Ouabain (Octahydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ouabain (Octahydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ouabain (Octahydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.121371
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0826697
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0624553
RASAL2 RAS protein activator like 2 0.0576024
SLC39A11 solute carrier family 39, member 11 0.0519034
FMN1 formin 1 0.047918
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0436
TXNRD1 thioredoxin reductase 1 0.0375468
EXT1 exostosin glycosyltransferase 1 0.0362855
CD44 CD44 molecule (Indian blood group) 0.0360771
LAMP2 lysosomal-associated membrane protein 2 0.0359722
ATP13A3 ATPase type 13A3 0.0355049
TFPI2 tissue factor pathway inhibitor 2 0.0338795
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0330554
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0322757
FRMD5 FERM domain containing 5 0.0309979
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0304006
CHD1 chromodomain helicase DNA binding protein 1 0.0298668
TSC22D2 TSC22 domain family, member 2 0.0288493
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0276375
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0276225
PEX5L peroxisomal biogenesis factor 5-like 0.0274412
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0272372
TM4SF1 transmembrane 4 L six family member 1 0.0271438
HMGA2 high mobility group AT-hook 2 0.0259522
GPHN gephyrin 0.0258116
ANKRD28 ankyrin repeat domain 28 0.0255071
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0253926
GLS2 glutaminase 2 (liver, mitochondrial) 0.0253915
NAV2 neuron navigator 2 0.0252522
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0251615
SPAG9 sperm associated antigen 9 0.0245767
SOD2 superoxide dismutase 2, mitochondrial 0.0245435
FSTL5 follistatin-like 5 0.0244692
FNIP1 folliculin interacting protein 1 0.0231341
ZFAND3 zinc finger, AN1-type domain 3 0.0226626
PTPRG protein tyrosine phosphatase, receptor type, G 0.0226311
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0223111
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0218289
CCNL1 cyclin L1 0.0218087
TUSC3 tumor suppressor candidate 3 0.0203697
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0198136
ANXA5 annexin A5 0.0196267
PUM3 pumilio RNA binding family member 3 0.0192032
MBNL1 muscleblind-like splicing regulator 1 0.0189599
CAMTA1 calmodulin binding transcription activator 1 0.0187582
ANLN anillin, actin binding protein 0.0187277
SMAD3 SMAD family member 3 0.0186267
CORO1C coronin, actin binding protein, 1C 0.0183881
EP300 E1A binding protein p300 0.0182609
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0181617
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0180995
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0180983
ALCAM activated leukocyte cell adhesion molecule 0.0179404
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0177373
PCLO piccolo presynaptic cytomatrix protein 0.0177246
COG5 component of oligomeric golgi complex 5 0.0176124
PUM2 pumilio RNA-binding family member 2 0.0173473
WDR43 WD repeat domain 43 0.0173456
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0173072
EPS8 epidermal growth factor receptor pathway substrate 8 0.0172789
VMP1 vacuole membrane protein 1 0.0171565
TRIQK triple QxxK/R motif containing 0.0171207
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0170472
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0170374
NOTCH2 notch 2 0.0167266
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.016682
CLTC clathrin, heavy chain (Hc) 0.0166723
RBM39 RNA binding motif protein 39 0.0161934
KYNU kynureninase 0.0161734
WDR36 WD repeat domain 36 0.0158538
ERBIN erbb2 interacting protein 0.0157776
MSN moesin 0.0157619
COMMD10 COMM domain containing 10 0.0156826
ECT2 epithelial cell transforming 2 0.0156546
LSAMP limbic system-associated membrane protein 0.0155597
NAMPT nicotinamide phosphoribosyltransferase 0.0153601
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0152749
CLINT1 clathrin interactor 1 0.0151945
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0151882
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0151458
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0151296
TASOR2 transcription activation suppressor family member 2 0.015103
LCORL ligand dependent nuclear receptor corepressor-like 0.0148846
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0147264
TRIO trio Rho guanine nucleotide exchange factor 0.0145881
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0145481
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0145362
NPC1 Niemann-Pick disease, type C1 0.0145264
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0144596
GOLGA4 golgin A4 0.0144092
ZEB2 zinc finger E-box binding homeobox 2 0.0142989
CENPF centromere protein F, 350/400kDa 0.0142569
PKP4 plakophilin 4 0.0142408
CRY1 cryptochrome circadian clock 1 0.0141969
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0141405
TCERG1 transcription elongation regulator 1 0.0141096
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0139774
ANXA2 annexin A2 0.0138989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.013881

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.0636011
VIM vimentin -0.0578922
FN1 fibronectin 1 -0.0575133
AKAP12 A kinase (PRKA) anchor protein 12 -0.0511918
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.045532
RAD51B RAD51 paralog B -0.0429386
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.041373
RPS3 ribosomal protein S3 -0.0394306
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0383426
FTL ferritin, light polypeptide -0.0378276
TMSB10 thymosin beta 10 -0.0372015
RPL35A ribosomal protein L35a -0.0365847
NRG3 neuregulin 3 -0.030476
MT2A metallothionein 2A -0.0301487
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0295246
IFI6 interferon, alpha-inducible protein 6 -0.029106
PTMA prothymosin, alpha -0.0283783
RPL23 ribosomal protein L23 -0.0273324
ZBTB20 zinc finger and BTB domain containing 20 -0.026843
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0254916
RPLP1 ribosomal protein, large, P1 -0.0254267
RPS8 ribosomal protein S8 -0.025139
FHIT fragile histidine triad -0.0240734
RPL11 ribosomal protein L11 -0.0234048
ACTG1 actin gamma 1 -0.022788
RPL31 ribosomal protein L31 -0.0221336
FNDC3B fibronectin type III domain containing 3B -0.0217204
MAML3 mastermind-like 3 (Drosophila) -0.0208721
RNF213 ring finger protein 213 -0.0208116
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0207874
ZMYND8 zinc finger, MYND-type containing 8 -0.020668
RPS12 ribosomal protein S12 -0.0195846
FLNB filamin B, beta -0.0195832
PGK1 phosphoglycerate kinase 1 -0.0193436
RPL34 ribosomal protein L34 -0.0189997
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0187309
TPT1 tumor protein, translationally-controlled 1 -0.0187179
RPLP2 ribosomal protein, large, P2 -0.0183631
RPL37A ribosomal protein L37a -0.0183468
NDRG1 N-myc downstream regulated 1 -0.0182705
RPS23 ribosomal protein S23 -0.0181647
IGF1R insulin-like growth factor 1 receptor -0.018157
RPS14 ribosomal protein S14 -0.0180189
MACROD2 MACRO domain containing 2 -0.0177106
B2M beta-2-microglobulin -0.0176102
HLA-B major histocompatibility complex, class I, B -0.0174647
VDAC1 voltage-dependent anion channel 1 -0.0170312
IGFBP3 insulin-like growth factor binding protein 3 -0.0167276
RPL38 ribosomal protein L38 -0.016657
CFAP20DC CFAP20 domain containing -0.0164777
RPS29 ribosomal protein S29 -0.0163772
RPS6 ribosomal protein S6 -0.0163498
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0163414
CNKSR3 CNKSR family member 3 -0.0162848
CADM1 cell adhesion molecule 1 -0.0160464
RPS13 ribosomal protein S13 -0.0160382
RPS27A ribosomal protein S27a -0.0156658
PRAME preferentially expressed antigen in melanoma -0.0156162
ANGPTL4 angiopoietin-like 4 -0.0155804
ENO2 enolase 2 (gamma, neuronal) -0.0154464
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0154166
RPS21 ribosomal protein S21 -0.0153302
S100A9 S100 calcium binding protein A9 -0.0150425
RPL19 ribosomal protein L19 -0.0149712
TPI1 triosephosphate isomerase 1 -0.0147384
RPS24 ribosomal protein S24 -0.0146046
RPL36 ribosomal protein L36 -0.0145297
SP100 SP100 nuclear antigen -0.0144482
RRBP1 ribosome binding protein 1 -0.0142914
HMGA1 high mobility group AT-hook 1 -0.0142707
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0141773
BBX bobby sox homolog (Drosophila) -0.013856
FOXP1 forkhead box P1 -0.0138376
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0136452
CYB5R3 cytochrome b5 reductase 3 -0.0135445
RPL36A ribosomal protein L36a -0.0133622
RPL28 ribosomal protein L28 -0.0132177
RPS16 ribosomal protein S16 -0.0131664
RPS19 ribosomal protein S19 -0.0130213
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0129973
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0129697
RPS17 ribosomal protein S17 -0.0128754
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.012856
RACK1 receptor for activated C kinase 1 -0.0126431
RPL12 ribosomal protein L12 -0.0125192
LOC112694756 uncharaterized LOC112694756 -0.0125131
WWOX WW domain containing oxidoreductase -0.0124783
EXOC4 exocyst complex component 4 -0.0124318
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0123866
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0122737
RPS4X ribosomal protein S4, X-linked -0.0120526
CTSD cathepsin D -0.0119898
SQSTM1 sequestosome 1 -0.0118034
LRMDA leucine rich melanocyte differentiation associated -0.0117361
PHF21A PHD finger protein 21A -0.0117229
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0116937
SOX10 SRY (sex determining region Y)-box 10 -0.0113648
RPL27 ribosomal protein L27 -0.0112273
RPS25 ribosomal protein S25 -0.0111914
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -0.0109787