Ouabain (Octahydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0801662
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0765358
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0499258
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.042513
IARS1 isoleucyl-tRNA synthetase 1 0.0356916
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0341859
ATP13A3 ATPase type 13A3 0.0320038
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0316658
RTN4 reticulon 4 0.0288866
TPD52 tumor protein D52 0.0281345
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0280973
CAPRIN2 caprin family member 2 0.0274211
ZEB1 zinc finger E-box binding homeobox 1 0.0264763
SPRED2 sprouty-related, EVH1 domain containing 2 0.0262155
NAMPT nicotinamide phosphoribosyltransferase 0.0254959
USP3 ubiquitin specific peptidase 3 0.025266
BIRC2 baculoviral IAP repeat containing 2 0.024646
MAST4 microtubule associated serine/threonine kinase family member 4 0.0244914
UPP1 uridine phosphorylase 1 0.0244626
JMJD1C jumonji domain containing 1C 0.02414
EMP1 epithelial membrane protein 1 0.0238984
RAD21 RAD21 homolog (S. pombe) 0.0235161
MAPK8 mitogen-activated protein kinase 8 0.0230971
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0225729
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0223784
ADAM17 ADAM metallopeptidase domain 17 0.0219027
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0211502
RASA2 RAS p21 protein activator 2 0.020892
UBA6 ubiquitin-like modifier activating enzyme 6 0.0205599
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0203966
NCKAP1 NCK-associated protein 1 0.0198693
KDM6A lysine (K)-specific demethylase 6A 0.0186035
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0184915
ABI1 abl-interactor 1 0.0184812
CKAP5 cytoskeleton associated protein 5 0.0180805
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0179982
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0178503
OXR1 oxidation resistance 1 0.0167463
SUCO SUN domain containing ossification factor 0.0167411
NEK7 NIMA-related kinase 7 0.01672
CCNL1 cyclin L1 0.0164454
MCL1 myeloid cell leukemia 1 0.0163828
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0163791
CDCP1 CUB domain containing protein 1 0.0156696
NKTR natural killer cell triggering receptor 0.0156303
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0155418
FAM91A1 family with sequence similarity 91, member A1 0.0152336
TPR translocated promoter region, nuclear basket protein 0.0152098
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0150296
BRD2 bromodomain containing 2 0.0147948
SNX9 sorting nexin 9 0.0147324
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0147126
CENPC centromere protein C 0.0146948
CDK17 cyclin-dependent kinase 17 0.0139772
ADAM9 ADAM metallopeptidase domain 9 0.0139234
MTMR3 myotubularin related protein 3 0.0139157
C2CD2 C2 calcium-dependent domain containing 2 0.0136599
RLF rearranged L-myc fusion 0.0134835
CCNY cyclin Y 0.0134697
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0134066
GARS1 glycyl-tRNA synthetase 1 0.0133767
COPA coatomer protein complex, subunit alpha 0.013329
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0132008
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0131249
RNF145 ring finger protein 145 0.0127884
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.012787
KDM5C lysine (K)-specific demethylase 5C 0.0127026
NCOR1 nuclear receptor corepressor 1 0.012682
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0126521
NUP153 nucleoporin 153kDa 0.0124295
RIPK2 receptor-interacting serine-threonine kinase 2 0.0124199
MARCHF6 membrane associated ring-CH-type finger 6 0.0123601
EIF4A1 eukaryotic translation initiation factor 4A1 0.012303
CTTNBP2NL CTTNBP2 N-terminal like 0.0122403
ELL2 elongation factor, RNA polymerase II, 2 0.0121706
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0121496
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0121349
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 0.0120863
USP9X ubiquitin specific peptidase 9, X-linked 0.0120372
FOXJ3 forkhead box J3 0.0119813
NUP58 nucleoporin 58 0.0118143
SCAF8 SR-related CTD-associated factor 8 0.0115831
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0115728
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0114966
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.01148
RSRC1 arginine/serine-rich coiled-coil 1 0.0114726
OTUD4 OTU deubiquitinase 4 0.0114505
USP24 ubiquitin specific peptidase 24 0.0114179
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0114147
PTBP2 polypyrimidine tract binding protein 2 0.0113376
MTMR2 myotubularin related protein 2 0.011288
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0112609
AFDN afadin, adherens junction formation factor 0.0112598
PDS5B PDS5 cohesin associated factor B 0.011135
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.011086
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0110412
TOP2B topoisomerase (DNA) II beta 180kDa 0.0109876
TLN1 talin 1 0.0109745
GLRX glutaredoxin (thioltransferase) 0.0109686
ECT2 epithelial cell transforming 2 0.0109472

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.127033
ZNF438 zinc finger protein 438 -0.126697
HDAC9 histone deacetylase 9 -0.114927
DLC1 DLC1 Rho GTPase activating protein -0.113923
RPS6 ribosomal protein S6 -0.109114
FRMD6 FERM domain containing 6 -0.0979861
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0911705
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0864903
HMGA2 high mobility group AT-hook 2 -0.0799375
RPLP2 ribosomal protein, large, P2 -0.0670737
PTMA prothymosin, alpha -0.0650113
LPP LIM domain containing preferred translocation partner in lipoma -0.0647253
PBX3 pre-B-cell leukemia homeobox 3 -0.0595404
MT2A metallothionein 2A -0.0592702
FRMD4A FERM domain containing 4A -0.0590391
RPS19 ribosomal protein S19 -0.0550902
TPT1 tumor protein, translationally-controlled 1 -0.0535401
SLC38A2 solute carrier family 38, member 2 -0.0521657
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0500155
NAP1L1 nucleosome assembly protein 1-like 1 -0.0496795
FLNB filamin B, beta -0.048519
RPS12 ribosomal protein S12 -0.0484743
TTR transthyretin -0.0478161
PCNX4 pecanex 4 -0.0477903
NABP1 nucleic acid binding protein 1 -0.0466863
RPL35A ribosomal protein L35a -0.0464706
RPL37A ribosomal protein L37a -0.0463913
RPS3 ribosomal protein S3 -0.0456802
NAV3 neuron navigator 3 -0.0456182
BNC2 basonuclin 2 -0.0447503
RAD51B RAD51 paralog B -0.0445635
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0431187
RPL8 ribosomal protein L8 -0.042478
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0417943
RPLP1 ribosomal protein, large, P1 -0.0409668
RPS8 ribosomal protein S8 -0.0399532
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.03928
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.039104
TMSB10 thymosin beta 10 -0.038652
IFI16 interferon, gamma-inducible protein 16 -0.0379211
NAV2 neuron navigator 2 -0.0378282
RPL23 ribosomal protein L23 -0.0377648
RPL7A ribosomal protein L7a -0.0373426
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0371775
ASPH aspartate beta-hydroxylase -0.0368029
CALD1 caldesmon 1 -0.035703
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0354572
EIF3A eukaryotic translation initiation factor 3, subunit A -0.035228
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0349527
MTAP methylthioadenosine phosphorylase -0.0348577
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0347896
RPS27A ribosomal protein S27a -0.0342498
ARHGAP22 Rho GTPase activating protein 22 -0.0341238
DENND1A DENN/MADD domain containing 1A -0.0340953
RPS29 ribosomal protein S29 -0.0333461
CUX1 cut-like homeobox 1 -0.0332517
RPL34 ribosomal protein L34 -0.0329853
TPM4 tropomyosin 4 -0.0329569
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329502
SAMD4A sterile alpha motif domain containing 4A -0.0329268
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.031444
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0314393
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0312871
DGKI diacylglycerol kinase, iota -0.0310237
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0309224
RPL9 ribosomal protein L9 -0.0308943
RPL26 ribosomal protein L26 -0.0306379
RPL7 ribosomal protein L7 -0.0300888
S100A9 S100 calcium binding protein A9 -0.0298952
ZBTB20 zinc finger and BTB domain containing 20 -0.0297838
RPS25 ribosomal protein S25 -0.0297231
EIF1 eukaryotic translation initiation factor 1 -0.0292292
RPS24 ribosomal protein S24 -0.0291171
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0289641
ALCAM activated leukocyte cell adhesion molecule -0.0288317
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0286274
RPL35 ribosomal protein L35 -0.0279177
SET SET nuclear proto-oncogene -0.0276552
MKI67 marker of proliferation Ki-67 -0.0276437
RPL12 ribosomal protein L12 -0.0272441
RPS21 ribosomal protein S21 -0.0271576
YBX1 Y box binding protein 1 -0.0268367
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0268243
RPL30 ribosomal protein L30 -0.0267635
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0263214
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.026273
RPS16 ribosomal protein S16 -0.0261934
SQSTM1 sequestosome 1 -0.0260934
RPS2 ribosomal protein S2 -0.025924
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0258217
TRIO trio Rho guanine nucleotide exchange factor -0.0257701
SON SON DNA binding protein -0.0256456
ENO1 enolase 1, (alpha) -0.0253302
RPL37 ribosomal protein L37 -0.0250835
RPS5 ribosomal protein S5 -0.0248183
EXT1 exostosin glycosyltransferase 1 -0.024709
CAVIN1 caveolae associated protein 1 -0.0245514
RPS13 ribosomal protein S13 -0.0245129
SRRM2 serine/arginine repetitive matrix 2 -0.0243657
EXOC4 exocyst complex component 4 -0.0243325