motif) ligand 8 0.0409484
LOC102724023 ES1 protein homolog, mitochondrial 0.0405045
ECT2 epithelial cell transforming 2 0.040204
SDC4 syndecan 4 0.0385621
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0383516
JUN jun proto-oncogene 0.0381428
ATP13A3 ATPase type 13A3 0.038079
ZC3H11A zinc finger CCCH-type containing 11A 0.0375678
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0375337
OGA O-GlcNAcase 0.0372956
AFF4 AF4/FMR2 family, member 4 0.0360129
TRIO trio Rho guanine nucleotide exchange factor 0.0358126
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0352003
WAC WW domain containing adaptor with coiled-coil 0.0346873
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0345046
MACC1 metastasis associated in colon cancer 1 0.0338944
SIK3 SIK family kinase 3 0.0337903
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0331615
ELL2 elongation factor, RNA polymerase II, 2 0.0326751
NF1 neurofibromin 1 0.0320712
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0319524
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0319321
TOP1 topoisomerase (DNA) I 0.0318418
ERRFI1 ERBB receptor feedback inhibitor 1 0.031692
RUNX1 runt-related transcription factor 1 0.0316391
SENP6 SUMO1/sentrin specific peptidase 6 0.0314829
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0314221
KIF18A kinesin family member 18A 0.0312143
DLG1 discs, large homolog 1 (Drosophila) 0.0311327
ATF3 activating transcription factor 3 0.0308739
PLK2 polo-like kinase 2 0.0306233
ARHGAP29 Rho GTPase activating protein 29 0.0305686
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.029934
DSCAM Down syndrome cell adhesion molecule 0.02967
ANLN anillin, actin binding protein 0.0296202
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0294113
NCEH1 neutral cholesterol ester hydrolase 1 0.0290264
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0288292
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0288
DIAPH3 diaphanous-related formin 3 0.0283996
LATS2 large tumor suppressor kinase 2 0.027988
SMAD3 SMAD family member 3 0.0274459
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.027222
CHD1 chromodomain helicase DNA binding protein 1 0.0268012
TJP1 tight junction protein 1 0.0267066
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.02664
AREG amphiregulin 0.0265631
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.026168
ARRDC4 arrestin domain containing 4 0.0261612
KDM6A lysine (K)-specific demethylase 6A 0.0260487
USP9X ubiquitin specific peptidase 9, X-linked 0.0259514
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0257906
UGCG UDP-glucose ceramide glucosyltransferase 0.0257443
PICALM phosphatidylinositol binding clathrin assembly protein 0.0256571
SMC4 structural maintenance of chromosomes 4 0.0256262
PUM2 pumilio RNA-binding family member 2 0.0255814
FRMD5 FERM domain containing 5 0.025133
PTK2 protein tyrosine kinase 2 0.0250802
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.025006
CRY1 cryptochrome circadian clock 1 0.0249459
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0247019
NCKAP1 NCK-associated protein 1 0.024539
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.0244284
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0243816
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0243669
MARCHF6 membrane associated ring-CH-type finger 6 0.0240355
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0239569
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.023932
SFPQ splicing factor proline/glutamine-rich 0.0238092
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0237468
LIMA1 LIM domain and actin binding 1 0.0237023
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0236723
ERBIN erbb2 interacting protein 0.023467
SHROOM3 shroom family member 3 0.0234345
FAF1 Fas (TNFRSF6) associated factor 1 0.0233112
MATR3 matrin 3 0.0232883
RLF rearranged L-myc fusion 0.0232809

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0881181
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0839133
RPS6 ribosomal protein S6 -0.0739048
HMGA1 high mobility group AT-hook 1 -0.0657578
LMO7 LIM domain 7 -0.0621104
TMSB10 thymosin beta 10 -0.0562986
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0521643
RPL23 ribosomal protein L23 -0.0515653
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0484408
RPS8 ribosomal protein S8 -0.0460164
CD44 CD44 molecule (Indian blood group) -0.0445007
ANXA2 annexin A2 -0.0430985
LAMB3 laminin, beta 3 -0.0420105
RPS3 ribosomal protein S3 -0.0419968
ASPH aspartate beta-hydroxylase -0.0414206
RPL35A ribosomal protein L35a -0.0413092
TPM4 tropomyosin 4 -0.0398079
G0S2 G0/G1 switch 2 -0.0389896
TPT1 tumor protein, translationally-controlled 1 -0.0389301
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0380484
RPS19 ribosomal protein S19 -0.0372173
RPS13 ribosomal protein S13 -0.0369371
EGFR epidermal growth factor receptor -0.0361667
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0358787
IL1RAP interleukin 1 receptor accessory protein -0.0350778
RPS27A ribosomal protein S27a -0.0347379
FLNB filamin B, beta -0.0335197
RPLP1 ribosomal protein, large, P1 -0.0334025
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.033315
BACE2 beta-site APP-cleaving enzyme 2 -0.03282
MBNL2 muscleblind-like splicing regulator 2 -0.0327822
S100A10 S100 calcium binding protein A10 -0.0323124
FN1 fibronectin 1 -0.0320774
S100A6 S100 calcium binding protein A6 -0.0320682
RNF213 ring finger protein 213 -0.031824
NDRG1 N-myc downstream regulated 1 -0.0318111
RPL34 ribosomal protein L34 -0.0315142
VIM vimentin -0.0308732
RPL37A ribosomal protein L37a -0.0305072
RPS29 ribosomal protein S29 -0.030204
RAD51B RAD51 paralog B -0.0300867
NAV2 neuron navigator 2 -0.0300047
PLSCR1 phospholipid scramblase 1 -0.0297183
SLC35F3 solute carrier family 35, member F3 -0.0296931
SMYD3 SET and MYND domain containing 3 -0.0295287
MUC4 mucin 4, cell surface associated -0.0292611
FTL ferritin, light polypeptide -0.0292121
SVIL supervillin -0.0290021
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.028911
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0286712
RPLP2 ribosomal protein, large, P2 -0.0282489
FNDC3B fibronectin type III domain containing 3B -0.027929
RPL36 ribosomal protein L36 -0.0273868
SEPTIN9 septin 9 -0.027187
CAPN2 calpain 2, (m/II) large subunit -0.0269468
OSMR oncostatin M receptor -0.0266586
YBX3 Y box binding protein 3 -0.0264949
INTS6 integrator complex subunit 6 -0.0264112
F3 coagulation factor III (thromboplastin, tissue factor) -0.0264066
RPL28 ribosomal protein L28 -0.0262978
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0262616
ETV6 ets variant 6 -0.0261907
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0261429
EIF1 eukaryotic translation initiation factor 1 -0.0260551
EHBP1 EH domain binding protein 1 -0.0260485
RPS12 ribosomal protein S12 -0.0256308
BMAL2 basic helix-loop-helix ARNT like 2 -0.025433
CDCP1 CUB domain containing protein 1 -0.0249342
RPS25 ribosomal protein S25 -0.0248749
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0248613
RACK1 receptor for activated C kinase 1 -0.0245259
RPL26 ribosomal protein L26 -0.0245006
S100A11 S100 calcium binding protein A11 -0.0244182
RPL37 ribosomal protein L37 -0.0233359
B2M beta-2-microglobulin -0.0229672
CD59 CD59 molecule, complement regulatory protein -0.0224365
HMGA2 high mobility group AT-hook 2 -0.0222788
RPL19 ribosomal protein L19 -0.0221834
RPL8 ribosomal protein L8 -0.021926
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0218862
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.021729
RPS15 ribosomal protein S15 -0.0213082
DSG2 desmoglein 2 -0.0210365
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0209923
RPL35 ribosomal protein L35 -0.020837
RPS23 ribosomal protein S23 -0.0207453
DIAPH2 diaphanous-related formin 2 -0.0205782
EFNA5 ephrin-A5 -0.0205689
PA2G4 proliferation-associated 2G4, 38kDa -0.0204832
MT2A metallothionein 2A -0.0203884
RPL27 ribosomal protein L27 -0.0203129
RPL31 ribosomal protein L31 -0.0203013
FOXO3 forkhead box O3 -0.020232
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0202236
FMNL2 formin-like 2 -0.0202009
IGFBP3 insulin-like growth factor binding protein 3 -0.0201849
IFI27 interferon, alpha-inducible protein 27 -0.0201235
RPS24 ribosomal protein S24 -0.0199598
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0198208
C6ORF132 chromosome 6 open reading frame 132 -0.0197782